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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxybuprocaine
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Accession:CHEBI:309594 term browser browse the term
Definition:A benzoate ester in which 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol have combined to form the ester bond; an ester-based local anaesthetic (ester 'caine') used especially in ophthalmology and otolaryngology.
Synonyms:exact_synonym: 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate
 related_synonym: 4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester;   4-Amino-3-n-butoxy-benzoesaeure-diaethylaminoaethylester;   Benoxil;   Benoxinate;   Butoxyaminobenzoyldiethylaminoethanol;   Formula=C17H28N2O3;   InChI=1S/C17H28N2O3/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3/h8-9,13H,4-7,10-12,18H2,1-3H3;   InChIKey=CMHHMUWAYWTMGS-UHFFFAOYSA-N;   Oxbarukain;   Oxibuprokain;   Oxybucaine;   Oxyriprocaine;   SMILES=CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC;   oxibuprocaina;   oxybuprocainum
 xref: Beilstein:2288926;   CAS:99-43-4;   DrugBank:DB00892;   Drug_Central:3016;   HMDB:HMDB0015029;   KEGG:D08319;   LINCS:LSM-2069
 xref_mesh: MESH:C005298
 xref: PMID:25360701;   PMID:3598888;   PMID:6621359;   PMID:8214534;   PMID:9013953;   PMID:9989796;   Patent:GB654484;   Reaxys:2288926;   Wikipedia:Oxybuprocaine


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oxybuprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO benoxinate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benoxinate results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19876
    role 19851
      application 19687
        pharmaceutical 19514
          drug 19514
            drug allergen 11507
              oxybuprocaine 3
                oxybuprocaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19876
    subatomic particle 19874
      composite particle 19874
        hadron 19874
          baryon 19874
            nucleon 19874
              atomic nucleus 19905
                atom 19905
                  main group element atom 19821
                    main group molecular entity 19821
                      s-block molecular entity 19655
                        hydrogen molecular entity 19644
                          hydrides 19127
                            inorganic hydride 18102
                              pnictogen hydride 18090
                                nitrogen hydride 17995
                                  azane 17795
                                    ammonia 17794
                                      organic amino compound 17794
                                        amino alcohol 1065
                                          ethanolamines 817
                                            ethanolamine 85
                                              2-diethylaminoethanol 20
                                                oxybuprocaine 3
                                                  oxybuprocaine hydrochloride 0
paths to the root