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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methylmalonic acid
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Accession:CHEBI:30860 term browser browse the term
Definition:A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Synonyms:related_synonym: 1,1-Ethanedicarboxylic acid;   2-methylmalonic acid;   Formula=C4H6O4;   InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8);   InChIKey=ZIYVHBGGAOATLY-UHFFFAOYSA-N;   Isosuccinic acid;   Methylpropanedioic acid;   SMILES=CC(C(O)=O)C(O)=O;   alpha-methylmalonic acid
 alt_id: CHEBI:25319;   CHEBI:42270;   CHEBI:6881
 xref: Beilstein:1756084;   CAS:516-05-2;   DrugBank:DB04183;   Gmelin:50008;   HMDB:HMDB0000202;   KEGG:C02170;   LIPID_MAPS_instance:LMFA01170118
 xref_mesh: MESH:D008764
 xref: MetaCyc:CPD-546;   PDBeChem:DXX;   PMID:11673368;   PMID:15770414;   PMID:17190852;   PMID:21478039;   PMID:21652239;   PMID:21687976;   PMID:21748409;   PMID:21802231;   PMID:21896502;   PMID:22104738;   PMID:22233538;   PMID:22301932;   PMID:22332180;   PMID:22377700;   PMID:22422209;   PMID:22424943;   PMID:22509143;   PMID:22537172;   PMID:22770225;   Reaxys:1756084;   Wikipedia:Methylmalonic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30861


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methylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein] CTD PMID:28223158 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein] CTD PMID:28223158 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of NOS2 protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]
CTD PMID:28223158 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of TNF protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]
CTD PMID:28223158 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            eukaryotic metabolite 19052
              animal metabolite 18892
                mammalian metabolite 18891
                  human metabolite 18351
                    methylmalonic acid 6
                      O-methylmalonyl-L-carnitine 0
                      aryl(methyl)malonic acid + 0
                      methylmalonyl-CoA + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      dicarboxylic acids and O-substituted derivatives 10366
                                        dicarboxylic acid 10358
                                          alpha,omega-dicarboxylic acid 2796
                                            malonic acid 60
                                              methylmalonic acid 6
                                                O-methylmalonyl-L-carnitine 0
                                                aryl(methyl)malonic acid + 0
                                                methylmalonyl-CoA + 0
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