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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-azaorotic acid
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Accession:CHEBI:30863 term browser browse the term
Definition:A 1,3,5-triazine that has formula C4H3N3O4.
Synonyms:related_synonym: 1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylic acid;   Formula=C4H3N3O4;   InChI=1S/C4H3N3O4/c8-2(9)1-5-3(10)7-4(11)6-1/h(H,8,9)(H2,5,6,7,10,11);   InChIKey=RYYCJUAHISIHTL-UHFFFAOYSA-N;   SMILES=OC(=O)c1nc(=O)[nH]c(=O)[nH]1;   oxonic acid
 xref: Beilstein:383990;   CAS:937-13-3;   DrugBank:DB03209;   Drug_Central:2002
 xref_mesh: MESH:D010094



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5-azaorotic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO [Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of ABCG2 mRNA; [Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of ABCG2 protein; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of ABCG2 mRNA]; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of ABCG2 protein]; Polysaccharides inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of ABCG2 mRNA]; Polysaccharides inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of ABCG2 protein] CTD PMID:34687833 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Lgals9 galectin 9 decreases expression EXP Oxonic Acid results in decreased expression of LGALS9 protein CTD PMID:19605544 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions
affects localization
EXP Allopurinol inhibits the reaction [Oxonic Acid affects the localization of NFAT5 protein] CTD PMID:30651350 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
JBrowse link
G Slc17a1 solute carrier family 17 member 1 multiple interactions ISO [Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC17A1 mRNA; [Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC17A1 protein; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC17A1 mRNA]; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC17A1 protein]; Polysaccharides inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC17A1 protein] CTD PMID:34687833 NCBI chr17:41,219,461...41,255,199
Ensembl chr17:41,222,049...41,253,304
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO [Oxonic Acid analog co-treated with Hypoxanthine] results in increased expression of SLC22A12 mRNA; [Oxonic Acid analog co-treated with Hypoxanthine] results in increased expression of SLC22A12 protein; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in increased expression of SLC22A12 protein]; Polysaccharides inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in increased expression of SLC22A12 mRNA]; Polysaccharides inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in increased expression of SLC22A12 protein] CTD PMID:34687833 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases expression EXP Oxonic Acid results in decreased expression of SLC22A2 protein CTD PMID:19605544 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP
ISO
[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A6 protein
[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC22A6 mRNA; [Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC22A6 protein; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC22A6 protein]; Polysaccharides inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC22A6 mRNA]; Polysaccharides inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in decreased expression of SLC22A6 protein]
CTD PMID:19605544 PMID:34687833 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP [Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A8 protein CTD PMID:19605544 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [Oxonic Acid analog co-treated with Hypoxanthine] results in increased activity of XDH protein; Allopurinol inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in increased activity of XDH protein]; Polysaccharides inhibits the reaction [[Oxonic Acid analog co-treated with Hypoxanthine] results in increased activity of XDH protein] CTD PMID:34687833 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      chemical role 19589
        donor 18895
          Bronsted acid 18783
            oxoacid 18744
              carbon oxoacid 18601
                carboxylic acid 18597
                  monocarboxylic acid 17843
                    5-azaorotic acid 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        monocarboxylic acid 17843
                                          5-azaorotic acid 9
paths to the root