|
G
|
Adh5
|
alcohol dehydrogenase 5 (class III), chi polypeptide
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]
|
CTD |
PMID:19428350 |
|
NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:226,947,466...226,987,591
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of AKT1 protein]
|
CTD |
PMID:34506767 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in increased cleavage of CASP3 protein]
|
CTD |
PMID:34506767 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Cldn1
|
claudin 1
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]
|
CTD |
PMID:34506767 |
|
NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724
|
|
G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
increases metabolic processing
|
ISO
|
CYP2E1 protein results in increased metabolism of lauric acid
|
CTD |
PMID:12464242 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
|
|
G
|
Cyp4a1
|
cytochrome P450, family 4, subfamily a, polypeptide 1
|
affects metabolic processing
|
EXP
|
CYP4A1 protein affects the metabolism of lauric acid
|
CTD |
PMID:15879494 |
|
NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:129,123,336...129,137,464
|
|
G
|
Cyp4a2
|
cytochrome P450, family 4, subfamily a, polypeptide 2
|
affects metabolic processing
|
EXP
|
CYP4A2 protein affects the metabolism of lauric acid
|
CTD |
PMID:15879494 |
|
NCBI chr 5:134,160,356...134,170,908
Ensembl chr 5:128,923,615...128,934,165
|
|
G
|
Cyp4a3
|
cytochrome P450, family 4, subfamily a, polypeptide 3
|
affects metabolic processing
|
EXP
|
CYP4A3 protein affects the metabolism of lauric acid
|
CTD |
PMID:15879494 |
|
NCBI chr 5:134,334,396...134,352,268
Ensembl chr 5:129,097,926...129,115,463
|
|
G
|
Cyp4b1
|
cytochrome P450, family 4, subfamily b, polypeptide 1
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine]
|
CTD |
PMID:9310344 |
|
NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
|
|
G
|
Krt20
|
keratin 20
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of KRT20 protein]
|
CTD |
PMID:34506767 |
|
NCBI chr10:84,384,790...84,394,125
Ensembl chr10:84,384,802...84,394,107
|
|
G
|
Lgr5
|
leucine rich repeat containing G protein coupled receptor 5
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of LGR5 protein]
|
CTD |
PMID:34506767 |
|
NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446
|
|
G
|
Lyz2
|
lysozyme 2
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of LYZ protein]
|
CTD |
PMID:34506767 |
|
NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:52,906,811...52,912,106
|
|
G
|
Mtor
|
mechanistic target of rapamycin kinase
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of MTOR protein]
|
CTD |
PMID:34506767 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
|
|
G
|
Muc2
|
mucin 2, oligomeric mucus/gel-forming
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of MUC2 protein]
|
CTD |
PMID:34506767 |
|
NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756
|
|
G
|
Nod2
|
nucleotide-binding oligomerization domain containing 2
|
multiple interactions
|
ISO
|
Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]]; lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]
|
CTD |
PMID:18413660 |
|
NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
multiple interactions
|
ISO
|
[NR1I2 protein affects the susceptibility to Pregnenolone Carbonitrile] which affects the abundance of lauric acid
|
CTD |
PMID:38971454 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
|
|
G
|
Ocln
|
occludin
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein]
|
CTD |
PMID:34506767 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150
|
|
G
|
Pcna
|
proliferating cell nuclear antigen
|
increases expression multiple interactions
|
ISO
|
lauric acid results in increased expression of PCNA protein lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of PCNA protein]
|
CTD |
PMID:34506767 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
affects binding
|
ISO
|
lauric acid binds to PPARA protein
|
CTD |
PMID:10403814 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
increases expression
|
ISO
|
lauric acid results in increased expression of PPARGC1A mRNA
|
CTD |
PMID:23056435 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions increases activity
|
ISO
|
Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein]; parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein]
|
CTD |
PMID:18413660 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Rps6
|
ribosomal protein S6
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of RPS6 protein]
|
CTD |
PMID:34506767 |
