CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: betaxolol
Accession: CHEBI:3082
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Definition: A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. It is also used to reduce non-fatal cardiac events in patients with heart failure.
Synonyms: exact_synonym: 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol
related_synonym: 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol; 1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol; Formula=C18H29NO3; InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3; InChIKey=NWIUTZDMDHAVTP-UHFFFAOYSA-N; SMILES=CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1; betaxololum
alt_id: CHEBI:101354
xref: CAS:63659-18-7; DrugBank:DB00195; Drug_Central:356; HMDB:HMDB0014341; KEGG:C06849; KEGG:D07526; LINCS:LSM-1255
xref_mesh: MESH:D015784
xref: PMID:10891117; PMID:1361581; PMID:14971904; PMID:15993593; PMID:1865331; PMID:2569884; Patent:DE2649605; Patent:US4252984; Reaxys:1991268; Wikipedia:Betaxolol
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Adrb1
adrenoceptor beta 1
multiple interactions affects binding
EXP ISO
Betaxolol affects the reaction [Cocaine affects the expression of ADRB1 protein]; Betaxolol inhibits the reaction [Cocaine affects the expression of ADRB1 protein] Betaxolol binds to and results in decreased activity of ADRB1 protein Betaxolol binds to ADRB1 protein
CTD
PMID:10372227 PMID:11436944 PMID:17513029 PMID:18596687
NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237
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Adrb2
adrenoceptor beta 2
multiple interactions
ISO
[Betaxolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Betaxolol binds to and results in decreased activity of ADRB2 protein
CTD
PMID:11436944 PMID:17925438
NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803
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Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
Betaxolol results in increased expression of AIFM1 protein
CTD
PMID:38325520
NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237
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Atm
ATM serine/threonine kinase
increases phosphorylation
ISO
Betaxolol results in increased phosphorylation of ATM protein
CTD
PMID:38325520
NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
Betaxolol results in increased expression of BAD protein
CTD
PMID:38325520
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
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Bax
BCL2 associated X, apoptosis regulator
affects expression
ISO
Betaxolol affects the expression of BAX protein
CTD
PMID:38325520
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Betaxolol results in decreased expression of BCL2 protein
CTD
PMID:38325520
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Bcl2l1
Bcl2-like 1
affects expression multiple interactions
ISO
Betaxolol affects the expression of BCL2L1 protein ABT-737 affects the reaction [Betaxolol affects the expression of BCL2L1 protein]
CTD
PMID:38325520
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907 Ensembl chr 1:161,745,540...161,764,907
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Casp2
caspase 2
decreases activity
ISO
Betaxolol results in decreased activity of CASP2 protein
CTD
PMID:38325520
NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022
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Casp3
caspase 3
decreases cleavage multiple interactions increases expression
ISO
Betaxolol results in decreased cleavage of CASP3 protein ABT-737 inhibits the reaction [Betaxolol results in decreased cleavage of CASP3 protein] Betaxolol results in increased expression of CASP3 protein
CTD
PMID:38325520
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Casp8
caspase 8
multiple interactions increases expression
ISO
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Betaxolol results in increased expression of CASP8 protein]
CTD
PMID:38325520
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
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Casp9
caspase 9
increases expression
ISO
Betaxolol results in increased expression of CASP9 protein
CTD
PMID:38325520
Ensembl chr 5:159,391,188...159,409,648
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Betaxolol results in increased expression of CDKN1A protein
CTD
PMID:38325520
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
increases expression
ISO
Betaxolol results in increased expression of CDKN2A protein
CTD
PMID:38325520
NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248
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Creb1
cAMP responsive element binding protein 1
multiple interactions
EXP
Betaxolol affects the reaction [Cocaine affects the phosphorylation of CREB1 protein]
CTD
PMID:18596687
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
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Crh
corticotropin releasing hormone
multiple interactions
EXP
Betaxolol affects the reaction [Cocaine affects the expression of CRH mRNA]
CTD
PMID:18596687
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
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Cycs
cytochrome c, somatic
increases expression
ISO
Betaxolol results in increased expression of CYCS protein
CTD
PMID:38325520
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
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Glb1
galactosidase, beta 1
increases expression
ISO
Betaxolol results in increased expression of GLB1 protein
CTD
PMID:38325520
NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326
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H2ax
H2A.X variant histone
increases expression
ISO
Betaxolol results in increased expression of H2AX protein
CTD
PMID:38325520
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079
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Il6
interleukin 6
increases expression
ISO
Betaxolol results in increased expression of IL6 protein
CTD
PMID:38325520
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Lmnb1
lamin B1
decreases expression
ISO
Betaxolol results in decreased expression of LMNB1 protein
CTD
PMID:38325520
NCBI chr18:52,373,939...52,413,284
Ensembl chr18:52,373,757...52,413,283
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Mlkl
mixed lineage kinase domain like pseudokinase
multiple interactions
ISO
Betaxolol results in increased expression of and results in increased phosphorylation of MLKL protein; necrostatin-1 inhibits the reaction [Betaxolol results in increased expression of and results in increased phosphorylation of MLKL protein]
CTD
PMID:38325520
NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858
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Nppa
natriuretic peptide A
decreases expression
EXP
Betaxolol results in decreased expression of NPPA mRNA; Betaxolol results in decreased expression of NPPA protein
CTD
PMID:12693380
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493
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Nppb
natriuretic peptide B
decreases expression
EXP
Betaxolol results in decreased expression of NPPB mRNA
CTD
PMID:12693380
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310
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Ripk1
receptor interacting serine/threonine kinase 1
multiple interactions increases expression
ISO
necrostatin-1 inhibits the reaction [Betaxolol results in increased expression of RIPK1 protein]
CTD
PMID:38325520
NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167
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Ripk3
receptor-interacting serine-threonine kinase 3
increases expression multiple interactions
ISO
Betaxolol results in increased expression of RIPK3 protein necrostatin-1 inhibits the reaction [Betaxolol results in increased expression of RIPK3 protein]
CTD
PMID:38325520
NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025
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Tp53
tumor protein p53
multiple interactions
ISO
Betaxolol results in increased expression of and results in increased phosphorylation of TP53 protein
CTD
PMID:38325520
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
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