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ONTOLOGY REPORT - ANNOTATIONS


Term:betulin
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Accession:CHEBI:3086 term browser browse the term
Definition:A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.
Synonyms:exact_synonym: (3beta)-lup-20(29)-ene-3,28-diol
 related_synonym: Betuline;   Betulinol;   Betulol;   Formula=C30H50O2;   InChI=1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1;   InChIKey=FVWJYYTZTCVBKE-ROUWMTJPSA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]1(CO)CC[C@@H](C(C)=C)[C@]21[H];   Trochol
 xref: CAS:473-98-3 "ChemIDplus";   CAS:473-98-3 "KEGG COMPOUND";   HMDB:HMDB0036838;   KEGG:C08618;   KNApSAcK:C00003740
 xref_mesh: MESH:C002503
 xref: PMID:10075776 "Europe PMC";   PMID:19222115 "Europe PMC";   PMID:19537177 "Europe PMC";   PMID:19821831 "Europe PMC";   PMID:21537960 "Europe PMC";   PMID:21598174 "Europe PMC";   PMID:21643657 "Europe PMC";   PMID:21647548 "Europe PMC";   PMID:22864237 "Europe PMC";   PMID:22978210 "Europe PMC";   PMID:22978211 "Europe PMC";   PMID:23017394 "Europe PMC";   PMID:23158079 "Europe PMC";   PMID:23203108 "Europe PMC";   PMID:23267736 "Europe PMC";   Reaxys:2064515 "Reaxys";   Wikipedia:Betulin


show annotations for term's descendants       view all columns           Sort by:
 
betulin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6480464
G Ca9 carbonic anhydrase 9 JBrowse link 5 59,008,277 59,015,535 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:6480464
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 JBrowse link 2 52,427,351 52,445,082 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Marveld1 MARVEL domain containing 1 JBrowse link 1 261,389,804 261,393,736 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6480464
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Timp2 TIMP metallopeptidase inhibitor 2 JBrowse link 10 107,338,465 107,386,072 RGD:6480464
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6480464
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        anti-inflammatory agent 14907
          betulin 27
            betulin di(3-carboxybutanoate) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            organic hydride 17528
                              organic fundamental parent 17528
                                hydrocarbon 16935
                                  terpene 9228
                                    triterpene 635
                                      triterpenoid 631
                                        pentacyclic triterpenoid 341
                                          betulin 27
                                            betulin di(3-carboxybutanoate) 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.