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G |
AKR1B1 |
aldo-keto reductase family 1 member B |
multiple interactions increases abundance |
EXP |
AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] AKR1B1 protein results in increased abundance of Sorbitol |
CTD |
PMID:25451566 PMID:25541468 |
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NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
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G |
ALOX5 |
arachidonate 5-lipoxygenase |
multiple interactions |
EXP |
[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; Sorbitol results in increased phosphorylation of and results in increased activity of ALOX5 protein |
CTD |
PMID:10779545 PMID:11698504 |
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NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
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G |
AQP9 |
aquaporin 9 |
multiple interactions increases uptake |
ISO |
Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite] AQP9 protein results in increased uptake of Sorbitol |
CTD |
PMID:9733774 PMID:19341753 |
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NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911
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G |
BOLA2 |
bolA family member 2 |
increases expression |
ISO |
Sorbitol results in increased expression of BOLA2 mRNA |
CTD |
PMID:35678645 |
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NCBI chr16:29,453,588...29,454,964
Ensembl chr16:30,192,932...30,194,306 Ensembl chr16:30,192,932...30,194,306
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G |
CAPRIN1 |
cell cycle associated protein 1 |
multiple interactions |
EXP |
Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] |
CTD |
PMID:33939924 |
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NCBI chr11:34,051,731...34,102,610
Ensembl chr11:34,051,731...34,102,610
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G |
CASP3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Sorbitol results in increased activity of CASP3 protein Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein] |
CTD |
PMID:20609311 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP8 |
caspase 8 |
increases activity multiple interactions |
ISO |
Sorbitol results in increased activity of CASP8 protein Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein] |
CTD |
PMID:20609311 |
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NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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G |
CASP9 |
caspase 9 |
increases activity multiple interactions |
ISO |
Sorbitol results in increased activity of CASP9 protein Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein] |
CTD |
PMID:20609311 |
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NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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G |
CCNA1 |
cyclin A1 |
decreases expression |
ISO |
Sorbitol results in decreased expression of CCNA1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr13:36,431,517...36,442,870
Ensembl chr13:36,431,520...36,442,870
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G |
CCNF |
cyclin F |
increases expression |
ISO |
Sorbitol results in increased expression of CCNF mRNA |
CTD |
PMID:35678645 |
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NCBI chr16:2,429,447...2,458,854
Ensembl chr16:2,429,394...2,458,854
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G |
CDK1 |
cyclin dependent kinase 1 |
decreases expression |
ISO |
Sorbitol results in decreased expression of CDK1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
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G |
CHKB |
choline kinase beta |
decreases expression |
ISO |
Sorbitol results in decreased expression of CHKB mRNA |
CTD |
PMID:35678645 |
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NCBI chr22:50,578,963...50,582,849
Ensembl chr22:50,578,959...50,601,455
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G |
CRK |
CRK proto-oncogene, adaptor protein |
increases phosphorylation |
ISO |
Sorbitol results in increased phosphorylation of CRK protein |
CTD |
PMID:16187300 |
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NCBI chr17:1,420,693...1,456,232
Ensembl chr17:1,420,689...1,463,162
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G |
DDB1 |
damage specific DNA binding protein 1 |
increases expression |
ISO |
Sorbitol results in increased expression of DDB1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr11:61,299,451...61,333,105
Ensembl chr11:61,299,451...61,342,596
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G |
EEF1D |
eukaryotic translation elongation factor 1 delta |
increases expression |
ISO |
Sorbitol results in increased expression of EEF1D mRNA |
CTD |
PMID:35678645 |
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NCBI chr 8:143,579,728...143,597,415
Ensembl chr 8:143,579,697...143,599,541
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EIF3H |
eukaryotic translation initiation factor 3 subunit H |
decreases expression |
ISO |
Sorbitol results in decreased expression of EIF3H mRNA |
