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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iron dichloride
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Accession:CHEBI:30812 term browser browse the term
Definition:An iron coordination entity that has formula Cl2Fe.
Synonyms:exact_synonym: iron(2+) chloride;   iron(II) chloride
 related_synonym: FeCl2;   Formula=Cl2Fe;   InChI=1S/2ClH.Fe/h2*1H;/q;;+2/p-2;   InChIKey=NMCUIPGRVMDVDB-UHFFFAOYSA-L;   SMILES=Cl[Fe]Cl;   ferrous chloride
 xref: CAS:7758-94-3;   Drug_Central:4543;   Gmelin:1398
 xref_mesh: MESH:C029451
 xref: MolBase:315;   Wikipedia:Iron(II)_chloride



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iron dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP ferrous chloride inhibits the reaction [Dithionite results in decreased activity of ACP5 protein] CTD PMID:6886379 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Aqp4 aquaporin 4 multiple interactions ISO [ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 mRNA; [ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein; SB 203580 inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]; U 0126 inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]; Vitamin E inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein] CTD PMID:30914277 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO ferrous chloride results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO ferrous chloride results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO ferrous chloride results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO ferrous chloride results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]; ferrous chloride inhibits the reaction [sodium arsenite results in decreased hydroxylation of HIF1A protein]; ferrous chloride inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]] CTD PMID:19263519 PMID:24188932 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO ferrous chloride results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferrous chloride results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [ferrous chloride results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein CTD PMID:30914277 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [ferrous chloride results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein CTD PMID:30914277 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO ferrous chloride results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO ferrous chloride results in increased expression of and affects the localization of NFE2L2 protein
ferrous chloride results in increased expression of NFE2L2 mRNA
CTD PMID:27037625 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G P4htm prolyl 4-hydroxylase, transmembrane multiple interactions ISO [Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] results in increased activity of P4HTM protein CTD PMID:19263519 NCBI chr 8:109,274,629...109,292,802
Ensembl chr 8:109,274,626...109,292,473
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO ferrous chloride results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO ferrous chloride results in increased expression of PIK3R5 protein CTD PMID:20025956 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO ferrous chloride results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression ISO ferrous chloride results in increased expression of RIF1 protein CTD PMID:20025956 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO ferrous chloride results in increased expression of SLC2A1 protein CTD PMID:20025956 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc39a1 solute carrier family 39 member 1 multiple interactions ISO ferrous chloride inhibits the reaction [SLC39A1 protein results in increased uptake of Zinc] CTD PMID:25089007 NCBI chr 2:175,703,413...175,709,063
Ensembl chr 2:175,703,441...175,709,058
JBrowse link
G Snca synuclein alpha multiple interactions
affects folding
increases response to substance
ISO Cytarabine promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]; Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to ferrous chloride]
ferrous chloride affects the folding of SNCA protein
CTD PMID:11553618 PMID:14535945 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions ISO ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] CTD PMID:22750002 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor multiple interactions ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]; manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]] CTD PMID:19263519 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    chemical entity 19795
      molecular entity 19794
        transition element molecular entity 16546
          transition element coordination entity 11157
            iron coordination entity 372
              iron dichloride 23
                iron dichloride tetrahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  metal atom 17427
                    transition element atom 16842
                      d-block element atom 16833
                        iron group element atom 876
                          iron atom 854
                            iron molecular entity 854
                              iron coordination entity 372
                                iron dichloride 23
                                  iron dichloride tetrahydrate 0
paths to the root