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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dodecanoic acid
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Accession:CHEBI:30805 term browser browse the term
Definition:A straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.
Synonyms:related_synonym: 1-undecanecarboxylic acid;   ABL;   C12 fatty acid;   C12:0;   CH3-[CH2]10-COOH;   Coconut oil fatty acids;   DAO;   Dodecylcarboxylate;   Dodecylic acid;   Duodecyclic acid;   Duodecylic acid;   Formula=C12H24O2;   InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14);   InChIKey=POULHZVOKOAJMA-UHFFFAOYSA-N;   Laurinsaeure;   Laurostearic acid;   N-dodecanoic acid;   SMILES=CCCCCCCCCCCC(O)=O;   Undecane-1-carboxylic acid;   Vulvic acid;   dodecoic acid;   lauric acid
 alt_id: CHEBI:23864;   CHEBI:23865;   CHEBI:41882;   CHEBI:4680
 xref: Beilstein:1099477;   CAS:143-07-7;   DrugBank:DB03017;   Drug_Central:4642;   Gmelin:103520;   HMDB:HMDB0000638;   KEGG:C02679;   KNApSAcK:C00001221;   LIPID_MAPS_instance:LMFA01010012
 xref_mesh: MESH:C030358
 xref: MetaCyc:DODECANOATE;   PDBeChem:DAO;   PMID:19387482;   PMID:26884207;   Reaxys:1099477;   UM-BBD_compID:c0566;   Wikipedia:Lauric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:18262


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dodecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO lauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:19428350 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of lauric acid CTD PMID:12464242 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 affects metabolic processing EXP CYP4A1 protein affects the metabolism of lauric acid CTD PMID:15879494 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 affects metabolic processing EXP CYP4A2 protein affects the metabolism of lauric acid CTD PMID:15879494 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 affects metabolic processing EXP CYP4A3 protein affects the metabolism of lauric acid CTD PMID:15879494 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 multiple interactions ISO lauric acid inhibits the reaction [CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine] CTD PMID:9310344 NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions ISO Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]]; lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein] CTD PMID:18413660 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects binding ISO lauric acid binds to PPARA protein CTD PMID:10403814 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO lauric acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein]; parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein] CTD PMID:18413660 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of lauric acid CTD PMID:16051554 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
12-hydroxylauric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases oxidation
affects binding
ISO ADH5 protein results in increased oxidation of 12-hydroxydodecanoic acid
12-hydroxydodecanoic acid binds to ADH5 protein
CTD PMID:12196016, PMID:12604204, PMID:19428350 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 multiple interactions
increases chemical synthesis
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [CYP4V2 protein results in increased chemical synthesis of 12-hydroxydodecanoic acid] CTD PMID:28729181 NCBI chr16:50,111,803...50,136,741
Ensembl chr16:50,111,306...50,136,727
JBrowse link
lauroyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO lauroyl-coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 multiple interactions ISO [lauroyl-coenzyme A co-treated with NADP] binds to HSDL2 protein CTD PMID:25526675 NCBI chr 5:76,812,881...76,848,853
Ensembl chr 5:76,812,931...76,848,101
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO [lauroyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
methyl laurate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO lauric acid methyl ester binds to and results in increased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO lauric acid methyl ester binds to and results in decreased activity of ESR2 protein; lauric acid methyl ester binds to and results in increased activity of ESR2 protein CTD PMID:27633901 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Pgr progesterone receptor multiple interactions ISO lauric acid methyl ester binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO lauric acid methyl ester binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO lauric acid methyl ester binds to and results in decreased activity of THRB protein CTD PMID:27633901 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
perfluorododecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd14b abhydrolase domain containing 14b decreases expression EXP perfluorododecanoic acid results in decreased expression of ABHD14B protein CTD PMID:26168851 NCBI chr 8:115,149,638...115,154,556
Ensembl chr 8:115,150,514...115,154,550
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression
multiple interactions
EXP perfluorododecanoic acid results in increased expression of ACOT1 mRNA; perfluorododecanoic acid results in increased expression of ACOT1 protein
perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of ACOT1 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of ACOT1 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT1 mRNA]
CTD PMID:26168851 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acot2 acyl-CoA thioesterase 2 multiple interactions
increases expression
EXP perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of ACOT2 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of ACOT2 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT2 mRNA]
perfluorododecanoic acid results in increased expression of ACOT2 mRNA; perfluorododecanoic acid results in increased expression of ACOT2 protein
CTD PMID:26168851 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acp1 acid phosphatase 1 increases expression EXP perfluorododecanoic acid results in increased expression of ACP1 protein CTD PMID:19854247 NCBI chr 6:49,836,064...49,851,714
Ensembl chr 6:49,836,075...49,851,714
JBrowse link
G Actg1 actin, gamma 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of ACTG1 protein CTD PMID:26168851 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Acy1 aminoacylase 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of ACY1 protein CTD PMID:26168851 NCBI chr 8:115,134,792...115,140,171
Ensembl chr 8:115,134,765...115,140,080
JBrowse link
G Adk adenosine kinase decreases expression EXP perfluorododecanoic acid results in decreased expression of ADK protein CTD PMID:26168851 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Ahcy adenosylhomocysteinase decreases expression EXP perfluorododecanoic acid results in decreased expression of AHCY protein CTD PMID:26168851 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Akap4 A-kinase anchoring protein 4 increases expression
decreases expression
EXP perfluorododecanoic acid results in increased expression of AKAP4 mRNA
perfluorododecanoic acid results in decreased expression of AKAP4 protein
CTD PMID:19854247 NCBI chr  X:16,296,027...16,306,078
Ensembl chr  X:16,296,735...16,306,078
JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases phosphorylation EXP perfluorododecanoic acid results in decreased phosphorylation of AKT2 protein CTD PMID:30489073 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alb albumin increases expression
decreases expression
EXP perfluorododecanoic acid results in increased expression of ALB protein
perfluorododecanoic acid results in decreased expression of ALB protein
CTD PMID:19854247, PMID:26168851 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression
multiple interactions
EXP perfluorododecanoic acid results in decreased expression of ALDH2 protein
PPARA mRNA promotes the reaction [perfluorododecanoic acid results in decreased expression of ALDH2 protein]
CTD PMID:26168851 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 decreases expression EXP perfluorododecanoic acid results in decreased expression of ALDH9A1 protein CTD PMID:26168851 NCBI chr13:85,580,828...85,597,497
Ensembl chr13:85,580,828...85,597,493
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO perfluorododecanoic acid results in increased expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Apoa2 apolipoprotein A2 affects expression ISO perfluorododecanoic acid affects the expression of APOA2 mRNA CTD PMID:23567314 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP perfluorododecanoic acid affects the expression of APOA4 mRNA CTD PMID:22071372 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Ar androgen receptor affects expression EXP perfluorododecanoic acid affects the expression of AR mRNA CTD PMID:19397962 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta increases expression EXP perfluorododecanoic acid results in increased expression of ARHGDIB protein CTD PMID:19854247 NCBI chr 4:170,913,920...170,932,789
Ensembl chr 4:170,913,923...170,932,618
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO perfluorododecanoic acid results in increased expression of ATF3 mRNA CTD PMID:23567314 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d decreases expression EXP perfluorododecanoic acid results in decreased expression of ATP5H mRNA CTD PMID:19854247 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression ISO perfluorododecanoic acid results in decreased expression of BAAT mRNA CTD PMID:23567314 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO perfluorododecanoic acid results in increased expression of CCND1 mRNA CTD PMID:23567314 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd36 CD36 molecule increases expression EXP perfluorododecanoic acid results in increased expression of CD36 mRNA CTD PMID:23353032 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cops4 COP9 signalosome subunit 4 increases expression EXP perfluorododecanoic acid results in increased expression of COPS4 protein CTD PMID:26168851 NCBI chr14:10,718,863...10,749,134
Ensembl chr14:10,718,844...10,749,120
JBrowse link
G Cops8 COP9 signalosome subunit 8 decreases expression EXP perfluorododecanoic acid results in decreased expression of COPS8 protein CTD PMID:19854247 NCBI chr 9:97,772,224...97,782,055
Ensembl chr 9:97,772,184...97,782,067
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A decreases expression
increases expression
EXP perfluorododecanoic acid results in decreased expression of COX5A protein
