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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bifenthrin
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Accession:CHEBI:3093 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation of cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylic acid and [(2-methyl-1,1'-biphenyl)-3-yl]methanol.
Synonyms:exact_synonym: (2-methyl-[1,1'-biphenyl]-3-yl)methyl rel-(1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylate
 related_synonym: Biphenthrin;   Formula=C23H22ClF3O2;   InChI=1S/C23H22ClF3O2/c1-14-16(10-7-11-17(14)15-8-5-4-6-9-15)13-29-21(28)20-18(22(20,2)3)12-19(24)23(25,26)27/h4-12,18,20H,13H2,1-3H3/b19-12-/t18-,20-/m0/s1;   InChIKey=OMFRMAHOUUJSGP-IRHGGOMRSA-N;   SMILES=Cc1c(COC(=O)[C@@H]2[C@H](\\C=C(/Cl)C(F)(F)F)C2(C)C)cccc1-c1ccccc1
 xref: Beilstein:8512305;   CAS:82657-04-3;   KEGG:C10980
 xref_mesh: MESH:C099952
 xref: PMID:19950221;   PMID:20563640;   PMID:21104824;   PMID:21246035;   PMID:21360666;   PMID:21370390;   PMID:21394881;   PMID:21503692;   PMID:21520766;   PMID:21563678;   PMID:21635642;   PMID:21718662;   PMID:21735922;   PMID:21770011;   PMID:21819079


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bifenthrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression ISO bifenthrin results in increased expression of ABCB1B mRNA CTD PMID:26071804 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases expression
EXP bifenthrin results in decreased expression of and results in decreased activity of ACHE protein
bifenthrin results in decreased expression of ACHE mRNA; bifenthrin results in decreased expression of ACHE protein
CTD PMID:29775722 PMID:30978409 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) increases expression ISO bifenthrin results in increased expression of ADH1 mRNA CTD PMID:26071804 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases expression ISO bifenthrin results in increased expression of ADH5 mRNA CTD PMID:26071804 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO bifenthrin results in increased expression of AHR mRNA CTD PMID:26071804 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO bifenthrin results in increased expression of ALDH1A1 mRNA CTD PMID:26071804 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type decreases expression ISO bifenthrin results in decreased expression of ALOX12 mRNA CTD PMID:26071804 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression ISO bifenthrin results in increased expression of ALOX15 mRNA CTD PMID:26071804 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO bifenthrin inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO bifenthrin results in increased expression of APAF1 mRNA CTD PMID:26071804 PMID:32408700 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apoe apolipoprotein E increases expression ISO bifenthrin results in increased expression of APOE mRNA CTD PMID:26071804 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Areg amphiregulin multiple interactions EXP bifenthrin inhibits the reaction [CGA protein results in increased expression of AREG mRNA] CTD PMID:21251947 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression ISO bifenthrin results in increased expression of ARNT mRNA CTD PMID:26071804 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO bifenthrin results in increased expression of BAX mRNA CTD PMID:32408700 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP bifenthrin results in decreased activity of BCHE protein CTD PMID:30978409 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO bifenthrin results in decreased expression of BCL2 mRNA CTD PMID:26071804 PMID:27916261 PMID:32408700 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO bifenthrin results in increased expression of BID mRNA CTD PMID:26071804 PMID:32408700 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Brca1 BRCA1, DNA repair associated affects binding ISO bifenthrin binds to BRCA1 protein CTD PMID:32278787 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
ISO
EXP
bifenthrin results in increased activity of CASP3 protein
bifenthrin results in increased expression of CASP3 protein
bifenthrin results in increased expression of CASP3 mRNA
CTD PMID:26071804 PMID:27916261 PMID:30978409 PMID:32408700 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
decreases expression
ISO bifenthrin results in increased activity of CASP8 protein
bifenthrin results in decreased expression of CASP8 mRNA
CTD PMID:26071804 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases expression ISO bifenthrin results in increased expression of CASP9 mRNA CTD PMID:32408700 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression
increases expression
affects activity
ISO
EXP
Quercetin inhibits the reaction [bifenthrin results in decreased activity of CAT protein]; Rutin inhibits the reaction [bifenthrin results in decreased activity of CAT protein]
bifenthrin results in decreased expression of CAT protein
bifenthrin analog results in increased expression of CAT mRNA; bifenthrin results in increased expression of CAT mRNA
bifenthrin affects the activity of CAT protein; bifenthrin analog affects the activity of CAT protein
