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ONTOLOGY REPORT - ANNOTATIONS
Term:betaxolol
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Accession:CHEBI:3082 term browser browse the term
Definition:A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. It is also used to reduce non-fatal cardiac events in patients with heart failure.
Synonyms:exact_synonym: 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol
 related_synonym: 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol;   1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol;   Formula=C18H29NO3;   InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;   InChIKey=NWIUTZDMDHAVTP-UHFFFAOYSA-N;   SMILES=CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1;   betaxololum
 alt_id: CHEBI:101354
 xref: Beilstein:1991268 "Beilstein";   CAS:63659-18-7 "ChemIDplus";   CAS:63659-18-7 "KEGG COMPOUND";   DrugBank:DB00195;   Drug_Central:356 "DrugCentral";   HMDB:HMDB0014341;   KEGG:C06849;   KEGG:D07526;   LINCS:LSM-1255
 xref_mesh: MESH:D015784
 xref: PMID:10891117 "ChEMBL";   PMID:1361581 "ChEMBL";   PMID:14971904 "ChEMBL";   PMID:15993593 "ChEMBL";   PMID:1865331 "Europe PMC";   PMID:2569884 "Europe PMC";   Patent:DE2649605;   Patent:US4252984;   Reaxys:1991268 "Reaxys";   Wikipedia:Betaxolol

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betaxolol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:6480464
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            cardiovascular drug 7550
              antihypertensive agent 1637
                betaxolol 6
                  (R)-betaxolol 0
                  (S)-betaxolol 0
                  betaxolol hydrochloride + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        amino alcohol 860
                                          propanolamine 164
                                            betaxolol 6
                                              (R)-betaxolol 0
                                              (S)-betaxolol 0
                                              betaxolol hydrochloride + 0
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