perfluorododecanoic acid results in increased expression of COX5A mRNA
CTD PMID:19854247 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression EXP perfluorododecanoic acid results in increased expression of COX5B mRNA CTD PMID:19854247 NCBI chr 9:43,259,706...43,262,039
Ensembl chr 9:43,259,709...43,262,040
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 decreases expression
multiple interactions
EXP perfluorododecanoic acid results in decreased expression of CPS1 mRNA; perfluorododecanoic acid results in decreased expression of CPS1 protein
PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in decreased expression of CPS1 mRNA]
CTD PMID:26168851 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression ISO perfluorododecanoic acid affects the expression of CPT1A mRNA CTD PMID:23567314 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crym crystallin, mu decreases expression EXP perfluorododecanoic acid results in decreased expression of CRYM protein CTD PMID:26168851 NCBI chr 1:189,944,895...189,960,069
Ensembl chr 1:189,944,895...189,960,073
JBrowse link
G Csk C-terminal Src kinase decreases expression EXP perfluorododecanoic acid results in decreased expression of CSK mRNA; perfluorododecanoic acid results in decreased expression of CSK protein CTD PMID:19854247 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Ctsa cathepsin A increases expression EXP perfluorododecanoic acid results in increased expression of CTSA protein CTD PMID:26168851 NCBI chr 3:161,298,750...161,304,627
Ensembl chr 3:161,298,962...161,304,625
JBrowse link
G Cuta cutA divalent cation tolerance homolog decreases expression EXP perfluorododecanoic acid results in decreased expression of CUTA protein CTD PMID:19854247 NCBI chr20:5,532,024...5,533,640
Ensembl chr20:5,532,024...5,533,620
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of CYP11A1 mRNA; perfluorododecanoic acid results in decreased expression of CYP11A1 protein CTD PMID:17400581, PMID:19397962, PMID:19429406, PMID:30489073 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of CYP17A1 mRNA; perfluorododecanoic acid results in decreased expression of CYP17A1 protein CTD PMID:17400581, PMID:30489073 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO perfluorododecanoic acid results in decreased expression of CYP1A1 mRNA CTD PMID:23567314 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression ISO perfluorododecanoic acid results in decreased expression of CYP2B10 mRNA CTD PMID:23567314 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of CYP4A1 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of CYP4A1 mRNA]
perfluorododecanoic acid results in increased expression of CYP4A1 mRNA
CTD PMID:26168851 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO perfluorododecanoic acid results in decreased expression of CYP7A1 mRNA CTD PMID:23567314 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP perfluorododecanoic acid results in increased expression of DDAH1 protein CTD PMID:26168851 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO perfluorododecanoic acid results in increased expression of DDIT3 mRNA CTD PMID:23567314 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression EXP perfluorododecanoic acid results in decreased expression of DDT protein CTD PMID:19854247 NCBI chr20:13,827,153...13,829,624
Ensembl chr20:13,827,132...13,831,588
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase increases expression EXP perfluorododecanoic acid results in increased expression of DLAT protein CTD PMID:26168851 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression
multiple interactions
EXP perfluorododecanoic acid results in increased expression of ECH1 mRNA; perfluorododecanoic acid results in increased expression of ECH1 protein
PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ECH1 mRNA]
CTD PMID:26168851 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Efhd2 EF-hand domain family, member D2 decreases expression EXP perfluorododecanoic acid results in decreased expression of EFHD2 protein CTD PMID:19854247 NCBI chr 5:160,407,777...160,423,811
Ensembl chr 5:160,407,778...160,423,811
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of ESR1 mRNA CTD PMID:19429406 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 decreases expression EXP perfluorododecanoic acid results in decreased expression of ESR2 mRNA CTD PMID:19429406 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase decreases expression EXP perfluorododecanoic acid results in decreased expression of ETHE1 protein CTD PMID:26168851 NCBI chr 1:81,457,008...81,472,061
Ensembl chr 1:81,456,984...81,472,097
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO perfluorododecanoic acid results in decreased expression of FABP1 mRNA CTD PMID:23567314 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fasn fatty acid synthase decreases expression EXP perfluorododecanoic acid results in decreased expression of FASN mRNA CTD PMID:23353032 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP perfluorododecanoic acid results in increased expression of FDFT1 mRNA CTD PMID:22071372 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase increases expression EXP perfluorododecanoic acid results in increased expression of FHIT protein CTD PMID:19854247 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression
