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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxybuprocaine
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Accession:CHEBI:309594 term browser browse the term
Definition:A benzoate ester in which 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol have combined to form the ester bond; an ester-based local anaesthetic (ester 'caine') used especially in ophthalmology and otolaryngology.
Synonyms:exact_synonym: 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate
 related_synonym: 4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester;   4-Amino-3-n-butoxy-benzoesaeure-diaethylaminoaethylester;   Benoxil;   Benoxinate;   Butoxyaminobenzoyldiethylaminoethanol;   Formula=C17H28N2O3;   InChI=1S/C17H28N2O3/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3/h8-9,13H,4-7,10-12,18H2,1-3H3;   InChIKey=CMHHMUWAYWTMGS-UHFFFAOYSA-N;   Oxbarukain;   Oxibuprokain;   Oxybucaine;   Oxyriprocaine;   SMILES=CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC;   oxibuprocaina;   oxybuprocainum
 xref: Beilstein:2288926;   CAS:99-43-4;   DrugBank:DB00892;   Drug_Central:3016;   HMDB:HMDB0015029;   KEGG:D08319;   LINCS:LSM-2069
 xref_mesh: MESH:C005298
 xref: PMID:25360701;   PMID:3598888;   PMID:6621359;   PMID:8214534;   PMID:9013953;   PMID:9989796;   Patent:GB654484;   Reaxys:2288926;   Wikipedia:Oxybuprocaine

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oxybuprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO benoxinate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benoxinate results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            drug allergen 10068
              oxybuprocaine 3
                oxybuprocaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        amino alcohol 1032
                                          ethanolamines 799
                                            ethanolamine 77
                                              2-diethylaminoethanol 16
                                                oxybuprocaine 3
                                                  oxybuprocaine hydrochloride 0
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