CTD PMID:19833193 PMID:23172818 PMID:25149237 PMID:27916261 PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760 PMID:32408700 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP bifenthrin inhibits the reaction [CGA protein results in increased expression of CCNE1 mRNA] CTD PMID:21251947 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd36 CD36 molecule increases expression ISO bifenthrin results in increased expression of CD36 mRNA CTD PMID:29554630 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP bifenthrin inhibits the reaction [CGA protein results in increased expression of CDKN1A mRNA] CTD PMID:21251947 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP bifenthrin inhibits the reaction [CGA protein results in increased expression of CEBPB mRNA] CTD PMID:21251947 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Ces2h carboxylesterase 2H increases metabolic processing ISO CES2 protein results in increased metabolism of bifenthrin CTD PMID:19249324 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions
increases secretion
EXP
ISO
bifenthrin analog inhibits the reaction [CGA protein results in increased abundance of Progesterone]; bifenthrin analog inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]; bifenthrin analog inhibits the reaction [CGA results in increased expression of CYP11A1 mRNA]; bifenthrin analog inhibits the reaction [CGA results in increased expression of DBI mRNA]; bifenthrin analog inhibits the reaction [CGA results in increased expression of PTGS2 mRNA]; bifenthrin analog inhibits the reaction [CGA results in increased expression of STAR mRNA]; bifenthrin analog inhibits the reaction [CGA results in increased expression of TSPO mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of AREG mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CCNE1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CDKN1A mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CEBPB mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CYP11A1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of EREG mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of PGR mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of PTGS2 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of RUNX1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of STAR mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of SULT1E1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of TGFB1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]
fulvestrant inhibits the reaction [bifenthrin results in increased secretion of CGA protein]
CTD PMID:21251947 PMID:21871944 PMID:24938463 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Chat choline O-acetyltransferase decreases expression EXP bifenthrin results in decreased expression of CHAT mRNA CTD PMID:29775722 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP bifenthrin results in decreased expression of CHRM1 mRNA CTD PMID:29775722 PMID:30978409 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit decreases expression EXP bifenthrin results in decreased expression of CHRNA2 mRNA CTD PMID:30978409 NCBI chr15:42,808,897...42,825,179
Ensembl chr15:42,808,897...42,825,179
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO bifenthrin results in decreased expression of CPT1A mRNA CTD PMID:29554630 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO bifenthrin results in decreased expression of CXCL1 mRNA CTD PMID:28251819 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 increases expression ISO bifenthrin results in increased expression of CYB5R3 mRNA CTD PMID:26071804 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO bifenthrin results in increased expression of CYCS mRNA CTD PMID:32408700 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression
EXP
ISO
bifenthrin analog inhibits the reaction [CGA results in increased expression of CYP11A1 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of CYP11A1 mRNA]
bifenthrin results in decreased expression of CYP11A1 mRNA
CTD PMID:21251947 PMID:21871944 PMID:23994515 PMID:24449165 PMID:32408700 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression
decreases expression
ISO bifenthrin results in increased expression of CYP17A1 mRNA
bifenthrin results in decreased expression of CYP17A1 mRNA
CTD PMID:23994515 PMID:24449165 PMID:24938463 PMID:26071804 PMID:32408700 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP
ISO
bifenthrin inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA]
bifenthrin results in increased expression of CYP19A1 mRNA
CTD PMID:21251947 PMID:24938463 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
decreases expression
EXP
ISO
bifenthrin results in increased activity of CYP1A1 protein
bifenthrin results in decreased expression of CYP1A1 mRNA
CTD PMID:20009351 PMID:26071804 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO bifenthrin results in increased expression of CYP2C29 mRNA CTD PMID:26071804 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO bifenthrin results in increased expression of CYP2E1 mRNA CTD PMID:26071804 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO bifenthrin results in increased expression of CYP3A4 mRNA CTD PMID:19249324 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 decreases expression ISO bifenthrin results in decreased expression of CYP4B1 mRNA CTD PMID:26071804 NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein multiple interactions EXP bifenthrin analog inhibits the reaction [CGA results in increased expression of DBI mRNA] CTD PMID:21871944 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO bifenthrin results in increased expression of EPHX1 mRNA CTD PMID:26071804 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects binding ISO bifenthrin binds to ERBB2 protein CTD PMID:32278787 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Ereg epiregulin multiple interactions EXP bifenthrin inhibits the reaction [CGA protein results in increased expression of EREG mRNA] CTD PMID:21251947 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
