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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
isoliquiritigenin binds to AFP protein |
CTD |
PMID:23013281 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein] |
CTD |
PMID:25110319 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases response to substance multiple interactions decreases phosphorylation |
ISO |
AKT1 protein modified form results in decreased susceptibility to isoliquiritigenin isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein] isoliquiritigenin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:23747687 PMID:25094029 PMID:27117918 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Arg1 |
arginase 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 protein] |
CTD |
PMID:25026504 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
isoliquiritigenin results in increased expression of BAX mRNA; isoliquiritigenin results in increased expression of BAX protein |
CTD |
PMID:11055382 PMID:27702603 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases phosphorylation |
ISO |
isoliquiritigenin results in decreased phosphorylation of BCL2 protein |
CTD |
PMID:23747687 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression decreases phosphorylation |
ISO |
isoliquiritigenin results in decreased expression of BCL2L1 protein isoliquiritigenin results in decreased phosphorylation of BCL2L1 protein |
CTD |
PMID:11055382 PMID:15729620 PMID:23747687 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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|
G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of BIRC2 protein |
CTD |
PMID:15729620 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of BIRC3 protein |
CTD |
PMID:15729620 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases cleavage |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP3 protein isoliquiritigenin results in increased activity of CASP3 protein |
CTD |
PMID:15729620 PMID:16158945 PMID:23747687 PMID:25094029 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
isoliquiritigenin results in increased activity of CASP8 protein |
CTD |
PMID:16158945 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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|
G |
Casp9 |
caspase 9 |
multiple interactions increases activity increases cleavage |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP9 protein isoliquiritigenin results in increased activity of CASP9 protein |
CTD |
PMID:16158945 PMID:23747687 PMID:25094029 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] |
CTD |
PMID:25450236 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cckar |
cholecystokinin A receptor |
multiple interactions increases expression |
ISO |
fulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA] |
CTD |
PMID:27702603 |
|
NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747
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G |
Ccnd2 |
cyclin D2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CCND2 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccne2 |
cyclin E2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CCNE2 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
isoliquiritigenin results in increased expression of CDKN1A mRNA; isoliquiritigenin results in increased expression of CDKN1A protein |
CTD |
PMID:27702603 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CDKN1B mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn1c |
cyclin-dependent kinase inhibitor 1C |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CDKN1C mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein] |
CTD |
PMID:27117918 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of CHUK protein] |
CTD |
PMID:18295200 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CXCL10 mRNA] |
CTD |
PMID:25026504 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:27773742 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CYP19A1 mRNA |
CTD |
PMID:27773742 |
|
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:25110319 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions decreases activity |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] isoliquiritigenin results in decreased activity of CYP1A2 protein |
CTD |
PMID:25110319 PMID:29753067 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] isoliquiritigenin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:25110319 PMID:26134484 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
isoliquiritigenin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein] |
CTD |
PMID:25450236 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
isoliquiritigenin results in decreased activity of CYP3A4 protein |
CTD |
PMID:29753067 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein] |
CTD |
PMID:27117918 |
|
NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
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G |
Gadd45gip1 |
GADD45G interacting protein 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of GADD45GIP1 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr19:23,320,662...23,323,211
Ensembl chr19:23,320,159...23,323,236
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of GFAP protein] |
CTD |
PMID:19834288 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of HMOX1 protein |
CTD |
PMID:23942037 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of HSD17B1 mRNA |
CTD |
PMID:27773742 |
|
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites] isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:23942037 PMID:25026504 PMID:26134484 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL10 protein] |
CTD |
PMID:25026504 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein] |
CTD |
PMID:25026504 |
|
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] |
CTD |
PMID:18295200 PMID:25026504 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Insr |
insulin receptor |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] |
CTD |
PMID:27117918 |
|
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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|
G |
Itgam |
