iron trichloride - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	iron trichloride	go back to main search page
Accession:	CHEBI:30808	browse the term
Definition:	An iron coordination entity that has formula Cl3Fe.
Synonyms:	exact_synonym:	iron(3+) chloride; iron(III) chloride
	related_synonym:	FeCl3; Formula=Cl3Fe; InChI=1S/3ClH.Fe/h3*1H;/q;;;+3/p-3; InChIKey=RBTARNINKXHZNM-UHFFFAOYSA-K; SMILES=Cl[Fe](Cl)Cl; ferric chloride
	xref:	CAS:7705-08-0; Gmelin:1903
	xref_mesh:	MESH:C024555
	xref:	MolBase:1292; Wikipedia:Iron(III)_chloride

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Genes (44)

iron trichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

multiple interactions

EXP

[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

apurinic/apyrimidinic endodeoxyribonuclease 1

affects localization
multiple interactions

ISO

ferric chloride affects the localization of APEX1 protein
[ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

ATM serine/threonine kinase

multiple interactions

ISO

ferric chloride results in increased phosphorylation of and results in increased activity of ATM protein

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

BTB domain and CNC homolog 1

multiple interactions

ISO

[ferric chloride results in increased oxidation of 2-tert-butylhydroquinone] promotes the reaction [2-tert-butylhydroquinone analog binds to BACH1 protein]; [ferric chloride results in increased oxidation of hydroquinone] promotes the reaction [hydroquinone analog binds to BACH1 protein]

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

caspase 3

multiple interactions

ISO

[ferric chloride co-treated with Hydrogen Peroxide co-treated with TNF protein] results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions
decreases activity

ISO

chromous chloride inhibits the reaction [ferric chloride results in decreased activity of CAT protein]; ferric chloride inhibits the reaction [chromous chloride results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin B1

increases expression

ISO

ferric chloride results in increased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

carboxylesterase 1D

multiple interactions

ISO
EXP

[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein; epigallocatechin gallate inhibits the reaction [[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein]
[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein; epigallocatechin gallate inhibits the reaction [[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein]; gallocatechol inhibits the reaction [[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein]

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

checkpoint kinase 1

increases expression

ISO

ferric chloride results in increased expression of CHEK1 protein

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

C-X-C motif chemokine ligand 2

multiple interactions

EXP

ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased expression of CXCL2]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases stability
multiple interactions

ISO

ferric chloride results in increased stability of CYP1A1 mRNA; ferric chloride results in increased stability of CYP1A1 protein
ferric chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

ferrochelatase

increases expression
multiple interactions

ISO

ferric chloride results in increased expression of FECH protein
ferric chloride inhibits the reaction [Deferoxamine results in decreased expression of FECH protein]; ferric chloride inhibits the reaction [pyridoxal isonicotinoyl hydrazone results in decreased expression of FECH protein]

NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

ferric chloride results in increased expression of FOSL1 protein

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

ferritin heavy chain 1

multiple interactions

ISO

[ferric chloride co-treated with TNF protein] results in increased expression of FTH1 protein

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

glucose-6-phosphate dehydrogenase

decreases activity
decreases expression

EXP

ferric chloride results in decreased activity of G6PD protein
ferric chloride results in decreased expression of G6PD mRNA; ferric chloride results in decreased expression of G6PD protein

PMID:24599681 PMID:30506659

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

ISO

[ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutathione-disulfide reductase

increases expression
decreases expression

EXP

ferric chloride results in increased expression of GSR protein
ferric chloride results in decreased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

hepcidin antimicrobial peptide

increases expression

EXP

ferric chloride results in increased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

helicase, lymphoid specific

increases expression

ISO

ferric chloride results in increased expression of HELLS protein

NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:246,114,096...246,159,228

G

heme oxygenase 1

multiple interactions

EXP
ISO

[ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 protein
ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of HMOX1 protein]

PMID:15019574 PMID:28645578

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 1 beta

multiple interactions

ISO
EXP

[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA; ferric chloride inhibits the reaction [Deferoxamine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]; Pentetic Acid inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]
ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased expression of IL1B mRNA]

