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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoliquiritigenin
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Accession:CHEBI:310312 term browser browse the term
Definition:A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.
Synonyms:exact_synonym: (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
 related_synonym: (E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone;   (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one;   2',4,4'-Trihydroxychalcone;   Formula=C15H12O4;   InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+;   InChIKey=DXDRHHKMWQZJHT-FPYGCLRLSA-N;   SMILES=Oc1ccc(cc1)\\C=C\\C(=O)c1ccc(O)cc1O;   trans-2',4,4'-trihydroxychalcone
 alt_id: CHEBI:43173;   CHEBI:6022
 xref: Beilstein:1914296;   CAS:961-29-5;   KEGG:C08650;   KNApSAcK:C00006925;   LIPID_MAPS_instance:LMPK12120096
 xref_mesh: MESH:C040920
 xref: MetaCyc:CPD-3041;   PDBeChem:HCC;   PMID:11501051;   PMID:11853176;   PMID:14510590;   PMID:14640516;   PMID:15878356;   PMID:19067384;   PMID:20146476;   PMID:21158449;   PMID:21691759;   PMID:21720042;   PMID:21815175;   PMID:21866899;   PMID:21945440;   PMID:22076338;   Patent:CN101524341;   Patent:CN102247339;   Reaxys:1914296;   Wikipedia:Isoliquiritigenin
 cyclic_relationship: is_conjugate_acid_of CHEBI:77948


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isoliquiritigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP isoliquiritigenin binds to AFP protein CTD PMID:23013281 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein] CTD PMID:25110319 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases response to substance
multiple interactions
decreases phosphorylation
ISO AKT1 protein modified form results in decreased susceptibility to isoliquiritigenin
isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]
isoliquiritigenin results in decreased phosphorylation of AKT1 protein
CTD PMID:23747687 PMID:25094029 PMID:27117918 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Arg1 arginase 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 protein] CTD PMID:25026504 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO isoliquiritigenin results in increased expression of BAX mRNA; isoliquiritigenin results in increased expression of BAX protein CTD PMID:11055382 PMID:27702603 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases phosphorylation ISO isoliquiritigenin results in decreased phosphorylation of BCL2 protein CTD PMID:23747687 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
decreases phosphorylation
ISO isoliquiritigenin results in decreased expression of BCL2L1 protein
isoliquiritigenin results in decreased phosphorylation of BCL2L1 protein
CTD PMID:11055382 PMID:15729620 PMID:23747687 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO isoliquiritigenin results in decreased expression of BIRC2 protein CTD PMID:15729620 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO isoliquiritigenin results in decreased expression of BIRC3 protein CTD PMID:15729620 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP3 protein
isoliquiritigenin results in increased activity of CASP3 protein
CTD PMID:15729620 PMID:16158945 PMID:23747687 PMID:25094029 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO isoliquiritigenin results in increased activity of CASP8 protein CTD PMID:16158945 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage
ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP9 protein
isoliquiritigenin results in increased activity of CASP9 protein
CTD PMID:16158945 PMID:23747687 PMID:25094029 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:25450236 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cckar cholecystokinin A receptor multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA] CTD PMID:27702603 NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO isoliquiritigenin results in decreased expression of CCND2 mRNA CTD PMID:27702603 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO isoliquiritigenin results in decreased expression of CCNE2 mRNA CTD PMID:27702603 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO isoliquiritigenin results in increased expression of CDKN1A mRNA; isoliquiritigenin results in increased expression of CDKN1A protein CTD PMID:27702603 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO isoliquiritigenin results in decreased expression of CDKN1B mRNA CTD PMID:27702603 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO isoliquiritigenin results in decreased expression of CDKN1C mRNA CTD PMID:27702603 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein] CTD PMID:27117918 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of CHUK protein] CTD PMID:18295200 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CXCL10 mRNA] CTD PMID:25026504 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO isoliquiritigenin results in decreased expression of CYP17A1 mRNA CTD PMID:27773742 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO isoliquiritigenin results in decreased expression of CYP19A1 mRNA CTD PMID:27773742 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:25110319 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
isoliquiritigenin results in decreased activity of CYP1A2 protein
CTD PMID:25110319 PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
isoliquiritigenin results in increased expression of CYP1B1 mRNA
CTD PMID:25110319 PMID:26134484 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity ISO isoliquiritigenin results in decreased activity of CYP2C9 protein CTD PMID:29753067 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO isoliquiritigenin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein] CTD PMID:25450236 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO isoliquiritigenin results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein] CTD PMID:27117918 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Gadd45gip1 GADD45G interacting protein 1 increases expression ISO isoliquiritigenin results in increased expression of GADD45GIP1 mRNA CTD PMID:27702603 NCBI chr19:23,320,662...23,323,211
Ensembl chr19:23,320,159...23,323,236
