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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxybuprocaine
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Accession:CHEBI:309594 term browser browse the term
Definition:A benzoate ester in which 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol have combined to form the ester bond; an ester-based local anaesthetic (ester 'caine') used especially in ophthalmology and otolaryngology.
Synonyms:exact_synonym: 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate
 related_synonym: 4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester;   4-Amino-3-n-butoxy-benzoesaeure-diaethylaminoaethylester;   Benoxil;   Benoxinate;   Butoxyaminobenzoyldiethylaminoethanol;   Formula=C17H28N2O3;   InChI=1S/C17H28N2O3/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3/h8-9,13H,4-7,10-12,18H2,1-3H3;   InChIKey=CMHHMUWAYWTMGS-UHFFFAOYSA-N;   Oxbarukain;   Oxibuprokain;   Oxybucaine;   Oxyriprocaine;   SMILES=CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC;   oxibuprocaina;   oxybuprocainum
 xref: CAS:99-43-4;   DrugBank:DB00892;   Drug_Central:3016;   HMDB:HMDB0015029;   KEGG:D08319;   LINCS:LSM-2069
 xref_mesh: MESH:C005298
 xref: PMID:25360701;   PMID:3598888;   PMID:6621359;   PMID:8214534;   PMID:9013953;   PMID:9989796;   Patent:GB654484;   Reaxys:2288926;   Wikipedia:Oxybuprocaine


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oxybuprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO benoxinate results in increased expression of AIFM1 protein CTD PMID:27590991 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO benoxinate results in increased expression of BAX protein CTD PMID:27590991 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO benoxinate results in decreased expression of BCL2L1 protein CTD PMID:27590991 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Casp2 caspase 2 increases activity ISO benoxinate results in increased activity of CASP2 protein CTD PMID:27590991 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022 		JBrowse link
G Casp3 caspase 3 increases activity ISO benoxinate results in increased activity of CASP3 protein CTD PMID:27590991 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 increases activity ISO benoxinate results in increased activity of CASP9 protein CTD PMID:27590991 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO benoxinate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benoxinate results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            drug allergen 12011
              oxybuprocaine 9
                oxybuprocaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino alcohol 1084
                                          ethanolamines 829
                                            ethanolamine 92
                                              2-diethylaminoethanol 28
                                                oxybuprocaine 9
                                                  oxybuprocaine hydrochloride 0
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