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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxybutyric acid
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Accession:CHEBI:30830 term browser browse the term
Definition:A 4-hydroxy monocarboxylic acid that is butyric acid in which one of the hydrogens at position 4 is replaced by a hydroxy group.
Synonyms:related_synonym: 3-carboxypropoxy acid;   4-Hydroxyalkanoic acid;   4-Hydroxybutanoate;   4-Hydroxybutanoic acid;   4-Hydroxycarboxylic acid;   4-hydroxy-butyric acid;   Formula=C4H8O3;   GHB;   Gamma Hydroxybutyric Acid;   InChI=1S/C4H8O3/c5-3-1-2-4(6)7/h5H,1-3H2,(H,6,7);   InChIKey=SJZRECIVHVDYJC-UHFFFAOYSA-N;   SMILES=OCCCC(O)=O;   Xyrem;   oxy-n-butyric acid
 alt_id: CHEBI:1860;   CHEBI:20402;   CHEBI:386065
 xref: Beilstein:1720582;   CAS:591-81-1;   DrugBank:DB01440;   KEGG:C00989;   KEGG:C01991;   LIPID_MAPS_instance:LMFA01050006
 xref_mesh: MESH:C111420
 xref: PMID:15927467;   PMID:3361576;   Reaxys:1720582;   Wikipedia:Oxybate
 cyclic_relationship: is_conjugate_base_of CHEBI:16724


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4-hydroxybutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 increases abundance ISO ALDH5A1 mutant form results in increased abundance of 4-hydroxybutyric acid
ALDH5A1 gene mutant form results in increased abundance of 4-hydroxybutyric acid
CTD PMID:17438226 PMID:29031482 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Gh1 growth hormone 1 multiple interactions
increases secretion
ISO Cocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein] CTD PMID:10657535 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        aetiopathogenetic role 18987
          neurotoxin 17659
            4-hydroxybutyric acid 2
              4-hydroxybutyryl-CoA 0
              mono(3-carboxypropyl) phthalate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic group 18631
                              organic divalent group 18622
                                organodiyl group 18622
                                  carbonyl group 18537
                                    carbonyl compound 18537
                                      carboxylic acid 18215
                                        monocarboxylic acid 17609
                                          fatty acid 16010
                                            short-chain fatty acid 15700
                                              fatty acid 4:0 7891
                                                butyric acid 6262
                                                  hydroxybutyric acid 22
                                                    4-hydroxybutyric acid 2
                                                      4-hydroxybutyryl-CoA 0
                                                      mono(3-carboxypropyl) phthalate 0
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