CTD |
PMID:35678645 |
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NCBI chr 8:116,642,130...116,766,374
Ensembl chr 8:116,642,130...116,766,925
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G |
EIF4E |
eukaryotic translation initiation factor 4E |
multiple interactions |
EXP |
Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] |
CTD |
PMID:9545260 |
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NCBI chr 4:98,879,276...98,929,133
Ensembl chr 4:98,879,276...98,929,133
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G |
EIF4EBP1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions |
EXP |
Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] |
CTD |
PMID:9545260 |
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NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
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G |
ENY2 |
ENY2 transcription and export complex 2 subunit |
increases expression |
ISO |
Sorbitol results in increased expression of ENY2 mRNA |
CTD |
PMID:35678645 |
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NCBI chr 8:109,334,347...109,345,954
Ensembl chr 8:109,334,324...109,345,954
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G |
FMR1 |
fragile X messenger ribonucleoprotein 1 |
increases abundance |
EXP |
FMR1 5' UTR mutant form results in increased abundance of Sorbitol |
CTD |
PMID:27385396 |
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NCBI chr X:147,911,919...147,951,125
Ensembl chr X:147,911,919...147,951,125
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G |
INS-IGF2 |
INS-IGF2 readthrough |
multiple interactions |
ISO |
Sorbitol promotes the reaction [Glucose results in increased secretion of INS1 protein] |
CTD |
PMID:10221768 |
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NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases phosphorylation |
EXP |
JNK-IN-8 inhibits the reaction [Sorbitol results in increased phosphorylation of JUN protein] |
CTD |
PMID:24184208 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
MAPK10 |
mitogen-activated protein kinase 10 |
multiple interactions increases activity |
EXP |
Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein] |
CTD |
PMID:10531305 |
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NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625
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G |
MAPK12 |
mitogen-activated protein kinase 12 |
increases phosphorylation |
EXP |
Sorbitol results in increased phosphorylation of MAPK12 protein |
CTD |
PMID:15362974 |
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NCBI chr22:50,252,901...50,261,683
Ensembl chr22:50,245,450...50,261,716
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G |
MAPK14 |
mitogen-activated protein kinase 14 |
increases phosphorylation |
EXP |
Sorbitol results in increased phosphorylation of MAPK14 protein |
CTD |
PMID:15362974 |
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NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
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G |
MAPK7 |
mitogen-activated protein kinase 7 |
increases activity |
ISO |
Sorbitol results in increased activity of MAPK7 protein |
CTD |
PMID:11163183 |
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NCBI chr17:19,377,750...19,383,544
Ensembl chr17:19,377,721...19,383,544
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
increases phosphorylation |
EXP |
Sorbitol results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:24184208 |
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NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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G |
MAPK9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
EXP |
Sorbitol results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:24184208 |
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NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
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G |
MAPKAPK2 |
MAPK activated protein kinase 2 |
increases activity increases phosphorylation multiple interactions |
EXP |
Sorbitol results in increased activity of MAPKAPK2 protein Sorbitol results in increased phosphorylation of MAPKAPK2 protein SB 203580 inhibits the reaction [Sorbitol results in increased phosphorylation of MAPKAPK2 protein] |
CTD |
PMID:9545260 PMID:15362974 |
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NCBI chr 1:206,684,905...206,734,281
Ensembl chr 1:206,684,905...206,734,281
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G |
MKNK1 |
MAPK interacting serine/threonine kinase 1 |
increases activity |
EXP |
Sorbitol results in increased activity of MKNK1 protein |
CTD |
PMID:9545260 |
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NCBI chr 1:46,557,407...46,604,268
Ensembl chr 1:46,557,407...46,616,843
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G |
MRPS16 |
mitochondrial ribosomal protein S16 |
decreases expression |
ISO |
Sorbitol results in decreased expression of MRPS16 mRNA |
CTD |
PMID:35678645 |
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NCBI chr10:73,248,849...73,252,644