affects binding
ISO bifenthrin results in decreased expression of ESR1 mRNA
bifenthrin binds to ESR1 protein
CTD PMID:20097460 PMID:32278787 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Faim Fas apoptotic inhibitory molecule decreases expression ISO bifenthrin results in decreased expression of FAIM mRNA CTD PMID:26071804 NCBI chr 8:107,225,119...107,247,228
Ensembl chr 8:107,225,212...107,241,224
Ensembl chr 8:107,225,212...107,241,224
JBrowse link
G Faslg Fas ligand decreases expression ISO bifenthrin results in decreased expression of FASL mRNA CTD PMID:26071804 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase increases expression
decreases expression
ISO bifenthrin results in increased expression of FASN mRNA
bifenthrin results in decreased expression of FASN mRNA
CTD PMID:29554630 PMID:32408700 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbp1 fructose-bisphosphatase 1 increases expression ISO bifenthrin results in increased expression of FBP1 mRNA CTD PMID:26071804 NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects binding ISO bifenthrin binds to FGFR2 protein CTD PMID:32278787 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression ISO bifenthrin results in increased expression of GGT1 mRNA CTD PMID:26071804 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression ISO bifenthrin results in increased expression of GNRH1 mRNA CTD PMID:24938463 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression ISO bifenthrin results in increased expression of GNRHR mRNA CTD PMID:24938463 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Gpi glucose-6-phosphate isomerase increases expression ISO bifenthrin results in increased expression of GPI1 mRNA CTD PMID:26071804 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
decreases expression
ISO bifenthrin results in increased expression of GPX1 mRNA
bifenthrin results in decreased expression of GPX1 mRNA
CTD PMID:26071804 PMID:27916261 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression
decreases expression
ISO bifenthrin results in increased expression of GPX2 mRNA
bifenthrin results in decreased expression of GPX2 mRNA
CTD PMID:26071804 PMID:27916261 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO bifenthrin results in increased expression of GPX3 mRNA CTD PMID:26071804 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO bifenthrin results in increased expression of GSTA3 mRNA CTD PMID:26071804 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO bifenthrin results in increased expression of GSTA1 mRNA CTD PMID:26071804 PMID:27916261 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO bifenthrin results in increased expression of GSTM1 mRNA CTD PMID:26071804 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO bifenthrin results in increased expression of GSTM2 mRNA CTD PMID:26071804 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO bifenthrin results in increased expression of GSTM5 mRNA CTD PMID:26071804 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO bifenthrin results in increased expression of GSTP1 mRNA CTD PMID:26071804 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hk2 hexokinase 2 increases expression ISO bifenthrin results in increased expression of HK2 mRNA CTD PMID:26071804 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO bifenthrin analog results in increased expression of HMOX1 mRNA; bifenthrin results in increased expression of HMOX1 mRNA CTD PMID:25149237 PMID:27916261 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression ISO bifenthrin results in decreased expression of HSD17B1 mRNA CTD PMID:24938463 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression ISO bifenthrin results in decreased expression of HSD17B3 mRNA CTD PMID:26071804 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO bifenthrin results in decreased expression of HSD3B1 mRNA CTD PMID:32408700
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO bifenthrin results in increased expression of HSD3B2 mRNA CTD PMID:24938463 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO bifenthrin results in decreased expression of HSPA1A protein CTD PMID:16271832 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO bifenthrin results in increased expression of HSPA5 protein CTD PMID:16271832 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO bifenthrin results in decreased expression of HSPA8 protein CTD PMID:16271832 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb2 heat shock protein family B (small) member 2 decreases expression ISO bifenthrin results in decreased expression of HSPB2 protein CTD PMID:16271832 NCBI chr 8:55,176,648...55,178,227
Ensembl chr 8:55,176,847...55,177,818
JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
multiple interactions
ISO
EXP
bifenthrin results in decreased expression of IL1B mRNA
bifenthrin results in increased expression of IL1B mRNA
bifenthrin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]
CTD PMID:27916261 PMID:28251819 PMID:30102949 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases expression ISO bifenthrin results in increased expression of IL2 mRNA CTD PMID:23172818 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 increases expression ISO bifenthrin results in increased expression of IL4 mRNA CTD PMID:23172818 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