decreases secretion
EXP perfluorododecanoic acid results in decreased expression of FSHB mRNA
perfluorododecanoic acid results in decreased secretion of FSHB protein
CTD PMID:19397962, PMID:30489073 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
increases expression
EXP perfluorododecanoic acid results in decreased expression of FTH1 protein
perfluorododecanoic acid results in increased expression of FTH1 mRNA
CTD PMID:19854247 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO perfluorododecanoic acid results in increased expression of GADD45B mRNA CTD PMID:23567314 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gc GC, vitamin D binding protein decreases expression EXP perfluorododecanoic acid results in decreased expression of GC protein CTD PMID:26168851 NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581
JBrowse link
G Gk glycerol kinase decreases expression ISO perfluorododecanoic acid results in decreased expression of GK mRNA CTD PMID:23567314 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Glod4 glyoxalase domain containing 4 decreases expression EXP perfluorododecanoic acid results in decreased expression of GLOD4 protein CTD PMID:19854247 NCBI chr10:64,379,922...64,398,263
Ensembl chr10:64,379,921...64,398,294
JBrowse link
G Gmfb glia maturation factor, beta decreases expression EXP perfluorododecanoic acid results in decreased expression of GMFB protein CTD PMID:26168851 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634
JBrowse link
G Gmfg glia maturation factor, gamma increases expression EXP perfluorododecanoic acid results in increased expression of GMFG protein CTD PMID:19854247 NCBI chr 1:85,312,473...85,322,860
Ensembl chr 1:85,312,528...85,317,968
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP perfluorododecanoic acid results in decreased expression of GNRHR mRNA CTD PMID:19397962 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 increases expression EXP perfluorododecanoic acid results in increased expression of GPD1 protein CTD PMID:26168851 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases expression
affects response to substance
EXP perfluorododecanoic acid results in decreased expression of GSK3A protein; perfluorododecanoic acid results in decreased expression of GSK3A protein modified form
GSK3A protein affects the susceptibility to perfluorododecanoic acid
CTD PMID:23353032 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects response to substance
decreases expression
EXP GSK3B protein affects the susceptibility to perfluorododecanoic acid
perfluorododecanoic acid results in decreased expression of GSK3B protein; perfluorododecanoic acid results in decreased expression of GSK3B protein modified form
CTD PMID:23353032 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase increases expression EXP perfluorododecanoic acid results in increased expression of HAAO protein CTD PMID:26168851 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha affects expression
multiple interactions
increases expression
ISO
EXP
perfluorododecanoic acid affects the expression of HADHA mRNA
PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of HADHA mRNA]
perfluorododecanoic acid results in increased expression of HADHA mRNA; perfluorododecanoic acid results in increased expression of HADHA protein
CTD PMID:22071372, PMID:23567314, PMID:26168851 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP perfluorododecanoic acid results in increased expression of HADHB mRNA CTD PMID:22071372 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
JBrowse link
G Hhex hematopoietically expressed homeobox increases expression EXP perfluorododecanoic acid results in increased expression of HHEX mRNA CTD PMID:22071372 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO perfluorododecanoic acid results in decreased expression of HMGCS2 mRNA CTD PMID:23567314 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO perfluorododecanoic acid results in increased expression of HMOX1 mRNA CTD PMID:23567314 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpx hemopexin increases expression EXP perfluorododecanoic acid results in increased expression of HPX protein CTD PMID:26168851 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of HSD11B1 mRNA; perfluorododecanoic acid results in decreased expression of HSD11B1 protein CTD PMID:30489073 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of HSD17B1 mRNA CTD PMID:19429406 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression EXP perfluorododecanoic acid results in decreased expression of HSD17B3 mRNA CTD PMID:17400581 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of HSD3B1 mRNA CTD PMID:17400581
