Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iron trichloride
go back to main search page
Accession:CHEBI:30808 term browser browse the term
Definition:An iron coordination entity that has formula Cl3Fe.
Synonyms:exact_synonym: iron(3+) chloride;   iron(III) chloride
 related_synonym: FeCl3;   Formula=Cl3Fe;   InChI=1S/3ClH.Fe/h3*1H;/q;;;+3/p-3;   InChIKey=RBTARNINKXHZNM-UHFFFAOYSA-K;   SMILES=Cl[Fe](Cl)Cl;   ferric chloride
 xref: CAS:7705-08-0;   Gmelin:1903
 xref_mesh: MESH:C024555
 xref: MolBase:1292;   Wikipedia:Iron(III)_chloride



show annotations for term's descendants           Sort by:
iron trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions EXP [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein CTD PMID:17657459 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 affects localization
multiple interactions
ISO ferric chloride affects the localization of APEX1 protein
[ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein
CTD PMID:12023366 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO ferric chloride results in increased phosphorylation of and results in increased activity of ATM protein CTD PMID:16959548 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO [ferric chloride results in increased oxidation of 2-tert-butylhydroquinone] promotes the reaction [2-tert-butylhydroquinone analog binds to BACH1 protein]; [ferric chloride results in increased oxidation of hydroquinone] promotes the reaction [hydroquinone analog binds to BACH1 protein] CTD PMID:28645578 NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ferric chloride co-treated with Hydrogen Peroxide co-treated with TNF protein] results in increased activity of CASP3 protein CTD PMID:19900513 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO chromous chloride inhibits the reaction [ferric chloride results in decreased activity of CAT protein]; ferric chloride inhibits the reaction [chromous chloride results in decreased activity of CAT protein] CTD PMID:30389395 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO ferric chloride results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO
EXP
[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein; epigallocatechin gallate inhibits the reaction [[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein]
[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein; epigallocatechin gallate inhibits the reaction [[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein]; gallocatechol inhibits the reaction [[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein]
CTD PMID:37353134 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO ferric chloride results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased expression of CXCL2] CTD PMID:21605006 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases stability
multiple interactions
ISO ferric chloride results in increased stability of CYP1A1 mRNA; ferric chloride results in increased stability of CYP1A1 protein
ferric chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]
CTD PMID:19896525 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Fech ferrochelatase increases expression
multiple interactions
ISO ferric chloride results in increased expression of FECH protein
ferric chloride inhibits the reaction [Deferoxamine results in decreased expression of FECH protein]; ferric chloride inhibits the reaction [pyridoxal isonicotinoyl hydrazone results in decreased expression of FECH protein]
CTD PMID:30517741 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO ferric chloride results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO [ferric chloride co-treated with TNF protein] results in increased expression of FTH1 protein CTD PMID:19900513 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
decreases expression
EXP ferric chloride results in decreased activity of G6PD protein
ferric chloride results in decreased expression of G6PD mRNA; ferric chloride results in decreased expression of G6PD protein
CTD PMID:24599681 PMID:30506659 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein CTD PMID:19900513 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
decreases expression
EXP ferric chloride results in increased expression of GSR protein
ferric chloride results in decreased expression of GSR mRNA
CTD PMID:30506659 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP ferric chloride results in increased expression of HAMP mRNA CTD PMID:30506659 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO ferric chloride results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:246,114,096...246,159,228
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO
[ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 protein
ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of HMOX1 protein]
CTD PMID:15019574 PMID:28645578 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA; ferric chloride inhibits the reaction [Deferoxamine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]; Pentetic Acid inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]
ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased expression of IL1B mRNA]
CTD PMID:9851740 PMID:22168577 PMID:28512001 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO ferric chloride results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891
JBrowse link
G Il6 interleukin 6 increases expression ISO ferric chloride results in increased expression of IL6 protein CTD PMID:15781289 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferric chloride results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Klkb1 kallikrein B1 decreases response to substance ISO KLKB1 gene mutant form results in decreased susceptibility to ferric chloride CTD PMID:25339356 NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP [Vanadates co-treated with ferric chloride] results in increased phosphorylation of MAPK1 protein; ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased phosphorylation of MAPK1 protein] CTD PMID:16728372 PMID:22168577 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [aluminum chloride co-treated with ferric chloride] results in increased phosphorylation of MAPK3 protein; [Vanadates co-treated with ferric chloride] results in increased phosphorylation of MAPK3 protein; ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased phosphorylation of MAPK3 protein] CTD PMID:16728372 PMID:22168577 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO ferric chloride results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP ferric chloride inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:16125204 NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO ferric chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Deferoxamine results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mt1a metallothionein 1A decreases response to substance ISO MT1A protein results in decreased susceptibility to ferric chloride CTD PMID:11878821 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200
JBrowse link
G Mt2 metallothionein 2 decreases expression ISO ferric chloride results in decreased expression of MT2A mRNA CTD PMID:26378417 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of NFE2L2 protein] CTD PMID:28645578 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [aluminum chloride co-treated with ferric chloride] results in increased expression of NOS2 protein CTD PMID:16728372 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of NQO1 protein] CTD PMID:28645578 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
JBrowse link
G Pgd phosphogluconate dehydrogenase affects expression
decreases activity
increases expression
decreases expression
EXP ferric chloride affects the expression of PGD mRNA
ferric chloride results in decreased activity of PGD protein
ferric chloride results in increased expression of PGD protein
ferric chloride results in decreased expression of PGD mRNA
CTD PMID:24599681 PMID:30506659 NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029
JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO ferric chloride results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:41,422,561...41,671,226
Ensembl chr  X:41,426,101...41,671,226
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO ferric chloride results in increased expression of PIK3R5 protein CTD PMID:20025956 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO ferric chloride results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:161,445,512...161,458,680
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO ferric chloride results in increased expression of SCARB1 protein CTD PMID:20025956 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO [Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride; [Zinc Sulfate results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride; bathophenanthroline disulfonic acid inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]; Zinc Sulfate inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride] CTD PMID:20096349 NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [ferric chloride co-treated with Oxyquinoline] results in decreased expression of SOD2 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 protein CTD PMID:15019574 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Tf transferrin multiple interactions ISO ferric chloride promotes the reaction [TF protein results in increased uptake of Iron] CTD PMID:11335103 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO ferric chloride results in increased expression of TNF protein
[ferric chloride co-treated with Hydrogen Peroxide co-treated with TNF protein] results in increased activity of CASP3 protein; [ferric chloride co-treated with TNF protein] results in increased expression of FTH1 protein; [ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein; TNF protein inhibits the reaction [ferric chloride results in increased chemical synthesis of Reactive Oxygen Species]; TNF results in decreased susceptibility to [ferric chloride co-treated with Hydrogen Peroxide]
[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA; manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]; Pentetic Acid inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]
CTD PMID:15781289 PMID:19900513 PMID:28512001 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        acid 19329
          Lewis acid 7687
            iron trichloride 44
              iron trichloride hexahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  metal atom 18405
                    transition element atom 17948
                      d-block element atom 17943
                        iron group element atom 1737
                          iron atom 1712
                            iron molecular entity 1712
                              iron coordination entity 1195
                                iron trichloride 44
                                  iron trichloride hexahydrate 0
paths to the root