|
G
|
Alb
|
albumin
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein
|
CTD |
PMID:17657459 |
|
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
|
|
G
|
Apex1
|
apurinic/apyrimidinic endodeoxyribonuclease 1
|
affects localization multiple interactions
|
ISO
|
ferric chloride affects the localization of APEX1 protein [ferric chloride co-treated with Tetradecanoylphorbol Acetate] affects the localization of APEX1 protein
|
CTD |
PMID:12023366 |
|
NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329
|
|
G
|
Atm
|
ATM serine/threonine kinase
|
multiple interactions
|
ISO
|
ferric chloride results in increased phosphorylation of and results in increased activity of ATM protein
|
CTD |
PMID:16959548 |
|
NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629
|
|
G
|
Bach1
|
BTB domain and CNC homolog 1
|
multiple interactions
|
ISO
|
[ferric chloride results in increased oxidation of 2-tert-butylhydroquinone] promotes the reaction [2-tert-butylhydroquinone analog binds to BACH1 protein]; [ferric chloride results in increased oxidation of hydroquinone] promotes the reaction [hydroquinone analog binds to BACH1 protein]
|
CTD |
PMID:28645578 |
|
NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
[ferric chloride co-treated with Hydrogen Peroxide co-treated with TNF protein] results in increased activity of CASP3 protein
|
CTD |
PMID:19900513 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Cat
|
catalase
|
multiple interactions decreases activity
|
ISO
|
chromous chloride inhibits the reaction [ferric chloride results in decreased activity of CAT protein]; ferric chloride inhibits the reaction [chromous chloride results in decreased activity of CAT protein]
|
CTD |
PMID:30389395 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccnb1
|
cyclin B1
|
increases expression
|
ISO
|
ferric chloride results in increased expression of CCNB1 protein
|
CTD |
PMID:20025956 |
|
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
|
|
G
|
Ces1d
|
carboxylesterase 1D
|
multiple interactions
|
ISO EXP
|
[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein; epigallocatechin gallate inhibits the reaction [[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein] [Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein; epigallocatechin gallate inhibits the reaction [[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein]; gallocatechol inhibits the reaction [[Arachidonic Acid co-treated with ferric chloride] results in decreased activity of CES1 protein]
|
CTD |
PMID:37353134 |
|
NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449
|
|
G
|
Chek1
|
checkpoint kinase 1
|
increases expression
|
ISO
|
ferric chloride results in increased expression of CHEK1 protein
|
CTD |
PMID:20025956 |
|
NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359
|
|
G
|
Cxcl2
|
C-X-C motif chemokine ligand 2
|
multiple interactions
|
EXP
|
ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased expression of CXCL2]
|
CTD |
PMID:21605006 |
|
NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
increases stability multiple interactions
|
ISO
|
ferric chloride results in increased stability of CYP1A1 mRNA; ferric chloride results in increased stability of CYP1A1 protein ferric chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]
|
CTD |
PMID:19896525 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
|
|
G
|
Fech
|
ferrochelatase
|
increases expression multiple interactions
|
ISO
|
ferric chloride results in increased expression of FECH protein ferric chloride inhibits the reaction [Deferoxamine results in decreased expression of FECH protein]; ferric chloride inhibits the reaction [pyridoxal isonicotinoyl hydrazone results in decreased expression of FECH protein]
|
CTD |
PMID:30517741 |
|
NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546
|
|
G
|
Fosl1
|
FOS like 1, AP-1 transcription factor subunit
|
increases expression
|
ISO
|
ferric chloride results in increased expression of FOSL1 protein
|
CTD |
PMID:20025956 |
|
NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391
|
|
G
|
Fth1
|
ferritin heavy chain 1
|
multiple interactions
|
ISO
|
[ferric chloride co-treated with TNF protein] results in increased expression of FTH1 protein
|
CTD |
PMID:19900513 |
|
NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214
|
|
G
|
G6pd
|
glucose-6-phosphate dehydrogenase
|
decreases activity decreases expression
|
EXP
|
ferric chloride results in decreased activity of G6PD protein ferric chloride results in decreased expression of G6PD mRNA; ferric chloride results in decreased expression of G6PD protein
|
CTD |
PMID:24599681 PMID:30506659 |
|
NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
multiple interactions
|
ISO
|
[ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein
|
CTD |
PMID:19900513 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
increases expression decreases expression
|
EXP
|
ferric chloride results in increased expression of GSR protein ferric chloride results in decreased expression of GSR mRNA
|
CTD |
PMID:30506659 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
|
|
G
|
Hamp
|
hepcidin antimicrobial peptide
|
increases expression
|
EXP
|
ferric chloride results in increased expression of HAMP mRNA
|
CTD |
PMID:30506659 |
|
NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297
|
|
G
|
Hells
|
helicase, lymphoid specific
|
increases expression
|
ISO
|
ferric chloride results in increased expression of HELLS protein
|
CTD |
PMID:20025956 |
|
NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:246,114,096...246,159,228
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
EXP ISO
|
[ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in decreased expression of HMOX1 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of HMOX1 protein ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of HMOX1 protein]
|
CTD |
PMID:15019574 PMID:28645578 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO EXP
|
[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA; ferric chloride inhibits the reaction [Deferoxamine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]; Pentetic Acid inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of IL1B mRNA] ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased expression of IL1B mRNA]
|
CTD |
PMID:9851740 PMID:22168577 PMID:28512001 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il1rl1
|
interleukin 1 receptor-like 1
|
increases expression
|
ISO
|
ferric chloride results in increased expression of IL1RL1 protein
|
CTD |
PMID:20025956 |
|
NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891
|
|
G
|
Il6
|
interleukin 6
|
increases expression
|
ISO
|
ferric chloride results in increased expression of IL6 protein