G Hspa5 heat shock protein family A (Hsp70) member 5 affects expression EXP perfluorododecanoic acid affects the expression of HSPA5 protein CTD PMID:26168851 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP perfluorododecanoic acid results in increased expression of HSPA8 protein CTD PMID:26168851 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression EXP perfluorododecanoic acid results in increased expression of HSPA9 protein CTD PMID:26168851 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP perfluorododecanoic acid results in increased expression of HSPD1 protein CTD PMID:26168851 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression EXP perfluorododecanoic acid results in decreased expression of IDH3A protein CTD PMID:26168851 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression EXP perfluorododecanoic acid results in increased expression of IDO1 protein CTD PMID:19854247 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ift20 intraflagellar transport 20 decreases expression EXP perfluorododecanoic acid results in decreased expression of IFT20 protein CTD PMID:19854247 NCBI chr10:65,805,808...65,811,353
Ensembl chr10:65,805,860...65,811,351
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of IGF1 mRNA CTD PMID:19397962 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression EXP perfluorododecanoic acid results in decreased expression of IGF1R mRNA CTD PMID:19397962 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il1a interleukin 1 alpha decreases expression EXP perfluorododecanoic acid results in decreased expression of IL1A mRNA CTD PMID:19397962 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Impa1 inositol monophosphatase 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of IMPA1 protein CTD PMID:19854247 NCBI chr 2:93,675,203...93,696,355
Ensembl chr 2:93,675,203...93,696,232
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of IRS1 protein modified form CTD PMID:23353032 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Itpa inosine triphosphatase increases expression EXP perfluorododecanoic acid results in increased expression of ITPA protein CTD PMID:26168851 NCBI chr 3:123,209,611...123,221,266
Ensembl chr 3:123,209,608...123,221,269
JBrowse link
G Ivd isovaleryl-CoA dehydrogenase decreases expression EXP perfluorododecanoic acid results in decreased expression of IVD protein CTD PMID:26168851 NCBI chr 3:110,669,355...110,689,789
Ensembl chr 3:110,669,312...110,690,173
JBrowse link
G Krt10 keratin 10 decreases expression EXP perfluorododecanoic acid results in decreased expression of KRT10 protein CTD PMID:19854247 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Krt14 keratin 14 decreases expression EXP perfluorododecanoic acid results in decreased expression of KRT14 protein CTD PMID:19854247 NCBI chr10:88,118,029...88,122,233
Ensembl chr10:88,055,823...88,122,233
JBrowse link
G Krt16 keratin 16 decreases expression EXP perfluorododecanoic acid results in decreased expression of KRT16 protein CTD PMID:19854247 NCBI chr10:88,149,210...88,152,167
Ensembl chr10:88,149,345...88,152,064
JBrowse link
G Krt8 keratin 8 increases expression EXP perfluorododecanoic acid results in increased expression of KRT8 protein CTD PMID:26168851 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
decreases secretion
EXP perfluorododecanoic acid results in decreased expression of LHB mRNA; perfluorododecanoic acid results in decreased expression of LHB protein
perfluorododecanoic acid results in decreased secretion of LHB protein
CTD PMID:17400581, PMID:19397962, PMID:30489073 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP perfluorododecanoic acid results in decreased expression of LHCGR mRNA; perfluorododecanoic acid results in decreased expression of LHCGR protein CTD PMID:19429406, PMID:30489073 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase decreases expression EXP perfluorododecanoic acid results in decreased expression of LHPP protein CTD PMID:26168851 NCBI chr 1:204,617,804...204,708,987
Ensembl chr 1:204,617,852...204,708,987
JBrowse link
G Mbl2 mannose binding lectin 2 decreases expression ISO perfluorododecanoic acid results in decreased expression of MBL2 mRNA CTD PMID:23567314 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression EXP perfluorododecanoic acid results in increased expression of MDH1 protein CTD PMID:26168851 NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of PZP protein CTD PMID:26168851 NCBI chr 4:154,676,382...154,729,288
Ensembl chr 4:154,391,647...154,729,310
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP perfluorododecanoic acid results in increased expression of NDUFV2 protein CTD PMID:26168851 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO perfluorododecanoic acid results in increased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO perfluorododecanoic acid results in increased activity of NR1I2 protein CTD PMID:28115241 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ntan1 N-terminal asparagine amidase increases expression EXP perfluorododecanoic acid results in increased expression of NTAN1 protein CTD PMID:19854247 NCBI chr10:3,218,414...3,235,229 JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression EXP perfluorododecanoic acid results in decreased expression of P4HB protein CTD PMID:26168851 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Park7 Parkinsonism associated deglycase decreases expression EXP perfluorododecanoic acid results in decreased expression of PARK7 protein CTD PMID:19854247 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pax8 paired box 8 increases expression EXP perfluorododecanoic acid results in increased expression of PAX8 mRNA CTD PMID:22071372 NCBI chr 3:1,527,316...1,586,019
