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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bethanechol
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Accession:CHEBI:3084 term browser browse the term
Definition:The carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
Synonyms:related_synonym: (2-hydroxypropyl)trimethylammonium carbamate;   2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium;   2-carbamoyloxypropyl-trimethylazanium;   Formula=C7H17N2O2;   InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1;   InChIKey=NZUPCNDJBJXXRF-UHFFFAOYSA-O;   SMILES=CC(C[N+](C)(C)C)OC(N)=O;   amidopropyldimethylbetaine;   carbamoyl-beta-methylcholine;   carbamyl-beta-methylcholine
 alt_id: CHEBI:506520
 xref: Beilstein:1773706;   CAS:674-38-4;   DrugBank:DB01019;   Drug_Central:358;   KEGG:C06850;   LINCS:LSM-5196
 xref_mesh: MESH:D018723
 xref: PMID:17889543


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bethanechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases secretion EXP Bethanechol results in increased secretion of APP protein modified form CTD PMID:7605915, PMID:8624119 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP CALCA protein inhibits the reaction [Bethanechol results in increased secretion of GAST protein]; CALCA protein promotes the reaction [Bethanechol affects the secretion of SST protein] CTD PMID:19296048 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
affects binding
ISO brucine promotes the reaction [Bethanechol binds to CHRM1 protein]
CHRM1 protein binds to Bethanechol
CTD PMID:9224827 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding
multiple interactions
ISO CHRM2 protein binds to Bethanechol
eburnamonine promotes the reaction [Bethanechol binds to CHRM2 protein]
CTD PMID:9224827 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding
multiple interactions
ISO CHRM3 protein binds to Bethanechol
brucine promotes the reaction [Bethanechol binds to CHRM3 protein]
CTD PMID:9224827 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects binding
multiple interactions
ISO CHRM4 protein binds to Bethanechol
brucine promotes the reaction [Bethanechol binds to CHRM4 protein]
CTD PMID:9224827 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Gast gastrin increases secretion
multiple interactions
EXP Bethanechol results in increased secretion of GAST protein
CALCA protein inhibits the reaction [Bethanechol results in increased secretion of GAST protein]
CTD PMID:19296048 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Sct secretin decreases activity EXP SCT protein results in decreased activity of Bethanechol CTD PMID:10198350 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Sst somatostatin affects secretion
multiple interactions
EXP Bethanechol affects the secretion of SST protein
CALCA protein promotes the reaction [Bethanechol affects the secretion of SST protein]
CTD PMID:19296048 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        ion 15916
          organic ion 8320
            organic cation 7133
              quaternary ammonium ion 5079
                bethanechol 9
                  (R)-bethanechol 0
                  (S)-bethanechol 0
                  bethanechol chloride + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic ester 14073
                                        carbamate ester 7378
                                          bethanechol 9
                                            (R)-bethanechol 0
                                            (S)-bethanechol 0
                                            bethanechol chloride + 0
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