Ensembl chr10:73,248,843...73,252,693
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G |
OAT |
ornithine aminotransferase |
multiple interactions |
ISO |
Sorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] |
CTD |
PMID:2827574 |
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NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
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G |
PPT1 |
palmitoyl-protein thioesterase 1 |
increases expression |
ISO |
Sorbitol results in increased expression of PPT1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr 1:40,071,461...40,097,252
Ensembl chr 1:40,072,710...40,097,260
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G |
PTEN |
phosphatase and tensin homolog |
affects localization |
EXP ISO |
Sorbitol affects the localization of PTEN protein |
CTD |
PMID:16807353 |
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NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
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G |
RPL18 |
ribosomal protein L18 |
increases expression |
ISO |
Sorbitol results in increased expression of RPL18 mRNA |
CTD |
PMID:35678645 |
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NCBI chr19:48,615,331...48,619,178
Ensembl chr19:48,615,328...48,619,184
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G |
SNRNP200 |
small nuclear ribonucleoprotein U5 subunit 200 |
multiple interactions |
EXP |
Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] |
CTD |
PMID:33939924 |
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NCBI chr 2:96,274,338...96,305,546
Ensembl chr 2:96,274,338...96,321,271
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G |
SORD |
sorbitol dehydrogenase |
increases abundance increases metabolic processing multiple interactions |
EXP |
SORD protein mutant form results in increased abundance of Sorbitol SORD protein results in increased metabolism of Sorbitol [SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose; epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]; ranirestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol] |
CTD |
PMID:32367058 |
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NCBI chr15:45,023,195...45,077,185
Ensembl chr15:45,023,147...45,077,185
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G |
TARDBP |
TAR DNA binding protein |
increases ubiquitination |
EXP |
Sorbitol results in increased ubiquitination of TARDBP protein |
CTD |
PMID:31780563 |
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NCBI chr 1:11,012,654...11,030,528
Ensembl chr 1:11,012,344...11,030,528
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G |
TK1 |
thymidine kinase 1 |
increases expression |
ISO |
Sorbitol results in increased expression of TK1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233
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G |
UBE2C |
ubiquitin conjugating enzyme E2 C |
decreases expression |
ISO |
Sorbitol results in decreased expression of UBE2C mRNA |
CTD |
PMID:35678645 |
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NCBI chr20:45,812,644...45,816,952
Ensembl chr20:45,812,576...45,816,957
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G |
UBXN1 |
UBX domain protein 1 |
increases phosphorylation |
ISO EXP |
Sorbitol results in increased phosphorylation of UBXN1 protein |
CTD |
PMID:15362974 |
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NCBI chr11:62,676,500...62,679,073
Ensembl chr11:62,676,498...62,679,117
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
decreases activity |
EXP |
Isosorbide Dinitrate results in decreased activity of CYP1A1 protein |
CTD |
PMID:33814510 |
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NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
EDN1 |
endothelin 1 |
multiple interactions |
EXP |
[Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA |
CTD |
PMID:15719745 |
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NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
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G |
G6PD |
glucose-6-phosphate dehydrogenase |
decreases response to substance |
EXP |
G6PD protein results in decreased susceptibility to Isosorbide Dinitrate |
CTD |
PMID:6401899 |
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NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572
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G |
NOS3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
[Isosorbide Dinitrate co-treated with Ascorbic Acid] affects the expression of NOS3 mRNA; [Isosorbide Dinitrate co-treated with Plant Preparations] results in increased expression of NOS3 mRNA |
CTD |
PMID:15719745 |
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NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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G |
PAFAH1B1 |
platelet activating factor acetylhydrolase 1b regulatory subunit 1 |
multiple interactions |
ISO |
isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein] |
CTD |
PMID:8738301 |
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NCBI chr17:2,593,183...2,685,615
Ensembl chr17:2,593,210...2,685,615
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