Ensembl chr 3:1,527,279...1,584,946
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of PBLD1 protein CTD PMID:26168851 NCBI chr20:27,103,300...27,118,650
Ensembl chr20:27,103,317...27,117,663
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta increases expression EXP perfluorododecanoic acid results in increased expression of PDHB protein CTD PMID:26168851 NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 affects expression EXP perfluorododecanoic acid affects the expression of PDIA6 protein CTD PMID:26168851 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO perfluorododecanoic acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases activity
decreases expression
EXP perfluorododecanoic acid results in decreased activity of PDPK1 protein
perfluorododecanoic acid results in decreased expression of PDPK1 protein; perfluorododecanoic acid results in decreased expression of PDPK1 protein modified form
CTD PMID:23353032 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression
increases expression
EXP perfluorododecanoic acid results in decreased expression of PEBP1 protein
perfluorododecanoic acid results in increased expression of PEBP1 mRNA
CTD PMID:19854247 NCBI chr12:45,026,948...45,031,148
Ensembl chr12:45,026,886...45,031,145
JBrowse link
G Phb prohibitin increases expression EXP perfluorododecanoic acid results in increased expression of PHB protein CTD PMID:26168851 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Pitpna phosphatidylinositol transfer protein, alpha decreases expression EXP perfluorododecanoic acid results in decreased expression of PITPNA protein CTD PMID:19854247 NCBI chr10:63,731,767...63,772,049
Ensembl chr10:63,731,767...63,772,049
JBrowse link
G Plin2 perilipin 2 increases expression
affects expression
ISO perfluorododecanoic acid results in increased expression of PLIN2 mRNA
perfluorododecanoic acid affects the expression of PLIN2 mRNA
CTD PMID:23567314 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO perfluorododecanoic acid results in increased expression of POR mRNA CTD PMID:23567314 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
increases response to substance
increases expression
multiple interactions
ISO
EXP
perfluorododecanoic acid results in increased activity of PPARA protein
PPARA mRNA results in increased susceptibility to perfluorododecanoic acid
perfluorododecanoic acid results in increased expression of PPARA mRNA; perfluorododecanoic acid results in increased expression of PPARA protein
perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of PPARA mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA]; PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in decreased expression of CPS1 mRNA]; PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in increased abundance of Reactive Oxygen Species]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in decreased expression of ALDH2 protein]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT1 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT2 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ECH1 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of HADHA mRNA]
CTD PMID:22107727, PMID:26168851, PMID:28857218 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO perfluorododecanoic acid results in increased expression of PPARD mRNA CTD PMID:23567314 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO perfluorododecanoic acid results in increased activity of PPARG protein CTD PMID:23391484, PMID:24998974 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression EXP perfluorododecanoic acid results in decreased expression of PPARGC1A protein CTD PMID:30489073 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prdx2 peroxiredoxin 2 decreases expression EXP perfluorododecanoic acid results in decreased expression of PRDX2 protein CTD PMID:26168851 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prdx4 peroxiredoxin 4 decreases expression EXP perfluorododecanoic acid results in decreased expression of PRDX4 protein CTD PMID:26168851 NCBI chr  X:43,495,453...43,512,994
Ensembl chr  X:43,497,763...43,512,991
JBrowse link
G Psmf1 proteasome inhibitor subunit 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of PSMF1 protein CTD PMID:19854247 NCBI chr 3:147,238,111...147,263,275
Ensembl chr 3:147,238,114...147,263,275
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorododecanoic acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Ranbp1 RAN binding protein 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of RANBP1 protein CTD PMID:19854247 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Rbp4 retinol binding protein 4 increases expression EXP perfluorododecanoic acid results in increased expression of RBP4 protein CTD PMID:26168851 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Rgn regucalcin decreases expression EXP perfluorododecanoic acid results in decreased expression of RGN protein CTD PMID:26168851 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of SCARB1 mRNA; perfluorododecanoic acid results in decreased expression of SCARB1 protein CTD PMID:17400581, PMID:30489073 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
increases expression
ISO
EXP
perfluorododecanoic acid results in decreased expression of SCD mRNA
