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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bicalutamide
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Accession:CHEBI:3090 term browser browse the term
Definition:A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.
Synonyms:exact_synonym: rac-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
 related_synonym: (RS)-4'-cyano-alpha',alpha',alpha',-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropiono-m-toluidide;   (RS)-bicalutamide;   Bicadex;   Bical;   Bicalox;   Bicamide;   Bicatlon;   Bicusan;   Binabic;   Bypro;   Calumid;   Calutide;   Calutol;   Casodex;   Cosudex;   Formula=C18H14F4N2O4S;   ICI 176,334;   ICI 176334;   Kalumid;   Ormandyl;   bicalutamida;   bicalutamidum;   racemic bicalutamide
 alt_id: CHEBI:91617
 xref: Beilstein:5364666;   CAS:90357-06-5;   DrugBank:DB01128;   Drug_Central:367;   HMDB:HMDB0015260;   KEGG:C08160;   KEGG:D00961;   LINCS:LSM-1437
 xref_mesh: MESH:C053541
 xref: PMID:11915584;   PMID:12015321;   PMID:12017896;   PMID:12421104;   PMID:12959312;   PMID:15509184;   PMID:17313204;   PMID:18062751;   PMID:19194583;   PMID:23527766;   PMID:30784326;   PMID:31099426;   Patent:EP100172;   Patent:US4636505;   Reaxys:5364666;   Wikipedia:Bicalutamide


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bicalutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aamp angio-associated, migratory cell protein increases expression ISO bicalutamide results in increased expression of AAMP mRNA CTD PMID:16631469 NCBI chr 9:75,863,382...75,869,188 JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO bicalutamide results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:54,016,854...54,112,797 JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO bicalutamide results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489 JBrowse link
G Acp3 acid phosphatase 3 decreases expression ISO bicalutamide results in decreased expression of ACP3 mRNA CTD PMID:15638997 NCBI chr 8:104,905,570...104,956,146 JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO bicalutamide results in increased expression of ACSL1 mRNA CTD PMID:15790403 NCBI chr16:45,755,246...45,821,541 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ADAM9 protein] CTD PMID:17342749 NCBI chr16:67,022,538...67,101,647 JBrowse link
G Adrb2 adrenoceptor beta 2 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of ADRB2 mRNA; bicalutamide results in decreased expression of ADRB2 protein
bicalutamide inhibits the reaction [Triiodothyronine results in increased expression of ADRB2 protein]
CTD PMID:18454446 NCBI chr18:55,642,459...55,644,501 JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member increases expression ISO bicalutamide results in increased expression of AGR2 mRNA CTD PMID:15638997 NCBI chr 6:52,708,602...52,729,378 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of AKT1 protein] CTD PMID:17325745 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ALDH1A3 mRNA] CTD PMID:17526768 NCBI chr 1:119,982,272...120,017,416 JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression ISO bicalutamide results in increased expression of ALDH3A2 mRNA CTD PMID:15638997 NCBI chr10:45,928,313...45,949,366 JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO bicalutamide results in decreased expression of AMACR mRNA CTD PMID:15638997 NCBI chr 2:59,946,158...59,958,255 JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 increases expression ISO bicalutamide results in increased expression of AMD1 mRNA CTD PMID:15790403 NCBI chr20:43,695,783...43,711,476 JBrowse link
G Ankib1 ankyrin repeat and IBR domain containing 1 increases expression ISO bicalutamide results in increased expression of ANKIB1 mRNA CTD PMID:16631469 NCBI chr 4:30,333,678...30,457,781 JBrowse link
G Ar androgen receptor decreases response to substance
decreases expression
multiple interactions
increases expression
decreases activity
affects binding
affects response to substance
affects localization
ISO
EXP
AR gene mutant form results in decreased susceptibility to bicalutamide; AR protein alternative form results in decreased susceptibility to bicalutamide
bicalutamide results in decreased expression of AR protein
bicalutamide binds to and results in decreased activity of AR protein; bicalutamide inhibits the reaction [[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]]
bicalutamide results in increased localization of and results in increased activity of AR protein
bicalutamide results in increased expression of AR; bicalutamide results in increased expression of AR protein
bicalutamide results in decreased expression of AR; bicalutamide results in decreased expression of AR mRNA
bicalutamide results in decreased activity of AR protein
[bicalutamide binds to AR protein] which binds to KLK3 promoter; bicalutamide binds to AR protein
AR protein affects the susceptibility to bicalutamide