|
NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
|
|
G
|
Rps6kb1
|
ribosomal protein S6 kinase B1
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of RPS6KB1 protein]
|
CTD |
PMID:34506767 |
|
NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
|
|
G
|
Tjp1
|
tight junction protein 1
|
multiple interactions increases expression
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 protein] lauric acid results in increased expression of TJP1 protein
|
CTD |
PMID:34506767 |
|
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432
|
|
G
|
Ugt1a2
|
UDP glucuronosyltransferase 1 family, polypeptide A2
|
increases glucuronidation
|
ISO
|
UGT1A3 protein results in increased glucuronidation of lauric acid
|
CTD |
PMID:16051554 |
|
NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465
|
|
G
|
Vil1
|
villin 1
|
multiple interactions
|
ISO
|
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of VIL1 protein]
|
CTD |
PMID:34506767 |
|
NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858
|
|
|
G
|
Iyd
|
iodotyrosine deiodinase
|
multiple interactions
|
ISO
|
1-monomyristin inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
|
CTD |
PMID:33352258 |
|
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
|
|
|
G
|
Adh5
|
alcohol dehydrogenase 5 (class III), chi polypeptide
|
increases oxidation affects binding
|
ISO
|
ADH5 protein results in increased oxidation of 12-hydroxydodecanoic acid 12-hydroxydodecanoic acid binds to ADH5 protein
|
CTD |
PMID:12196016 PMID:12604204 PMID:19428350 |
|
NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:226,947,466...226,987,591
|
|
G
|
Cyp4v3
|
cytochrome P450, family 4, subfamily v, polypeptide 3
|
multiple interactions increases chemical synthesis
|
ISO
|
2-chloro-5-nitrobenzanilide inhibits the reaction [CYP4V2 protein results in increased chemical synthesis of 12-hydroxydodecanoic acid]
|
CTD |
PMID:28729181 |
|
NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395
|
|
|
G
|
Gsta1
|
glutathione S-transferase alpha 1
|
multiple interactions
|
ISO
|
lauroyl-coenzyme A binds to and results in decreased activity of GSTA1 protein
|
CTD |
PMID:10542059 |
|
NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121
|
|
G
|
Hsdl2
|
hydroxysteroid dehydrogenase like 2
|
multiple interactions
|
ISO
|
[lauroyl-coenzyme A co-treated with NADP] binds to HSDL2 protein
|
CTD |
PMID:25526675 |
|
NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:74,443,872...74,479,839
|
|
G
|
Pecr
|
peroxisomal trans-2-enoyl-CoA reductase
|
multiple interactions
|
ISO
|
[lauroyl-coenzyme A co-treated with NADP] binds to PECR protein
|
CTD |
PMID:25526675 |
|
NCBI chr 9:81,347,170...81,375,809
Ensembl chr 9:73,897,880...73,926,511
|
|
|
G
|
Esr1
|
estrogen receptor 1
|
multiple interactions
|
ISO
|
lauric acid methyl ester binds to and results in increased activity of ESR1 protein
|
CTD |
PMID:27633901 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
|
|
G
|
Esr2
|
estrogen receptor 2
|
multiple interactions
|
ISO
|
lauric acid methyl ester binds to and results in decreased activity of ESR2 protein; lauric acid methyl ester binds to and results in increased activity of ESR2 protein
|
CTD |
PMID:27633901 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
|
|
G
|
Pgr
|
progesterone receptor
|
multiple interactions
|
ISO
|
lauric acid methyl ester binds to and results in decreased activity of PGR protein
|
CTD |
PMID:27633901 |
|
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
ISO
|
lauric acid methyl ester binds to and results in decreased activity of PPARG protein
|
CTD |
PMID:27633901 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
|
|
G
|
Thrb
|
thyroid hormone receptor beta
|
multiple interactions
|
ISO
|
lauric acid methyl ester binds to and results in decreased activity of THRB protein
|
CTD |
PMID:27633901 |
|
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
|
|
|
G
|
Abca1
|
ATP binding cassette subfamily A member 1
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of ABCA1 mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
|
|
G
|
Abhd14b
|
abhydrolase domain containing 14b
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of ABHD14B protein
|
CTD |
PMID:26168851 |
|
NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:107,088,069...107,092,119
|
|
G
|
Acot1
|
acyl-CoA thioesterase 1
|
increases expression multiple interactions
|
EXP
|
