CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: trichloroacetic acid
Accession: CHEBI:30956
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Definition: A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.
Synonyms: related_synonym: Formula=C2HCl3O2; InChI=1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7); InChIKey=YNJBWRMUSHSURL-UHFFFAOYSA-N; SMILES=OC(=O)C(Cl)(Cl)Cl; TCA; Trichloressigsaeure; trichloracetic acid; trichloroethanoic acid
alt_id: CHEBI:27095; CHEBI:9684
xref: Beilstein:970119; CAS:76-03-9; Drug_Central:3627; Gmelin:2842; KEGG:C11150; KEGG:D08633
xref_mesh: MESH:D014238
xref: MetaCyc:CPD-9675; PMID:12573897; PMID:16298895; PMID:16815816; PMID:16901594; PMID:21269351; PMID:21332915; PMID:21457391; PMID:21497335; PMID:21523508; PMID:21529453; PMID:21549800; PMID:21716542; Reaxys:970119; Wikipedia:Trichloroacetic_Acid
cyclic_relationship: is_conjugate_acid_of CHEBI:27455
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Acaa1a
acetyl-CoA acyltransferase 1A
increases expression
ISO
Trichloroacetic Acid results in increased expression of ACAA1A mRNA
CTD
PMID:23575800
NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
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Acadl
acyl-CoA dehydrogenase, long chain
increases expression
ISO
Trichloroacetic Acid results in increased expression of ACADL mRNA
CTD
PMID:23575800
NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
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Acot1
acyl-CoA thioesterase 1
increases expression
ISO
Trichloroacetic Acid results in increased expression of ACOT1 mRNA
CTD
PMID:23575800
NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
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Acox1
acyl-CoA oxidase 1
increases expression
ISO
Trichloroacetic Acid results in increased expression of ACOX1 mRNA
CTD
PMID:23575800
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
increases expression
EXP
Trichloroacetic Acid results in increased expression of ATP2A2 mRNA
CTD
PMID:14565619
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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C1qbp
complement C1q binding protein
decreases expression
EXP
Trichloroacetic Acid results in decreased expression of C1QBP mRNA
CTD
PMID:14565619
NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
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Cd69
Cd69 molecule
multiple interactions
ISO
[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein
CTD
PMID:26343699
NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
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Cpt2
carnitine palmitoyltransferase 2
increases expression
ISO
Trichloroacetic Acid results in increased expression of CPT2 mRNA
CTD
PMID:23575800
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
[CYP2E1 protein results in increased oxidation of Tetrachloroethylene] which results in increased abundance of Trichloroacetic Acid; [CYP2E1 protein results in increased oxidation of Trichloroethylene] which results in increased abundance of Trichloroacetic Acid
CTD
PMID:29897530
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
increases expression
ISO
Trichloroacetic Acid results in increased expression of EHHADH mRNA
CTD
PMID:23575800
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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Hmox1
heme oxygenase 1
increases expression
ISO
Trichloroacetic Acid results in increased expression of HMOX1 mRNA
CTD
PMID:31755747
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspe1
heat shock protein family E (Hsp10) member 1
decreases expression
EXP
Trichloroacetic Acid results in decreased expression of HSPE1 mRNA
CTD
PMID:14565619
NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
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Ifng
interferon gamma
multiple interactions
ISO
[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA
CTD
PMID:26343699
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Igf2
insulin-like growth factor 2
decreases methylation
ISO
Trichloroacetic Acid results in decreased methylation of IGF2 gene
CTD
PMID:15036762
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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Il10
interleukin 10
decreases secretion
ISO
Trichloroacetic Acid results in decreased secretion of IL10 protein
CTD
PMID:29953848
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
increases expression
ISO
Trichloroacetic Acid results in increased expression of IL1B protein
CTD
PMID:29953848
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
multiple interactions
ISO
[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA; [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein
CTD
PMID:26343699
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il2ra
interleukin 2 receptor subunit alpha
multiple interactions
ISO
[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein
CTD
PMID:26343699
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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Il6
interleukin 6
increases expression
ISO
Trichloroacetic Acid results in increased expression of IL6 protein
CTD
PMID:29953848
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions decreases methylation increases expression
ISO
[Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA; Methionine inhibits the reaction [[Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA]; Methionine inhibits the reaction [Trichloroacetic Acid results in increased expression of JUN protein]
CTD
PMID:10774822
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Mpo
myeloperoxidase
increases activity
ISO
Trichloroacetic Acid results in increased activity of MPO protein
CTD
PMID:20391627
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions increases expression decreases methylation
ISO
[Trichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA; Methionine inhibits the reaction [[Trichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA]; Methionine inhibits the reaction [Trichloroacetic Acid results in increased expression of MYC protein] Trichloroacetic Acid results in increased expression of MYC mRNA; Trichloroacetic Acid results in increased expression of MYC protein Trichloroacetic Acid results in decreased methylation of MYC gene; Trichloroacetic Acid results in decreased methylation of MYC promoter
CTD
PMID:10774822 PMID:11284051 PMID:11532874 PMID:16014735
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Pcna
proliferating cell nuclear antigen
increases expression
ISO
Trichloroacetic Acid results in increased expression of PCNA protein
CTD
PMID:11284051
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Ppara
peroxisome proliferator activated receptor alpha
increases activity affects activity
ISO
Trichloroacetic Acid results in increased activity of PPARA protein Trichloroacetic Acid affects the activity of PPARA protein
CTD
PMID:9703482 PMID:10581215 PMID:23575800
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Rps10
ribosomal protein S10
decreases expression
EXP
Trichloroacetic Acid results in decreased expression of RPS10 mRNA
CTD
PMID:14565619
NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044
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Sdha
succinate dehydrogenase complex flavoprotein subunit A
increases expression
EXP
Trichloroacetic Acid results in increased expression of SDHA mRNA
CTD
PMID:14565619
NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
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Tnf
tumor necrosis factor
increases expression multiple interactions
ISO
Trichloroacetic Acid results in increased expression of TNF protein Trichloroacetic Acid results in increased expression of and results in decreased secretion of TNF protein
CTD
PMID:20391627 PMID:29953848
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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