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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bethanechol
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Accession:CHEBI:3084 term browser browse the term
Definition:The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Synonyms:related_synonym: (2-hydroxypropyl)trimethylammonium carbamate;   2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium;   2-carbamoyloxypropyl-trimethylazanium;   Formula=C7H17N2O2;   InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1;   InChIKey=NZUPCNDJBJXXRF-UHFFFAOYSA-O;   SMILES=CC(C[N+](C)(C)C)OC(N)=O;   amidopropyldimethylbetaine;   carbamoyl-beta-methylcholine;   carbamyl-beta-methylcholine
 alt_id: CHEBI:506520
 xref: Beilstein:1773706;   CAS:674-38-4;   DrugBank:DB01019;   Drug_Central:358;   KEGG:C06850;   LINCS:LSM-5196
 xref_mesh: MESH:D018723
 xref: PMID:17889543


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bethanechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta (A4) precursor protein increases secretion ISO Bethanechol results in increased secretion of APP protein modified form CTD PMID:7605915 PMID:8624119 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO CALCA protein inhibits the reaction [Bethanechol results in increased secretion of GAST protein]; CALCA protein promotes the reaction [Bethanechol affects the secretion of SST protein] CTD PMID:19296048 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions
affects binding
ISO brucine promotes the reaction [Bethanechol binds to CHRM1 protein]
CHRM1 protein binds to Bethanechol
CTD PMID:9224827 NCBI chr19:8,664,005...8,683,606
Ensembl chr19:8,663,789...8,683,587
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac affects binding
multiple interactions
ISO CHRM2 protein binds to Bethanechol
eburnamonine promotes the reaction [Bethanechol binds to CHRM2 protein]
CTD PMID:9224827 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac affects binding
multiple interactions
ISO CHRM3 protein binds to Bethanechol
brucine promotes the reaction [Bethanechol binds to CHRM3 protein]
CTD PMID:9224827 NCBI chr13:9,875,486...10,361,062
Ensembl chr13:9,875,486...10,360,847
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects binding
multiple interactions
ISO CHRM4 protein binds to Bethanechol
brucine promotes the reaction [Bethanechol binds to CHRM4 protein]
CTD PMID:9224827 NCBI chr 2:91,922,189...91,929,835
Ensembl chr 2:91,927,249...91,928,688
JBrowse link
G Gast gastrin increases secretion
multiple interactions
ISO Bethanechol results in increased secretion of GAST protein
CALCA protein inhibits the reaction [Bethanechol results in increased secretion of GAST protein]
CTD PMID:19296048 NCBI chr11:100,334,407...100,336,997
Ensembl chr11:100,334,407...100,336,996
JBrowse link
G Sct secretin decreases activity ISO SCT protein results in decreased activity of Bethanechol CTD PMID:10198350 NCBI chr 7:141,278,329...141,279,174
Ensembl chr 7:141,278,330...141,279,133
JBrowse link
G Sst somatostatin affects secretion
multiple interactions
ISO Bethanechol affects the secretion of SST protein
CALCA protein promotes the reaction [Bethanechol affects the secretion of SST protein]
CTD PMID:19296048 NCBI chr16:23,889,573...23,891,342
Ensembl chr16:23,889,573...23,890,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21746
    chemical entity 21744
      molecular entity 21731
        ion 16630
          organic ion 8633
            organic cation 7456
              quaternary ammonium ion 5255
                bethanechol 9
                  (R)-bethanechol 0
                  (S)-bethanechol 0
                  bethanechol chloride + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21746
    subatomic particle 21732
      composite particle 21732
        hadron 21732
          baryon 21732
            nucleon 21732
              atomic nucleus 21732
                atom 21732
                  main group element atom 21647
                    p-block element atom 21647
                      carbon group element atom 21454
                        carbon atom 21353
                          organic molecular entity 21353
                            organic group 19931
                              organic divalent group 19918
                                organodiyl group 19918
                                  carbonyl group 19903
                                    carbonyl compound 19903
                                      carboxylic ester 16202
                                        carbamate ester 7498
                                          bethanechol 9
                                            (R)-bethanechol 0
                                            (S)-bethanechol 0
                                            bethanechol chloride + 0
paths to the root