multiple interactions
ISO
EXP
bifenthrin results in decreased expression of IL6 mRNA
bifenthrin results in increased expression of IL6 protein
bifenthrin results in increased expression of IL6 mRNA
bifenthrin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
CTD PMID:27916261 PMID:28251819 PMID:29793499 PMID:30102949 PMID:32061760 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO bifenthrin results in decreased expression of LDLR mRNA CTD PMID:24449165 PMID:32408700 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO bifenthrin analog results in increased phosphorylation of MAPK1 protein CTD PMID:19442700 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO bifenthrin analog results in increased phosphorylation of MAPK3 protein CTD PMID:19442700 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO bifenthrin results in decreased expression of MGST2 mRNA CTD PMID:26071804 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 increases expression ISO bifenthrin results in increased expression of MGST3 mRNA CTD PMID:26071804 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
JBrowse link
G Mir122 microRNA 122 increases expression ISO bifenthrin results in increased expression of MIR122 mRNA CTD PMID:32408700 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir17 microRNA 17 decreases expression ISO bifenthrin results in decreased expression of MIR17 mRNA CTD PMID:32408700 NCBI chr15:100,179,879...100,179,962
Ensembl chr15:100,179,879...100,179,962
JBrowse link
G Mir34b microRNA 34b decreases expression ISO bifenthrin results in decreased expression of MIR34B mRNA CTD PMID:32408700 NCBI chr 8:55,492,542...55,492,625
Ensembl chr 8:55,492,542...55,492,625
JBrowse link
G Mir34c microRNA 34c decreases expression ISO bifenthrin results in decreased expression of MIR34C mRNA CTD PMID:32408700 NCBI chr 8:55,492,024...55,492,100
Ensembl chr 8:55,492,024...55,492,100
JBrowse link
G Mir449a microRNA 449a decreases expression ISO bifenthrin results in decreased expression of MIR449A mRNA CTD PMID:32408700 NCBI chr 2:44,897,601...44,897,691
Ensembl chr 2:44,897,601...44,897,691
JBrowse link
G Mir449c microRNA 449c decreases expression ISO bifenthrin results in decreased expression of MIR449C mRNA CTD PMID:32408700 NCBI chr 2:44,896,066...44,896,164
Ensembl chr 2:44,896,066...44,896,164
JBrowse link
G Mt2A metallothionein 2A increases expression ISO bifenthrin results in increased expression of MT2 mRNA CTD PMID:26071804 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mt3 metallothionein 3 increases expression ISO bifenthrin results in increased expression of MT3 mRNA CTD PMID:26071804 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases expression ISO bifenthrin results in increased expression of MTHFR mRNA CTD PMID:26071804 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Nat1 N-acetyltransferase 1 increases expression ISO bifenthrin results in increased expression of NAT1 mRNA CTD PMID:26071804 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
increases expression
EXP
ISO
bifenthrin results in decreased expression of NFE2L2 mRNA; bifenthrin results in decreased expression of NFE2L2 protein
bifenthrin results in increased expression of NFE2L2 mRNA; bifenthrin results in increased expression of NFE2L2 protein
CTD PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
affects binding
ISO bifenthrin results in decreased expression of NQO1 mRNA
bifenthrin binds to NQO1 protein
CTD PMID:27916261 PMID:32278787 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO bifenthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression
affects binding
ISO
EXP
bifenthrin results in increased activity of NR1I2 protein
bifenthrin results in increased expression of NR1I2 mRNA; bifenthrin results in increased expression of NR1I2 protein
bifenthrin binds to NR1I2 protein
CTD PMID:19249324 PMID:29554630 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO bifenthrin inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO bifenthrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; bifenthrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP bifenthrin results in decreased expression of NR4A2 mRNA; bifenthrin results in decreased expression of NR4A2 protein CTD PMID:30978409 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP bifenthrin inhibits the reaction [Hydrocortisone results in increased expression of PCK1 mRNA] CTD PMID:26647222 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
EXP
ISO
bifenthrin inhibits the reaction [CGA protein results in increased expression of PGR mRNA]
fulvestrant inhibits the reaction [bifenthrin results in increased expression of PGR mRNA]
bifenthrin results in increased expression of PGR; bifenthrin results in increased expression of PGR mRNA
CTD PMID:21251947 PMID:24938463 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO bifenthrin results in decreased expression of PKLR mRNA CTD PMID:26071804 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression ISO bifenthrin results in increased expression of PKM mRNA CTD PMID:26071804 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pon1 paraoxonase 1 increases expression ISO bifenthrin results in increased expression of PON1 mRNA CTD PMID:26071804 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pon3 paraoxonase 3 increases expression ISO bifenthrin results in increased expression of PON3 mRNA CTD PMID:26071804 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding ISO bifenthrin binds to PPARD protein CTD PMID:32278787 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO bifenthrin results in increased expression of PPARG mRNA CTD PMID:29554630 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptges prostaglandin E synthase increases expression EXP