[Azacitidine analog results in increased expression of AR protein] which results in increased susceptibility to bicalutamide; [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; [bicalutamide co-treated with Testosterone] affects the expression of and results in decreased activity of AR protein; [bicalutamide results in decreased susceptibility to bicalutamide] which results in increased expression of and affects the localization of AR protein alternative form; [bicalutamide results in decreased susceptibility to bicalutamide] which results in increased expression of AR mRNA; [bicalutamide results in decreased susceptibility to bicalutamide] which results in increased expression of AR mRNA alternative form; [bicalutamide results in decreased susceptibility to bicalutamide] which results in increased expression of AR protein; [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to PHB protein]; [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to SMARCA4 protein]; [Goserelin co-treated with bicalutamide] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of AR protein; AR protein promotes the reaction [bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]]; bicalutamide binds to and affects the localization of and affects the activity of AR protein; bicalutamide binds to and results in decreased activity of AR protein; bicalutamide binds to and results in increased activity of AR protein mutant form; bicalutamide inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; bicalutamide inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; bicalutamide inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]; bicalutamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; bicalutamide inhibits the reaction [AR protein alternative form promotes the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; bicalutamide inhibits the reaction [AR protein binds to KLK3 promoter]; bicalutamide inhibits the reaction [AR protein binds to NCOA1 protein]; bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]]; bicalutamide inhibits the reaction [Cadmium Chloride results in decreased expression of AR mRNA]; bicalutamide inhibits the reaction [Cadmium Chloride results in decreased expression of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone affects the localization of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone binds to AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of AR mRNA]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of and results in increased phosphorylation of AR protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; bicalutamide inhibits the reaction [Estradiol results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Estradiol results in increased activity of AR protein]; bicalutamide inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Flutamide results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; bicalutamide inhibits the reaction [Metribolone results in increased folding of and results in increased stability of AR protein]; bicalutamide inhibits the reaction [OSM protein results in increased activity of AR protein]; bicalutamide inhibits the reaction [Sirolimus results in increased activity of AR protein]; bicalutamide inhibits the reaction [Testosterone results in increased activity of AR protein]; bicalutamide promotes the reaction [AR protein binds to KLK3 promoter]; bicalutamide promotes the reaction [AR protein binds to NCOR2 protein]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; methoxyacetic acid inhibits the reaction [bicalutamide inhibits the reaction [Testosterone results in increased activity of AR protein]]; mibolerone inhibits the reaction [bicalutamide results in increased expression of AR protein]; Resveratrol promotes the reaction [bicalutamide results in decreased activity of AR protein]
bicalutamide affects the localization of AR protein
CTD PMID:10053169 PMID:11751618 PMID:11845989 PMID:11956172 PMID:11981028 PMID:12015321 PMID:12114440 PMID:12376534 PMID:12730620 PMID:12970580 PMID:15171712 PMID:15308689 PMID:15336702 PMID:15638997 PMID:15994348 PMID:16015592 PMID:16266977 PMID:16877366 PMID:17606915 PMID:17723170 PMID:17804755 PMID:18324645 PMID:18324785 PMID:18486176 PMID:18487222 PMID:18776922 PMID:18922931 PMID:19131511 PMID:19359544 PMID:19587329 PMID:20032058 PMID:20729295 PMID:21036700 PMID:21308717 PMID:21506597 PMID:23562765 PMID:23603339 PMID:24323034 PMID:24759320 PMID:25752796 PMID:26867867 PMID:27473015 PMID:27720946 PMID:28500234 PMID:28757136 PMID:29383186 PMID:29427707 PMID:29462692 PMID:33049310 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Arg1 arginase 1 decreases expression ISO bicalutamide results in decreased expression of ARG1 protein CTD PMID:20711410 NCBI chr 1:20,475,878...20,488,422 JBrowse link
G Arg2 arginase 2 increases expression ISO bicalutamide results in increased expression of ARG2 protein CTD PMID:20711410 NCBI chr 6:97,936,002...97,961,379 JBrowse link
G Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 increases expression ISO bicalutamide results in increased expression of ASAP2 mRNA CTD PMID:16631469 NCBI chr 6:40,658,201...40,821,017 JBrowse link
G Atf3 activating transcription factor 3 decreases expression
increases expression
ISO bicalutamide results in decreased expression of ATF3 protein
bicalutamide results in increased expression of ATF3 mRNA
CTD PMID:15638997 PMID:16516039 NCBI chr13:102,751,278...102,800,520 JBrowse link
G Atp5me ATP synthase membrane subunit e increases expression ISO bicalutamide results in increased expression of ATP5ME mRNA CTD PMID:16631469 NCBI chr14:1,319,868...1,320,996 JBrowse link
G B4galt6 beta-1,4-galactosyltransferase 6 increases expression ISO bicalutamide results in increased expression of B4GALT6 mRNA CTD PMID:16631469 NCBI chr18:11,958,382...12,015,247 JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression ISO bicalutamide results in decreased expression of BARD1 mRNA CTD PMID:15638997 NCBI chr 9:72,616,070...72,694,553 JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
ISO bicalutamide results in decreased expression of BAX
bicalutamide results in increased expression of BAX protein
[bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]
