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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxybutyric acid
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Accession:CHEBI:30830 term browser browse the term
Definition:A 4-hydroxy monocarboxylic acid that is butyric acid in which one of the hydrogens at position 4 is replaced by a hydroxy group.
Synonyms:related_synonym: 3-carboxypropoxy acid;   4-Hydroxyalkanoic acid;   4-Hydroxybutanoate;   4-Hydroxybutanoic acid;   4-Hydroxycarboxylic acid;   4-hydroxy-butyric acid;   Formula=C4H8O3;   GHB;   Gamma Hydroxybutyric Acid;   InChI=1S/C4H8O3/c5-3-1-2-4(6)7/h5H,1-3H2,(H,6,7);   InChIKey=SJZRECIVHVDYJC-UHFFFAOYSA-N;   SMILES=OCCCC(O)=O;   Xyrem;   oxy-n-butyric acid
 alt_id: CHEBI:1860;   CHEBI:20402;   CHEBI:386065
 xref: Beilstein:1720582;   CAS:591-81-1;   DrugBank:DB01440;   KEGG:C00989;   KEGG:C01991;   LIPID_MAPS_instance:LMFA01050006
 xref_mesh: MESH:C111420
 xref: PMID:15927467;   PMID:3361576;   Reaxys:1720582;   Wikipedia:Oxybate
 cyclic_relationship: is_conjugate_base_of CHEBI:16724



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4-hydroxybutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 increases abundance ISO ALDH5A1 mutant form results in increased abundance of 4-hydroxybutyric acid
ALDH5A1 gene mutant form results in increased abundance of 4-hydroxybutyric acid
CTD PMID:17438226 PMID:29031482 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
JBrowse link
G Gh1 growth hormone 1 multiple interactions
increases secretion
ISO Cocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein] CTD PMID:10657535 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        aetiopathogenetic role 19302
          neurotoxin 18009
            4-hydroxybutyric acid 2
              4-hydroxybutyryl-CoA 0
              mono(3-carboxypropyl) phthalate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        monocarboxylic acid 17843
                                          fatty acid 16480
                                            short-chain fatty acid 15801
                                              fatty acid 4:0 7905
                                                butyric acid 6274
                                                  hydroxybutyric acid 22
                                                    4-hydroxybutyric acid 2
                                                      4-hydroxybutyryl-CoA 0
                                                      mono(3-carboxypropyl) phthalate 0
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