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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trichloroacetic acid
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Accession:CHEBI:30956 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.
Synonyms:related_synonym: Formula=C2HCl3O2;   InChI=1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7);   InChIKey=YNJBWRMUSHSURL-UHFFFAOYSA-N;   SMILES=OC(=O)C(Cl)(Cl)Cl;   TCA;   Trichloressigsaeure;   trichloracetic acid;   trichloroethanoic acid
 alt_id: CHEBI:27095;   CHEBI:9684
 xref: Beilstein:970119;   CAS:76-03-9;   Drug_Central:3627;   Gmelin:2842;   KEGG:C11150;   KEGG:D08633
 xref_mesh: MESH:D014238
 xref: MetaCyc:CPD-9675;   PMID:12573897;   PMID:16298895;   PMID:16815816;   PMID:16901594;   PMID:21269351;   PMID:21332915;   PMID:21457391;   PMID:21497335;   PMID:21523508;   PMID:21529453;   PMID:21549800;   PMID:21716542;   Reaxys:970119;   Wikipedia:Trichloroacetic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:27455


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trichloroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A increases expression ISO Trichloroacetic Acid results in increased expression of ACAA1A mRNA CTD PMID:23575800 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain increases expression ISO Trichloroacetic Acid results in increased expression of ACADL mRNA CTD PMID:23575800 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO Trichloroacetic Acid results in increased expression of ACOT1 mRNA CTD PMID:23575800 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Trichloroacetic Acid results in increased expression of ACOX1 mRNA CTD PMID:23575800 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Trichloroacetic Acid results in increased expression of ATP2A2 mRNA CTD PMID:14565619 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G C1qbp complement C1q binding protein decreases expression EXP Trichloroacetic Acid results in decreased expression of C1QBP mRNA CTD PMID:14565619 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein CTD PMID:26343699 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression ISO Trichloroacetic Acid results in increased expression of CPT2 mRNA CTD PMID:23575800 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [CYP2E1 protein results in increased oxidation of Tetrachloroethylene] which results in increased abundance of Trichloroacetic Acid; [CYP2E1 protein results in increased oxidation of Trichloroethylene] which results in increased abundance of Trichloroacetic Acid CTD PMID:29897530 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO Trichloroacetic Acid results in increased expression of EHHADH mRNA CTD PMID:23575800 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Trichloroacetic Acid results in increased expression of HMOX1 mRNA CTD PMID:31755747 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression EXP Trichloroacetic Acid results in decreased expression of HSPE1 mRNA CTD PMID:14565619 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA CTD PMID:26343699 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf2 insulin-like growth factor 2 decreases methylation ISO Trichloroacetic Acid results in decreased methylation of IGF2 gene CTD PMID:15036762 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Trichloroacetic Acid results in decreased secretion of IL10 protein CTD PMID:29953848 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Trichloroacetic Acid results in increased expression of IL1B protein CTD PMID:29953848 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA; [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein CTD PMID:26343699 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein CTD PMID:26343699 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il6 interleukin 6 increases expression ISO Trichloroacetic Acid results in increased expression of IL6 protein CTD PMID:29953848 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases methylation
increases expression
ISO [Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA; Methionine inhibits the reaction [[Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA]; Methionine inhibits the reaction [Trichloroacetic Acid results in increased expression of JUN protein] CTD PMID:10774822 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mpo myeloperoxidase increases activity ISO Trichloroacetic Acid results in increased activity of MPO protein CTD PMID:20391627 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases methylation
ISO [Trichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA; Methionine inhibits the reaction [[Trichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA]; Methionine inhibits the reaction [Trichloroacetic Acid results in increased expression of MYC protein]
Trichloroacetic Acid results in increased expression of MYC mRNA; Trichloroacetic Acid results in increased expression of MYC protein
Trichloroacetic Acid results in decreased methylation of MYC gene; Trichloroacetic Acid results in decreased methylation of MYC promoter
CTD PMID:10774822 PMID:11284051 PMID:11532874 PMID:16014735 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Trichloroacetic Acid results in increased expression of PCNA protein CTD PMID:11284051 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
affects activity
ISO Trichloroacetic Acid results in increased activity of PPARA protein
Trichloroacetic Acid affects the activity of PPARA protein
CTD PMID:9703482 PMID:10581215 PMID:23575800 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Rps10 ribosomal protein S10 decreases expression EXP Trichloroacetic Acid results in decreased expression of RPS10 mRNA CTD PMID:14565619 NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A increases expression EXP Trichloroacetic Acid results in increased expression of SDHA mRNA CTD PMID:14565619 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Trichloroacetic Acid results in increased expression of TNF protein
Trichloroacetic Acid results in increased expression of and results in decreased secretion of TNF protein
CTD PMID:20391627 PMID:29953848 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            trichloroacetic acid 27
              TCA-ethadyl 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          acetic acid 10853
                                            trichloroacetic acid 27
                                              TCA-ethadyl 0
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