perfluorododecanoic acid results in increased expression of SCD1 mRNA
CTD PMID:23353032, PMID:23567314 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpind1 serpin family D member 1 decreases expression ISO perfluorododecanoic acid results in decreased expression of SERPIND1 mRNA CTD PMID:23567314 NCBI chr11:87,913,814...87,924,880
Ensembl chr11:87,913,806...87,924,816
JBrowse link
G Serpinf2 serpin family F member 2 decreases expression ISO perfluorododecanoic acid results in decreased expression of SERPINF2 mRNA CTD PMID:23567314 NCBI chr10:62,264,247...62,272,353
Ensembl chr10:62,264,788...62,273,119
JBrowse link
G Sirt1 sirtuin 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of SIRT1 protein CTD PMID:30489073 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc25a20 solute carrier family 25 member 20 decreases expression ISO perfluorododecanoic acid results in decreased expression of SLC25A20 mRNA CTD PMID:23567314 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc27a1 solute carrier family 27 member 1 increases expression ISO perfluorododecanoic acid results in increased expression of SLC27A1 mRNA CTD PMID:23567314 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of SOD1 mRNA CTD PMID:19854247 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP perfluorododecanoic acid results in increased expression of SREBF1 mRNA CTD PMID:23353032 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
ISO
EXP
Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR mRNA]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR protein]]; perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR mRNA]; perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR protein]
perfluorododecanoic acid results in decreased expression of STAR mRNA; perfluorododecanoic acid results in decreased expression of STAR protein
CTD PMID:17400581, PMID:19397962, PMID:19429406, PMID:20100736, PMID:30489073 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP perfluorododecanoic acid results in decreased expression of STMN1 protein CTD PMID:19854247 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta increases expression EXP perfluorododecanoic acid results in increased expression of SUCLG2 protein CTD PMID:26168851 NCBI chr 4:127,552,100...127,824,970
Ensembl chr 4:127,552,101...127,824,970
JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP perfluorododecanoic acid results in decreased expression of SULT1C3 protein CTD PMID:26168851 NCBI chr 9:4,931,038...4,978,847
Ensembl chr 9:4,930,818...4,978,892
JBrowse link
G Suox sulfite oxidase increases expression EXP perfluorododecanoic acid results in increased expression of SUOX protein CTD PMID:26168851 NCBI chr 7:3,098,228...3,102,179
Ensembl chr 7:3,098,245...3,102,142
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO perfluorododecanoic acid binds to THRA protein CTD PMID:24819616 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tpm1 tropomyosin 1 increases expression EXP perfluorododecanoic acid results in increased expression of TPM1 protein CTD PMID:26168851 NCBI chr 8:72,814,737...72,841,496
Ensembl chr 8:72,814,740...72,842,228
JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression EXP perfluorododecanoic acid results in increased expression of TRAP1 protein CTD PMID:26168851 NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681
JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorododecanoic acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Txnip thioredoxin interacting protein affects expression ISO perfluorododecanoic acid affects the expression of TXNIP mRNA CTD PMID:23567314 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N decreases expression EXP perfluorododecanoic acid results in decreased expression of UBE2N protein CTD PMID:19854247 NCBI chr 7:36,610,147...36,640,190
Ensembl chr 7:36,610,147...36,640,189
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 increases expression EXP perfluorododecanoic acid results in increased expression of UQCRC1 protein CTD PMID:26168851 NCBI chr 8:117,679,328...117,691,073
Ensembl chr 8:117,679,278...117,691,071
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression
increases expression
EXP perfluorododecanoic acid results in decreased expression of UQCRH protein
perfluorododecanoic acid results in increased expression of UQCRH mRNA
CTD PMID:19854247 NCBI chr 5:134,919,040...134,927,235
Ensembl chr 5:134,919,044...134,927,235
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression
increases expression
EXP perfluorododecanoic acid results in decreased expression of YWHAE protein
perfluorododecanoic acid results in increased expression of YWHAE mRNA
CTD PMID:19854247 NCBI chr10:63,884,338...63,921,709
Ensembl chr10:63,884,338...63,921,709
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antibacterial agent 13019
            dodecanoic acid 164
              1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol 0
              1,2-didodecanoyl-sn-glycero-3-cytidine 5'-diphosphate 0
              1,2-dioleoyl-3-lauroyl-sn-glycerol 0
              1-O-(alpha-D-galactopyranosyl)-N-dodecanoylphytosphingosine 0
              1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine 0
              10-methyldodecanoic acid 0
