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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trichloroacetic acid
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Accession:CHEBI:30956 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.
Synonyms:related_synonym: Formula=C2HCl3O2;   InChI=1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7);   InChIKey=YNJBWRMUSHSURL-UHFFFAOYSA-N;   SMILES=OC(=O)C(Cl)(Cl)Cl;   TCA;   Trichloressigsaeure;   trichloracetic acid;   trichloroethanoic acid
 alt_id: CHEBI:27095;   CHEBI:9684
 xref: Beilstein:970119;   CAS:76-03-9;   Drug_Central:3627;   Gmelin:2842;   KEGG:C11150;   KEGG:D08633
 xref_mesh: MESH:D014238
 xref: MetaCyc:CPD-9675;   PMID:12573897;   PMID:16298895;   PMID:16815816;   PMID:16901594;   PMID:21269351;   PMID:21332915;   PMID:21457391;   PMID:21497335;   PMID:21523508;   PMID:21529453;   PMID:21549800;   PMID:21716542;   Reaxys:970119;   Wikipedia:Trichloroacetic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:27455


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trichloroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A increases expression ISO Trichloroacetic Acid results in increased expression of ACAA1A mRNA CTD PMID:23575800 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain increases expression ISO Trichloroacetic Acid results in increased expression of ACADL mRNA CTD PMID:23575800 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO Trichloroacetic Acid results in increased expression of ACOT1 mRNA CTD PMID:23575800 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Trichloroacetic Acid results in increased expression of ACOX1 mRNA CTD PMID:23575800 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Trichloroacetic Acid results in increased expression of ATP2A2 mRNA CTD PMID:14565619 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G C1qbp complement C1q binding protein decreases expression EXP Trichloroacetic Acid results in decreased expression of C1QBP mRNA CTD PMID:14565619 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein CTD PMID:26343699 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression ISO Trichloroacetic Acid results in increased expression of CPT2 mRNA CTD PMID:23575800 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [CYP2E1 protein results in increased oxidation of Tetrachloroethylene] which results in increased abundance of Trichloroacetic Acid; [CYP2E1 protein results in increased oxidation of Trichloroethylene] which results in increased abundance of Trichloroacetic Acid CTD PMID:29897530 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO Trichloroacetic Acid results in increased expression of EHHADH mRNA CTD PMID:23575800 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Trichloroacetic Acid results in increased expression of HMOX1 mRNA CTD PMID:31755747 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression EXP Trichloroacetic Acid results in decreased expression of HSPE1 mRNA CTD PMID:14565619 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA CTD PMID:26343699 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf2 insulin-like growth factor 2 decreases methylation ISO Trichloroacetic Acid results in decreased methylation of IGF2 gene CTD PMID:15036762 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Trichloroacetic Acid results in decreased secretion of IL10 protein CTD PMID:29953848 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Trichloroacetic Acid results in increased expression of IL1B protein CTD PMID:29953848 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA; [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein CTD PMID:26343699 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein CTD PMID:26343699 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il6 interleukin 6 increases expression ISO Trichloroacetic Acid results in increased expression of IL6 protein CTD PMID:29953848 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases methylation
increases expression
ISO [Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA; Methionine inhibits the reaction [[Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA]; Methionine inhibits the reaction [Trichloroacetic Acid results in increased expression of JUN protein] CTD PMID:10774822 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mpo myeloperoxidase increases activity ISO Trichloroacetic Acid results in increased activity of MPO protein CTD PMID:20391627 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases methylation
ISO [Trichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA; Methionine inhibits the reaction [[Trichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA]; Methionine inhibits the reaction [Trichloroacetic Acid results in increased expression of MYC protein]
Trichloroacetic Acid results in increased expression of MYC mRNA; Trichloroacetic Acid results in increased expression of MYC protein
Trichloroacetic Acid results in decreased methylation of MYC gene; Trichloroacetic Acid results in decreased methylation of MYC promoter
CTD PMID:10774822, PMID:11284051, PMID:11532874, PMID:16014735 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Trichloroacetic Acid results in increased expression of PCNA protein CTD PMID:11284051 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
affects activity
ISO Trichloroacetic Acid results in increased activity of PPARA protein
Trichloroacetic Acid affects the activity of PPARA protein
CTD PMID:9703482, PMID:10581215, PMID:23575800 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rps10 ribosomal protein S10 decreases expression EXP Trichloroacetic Acid results in decreased expression of RPS10 mRNA CTD PMID:14565619 NCBI chr20:7,215,762...7,220,331
Ensembl chr20:7,215,774...7,219,548
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A increases expression EXP Trichloroacetic Acid results in increased expression of SDHA mRNA CTD PMID:14565619 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Trichloroacetic Acid results in increased expression of TNF protein
Trichloroacetic Acid results in increased expression of and results in decreased secretion of TNF protein
CTD PMID:20391627, PMID:29953848 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            trichloroacetic acid 27
              TCA-ethadyl 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          acetic acid 10697
                                            trichloroacetic acid 27
                                              TCA-ethadyl 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.