CTD PMID:11845989 PMID:27132804 PMID:28500234 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bche butyrylcholinesterase decreases expression ISO bicalutamide results in decreased expression of BCHE mRNA CTD PMID:15638997 NCBI chr 2:158,308,674...158,401,148 JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO bicalutamide results in increased expression of BCL2
bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]
CTD PMID:11845989 PMID:28500234 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of BCL2L1 protein
bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein]
CTD PMID:28500234 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO bicalutamide results in decreased expression of BIRC5 mRNA CTD PMID:15638997 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO bicalutamide results in increased expression of BNIP3 mRNA CTD PMID:15790403 NCBI chr 1:193,708,164...193,725,348 JBrowse link
G Btbd3 BTB domain containing 3 increases expression ISO bicalutamide results in increased expression of BTBD3 mRNA CTD PMID:16631469 NCBI chr 3:125,591,427...125,621,660 JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO bicalutamide results in decreased expression of BUB1B mRNA CTD PMID:15638997 NCBI chr 3:105,563,089...105,615,547 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; bicalutamide results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:15638997 PMID:27132804 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp7 caspase 7 multiple interactions ISO bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form] CTD PMID:28500234 NCBI chr 1:255,437,195...255,476,737 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]] CTD PMID:16317058 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccna2 cyclin A2 decreases expression ISO bicalutamide results in decreased expression of CCNA2 mRNA CTD PMID:15887248 NCBI chr 2:119,427,239...119,433,645 JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO bicalutamide results in decreased expression of CCNB1 mRNA CTD PMID:15887248 NCBI chr 2:31,912,190...31,921,163 JBrowse link
G Ccnb1ip1 cyclin B1 interacting protein 1 increases expression ISO bicalutamide results in increased expression of CCNB1IP1 mRNA CTD PMID:15638997 NCBI chr15:24,014,905...24,031,357 JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein] CTD PMID:28500234 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Ccng2 cyclin G2 increases expression ISO bicalutamide results in increased expression of CCNG2 mRNA CTD PMID:15790403 NCBI chr14:14,804,321...14,812,819 JBrowse link
G Ccpg1 cell cycle progression 1 increases expression ISO bicalutamide results in increased expression of CCPG1 mRNA CTD PMID:15638997 NCBI chr 8:73,719,960...73,752,437 JBrowse link
G Cd40 CD40 molecule multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]] CTD PMID:16317058 NCBI chr 3:153,790,372...153,805,279 JBrowse link
G Cd9 CD9 molecule increases expression ISO bicalutamide results in increased expression of CD9 mRNA CTD PMID:15790403 NCBI chr 4:158,256,328...158,289,136 JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO bicalutamide results in decreased expression of CDC20 mRNA CTD PMID:15638997 NCBI chr 5:131,966,203...131,970,406 JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO bicalutamide results in decreased expression of CDC6 mRNA; bicalutamide results in decreased expression of CDC6 protein CTD PMID:15887248 NCBI chr10:83,864,189...83,878,011 JBrowse link
G Cdh1 cadherin 1 affects localization ISO bicalutamide affects the localization of CDH1 protein CTD PMID:17440980 NCBI chr19:34,492,371...34,561,775 JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO bicalutamide results in decreased expression of CDK1 mRNA CTD PMID:15638997 NCBI chr20:19,266,226...19,281,417 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO bicalutamide results in increased expression of CDKN1A; bicalutamide results in increased expression of CDKN1A mRNA; bicalutamide results in increased expression of CDKN1A protein
[bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein
CTD PMID:11845989 PMID:15638997 PMID:27132804 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO bicalutamide results in increased expression of CDKN1B CTD PMID:11845989 NCBI chr 4:167,760,067...167,765,177 JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO bicalutamide results in decreased expression of CDKN2C mRNA CTD PMID:15638997 NCBI chr 5:124,411,123...124,416,278 JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO bicalutamide results in decreased expression of CKS2 mRNA CTD PMID:15638997 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Clgn calmegin increases expression ISO bicalutamide results in increased expression of CLGN mRNA CTD PMID:15638997 NCBI chr19:24,695,140...24,728,542 JBrowse link
G Clu clusterin multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU protein] CTD PMID:17148459 PMID:17325745 NCBI chr15:40,161,068...40,200,315 JBrowse link
G Copb2 COPI coat complex subunit beta 2 increases expression ISO bicalutamide results in increased expression of COPB2 mRNA CTD PMID:16631469 NCBI chr 8:99,161,324...99,183,452 JBrowse link
G Crebbp CREB binding protein multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in decreased expression of CREBBP protein] CTD PMID:15378487 NCBI chr10:11,335,551...11,461,888 JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP11A1 protein]; bicalutamide inhibits the reaction [Testosterone results in increased expression of CYP11A1 protein] CTD PMID:21273442 NCBI chr 8:58,422,807...58,434,342 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP19A1 protein]; bicalutamide inhibits the reaction [Testosterone results in increased expression of CYP19A1 protein] CTD PMID:21273442 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased degradation of CYP1A2 mRNA] CTD PMID:23603339 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions EXP bicalutamide inhibits the reaction [[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]] CTD PMID:20032058 NCBI chr20:27,891,989...27,894,088 JBrowse link