PMID:9851740 PMID:22168577 PMID:28512001

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor-like 1

increases expression

ISO

ferric chloride results in increased expression of IL1RL1 protein

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 6

increases expression

ISO

ferric chloride results in increased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

ferric chloride results in increased expression of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

kallikrein B1

decreases response to substance

ISO

KLKB1 gene mutant form results in decreased susceptibility to ferric chloride

NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339

G

mitogen activated protein kinase 1

multiple interactions

EXP

[Vanadates co-treated with ferric chloride] results in increased phosphorylation of MAPK1 protein; ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased phosphorylation of MAPK1 protein]

PMID:16728372 PMID:22168577

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

EXP

[aluminum chloride co-treated with ferric chloride] results in increased phosphorylation of MAPK3 protein; [Vanadates co-treated with ferric chloride] results in increased phosphorylation of MAPK3 protein; ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased phosphorylation of MAPK3 protein]

PMID:16728372 PMID:22168577

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

minichromosome maintenance complex component 3

increases expression

ISO

ferric chloride results in increased expression of MCM3 protein

NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746

G

microsomal glutathione S-transferase 1

multiple interactions

EXP

ferric chloride inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

matrix metallopeptidase 2

multiple interactions

ISO

ferric chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Deferoxamine results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

metallothionein 1A

decreases response to substance

ISO

MT1A protein results in decreased susceptibility to ferric chloride

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

decreases expression

ISO

ferric chloride results in decreased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nitric oxide synthase 2

multiple interactions

EXP

[aluminum chloride co-treated with ferric chloride] results in increased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

phosphogluconate dehydrogenase

affects expression
decreases activity
increases expression
decreases expression

EXP

ferric chloride affects the expression of PGD mRNA
ferric chloride results in decreased activity of PGD protein
ferric chloride results in increased expression of PGD protein
ferric chloride results in decreased expression of PGD mRNA

PMID:24599681 PMID:30506659

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

phosphate regulating endopeptidase X-linked

increases expression

ISO

ferric chloride results in increased expression of PHEX protein

NCBI chr X:41,422,561...41,671,226
Ensembl chr X:41,426,101...41,671,226

G

phosphoinositide-3-kinase, regulatory subunit 5

increases expression

ISO

ferric chloride results in increased expression of PIK3R5 protein

NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539

G

RAD51 associated protein 1

increases expression

ISO

ferric chloride results in increased expression of RAD51AP1 protein

NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:161,445,512...161,458,680

G

scavenger receptor class B, member 1

increases expression

ISO

ferric chloride results in increased expression of SCARB1 protein

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

solute carrier family 11 member 2

multiple interactions

ISO

[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride; [Zinc Sulfate results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride; bathophenanthroline disulfonic acid inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]; Zinc Sulfate inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]

NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941

G

superoxide dismutase 2

multiple interactions

EXP

[ferric chloride co-treated with Oxyquinoline] results in decreased expression of SOD2 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 protein

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

transferrin

multiple interactions

ISO

ferric chloride promotes the reaction [TF protein results in increased uptake of Iron]

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400

G

tumor necrosis factor

increases expression
multiple interactions

ISO

ferric chloride results in increased expression of TNF protein
[ferric chloride co-treated with Hydrogen Peroxide co-treated with TNF protein] results in increased activity of CASP3 protein; [ferric chloride co-treated with TNF protein] results in increased expression of FTH1 protein; [ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein; TNF protein inhibits the reaction [ferric chloride results in increased chemical synthesis of Reactive Oxygen Species]; TNF results in decreased susceptibility to [ferric chloride co-treated with Hydrogen Peroxide]
[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA; manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]; Pentetic Acid inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]

PMID:15781289 PMID:19900513 PMID:28512001

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
role	20820
chemical role	20396
acid	19329
Lewis acid	7687
iron trichloride	44
iron trichloride hexahydrate	0
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
metal atom	18405
transition element atom	17948
d-block element atom	17943
iron group element atom	1737
iron atom	1712
iron molecular entity	1712
iron coordination entity	1195
iron trichloride	44
iron trichloride hexahydrate	0

paths to the root