|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
betulin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; betulin inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123] |
CTD |
PMID:33321149 |
|
NCBI chr 4:26,312,403...26,488,456
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
betulin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] |
CTD |
PMID:21172400 |
|
NCBI chr 1:241,159,723...241,172,503
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of AHR protein] |
CTD |
PMID:33759307 |
|
NCBI chr 6:57,961,423...57,998,901
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
ISO |
betulin results in increased phosphorylation of AKT1 protein |
CTD |
PMID:32190974 |
|
NCBI chr 6:137,534,810...137,555,131
|
|
G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
EXP |
betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of ARNT protein] |
CTD |
PMID:33759307 |
|
NCBI chr 2:182,997,731...183,056,584
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
betulin results in increased expression of BAX protein |
CTD |
PMID:33181113 |
|
NCBI chr 1:105,076,472...105,081,906
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[betulin co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein |
CTD |
PMID:33181113 |
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO |
betulin analog promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein] betulin analog results in decreased expression of BIRC5 protein |
CTD |
PMID:26540049 |
|
NCBI chr10:103,567,369...103,580,069
|
|
G |
Braf |
B-Raf proto-oncogene, serine/threonine kinase |
multiple interactions |
ISO |
betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]]; betulin affects the reaction [BRAF protein affects the susceptibility to [dabrafenib co-treated with trametinib]]; betulin affects the reaction [BRAF protein affects the susceptibility to Vemurafenib] |
CTD |
PMID:29950559 |
|
NCBI chr 4:69,329,772...69,476,931
|
|
G |
Car9 |
carbonic anhydrase 9 |
multiple interactions |
ISO |
betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein] |
CTD |
PMID:26540049 |
|
NCBI chr 5:57,763,234...57,769,838
|
|
G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions |
ISO |
betulin results in increased cleavage of CASP3 protein Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein] |
CTD |
PMID:32190974 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
betulin results in increased cleavage of CASP8 protein |
CTD |
PMID:32190974 |
|
NCBI chr 9:67,747,109...67,806,699
|
|
G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
betulin results in increased cleavage of CASP9 protein |
CTD |
PMID:32190974 |
|
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein] |
CTD |
PMID:33759307 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
[betulin co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein |
CTD |
PMID:33181113 |
|
NCBI chr 8:129,517,576...129,544,661
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein] |
CTD |
PMID:33759307 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases phosphorylation |
ISO |
[Gefitinib co-treated with betulin] results in decreased expression of and results in decreased phosphorylation of EGFR protein betulin results in decreased phosphorylation of EGFR protein |
CTD |
PMID:27447558 |
|
NCBI chr14:95,378,626...95,551,358
|
|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases phosphorylation |
ISO |
betulin results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:32190974 |
|
NCBI chr16:71,495,457...71,508,845
|
|
G |
Fasn |
fatty acid synthase |
decreases expression |
ISO |
betulin results in decreased expression of FASN mRNA; betulin results in decreased expression of FASN protein |
CTD |
PMID:27378817 PMID:27447558 |
|
NCBI chr10:106,570,415...106,588,581
|
|
G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression |
ISO |
betulin results in decreased expression of G6PC1 protein |
CTD |
PMID:34500009 |
|
NCBI chr10:86,307,400...86,318,766
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
[betulin co-treated with Oxygen deficiency] affects the phosphorylation of GSK3B protein |
CTD |
PMID:33181113 |
|
NCBI chr11:76,004,502...76,154,665
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression multiple interactions |
ISO |
betulin analog results in decreased expression of HIF1A protein; betulin results in decreased expression of HIF1A protein betulin analog inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] |
CTD |
PMID:26540049 PMID:33181113 |
|
NCBI chr 6:98,357,788...98,405,068
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases expression |
ISO |
betulin results in decreased expression of HMGCR mRNA; betulin results in decreased expression of HMGCR protein |
CTD |
PMID:27378817 PMID:27447558 |
|
NCBI chr 2:29,732,163...29,754,276
|
|
G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
decreases expression |
ISO |
betulin results in decreased expression of HMGCS1 mRNA |
CTD |
PMID:27378817 |
|
NCBI chr 2:53,379,457...53,399,807
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HMOX1 protein] |
CTD |
PMID:33759307 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Ifng |
interferon gamma |
increases secretion |
ISO |
betulin results in increased secretion of IFNG protein |
CTD |
PMID:25756279 |
|
NCBI chr 7:55,789,180...55,793,216
|
|
G |
Il12a |
interleukin 12A |
multiple interactions increases expression |
ISO |
betulin results in increased secretion of [IL12A protein binds to IL12B protein] betulin results in increased expression of IL12A mRNA |
CTD |
PMID:25756279 |
|
NCBI chr 2:155,275,734...155,282,997
|
|
G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
