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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methylmalonic acid
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Accession:CHEBI:30860 term browser browse the term
Definition:A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Synonyms:related_synonym: 1,1-Ethanedicarboxylic acid;   2-methylmalonic acid;   Formula=C4H6O4;   InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8);   InChIKey=ZIYVHBGGAOATLY-UHFFFAOYSA-N;   Isosuccinic acid;   Methylpropanedioic acid;   SMILES=CC(C(O)=O)C(O)=O;   alpha-methylmalonic acid
 alt_id: CHEBI:25319;   CHEBI:42270;   CHEBI:6881
 xref: Beilstein:1756084;   CAS:516-05-2;   DrugBank:DB04183;   Gmelin:50008;   HMDB:HMDB0000202;   KEGG:C02170;   LIPID_MAPS_instance:LMFA01170118
 xref_mesh: MESH:D008764
 xref: MetaCyc:CPD-546;   PDBeChem:DXX;   PMID:11673368;   PMID:15770414;   PMID:17190852;   PMID:21478039;   PMID:21652239;   PMID:21687976;   PMID:21748409;   PMID:21802231;   PMID:21896502;   PMID:22104738;   PMID:22233538;   PMID:22301932;   PMID:22332180;   PMID:22377700;   PMID:22422209;   PMID:22424943;   PMID:22509143;   PMID:22537172;   PMID:22770225;   Reaxys:1756084;   Wikipedia:Methylmalonic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30861


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methylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein] CTD PMID:28223158 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein] CTD PMID:28223158 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of NOS2 protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]
CTD PMID:28223158 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of TNF protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]
CTD PMID:28223158 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          metabolite 19218
            eukaryotic metabolite 18842
              animal metabolite 18569
                mammalian metabolite 18558
                  human metabolite 18231
                    methylmalonic acid 6
                      O-methylmalonyl-L-carnitine 0
                      aryl(methyl)malonic acid + 0
                      methylmalonyl-CoA + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      dicarboxylic acids and O-substituted derivatives 10278
                                        dicarboxylic acid 10271
                                          alpha,omega-dicarboxylic acid 2777
                                            malonic acid 58
                                              methylmalonic acid 6
                                                O-methylmalonyl-L-carnitine 0
                                                aryl(methyl)malonic acid + 0
                                                methylmalonyl-CoA + 0
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