|
CTD |
PMID:15781289 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
increases expression
|
ISO
|
ferric chloride results in increased expression of JUN protein
|
CTD |
PMID:20025956 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
|
|
G
|
Klkb1
|
kallikrein B1
|
decreases response to substance
|
ISO
|
KLKB1 gene mutant form results in decreased susceptibility to ferric chloride
|
CTD |
PMID:25339356 |
|
NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
EXP
|
[Vanadates co-treated with ferric chloride] results in increased phosphorylation of MAPK1 protein; ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:16728372 PMID:22168577 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
EXP
|
[aluminum chloride co-treated with ferric chloride] results in increased phosphorylation of MAPK3 protein; [Vanadates co-treated with ferric chloride] results in increased phosphorylation of MAPK3 protein; ferric chloride inhibits the reaction [Asbestos, Amphibole results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:16728372 PMID:22168577 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mcm3
|
minichromosome maintenance complex component 3
|
increases expression
|
ISO
|
ferric chloride results in increased expression of MCM3 protein
|
CTD |
PMID:20025956 |
|
NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746
|
|
G
|
Mgst1
|
microsomal glutathione S-transferase 1
|
multiple interactions
|
EXP
|
ferric chloride inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]
|
CTD |
PMID:16125204 |
|
NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions
|
ISO
|
ferric chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Deferoxamine results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]
|
CTD |
PMID:10086886 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
|
|
G
|
Mt1a
|
metallothionein 1A
|
decreases response to substance
|
ISO
|
MT1A protein results in decreased susceptibility to ferric chloride
|
CTD |
PMID:11878821 |
|
NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200 Ensembl chr X:79,695,809...79,696,200 Ensembl chr19:79,695,809...79,696,200
|
|
G
|
Mt2
|
metallothionein 2
|
decreases expression
|
ISO
|
ferric chloride results in decreased expression of MT2A mRNA
|
CTD |
PMID:26378417 |
|
NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions
|
ISO
|
ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of NFE2L2 protein]
|
CTD |
PMID:28645578 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
EXP
|
[aluminum chloride co-treated with ferric chloride] results in increased expression of NOS2 protein
|
CTD |
PMID:16728372 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
multiple interactions
|
ISO
|
ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 protein]; ferric chloride promotes the reaction [hydroquinone results in increased expression of NQO1 protein]
|
CTD |
PMID:28645578 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
|
|
G
|
Pgd
|
phosphogluconate dehydrogenase
|
affects expression decreases activity increases expression decreases expression
|
EXP
|
ferric chloride affects the expression of PGD mRNA ferric chloride results in decreased activity of PGD protein ferric chloride results in increased expression of PGD protein ferric chloride results in decreased expression of PGD mRNA
|
CTD |
PMID:24599681 PMID:30506659 |
|
NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029
|
|
G
|
Phex
|
phosphate regulating endopeptidase X-linked
|
increases expression
|
ISO
|
ferric chloride results in increased expression of PHEX protein
|
CTD |
PMID:20025956 |
|
NCBI chr X:41,422,561...41,671,226
Ensembl chr X:41,426,101...41,671,226
|
|
G
|
Pik3r5
|
phosphoinositide-3-kinase, regulatory subunit 5
|
increases expression
|
ISO
|
ferric chloride results in increased expression of PIK3R5 protein
|
CTD |
PMID:20025956 |
|
NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539
|
|
G
|
Rad51ap1
|
RAD51 associated protein 1
|
increases expression
|
ISO
|
ferric chloride results in increased expression of RAD51AP1 protein
|
CTD |
PMID:20025956 |
|
NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:161,445,512...161,458,680
|
|
G
|
Scarb1
|
scavenger receptor class B, member 1
|
increases expression
|
ISO
|
ferric chloride results in increased expression of SCARB1 protein
|
CTD |
PMID:20025956 |
|
NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980
|
|
G
|
Slc11a2
|
solute carrier family 11 member 2
|
multiple interactions
|
ISO
|
[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride; [Zinc Sulfate results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride; bathophenanthroline disulfonic acid inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]; Zinc Sulfate inhibits the reaction [[Hydrogen Peroxide results in increased expression of SLC11A2 protein] which results in increased uptake of ferric chloride]
|
CTD |
PMID:20096349 |
|
NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941
|
|
G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions
|
EXP
|
[ferric chloride co-treated with Oxyquinoline] results in decreased expression of SOD2 protein; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 mRNA; [ferric chloride co-treated with Oxyquinoline] results in increased expression of SOD2 protein
|
CTD |
PMID:15019574 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
|
|
G
|
Tf
|
transferrin
|
multiple interactions
|
ISO
|
ferric chloride promotes the reaction [TF protein results in increased uptake of Iron]
|
CTD |
PMID:11335103 |
|
NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
|
|
G
|
Tnf
|
tumor necrosis factor
|
increases expression multiple interactions
|
ISO
|
ferric chloride results in increased expression of TNF protein [ferric chloride co-treated with Hydrogen Peroxide co-treated with TNF protein] results in increased activity of CASP3 protein; [ferric chloride co-treated with TNF protein] results in increased expression of FTH1 protein; [ferric chloride co-treated with TNF protein] results in increased expression of GCLC protein; TNF protein inhibits the reaction [ferric chloride results in increased chemical synthesis of Reactive Oxygen Species]; TNF results in decreased susceptibility to [ferric chloride co-treated with Hydrogen Peroxide] [Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA; manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]; Pentetic Acid inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]; tricyclodecane-9-yl-xanthogenate inhibits the reaction [[Silicon Dioxide co-treated with ferric chloride] results in increased expression of TNF mRNA]
|
CTD |
PMID:15781289 PMID:19900513 PMID:28512001 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|