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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methylmalonic acid
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Accession:CHEBI:30860 term browser browse the term
Definition:A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Synonyms:exact_synonym: methylpropanedioic acid
 related_synonym: 1,1-Ethanedicarboxylic acid;   2-methylmalonic acid;   Formula=C4H6O4;   InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8);   InChIKey=ZIYVHBGGAOATLY-UHFFFAOYSA-N;   Isosuccinic acid;   SMILES=CC(C(O)=O)C(O)=O;   alpha-methylmalonic acid
 alt_id: CHEBI:25319;   CHEBI:42270;   CHEBI:6881
 xref: Beilstein:1756084;   CAS:516-05-2;   DrugBank:DB04183;   Gmelin:50008;   HMDB:HMDB0000202;   KEGG:C02170;   LIPID_MAPS_instance:LMFA01170118
 xref_mesh: MESH:D008764
 xref: MetaCyc:CPD-546;   PDBeChem:DXX;   PMID:11673368;   PMID:15770414;   PMID:17190852;   PMID:21478039;   PMID:21652239;   PMID:21687976;   PMID:21748409;   PMID:21802231;   PMID:21896502;   PMID:22104738;   PMID:22233538;   PMID:22301932;   PMID:22332180;   PMID:22377700;   PMID:22422209;   PMID:22424943;   PMID:22509143;   PMID:22537172;   PMID:22770225;   Reaxys:1756084;   Wikipedia:Methylmalonic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30861


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methylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression		 EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein] CTD PMID:28223158 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein] CTD PMID:28223158 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP Methylmalonic Acid results in increased expression of NOS2 protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]		 CTD PMID:28223158 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP Methylmalonic Acid results in increased expression of TNF protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]		 CTD PMID:28223158 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          metabolite 19562
            eukaryotic metabolite 19390
              animal metabolite 19256
                mammalian metabolite 19255
                  human metabolite 18771
                    methylmalonic acid 6
                      O-methylmalonyl-L-carnitine 0
                      aryl(methyl)malonic acid + 0
                      methylmalonyl-CoA + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbonyl compound 18937
                                    dicarboxylic acids and O-substituted derivatives 11137
                                      dicarboxylic acid 11113
                                        alpha,omega-dicarboxylic acid 3171
                                          malonic acid 62
                                            methylmalonic acid 6
                                              O-methylmalonyl-L-carnitine 0
                                              aryl(methyl)malonic acid + 0
                                              methylmalonyl-CoA + 0
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