G Deptor DEP domain containing MTOR-interacting protein multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of DEPTOR mRNA] CTD PMID:26558456 NCBI chr 7:86,514,859...86,668,817 JBrowse link
G Dio3 iodothyronine deiodinase 3 increases expression ISO bicalutamide results in increased expression of DIO3 mRNA CTD PMID:15638997 NCBI chr 6:129,285,747...129,287,608 JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 decreases expression ISO bicalutamide results in decreased expression of DKC1 mRNA CTD PMID:15638997
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO bicalutamide results in increased expression of DNAJB9 mRNA CTD PMID:15638997 NCBI chr 6:61,270,385...61,276,795 JBrowse link
G Drd4 dopamine receptor D4 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of DRD4 mRNA
FSHB protein inhibits the reaction [bicalutamide results in decreased expression of DRD4 protein]
CTD PMID:19587329 NCBI chr 1:196,396,366...196,400,824 JBrowse link
G Ebp EBP, cholestenol delta-isomerase decreases expression ISO bicalutamide results in decreased expression of EBP mRNA CTD PMID:15638997 NCBI chr  X:14,299,427...14,305,826 JBrowse link
G Egf epidermal growth factor multiple interactions ISO bicalutamide inhibits the reaction [FOS protein results in increased expression of EGF mRNA] CTD PMID:15466214 NCBI chr 2:218,219,408...218,302,370 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]]; bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]]; bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of EGFR protein] CTD PMID:29383186 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [bicalutamide co-treated with Testosterone] results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:21036700 NCBI chr16:64,792,595...64,805,984 JBrowse link
G Eppin epididymal peptidase inhibitor decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of EPPIN mRNA
FSHB protein inhibits the reaction [bicalutamide results in decreased expression of EPPIN protein]
CTD PMID:19587329 NCBI chr 3:153,312,396...153,319,310 JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO bicalutamide binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104 JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]] CTD PMID:29383186 NCBI chr 6:94,858,438...94,909,630 JBrowse link
G Etl4 enhancer trap locus 4 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of KIAA1217 mRNA] CTD PMID:17624924 NCBI chr17:82,841,075...83,304,868 JBrowse link
G Etv1 ETS variant transcription factor 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ETV1 mRNA] CTD PMID:28757136 NCBI chr 6:55,590,149...55,681,784 JBrowse link
G Ezr ezrin multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of EZR mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of EZR protein] CTD PMID:16873375 NCBI chr 1:46,967,961...47,011,505 JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of FABP4 protein] CTD PMID:18801408 NCBI chr 2:91,580,858...91,585,578 JBrowse link
G Fgf13 fibroblast growth factor 13 increases expression ISO bicalutamide results in increased expression of FGF13 mRNA CTD PMID:15638997 NCBI chr  X:137,276,498...137,800,056 JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 increases expression ISO bicalutamide results in increased expression of FKBP11 mRNA CTD PMID:15638997 NCBI chr 7:129,871,870...129,877,760 JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of FKBP5 mRNA
[Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA
CTD PMID:28500234 NCBI chr20:6,457,207...6,575,404 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of FOS mRNA]; bicalutamide inhibits the reaction [FOS protein results in increased expression of EGF mRNA] CTD PMID:15466214 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO FSHB protein inhibits the reaction [bicalutamide results in decreased expression of DRD4 protein]; FSHB protein inhibits the reaction [bicalutamide results in decreased expression of EPPIN protein]; FSHB protein inhibits the reaction [bicalutamide results in decreased expression of GPD1 protein]; FSHB protein inhibits the reaction [bicalutamide results in decreased expression of RHOX5 protein] CTD PMID:19587329 NCBI chr 3:93,548,560...93,552,370 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO bicalutamide results in increased expression of GADD45A mRNA CTD PMID:15638997 NCBI chr 4:96,154,789...96,157,091 JBrowse link
G Gcg glucagon decreases expression ISO bicalutamide results in decreased expression of GCG mRNA CTD PMID:15638997 NCBI chr 3:47,113,914...47,122,929 JBrowse link
G Gpc1 glypican 1 decreases expression ISO bicalutamide results in decreased expression of GPC1 mRNA CTD PMID:15638997 NCBI chr 9:93,396,234...93,424,047 JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of GPD1 mRNA
FSHB protein inhibits the reaction [bicalutamide results in decreased expression of GPD1 protein]
CTD PMID:19587329 NCBI chr 7:130,842,526...130,851,530 JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO bicalutamide results in increased expression of GPNMB mRNA CTD PMID:15638997 NCBI chr 4:78,010,247...78,031,491 JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A decreases expression ISO bicalutamide results in decreased expression of GPRC5A mRNA CTD PMID:15638997 NCBI chr 4:167,903,542...167,922,276 JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO bicalutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA] CTD PMID:16496412 NCBI chr 6:39,440,522...39,562,364 JBrowse link