betulin results in increased secretion of [IL12A protein binds to IL12B protein] |
CTD |
PMID:25756279 |
|
NCBI chr10:29,390,300...29,405,194
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
betulin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:34500009 |
|
NCBI chr 3:137,030,200...137,036,581
|
|
G |
Il2 |
interleukin 2 |
increases secretion |
ISO |
betulin results in increased secretion of IL2 protein |
CTD |
PMID:25756279 |
|
NCBI chr 2:121,932,968...121,937,672
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
EXP |
betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 protein] |
CTD |
PMID:33759307 |
|
NCBI chr 8:19,768,375...19,777,862
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
[betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein betulin results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:33181113 |
|
NCBI chr11:97,462,025...97,529,193
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO EXP |
betulin results in increased phosphorylation of MAPK3 protein [betulin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MAPK3 mRNA] |
CTD |
PMID:33181113 PMID:33759307 |
|
NCBI chr 1:190,797,189...190,803,411
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MAPK8 mRNA] |
CTD |
PMID:33759307 |
|
NCBI chr16:8,645,171...8,728,225
|
|
G |
Marveld1 |
MARVEL domain containing 1 |
decreases expression |
ISO |
betulin results in decreased expression of MARVELD1 mRNA |
CTD |
PMID:27447558 |
|
NCBI chr 1:240,954,050...240,958,101
|
|
G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
ISO |
[Gefitinib co-treated with betulin] results in decreased expression of MKI67 protein |
CTD |
PMID:27447558 |
|
NCBI chr 1:199,926,150...199,952,847
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
betulin inhibits the reaction [Ethanol results in increased expression of MMP2 protein] |
CTD |
PMID:21172400 |
|
NCBI chr19:30,327,643...30,355,856
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
betulin results in decreased phosphorylation of MTOR protein |
CTD |
PMID:32190974 |
|
NCBI chr 5:164,167,985...164,277,438
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
[betulin co-treated with Oxygen deficiency] results in decreased expression of MYC protein |
CTD |
PMID:33181113 |
|
NCBI chr 7:95,483,105...95,488,031
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
betulin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFE2L2 protein] |
CTD |
PMID:33759307 |
|
NCBI chr 3:81,001,529...81,031,165
|
|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
betulin binds to and affects the localization of NR3C1 protein |
CTD |
PMID:34500009 |
|
NCBI chr18:31,522,783...31,644,508
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
[betulin co-treated with Oxygen] results in increased cleavage of PARP1 protein; betulin analog promotes the reaction [Oxygen deficiency results in increased expression of PARP1 protein modified form]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein] |
CTD |
PMID:26540049 PMID:32190974 PMID:33181113 |
|
NCBI chr13:94,839,484...94,871,295
|
|
G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
increases expression |
ISO |
betulin results in increased expression of PCK1 protein |
CTD |
PMID:34500009 |
|
NCBI chr 3:182,348,572...182,354,521
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
betulin inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] |
CTD |
PMID:21172400 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Scd |
stearoyl-CoA desaturase |
decreases expression |
ISO |
betulin results in decreased expression of SCD mRNA; betulin results in decreased expression of SCD protein |
CTD |
PMID:27378817 PMID:27447558 |
|
NCBI chr 1:253,218,968...253,232,101
|
|
G |
Smad3 |
SMAD family member 3 |
multiple interactions |
EXP |
betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:21172400 |
|
NCBI chr 8:64,126,829...64,236,960
|
|
G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
decreases cleavage decreases expression multiple interactions |
ISO |
betulin results in decreased cleavage of SREBF1 protein betulin results in decreased expression of SREBF1 protein [Gefitinib co-treated with betulin] results in decreased expression of SREBF1 protein; betulin affects the reaction [BRAF protein affects the reaction [Vemurafenib results in decreased cleavage of SREBF1 protein]] |
CTD |
PMID:27447558 PMID:29950559 |
|
NCBI chr10:45,507,152...45,529,164
|
|
G |
Sult2a1 |
sulfotransferase family 2A member 1 |
increases sulfation |
ISO |
SULT2A1 protein results in increased sulfation of betulin |
CTD |
PMID:30776358 |
|
NCBI chr 1:84,582,011...84,639,001
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
betulin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] |
CTD |
PMID:21172400 |
|
NCBI chr 1:90,324,312...90,340,627
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
betulin inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] |
CTD |
PMID:21172400 |
|
NCBI chr X:3,766,509...3,772,578
|
|
G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
multiple interactions |
EXP |
betulin inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] |
CTD |
PMID:21172400 |
|
NCBI chr10:104,041,604...104,089,214
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
betulin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:34500009 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of betulin |
CTD |
PMID:30776358 |
|
NCBI chr 9:96,239,019...96,256,264
|
|
G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases glucuronidation |
ISO |
UGT1A4 protein results in increased glucuronidation of betulin |
CTD |
PMID:30776358 |
|
NCBI chr 9:96,210,053...96,256,264
|
|