integrin subunit alpha M |
multiple interactions increases expression |
ISO |
TEMPOL-H inhibits the reaction [isoliquiritigenin results in increased expression of ITGAM protein] |
CTD |
PMID:24369695 |
|
NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:18295200 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18295200 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of MKI67 mRNA; isoliquiritigenin results in decreased expression of MKI67 protein |
CTD |
PMID:27702603 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein] isoliquiritigenin results in decreased expression of MMP2 mRNA; isoliquiritigenin results in decreased expression of MMP2 protein |
CTD |
PMID:25094029 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein] isoliquiritigenin results in decreased expression of MMP9 mRNA; isoliquiritigenin results in decreased expression of MMP9 protein |
CTD |
PMID:25094029 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mrc1 |
mannose receptor, C type 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein] |
CTD |
PMID:25026504 |
|
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of NFKB1 protein] |
CTD |
PMID:18295200 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression multiple interactions decreases phosphorylation |
ISO |
isoliquiritigenin results in increased expression of NFKBIA protein isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of and results in increased phosphorylation of NFKBIA protein] isoliquiritigenin results in decreased phosphorylation of NFKBIA protein |
CTD |
PMID:15729620 PMID:18295200 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of NOS2 protein] |
CTD |
PMID:18295200 PMID:19834288 PMID:25026504 PMID:26134484 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of NQO1 protein |
CTD |
PMID:26473469 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity increases expression |
ISO |
isoliquiritigenin results in increased activity of NR1I2 protein isoliquiritigenin results in increased expression of NR1I2 mRNA |
CTD |
PMID:29933105 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
isoliquiritigenin results in increased cleavage of PARP1 protein benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of PARP1 protein] |
CTD |
PMID:23747687 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
decreases phosphorylation |
ISO |
isoliquiritigenin results in decreased phosphorylation of PDK1 protein |
CTD |
PMID:25094029 |
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NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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G |
Pla2g5 |
phospholipase A2, group V |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of PLA2G5 mRNA |
CTD |
PMID:23747687 |
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NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein] |
CTD |
PMID:27117918 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptger4 |
prostaglandin E receptor 4 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of PTGER4 mRNA; isoliquiritigenin results in decreased expression of PTGER4 protein |
CTD |
PMID:25094029 |
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NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of PTGS1 mRNA |
CTD |
PMID:25094029 |
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression multiple interactions |
ISO EXP |
isoliquiritigenin results in decreased expression of PTGS2 mRNA isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] |
CTD |
PMID:18295200 PMID:23747687 PMID:25026504 PMID:25450236 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein] |
CTD |
PMID:27117918 |
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NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization multiple interactions decreases activity |
ISO |
isoliquiritigenin affects the localization of RELA protein isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] isoliquiritigenin results in decreased activity of RELA protein |
CTD |
PMID:15729620 PMID:18295200 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions decreases activity |
ISO |
isoliquiritigenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose] isoliquiritigenin results in decreased activity of SLC2A1 protein |
CTD |
PMID:14642735 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein] |
CTD |
PMID:27117918 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Slc6a3 |
solute carrier family 6 member 3 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] |
CTD |
PMID:19834288 |
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NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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G |
Slco1a1 |
solute carrier organic anion transporter family, member 1a1 |
multiple interactions decreases activity |
EXP |
[isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate |
CTD |
PMID:32259555 |
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NCBI chr 4:174,877,045...174,950,857
Ensembl chr 4:174,876,593...174,950,873
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G |
Sod2 |
superoxide dismutase 2 |
affects response to substance |
ISO |
SOD2 protein affects the susceptibility to isoliquiritigenin |
CTD |
PMID:23526725 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Star |
steroidogenic acute regulatory protein |
increases expression |
ISO |
isoliquiritigenin results in increased expression of STAR mRNA |
CTD |
PMID:27773742 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:25026504 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein] |
CTD |
PMID:25026504 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TNF protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] |
CTD |
PMID:18295200 PMID:25026504 PMID:25450236 PMID:26134484 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of TRP53 mRNA |
CTD |
PMID:27702603 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of isoliquiritigenin |
CTD |
PMID:14557274 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of isoliquiritigenin |
CTD |
PMID:14557274 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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