G Gtpbp2 GTP binding protein 2 increases expression ISO bicalutamide results in increased expression of GTPBP2 mRNA CTD PMID:15638997 NCBI chr 9:14,813,964...14,823,419 JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO bicalutamide results in increased expression of HYOU1 mRNA CTD PMID:15638997 NCBI chr 8:44,706,073...44,718,189 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]] CTD PMID:16317058 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression
ISO [bicalutamide co-treated with Tamoxifen] results in decreased expression of IGF1 protein; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1 mRNA]
bicalutamide results in increased expression of IGF1 mRNA; bicalutamide results in increased expression of IGF1 protein
CTD PMID:16368782 PMID:16847815 NCBI chr 7:22,282,895...22,361,972 JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO [bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP1 protein CTD PMID:16847815 NCBI chr14:82,047,415...82,052,482 JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 multiple interactions
increases expression
ISO
EXP
bicalutamide promotes the reaction [Dihydrotestosterone results in increased expression of IGFBP2 mRNA]
bicalutamide results in increased expression of IGFBP2 mRNA
CTD PMID:10604720 PMID:16368782 NCBI chr 9:74,415,574...74,442,945 JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions
increases expression
decreases secretion
decreases expression
ISO
EXP
[bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP3 protein
bicalutamide results in increased expression of IGFBP3 protein
bicalutamide results in increased expression of IGFBP3 mRNA
bicalutamide results in decreased secretion of IGFBP3 protein
bicalutamide results in decreased expression of IGFBP3 mRNA
CTD PMID:10604720 PMID:16368782 PMID:16847815 NCBI chr14:82,056,347...82,064,083 JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 increases expression EXP bicalutamide results in increased expression of IGFBP4 mRNA CTD PMID:10604720 NCBI chr10:83,995,253...84,007,272 JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 increases expression EXP bicalutamide results in increased expression of IGFBP5 mRNA CTD PMID:10604720 NCBI chr 9:74,452,371...74,464,953 JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein results in increased expression of NCOA2 protein] which results in decreased susceptibility to bicalutamide; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [BCG Vaccine results in increased expression of IL6 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; bicalutamide inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA] CTD PMID:11410519 PMID:14532843 PMID:16317058 PMID:19240160 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO bicalutamide results in decreased expression of KIF20A mRNA CTD PMID:15638997 NCBI chr18:26,230,294...26,238,780 JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression ISO bicalutamide results in increased expression of LAMP2 mRNA CTD PMID:16631469 NCBI chr  X:117,173,097...117,222,090 JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 increases expression ISO bicalutamide results in increased expression of LAMP3 mRNA CTD PMID:15638997 NCBI chr11:81,153,491...81,224,643 JBrowse link
G Lcn2 lipocalin 2 increases expression ISO bicalutamide results in increased expression of LCN2 mRNA CTD PMID:15638997 NCBI chr 3:15,680,688...15,684,033 JBrowse link
G Ldlr low density lipoprotein receptor affects localization ISO bicalutamide affects the localization of LDLR protein CTD PMID:17440980 NCBI chr 8:20,270,020...20,292,981 JBrowse link
G Lmnb1 lamin B1 decreases expression ISO bicalutamide results in decreased expression of LMNB1 mRNA CTD PMID:15638997 NCBI chr18:50,175,861...50,215,210 JBrowse link
G LOC102549061 histone H2B type 1-N-like increases expression ISO bicalutamide results in increased expression of H2BC3 mRNA CTD PMID:15790403 NCBI chr17:41,380,058...41,380,685 JBrowse link
G Lrba LPS responsive beige-like anchor protein increases expression ISO bicalutamide results in increased expression of LRBA mRNA CTD PMID:15790403 NCBI chr 2:171,623,668...172,202,576 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO bicalutamide results in decreased expression of MAD2L1 mRNA CTD PMID:15638997 NCBI chr 4:95,906,692...95,918,885 JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 increases expression ISO bicalutamide results in increased expression of MAN1A1 mRNA CTD PMID:15638997 NCBI chr20:33,202,509...33,385,747 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15466214 NCBI chr 8:64,683,449...64,754,900 JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15466214 NCBI chr 7:8,590,729...8,610,279 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bicalutamide results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15466214 PMID:29383186 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bicalutamide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15466214 PMID:29383186 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 increases expression ISO bicalutamide results in increased expression of MBD2 mRNA CTD PMID:16631469 NCBI chr18:64,174,002...64,240,795 JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO bicalutamide results in decreased expression of MCM2 mRNA CTD PMID:15638997 NCBI chr 4:121,346,434...121,360,962 JBrowse link
G Mdk midkine increases expression ISO bicalutamide results in increased expression of MDK mRNA CTD PMID:15638997 NCBI chr 3:77,901,156...77,903,997 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO bicalutamide inhibits the reaction [Testosterone results in increased expression of MET mRNA] CTD PMID:11139396 PMID:17371283 NCBI chr 4:45,790,456...45,898,139 JBrowse link
