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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:betaxolol
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Accession:CHEBI:3082 term browser browse the term
Definition:A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. It is also used to reduce non-fatal cardiac events in patients with heart failure.
Synonyms:exact_synonym: 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol
 related_synonym: 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol;   1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol;   Formula=C18H29NO3;   InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;   InChIKey=NWIUTZDMDHAVTP-UHFFFAOYSA-N;   SMILES=CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1;   betaxololum
 alt_id: CHEBI:101354
 xref: CAS:63659-18-7;   DrugBank:DB00195;   Drug_Central:356;   HMDB:HMDB0014341;   KEGG:C06849;   KEGG:D07526;   LINCS:LSM-1255
 xref_mesh: MESH:D015784
 xref: PMID:10891117;   PMID:1361581;   PMID:14971904;   PMID:15993593;   PMID:1865331;   PMID:2569884;   Patent:DE2649605;   Patent:US4252984;   Reaxys:1991268;   Wikipedia:Betaxolol


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betaxolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions
affects binding 		EXP
ISO 		Betaxolol affects the reaction [Cocaine affects the expression of ADRB1 protein]; Betaxolol inhibits the reaction [Cocaine affects the expression of ADRB1 protein]
Betaxolol binds to and results in decreased activity of ADRB1 protein
Betaxolol binds to ADRB1 protein 		CTD PMID:10372227 PMID:11436944 PMID:17513029 PMID:18596687 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Betaxolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Betaxolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944 PMID:17925438 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Betaxolol results in increased expression of AIFM1 protein CTD PMID:38325520 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Betaxolol results in increased phosphorylation of ATM protein CTD PMID:38325520 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Betaxolol results in increased expression of BAD protein CTD PMID:38325520 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression ISO Betaxolol affects the expression of BAX protein CTD PMID:38325520 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Betaxolol results in decreased expression of BCL2 protein CTD PMID:38325520 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression
multiple interactions 		ISO Betaxolol affects the expression of BCL2L1 protein
ABT-737 affects the reaction [Betaxolol affects the expression of BCL2L1 protein] 		CTD PMID:38325520 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Casp2 caspase 2 decreases activity ISO Betaxolol results in decreased activity of CASP2 protein CTD PMID:38325520 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022 		JBrowse link
G Casp3 caspase 3 decreases cleavage
multiple interactions
increases expression 		ISO Betaxolol results in decreased cleavage of CASP3 protein
ABT-737 inhibits the reaction [Betaxolol results in decreased cleavage of CASP3 protein]
Betaxolol results in increased expression of CASP3 protein 		CTD PMID:38325520 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression 		ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Betaxolol results in increased expression of CASP8 protein] CTD PMID:38325520 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases expression ISO Betaxolol results in increased expression of CASP9 protein CTD PMID:38325520 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Betaxolol results in increased expression of CDKN1A protein CTD PMID:38325520 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Betaxolol results in increased expression of CDKN2A protein CTD PMID:38325520 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Betaxolol affects the reaction [Cocaine affects the phosphorylation of CREB1 protein] CTD PMID:18596687 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Betaxolol affects the reaction [Cocaine affects the expression of CRH mRNA] CTD PMID:18596687 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Betaxolol results in increased expression of CYCS protein CTD PMID:38325520 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Glb1 galactosidase, beta 1 increases expression ISO Betaxolol results in increased expression of GLB1 protein CTD PMID:38325520 NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Betaxolol results in increased expression of H2AX protein CTD PMID:38325520 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Il6 interleukin 6 increases expression ISO Betaxolol results in increased expression of IL6 protein CTD PMID:38325520 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Lmnb1 lamin B1 decreases expression ISO Betaxolol results in decreased expression of LMNB1 protein CTD PMID:38325520 NCBI chr18:52,373,939...52,413,284
Ensembl chr18:52,373,757...52,413,283 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO Betaxolol results in increased expression of and results in increased phosphorylation of MLKL protein; necrostatin-1 inhibits the reaction [Betaxolol results in increased expression of and results in increased phosphorylation of MLKL protein] CTD PMID:38325520 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858 		JBrowse link
G Nppa natriuretic peptide A decreases expression EXP Betaxolol results in decreased expression of NPPA mRNA; Betaxolol results in decreased expression of NPPA protein CTD PMID:12693380 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Nppb natriuretic peptide B decreases expression EXP Betaxolol results in decreased expression of NPPB mRNA CTD PMID:12693380 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions
increases expression 		ISO necrostatin-1 inhibits the reaction [Betaxolol results in increased expression of RIPK1 protein] CTD PMID:38325520 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression
multiple interactions 		ISO Betaxolol results in increased expression of RIPK3 protein
necrostatin-1 inhibits the reaction [Betaxolol results in increased expression of RIPK3 protein] 		CTD PMID:38325520 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Betaxolol results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:38325520 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20871
    role 20829
      application 20632
        pharmaceutical 20427
          drug 20427
            cardiovascular drug 8992
              antihypertensive agent 1963
                betaxolol 27
                  (R)-betaxolol 0
                  (S)-betaxolol 0
                  betaxolol hydrochloride + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20871
    subatomic particle 20869
      composite particle 20869
        hadron 20869
          baryon 20869
            nucleon 20869
              atomic nucleus 20869
                atom 20869
                  main group element atom 20792
                    main group molecular entity 20792
                      s-block molecular entity 20587
                        hydrogen molecular entity 20571
                          hydrides 19700
                            inorganic hydride 18600
                              pnictogen hydride 18587
                                nitrogen hydride 18501
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino alcohol 1087
                                          propanolamine 191
                                            betaxolol 27
                                              (R)-betaxolol 0
                                              (S)-betaxolol 0
                                              betaxolol hydrochloride + 0
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