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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:keto-phenylpyruvic acid
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Accession:CHEBI:30851 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is 3-phenylpropanoic acid substituted by an oxo group at position 2. It is an intermediate metabolite in the phenylalanine pathway.
Synonyms:exact_synonym: 2-oxo-3-phenylpropanoic acid
 related_synonym: 3-PHENYLPYRUVIC ACID;   3-Phenyl-2-oxopropanoate;   3-phenyl-2-oxopropanoic acid;   Formula=C9H8O3;   InChI=1S/C9H8O3/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,11,12);   InChIKey=BTNMPGBKDVTSJY-UHFFFAOYSA-N;   Phenylbrenztraubensaeure;   Phenylpyruvate;   Phenylpyruvic acid;   SMILES=OC(=O)C(=O)Cc1ccccc1;   alpha-Ketohydrocinnamic acid;   alpha-oxo-benzenepropanoic acid;   beta-phenylpyruvic acid;   keto-Phenylpyruvate
 alt_id: CHEBI:26009;   CHEBI:45005;   CHEBI:8105
 xref: Beilstein:2207312;   CAS:156-06-9;   DrugBank:DB03884;   ECMDB:ECMDB00205;   Gmelin:972243;   HMDB:HMDB0000205;   KEGG:C00166;   KNApSAcK:C00000751
 xref_mesh: MESH:C031606
 xref: PDBeChem:PPY;   PMID:132040;   PMID:153583;   PMID:16742815;   PMID:20504690;   PMID:2291475;   PMID:4025205;   PMID:719897;   PMID:8216688;   PMID:9869358;   Reaxys:2207312;   Wikipedia:Phenylpyruvic_acid;   YMDB:YMDB00786
 cyclic_relationship: is_conjugate_acid_of CHEBI:18005;   is_tautomer_of CHEBI:32815

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keto-phenylpyruvic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO phenylpyruvic acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid] CTD PMID:22981274 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        biochemical role 19310
          cofactor 15544
            pyruvic acid 47
              keto-phenylpyruvic acid 2
                phenylpyruvic acid oxime 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        monocarboxylic acid 17526
                                          fatty acid 16004
                                            saturated fatty acid 15980
                                              propionic acid 3678
                                                pyruvic acid 47
                                                  keto-phenylpyruvic acid 2
                                                    phenylpyruvic acid oxime 0
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