G Mir21 microRNA 21 multiple interactions ISO bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] CTD PMID:23052036 PMID:25969534 NCBI chr10:71,405,257...71,405,348 JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO bicalutamide results in decreased expression of MKI67 mRNA CTD PMID:15638997 NCBI chr 1:190,496,319...190,522,983 JBrowse link
G Mme membrane metallo-endopeptidase increases expression ISO bicalutamide results in increased expression of MME mRNA CTD PMID:15790403 NCBI chr 2:147,686,913...147,803,808 JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO bicalutamide inhibits the reaction [Androgens results in increased expression of MMP13 mRNA] CTD PMID:15138554 NCBI chr 8:4,497,960...4,508,239 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO bicalutamide inhibits the reaction [Metribolone results in increased expression of MMP2 mRNA] CTD PMID:16888681 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Msmb microseminoprotein, beta decreases expression ISO bicalutamide results in decreased expression of MSMB mRNA CTD PMID:33932781 NCBI chr16:7,366,536...7,387,124 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases expression
ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC protein; bicalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC mRNA]; Niclosamide inhibits the reaction [bicalutamide results in increased expression of MYC protein]
bicalutamide results in decreased expression of MYC mRNA
CTD PMID:15638997 PMID:24759320 PMID:28500234 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Myo6 myosin VI increases expression ISO bicalutamide results in increased expression of MYO6 mRNA CTD PMID:15790403 PMID:16631469 NCBI chr 8:81,087,157...81,242,022 JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO bicalutamide inhibits the reaction [AR protein binds to NCOA1 protein] CTD PMID:11981028 NCBI chr 6:27,232,609...27,507,992 JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO [IL6 protein results in increased expression of NCOA2 protein] which results in decreased susceptibility to bicalutamide CTD PMID:19240160 NCBI chr 5:5,835,642...6,069,693 JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO bicalutamide promotes the reaction [AR protein binds to NCOR2 protein] CTD PMID:11981028 NCBI chr12:31,466,418...31,628,319 JBrowse link
G Nebl nebulette increases expression ISO bicalutamide results in increased expression of NEBL mRNA CTD PMID:15638997 NCBI chr17:80,113,891...80,466,331 JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO bicalutamide results in decreased expression of NEK2 mRNA CTD PMID:15638997 NCBI chr13:103,405,818...103,419,063 JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO bicalutamide results in increased expression of NIBAN1 mRNA CTD PMID:15638997 NCBI chr13:63,674,240...63,827,748 JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
decreases expression
ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA; bicalutamide inhibits the reaction [Antimony Potassium Tartrate results in increased expression of NKX3-1 mRNA]; bicalutamide inhibits the reaction [Cadmium Chloride results in increased expression of NKX3-1 mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA]
bicalutamide results in decreased expression of NKX3-1 mRNA
CTD PMID:11751618 PMID:15638997 PMID:28500234 PMID:29462692 NCBI chr15:44,473,851...44,476,443 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO bicalutamide binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665 JBrowse link
G Nrp1 neuropilin 1 decreases expression ISO bicalutamide results in decreased expression of NRP1 mRNA CTD PMID:15638997 NCBI chr19:56,359,455...56,514,628 JBrowse link
G Nts neurotensin decreases response to substance ISO NTS protein results in decreased susceptibility to bicalutamide CTD PMID:17044078 NCBI chr 7:37,564,944...37,574,350 JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO bicalutamide results in decreased expression of NUSAP1 mRNA CTD PMID:15638997 NCBI chr 3:106,603,273...106,633,624 JBrowse link
G Osm oncostatin M multiple interactions ISO bicalutamide inhibits the reaction [OSM protein results in increased activity of AR protein] CTD PMID:12114440 NCBI chr14:79,103,638...79,108,500 JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions
increases response to substance
ISO bicalutamide promotes the reaction [PA2G4 protein binds to KLK3 promoter]
PA2G4 protein results in increased susceptibility to bicalutamide
CTD PMID:15994225 NCBI chr 7:984,795...992,264 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form] CTD PMID:28500234 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Pbk PDZ binding kinase decreases expression ISO bicalutamide results in decreased expression of PBK mRNA CTD PMID:15638997 NCBI chr15:40,022,873...40,034,014 JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO bicalutamide results in decreased expression of PCNA mRNA CTD PMID:15638997 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Pds5b PDS5 cohesin associated factor B multiple interactions ISO bicalutamide inhibits the reaction [Calcitriol results in increased expression of APRIN] CTD PMID:15754350 NCBI chr12:202,481...345,596 JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase increases expression ISO bicalutamide results in increased expression of PECR mRNA CTD PMID:15638997 NCBI chr 9:73,897,877...73,926,511 JBrowse link
G Pgr progesterone receptor multiple interactions ISO bicalutamide binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552 JBrowse link
