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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxybuprocaine
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Accession:CHEBI:309594 term browser browse the term
Definition:A benzoate ester in which 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol have combined to form the ester bond; an ester-based local anaesthetic (ester 'caine') used especially in ophthalmology and otolaryngology.
Synonyms:exact_synonym: 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate
 related_synonym: 4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester;   4-Amino-3-n-butoxy-benzoesaeure-diaethylaminoaethylester;   Benoxil;   Benoxinate;   Butoxyaminobenzoyldiethylaminoethanol;   Formula=C17H28N2O3;   InChI=1S/C17H28N2O3/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3/h8-9,13H,4-7,10-12,18H2,1-3H3;   InChIKey=CMHHMUWAYWTMGS-UHFFFAOYSA-N;   Oxbarukain;   Oxibuprokain;   Oxybucaine;   Oxyriprocaine;   SMILES=CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC;   oxibuprocaina;   oxybuprocainum
 xref: Beilstein:2288926;   CAS:99-43-4;   DrugBank:DB00892;   Drug_Central:3016;   HMDB:HMDB0015029;   KEGG:D08319;   LINCS:LSM-2069
 xref_mesh: MESH:C005298
 xref: PMID:25360701;   PMID:3598888;   PMID:6621359;   PMID:8214534;   PMID:9013953;   PMID:9989796;   Patent:GB654484;   Reaxys:2288926;   Wikipedia:Oxybuprocaine


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oxybuprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO benoxinate results in increased expression of AIFM1 protein CTD PMID:27590991 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO benoxinate results in increased expression of BAX protein CTD PMID:27590991 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO benoxinate results in decreased expression of BCL2L1 protein CTD PMID:27590991 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp2 caspase 2 increases activity ISO benoxinate results in increased activity of CASP2 protein CTD PMID:27590991 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases activity ISO benoxinate results in increased activity of CASP3 protein CTD PMID:27590991 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO benoxinate results in increased activity of CASP9 protein CTD PMID:27590991 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO benoxinate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benoxinate results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        pharmaceutical 19556
          drug 19556
            drug allergen 11848
              oxybuprocaine 9
                oxybuprocaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        amino alcohol 1073
                                          ethanolamines 825
                                            ethanolamine 92
                                              2-diethylaminoethanol 28
                                                oxybuprocaine 9
                                                  oxybuprocaine hydrochloride 0
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