              11-hydroxylauric acid + 0
              12-bromododecanoic acid 0
              12-hydroxylauric acid + 2
              12-oxododecanoic acid 0
              2-dodecanoyl-sn-glycero-3-phosphocholine 0
              2-hydroxydodecanoic acid + 0
              3,12-dihydroxylauric acid 0
              3-hydroxylauric acid + 0
              3-oxolauric acid + 0
              4-hydroxylauric acid + 0
              7-hydroxylauric acid 0
              L-erythro-N-dodecanoylsphingosine 0
              N-(dodecanoyl)ethanolamine 0
              N-dodecanoyl-(2S)-hydroxyglycine 0
              N-dodecanoylglycine 0
              N-dodecanoylphytosphingosine 0
              N-dodecanoylsphinganine 0
              N-dodecanoylsphingosine 0
              N-dodecanoylsphingosine 1-phosphate 0
              N-dodecanoyltaurine 0
              N-lauroyl-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine 0
              S-dodecanoyl-4'-phosphopantetheine 0
              all-trans-retinyl dodecanoate 0
              dilauroyl phosphatidylglycerol 0
              dodecanamide 0
              dodecanoate ester + 5
              dodecanoic anhydride 0
              dodecanoyl group 0
              dodecanoyl-AMP 0
              isopropyl dodecanoate 0
              kansuiphorin A 0
              kansuiphorin B 0
              lauroyl-CoA + 3
              perfluorododecanoic acid 150
              pescaprein XXI 0
              pescaprein XXII 0
              pescaprein XXV 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          fatty acid 15844
                                            saturated fatty acid 15811
                                              straight-chain saturated fatty acid 15226
                                                dodecanoic acid 164
                                                  1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol 0
                                                  1,2-didodecanoyl-sn-glycero-3-cytidine 5'-diphosphate 0
                                                  1,2-dioleoyl-3-lauroyl-sn-glycerol 0
                                                  1-O-(alpha-D-galactopyranosyl)-N-dodecanoylphytosphingosine 0
                                                  1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine 0
                                                  10-methyldodecanoic acid 0
                                                  11-hydroxylauric acid + 0
                                                  12-bromododecanoic acid 0
                                                  12-hydroxylauric acid + 2
                                                  12-oxododecanoic acid 0
                                                  2-dodecanoyl-sn-glycero-3-phosphocholine 0
                                                  2-hydroxydodecanoic acid + 0
                                                  3,12-dihydroxylauric acid 0
                                                  3-hydroxylauric acid + 0
                                                  3-oxolauric acid + 0
                                                  4-hydroxylauric acid + 0
                                                  7-hydroxylauric acid 0
                                                  L-erythro-N-dodecanoylsphingosine 0
                                                  N-(dodecanoyl)ethanolamine 0
                                                  N-dodecanoyl-(2S)-hydroxyglycine 0
                                                  N-dodecanoylglycine 0
                                                  N-dodecanoylphytosphingosine 0
                                                  N-dodecanoylsphinganine 0
                                                  N-dodecanoylsphingosine 0
                                                  N-dodecanoylsphingosine 1-phosphate 0
                                                  N-dodecanoyltaurine 0
                                                  N-lauroyl-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine 0
                                                  S-dodecanoyl-4'-phosphopantetheine 0
                                                  all-trans-retinyl dodecanoate 0
                                                  dilauroyl phosphatidylglycerol 0
                                                  dodecanamide 0
                                                  dodecanoate ester + 5
                                                  dodecanoic anhydride 0
                                                  dodecanoyl group 0
                                                  dodecanoyl-AMP 0
                                                  isopropyl dodecanoate 0
                                                  kansuiphorin A 0
                                                  kansuiphorin B 0
                                                  lauroyl-CoA + 3
                                                  perfluorododecanoic acid 150
                                                  pescaprein XXI 0
                                                  pescaprein XXII 0
                                                  pescaprein XXV 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.