G Phb prohibitin multiple interactions ISO [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to PHB protein]; AR protein promotes the reaction [bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]; PHB protein promotes the reaction [bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; PHB protein promotes the reaction [bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]] CTD PMID:18487222 NCBI chr10:80,605,268...80,618,043 JBrowse link
G Pip prolactin induced protein decreases expression
multiple interactions
ISO bicalutamide results in decreased expression of PIP mRNA
bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of PIP mRNA]
CTD PMID:10402478 NCBI chr 4:70,787,627...70,791,921 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO bicalutamide binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO bicalutamide results in decreased expression of PRC1 mRNA CTD PMID:15638997 NCBI chr 1:134,250,086...134,271,765 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases activity
ISO bicalutamide promotes the reaction [PTEN protein results in decreased expression of KLK3 mRNA]
bicalutamide results in increased activity of PTEN protein
CTD PMID:16637073 NCBI chr 1:230,631,303...230,696,754 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] CTD PMID:16317058 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO bicalutamide results in decreased expression of RACGAP1 mRNA CTD PMID:15638997 NCBI chr 7:130,750,936...130,780,891 JBrowse link
G Ranbp1 RAN binding protein 1 decreases expression ISO bicalutamide results in decreased expression of RANBP1 mRNA CTD PMID:15638997 NCBI chr11:82,742,603...82,750,836 JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO bicalutamide results in increased expression of RARB mRNA CTD PMID:15790403 NCBI chr15:8,700,533...9,051,288 JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation ISO bicalutamide results in increased phosphorylation of RB1 protein CTD PMID:17599054 NCBI chr15:48,371,295...48,502,473 JBrowse link
G Rom1 retinal outer segment membrane protein 1 increases expression ISO bicalutamide results in increased expression of ROM1 mRNA CTD PMID:15790403 NCBI chr 1:205,824,050...205,826,058 JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO [bicalutamide co-treated with Testosterone] results in decreased phosphorylation of RPS6 protein CTD PMID:21036700 NCBI chr 5:101,371,716...101,374,576 JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [bicalutamide co-treated with Testosterone] results in decreased phosphorylation of RPS6KB1 protein CTD PMID:21036700 NCBI chr10:71,323,777...71,367,908 JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO bicalutamide results in decreased expression of RRM2 mRNA CTD PMID:15638997 NCBI chr 6:41,339,858...41,346,774 JBrowse link
G Rxrb retinoid X receptor beta decreases expression ISO bicalutamide results in decreased expression of RXRB CTD PMID:11845989 NCBI chr20:4,816,813...4,823,267 JBrowse link
G Scgb2a1 secretoglobin, family 2A, member 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SCGB2A1 mRNA] CTD PMID:16020486 NCBI chr 1:206,497,848...206,501,211 JBrowse link
G Sem1 SEM1 26S proteasome subunit increases expression ISO bicalutamide results in increased expression of SEM1 mRNA CTD PMID:16631469 NCBI chr 4:34,671,848...34,692,005 JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]] CTD PMID:16317058 NCBI chr12:19,601,272...19,611,657 JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO bicalutamide results in increased expression of SLC3A2 mRNA CTD PMID:15638997 NCBI chr 1:205,604,468...205,618,931 JBrowse link
G Slc4a4 solute carrier family 4 member 4 decreases expression ISO bicalutamide results in decreased expression of SLC4A4 mRNA CTD PMID:15638997 NCBI chr14:18,841,289...19,293,297 JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO bicalutamide results in increased expression of SLC7A11 mRNA CTD PMID:15638997 NCBI chr 2:134,382,002...134,517,622 JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 multiple interactions ISO [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to SMARCA4 protein]; bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]; PHB protein promotes the reaction [bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]] CTD PMID:18487222 NCBI chr 8:20,167,717...20,258,975 JBrowse link
G Snap25 synaptosome associated protein 25 increases expression ISO bicalutamide results in increased expression of SNAP25 mRNA CTD PMID:15790403 NCBI chr 3:124,041,898...124,123,761 JBrowse link
G Sord sorbitol dehydrogenase increases expression ISO bicalutamide results in increased expression of SORD mRNA CTD PMID:15790403 NCBI chr 3:109,184,697...109,216,133 JBrowse link
G Spint2 serine peptidase inhibitor, Kunitz type, 2 increases expression ISO bicalutamide results in increased expression of SPINT2 mRNA CTD PMID:15790403 NCBI chr 1:84,558,159...84,580,616 JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO bicalutamide results in increased expression of SQSTM1 mRNA CTD PMID:15638997 NCBI chr10:34,525,517...34,536,685 JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO bicalutamide results in decreased expression of STIP1 mRNA CTD PMID:15638997 NCBI chr 1:204,209,434...204,228,452 JBrowse link
G Tamm41 TAM41 mitochondrial translocator assembly and maintenance homolog increases expression ISO bicalutamide results in increased expression of TAMM41 mRNA CTD PMID:16631469 NCBI chr 4:148,070,388...148,103,728 JBrowse link
G Tert telomerase reverse transcriptase decreases activity
decreases expression
ISO bicalutamide results in decreased activity of TERT protein
bicalutamide results in decreased expression of TERT mRNA
