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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bethanechol
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Accession:CHEBI:3084 term browser browse the term
Definition:The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Synonyms:related_synonym: (2-hydroxypropyl)trimethylammonium carbamate;   2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium;   2-carbamoyloxypropyl-trimethylazanium;   Formula=C7H17N2O2;   InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1;   InChIKey=NZUPCNDJBJXXRF-UHFFFAOYSA-O;   SMILES=CC(C[N+](C)(C)C)OC(N)=O;   amidopropyldimethylbetaine;   carbamoyl-beta-methylcholine;   carbamyl-beta-methylcholine
 alt_id: CHEBI:506520
 xref: Beilstein:1773706;   CAS:674-38-4;   DrugBank:DB01019;   Drug_Central:358;   KEGG:C06850;   LINCS:LSM-5196
 xref_mesh: MESH:D018723
 xref: PMID:17889543


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bethanechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases secretion EXP Bethanechol results in increased secretion of APP protein modified form CTD PMID:7605915 PMID:8624119 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP CALCA protein inhibits the reaction [Bethanechol results in increased secretion of GAST protein]; CALCA protein promotes the reaction [Bethanechol affects the secretion of SST protein] CTD PMID:19296048 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
affects binding
ISO brucine promotes the reaction [Bethanechol binds to CHRM1 protein]
CHRM1 protein binds to Bethanechol
CTD PMID:9224827 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding
multiple interactions
ISO CHRM2 protein binds to Bethanechol
eburnamonine promotes the reaction [Bethanechol binds to CHRM2 protein]
CTD PMID:9224827 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding
multiple interactions
ISO CHRM3 protein binds to Bethanechol
brucine promotes the reaction [Bethanechol binds to CHRM3 protein]
CTD PMID:9224827 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects binding
multiple interactions
ISO CHRM4 protein binds to Bethanechol
brucine promotes the reaction [Bethanechol binds to CHRM4 protein]
CTD PMID:9224827 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Gast gastrin increases secretion
multiple interactions
EXP Bethanechol results in increased secretion of GAST protein
CALCA protein inhibits the reaction [Bethanechol results in increased secretion of GAST protein]
CTD PMID:19296048 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Sct secretin decreases activity EXP SCT protein results in decreased activity of Bethanechol CTD PMID:10198350 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Sst somatostatin affects secretion
multiple interactions
EXP Bethanechol affects the secretion of SST protein
CALCA protein promotes the reaction [Bethanechol affects the secretion of SST protein]
CTD PMID:19296048 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    chemical entity 19781
      molecular entity 19779
        ion 15942
          organic ion 8462
            organic cation 7320
              quaternary ammonium ion 5109
                bethanechol 9
                  (R)-bethanechol 0
                  (S)-bethanechol 0
                  bethanechol chloride + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      carboxylic ester 15517
                                        carbamate ester 7445
                                          bethanechol 9
                                            (R)-bethanechol 0
                                            (S)-bethanechol 0
                                            bethanechol chloride + 0
paths to the root