ISO
bifenthrin results in increased expression of PTGES mRNA; bifenthrin results in increased expression of PTGES protein CTD PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP
ISO
bifenthrin analog inhibits the reaction [CGA results in increased expression of PTGS2 mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of PTGS2 mRNA]; bifenthrin inhibits the reaction [Colforsin results in increased expression of PTGS2 mRNA]
bifenthrin results in increased expression of PTGS2 mRNA; bifenthrin results in increased expression of PTGS2 protein
CTD PMID:21251947 PMID:21871944 PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression EXP
ISO
bifenthrin results in increased expression of RELA mRNA; bifenthrin results in increased expression of RELA protein CTD PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO bifenthrin binds to RORA protein CTD PMID:32278787 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Rorc RAR-related orphan receptor C affects binding ISO bifenthrin binds to RORC protein CTD PMID:32278787 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Runx1 RUNX family transcription factor 1 multiple interactions EXP bifenthrin inhibits the reaction [CGA protein results in increased expression of RUNX1 mRNA] CTD PMID:21251947 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression ISO bifenthrin results in decreased expression of SCARB1 mRNA CTD PMID:23994515 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO bifenthrin results in increased expression of SCD mRNA CTD PMID:29554630 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions EXP bifenthrin affects the reaction [SCN10A protein results in increased transport of Sodium] CTD PMID:16051293 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO bifenthrin binds to SHBG protein CTD PMID:32278787 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bifenthrin analog results in increased expression of SOD1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [bifenthrin analog results in increased expression of SOD1 protein]
bifenthrin analog results in increased expression of SOD1 mRNA; bifenthrin results in increased expression of SOD1 mRNA
CTD PMID:22718203 PMID:25149237 PMID:27916261 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bifenthrin analog results in increased expression of SOD2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [bifenthrin analog results in increased expression of SOD2 protein]
bifenthrin results in increased expression of SOD2 mRNA
CTD PMID:22718203 PMID:27916261 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase affects binding ISO bifenthrin binds to SRC protein CTD PMID:32278787 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO bifenthrin results in decreased expression of SRD5A2 mRNA CTD PMID:26071804 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
EXP
ISO
bifenthrin analog inhibits the reaction [CGA results in increased expression of STAR mRNA]; bifenthrin inhibits the reaction [CGA protein results in increased expression of STAR mRNA]
bifenthrin results in decreased expression of STAR mRNA
CTD PMID:21251947 PMID:21871944 PMID:23994515 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions EXP bifenthrin inhibits the reaction [CGA protein results in increased expression of SULT1E1 mRNA] CTD PMID:21251947 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO bifenthrin results in increased expression of TFF1 mRNA CTD PMID:20097460 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP bifenthrin inhibits the reaction [CGA protein results in increased expression of TGFB1 mRNA] CTD PMID:21251947 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression
ISO
EXP
bifenthrin results in increased expression of TNF mRNA
bifenthrin results in increased expression of TNF protein
bifenthrin results in increased expression of TNF mRNA; bifenthrin results in increased expression of TNF protein
bifenthrin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]
bifenthrin results in decreased expression of TNF mRNA
CTD PMID:23172818 PMID:26071804 PMID:27916261 PMID:28251819 PMID:29775722 PMID:29793499 PMID:30102949 PMID:32061760 PMID:32408700 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression
ISO bifenthrin results in increased expression of TRP53 mRNA
bifenthrin results in decreased expression of TRP53 mRNA
CTD PMID:20097460 PMID:26071804 PMID:27916261 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tspo translocator protein multiple interactions
decreases expression
EXP
ISO
bifenthrin analog inhibits the reaction [CGA results in increased expression of TSPO mRNA]
bifenthrin results in decreased expression of TSPO mRNA
CTD PMID:21871944 PMID:23994515 PMID:24449165 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        pesticide 16587
          acaricide 9751
            pyrethroid ester acaricide 2014
              bifenthrin 131
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        monocarboxylic acid 17530
                                          cyclopropanecarboxylic acid 799
                                            chrysanthemic acid 232
                                              cis-chrysanthemic acid 131
                                                bifenthrin 131
paths to the root