CTD PMID:15638997 NCBI chr 1:29,637,213...29,659,509 JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO bicalutamide binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408 JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO bicalutamide binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920 JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO bicalutamide results in decreased expression of TK1 mRNA CTD PMID:15638997 NCBI chr10:103,034,755...103,046,125 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]] CTD PMID:16317058 NCBI chr 5:80,145,867...80,159,501 JBrowse link
G Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of TMEFF2 protein] CTD PMID:23405127 NCBI chr 9:50,445,550...50,733,482 JBrowse link
G Tmprss2 transmembrane serine protease 2 multiple interactions ISO [Goserelin co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of TMPRSS2 protein; [Goserelin co-treated with Dutasteride co-treated with bicalutamide] results in decreased expression of TMPRSS2 protein; bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA] CTD PMID:23708653 PMID:24323034 PMID:28757136 NCBI chr11:36,934,306...36,973,779 JBrowse link
G Tmsb4x thymosin beta 4, X-linked multiple interactions
increases expression
ISO bicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of TMSB4X mRNA]
bicalutamide results in increased expression of TMSB4X mRNA
CTD PMID:17916567 NCBI chr  X:27,144,677...27,146,667 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:16317058 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO bicalutamide results in increased expression of TP53 protein
bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of TP53 protein]
CTD PMID:15638997 PMID:29383186 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO bicalutamide results in increased expression of TP53I3 mRNA CTD PMID:15638997 NCBI chr13:69,612,605...69,655,018 JBrowse link
G Tpd52 tumor protein D52 decreases response to substance ISO TPD52 protein results in decreased susceptibility to bicalutamide CTD PMID:17875733 NCBI chr 2:92,735,246...92,816,079 JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO bicalutamide results in decreased expression of TPX2 mRNA CTD PMID:15638997 NCBI chr 3:141,318,428...141,360,684 JBrowse link
G Tram1 translocation associated membrane protein 1 increases expression ISO bicalutamide results in increased expression of TRAM1 mRNA CTD PMID:16631469 NCBI chr 5:5,642,579...5,667,666 JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO bicalutamide results in increased expression of TRIB3 mRNA CTD PMID:15638997 NCBI chr 3:140,809,634...140,815,230 JBrowse link
G Tyms thymidylate synthetase decreases expression ISO bicalutamide results in decreased expression of TYMS protein CTD PMID:17599054 NCBI chr 9:113,313,454...113,329,551 JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression ISO bicalutamide results in increased expression of UAP1 mRNA CTD PMID:15790403 NCBI chr13:82,342,946...82,377,558 JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO [Niclosamide co-treated with bicalutamide] results in decreased expression of UBE2C mRNA CTD PMID:28500234 NCBI chr 3:153,506,636...153,509,036 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression ISO bicalutamide results in decreased expression of UGT2B17 mRNA CTD PMID:15638997 NCBI chr14:21,024,035...21,035,784 JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO bicalutamide results in increased expression of UPP1 mRNA CTD PMID:15638997 NCBI chr14:83,809,495...83,829,299 JBrowse link
G Uxt ubiquitously-expressed, prefoldin-like chaperone affects response to substance ISO UXT protein affects the susceptibility to bicalutamide CTD PMID:19318562 NCBI chr  X:1,126,110...1,138,670 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:16317058 NCBI chr 2:204,038,120...204,057,852 JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO bicalutamide results in increased expression of WARS1 mRNA CTD PMID:15638997 NCBI chr 6:127,776,088...127,807,273 JBrowse link
G Ythdf3 YTH N(6)-methyladenosine RNA binding protein 3 increases expression ISO bicalutamide results in increased expression of YTHDF3 mRNA CTD PMID:16631469 NCBI chr 2:98,350,304...98,384,608 JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO bicalutamide results in increased expression of ZMAT3 mRNA CTD PMID:15638997 NCBI chr 2:115,106,050...115,136,863 JBrowse link
G Zwint ZW10 interacting kinetochore protein decreases expression ISO bicalutamide results in decreased expression of ZWINT mRNA CTD PMID:15638997 NCBI chr20:15,938,157...15,953,997 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        xenobiotic 18395
          bicalutamide 194
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18611
                              organic divalent group 18602
                                organodiyl group 18602
                                  carbonyl group 18519
                                    carbonyl compound 18519
                                      carboxylic acid 18195
                                        carboacyl group 17423
                                          univalent carboacyl group 17423
                                            carbamoyl group 17230
                                              carboxamide 17230
                                                monocarboxylic acid amide 14854
                                                  N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide 194
                                                    (S)-bicalutamide 194
                                                      bicalutamide 194
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