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of GFAP protein] CTD PMID:19834288 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoliquiritigenin results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression ISO isoliquiritigenin results in decreased expression of HSD17B1 mRNA CTD PMID:27773742 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Ifng interferon gamma multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]
CTD PMID:23942037 PMID:25026504 PMID:26134484 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL10 protein] CTD PMID:25026504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein] CTD PMID:25026504 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il6 interleukin 6 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] CTD PMID:18295200 PMID:25026504 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] CTD PMID:27117918 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Itgam integrin subunit alpha M multiple interactions
increases expression
ISO TEMPOL-H inhibits the reaction [isoliquiritigenin results in increased expression of ITGAM protein] CTD PMID:24369695 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:18295200 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:18295200 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO isoliquiritigenin results in decreased expression of MKI67 mRNA; isoliquiritigenin results in decreased expression of MKI67 protein CTD PMID:27702603 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]
isoliquiritigenin results in decreased expression of MMP2 mRNA; isoliquiritigenin results in decreased expression of MMP2 protein
CTD PMID:25094029 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]
isoliquiritigenin results in decreased expression of MMP9 mRNA; isoliquiritigenin results in decreased expression of MMP9 protein
CTD PMID:25094029 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein] CTD PMID:25026504 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of NFKB1 protein] CTD PMID:18295200 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
decreases phosphorylation
ISO isoliquiritigenin results in increased expression of NFKBIA protein
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
isoliquiritigenin results in decreased phosphorylation of NFKBIA protein
CTD PMID:15729620 PMID:18295200 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of NOS2 protein] CTD PMID:18295200 PMID:19834288 PMID:25026504 PMID:26134484 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO isoliquiritigenin results in increased expression of NQO1 protein CTD PMID:26473469 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression
ISO isoliquiritigenin results in increased activity of NR1I2 protein
isoliquiritigenin results in increased expression of NR1I2 mRNA
CTD PMID:29933105 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO isoliquiritigenin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of PARP1 protein]
CTD PMID:23747687 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases phosphorylation ISO isoliquiritigenin results in decreased phosphorylation of PDK1 protein CTD PMID:25094029 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression ISO isoliquiritigenin results in decreased expression of PLA2G5 mRNA CTD PMID:23747687 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein] CTD PMID:27117918 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO isoliquiritigenin results in decreased expression of PTGER4 mRNA; isoliquiritigenin results in decreased expression of PTGER4 protein CTD PMID:25094029 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO isoliquiritigenin results in decreased expression of PTGS1 mRNA CTD PMID:25094029 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO
EXP
isoliquiritigenin results in decreased expression of PTGS2 mRNA
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
CTD PMID:18295200 PMID:23747687 PMID:25026504 PMID:25450236 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein] CTD PMID:27117918 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
decreases activity
ISO isoliquiritigenin affects the localization of RELA protein
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]
isoliquiritigenin results in decreased activity of RELA protein
CTD PMID:15729620 PMID:18295200 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity
ISO isoliquiritigenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
isoliquiritigenin results in decreased activity of SLC2A1 protein
CTD PMID:14642735 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein] CTD PMID:27117918 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO isoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] CTD PMID:19834288 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases activity
EXP [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate CTD PMID:32259555 NCBI chr 4:174,877,045...174,950,857
Ensembl chr 4:174,876,593...174,950,873
JBrowse link
G Sod2 superoxide dismutase 2 affects response to substance ISO SOD2 protein affects the susceptibility to isoliquiritigenin CTD PMID:23526725 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO isoliquiritigenin results in increased expression of STAR mRNA CTD PMID:27773742 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of STAT3 protein] CTD PMID:25026504 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein] CTD PMID:25026504 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TNF protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
CTD PMID:18295200 PMID:25026504 PMID:25450236 PMID:26134484 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO isoliquiritigenin results in increased expression of TRP53 mRNA CTD PMID:27702603 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of isoliquiritigenin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of isoliquiritigenin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            isoliquiritigenin 74
              2'-O-methylisoliquiritigenin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        alpha,beta-unsaturated ketone 9265
                                          enone 9265
                                            chalcones 902
                                              chalcone 104
                                                trans-chalcone 104
                                                  isoliquiritigenin 74
                                                    2'-O-methylisoliquiritigenin 0
paths to the root