perfluorododecanoic acid results in increased expression of ACOT1 mRNA; perfluorododecanoic acid results in increased expression of ACOT1 protein perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of ACOT1 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of ACOT1 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT1 mRNA]
|
CTD |
PMID:26168851 |
|
NCBI chr 6:109,367,274...109,375,268
Ensembl chr 6:103,636,041...103,644,163
|
|
G
|
Acot2
|
acyl-CoA thioesterase 2
|
multiple interactions increases expression
|
EXP ISO
|
perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of ACOT2 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of ACOT2 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT2 mRNA] perfluorododecanoic acid results in increased expression of ACOT2 mRNA; perfluorododecanoic acid results in increased expression of ACOT2 protein
|
CTD |
PMID:26168851 PMID:35337807 |
|
NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:103,611,544...103,619,245
|
|
G
|
Acp1
|
acid phosphatase 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of ACP1 protein
|
CTD |
PMID:19854247 |
|
NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021
|
|
G
|
Actg1
|
actin, gamma 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of ACTG1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr10:106,118,106...106,120,951
Ensembl chr10:105,619,737...105,624,232 Ensembl chr 3:105,619,737...105,624,232
|
|
G
|
Acy1
|
aminoacylase 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of ACY1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682
|
|
G
|
Adk
|
adenosine kinase
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of ADK protein
|
CTD |
PMID:26168851 |
|
NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,863,244...3,246,510
|
|
G
|
Ahcy
|
adenosylhomocysteinase
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of AHCY protein
|
CTD |
PMID:26168851 |
|
NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
|
|
G
|
Akap4
|
A-kinase anchoring protein 4
|
increases expression decreases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of AKAP4 mRNA perfluorododecanoic acid results in decreased expression of AKAP4 protein
|
CTD |
PMID:19854247 |
|
NCBI chr X:18,107,256...18,117,549
Ensembl chr X:15,435,410...15,445,684
|
|
G
|
Akt2
|
AKT serine/threonine kinase 2
|
decreases phosphorylation
|
EXP
|
perfluorododecanoic acid results in decreased phosphorylation of AKT2 protein
|
CTD |
PMID:30489073 |
|
NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817
|
|
G
|
Alb
|
albumin
|
increases expression decreases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of ALB protein perfluorododecanoic acid results in decreased expression of ALB protein
|
CTD |
PMID:19854247 PMID:26168851 |
|
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
|
|
G
|
Aldh2
|
aldehyde dehydrogenase 2 family member
|
decreases expression multiple interactions
|
EXP
|
perfluorododecanoic acid results in decreased expression of ALDH2 protein PPARA mRNA promotes the reaction [perfluorododecanoic acid results in decreased expression of ALDH2 protein]
|
CTD |
PMID:26168851 |
|
NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521
|
|
G
|
Aldh9a1
|
aldehyde dehydrogenase 9 family, member A1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of ALDH9A1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr13:82,038,679...82,055,478
Ensembl chr13:79,505,695...79,540,568
|
|
G
|
Angptl4
|
angiopoietin-like 4
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of ANGPTL4 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
|
|
G
|
Apoa2
|
apolipoprotein A2
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of APOA2 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr13:86,176,767...86,178,819
Ensembl chr13:83,644,470...83,646,355
|
|
G
|
Apoa4
|
apolipoprotein A4
|
affects expression
|
EXP
|
perfluorododecanoic acid affects the expression of APOA4 mRNA
|
CTD |
PMID:22071372 |
|
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
|
|
G
|
Ar
|
androgen receptor
|
affects expression
|
EXP
|
perfluorododecanoic acid affects the expression of AR mRNA
|
CTD |
PMID:19397962 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
|
|
G
|
Arhgdib
|
Rho GDP dissociation inhibitor beta
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of ARHGDIB protein
|
CTD |
PMID:19854247 |
|
NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:169,822,952...169,841,658
|
|
G
|
Atf3
|
activating transcription factor 3
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of ATF3 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
|
|
G
|
Atp5pd
|
ATP synthase peripheral stalk subunit d
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of ATP5PD mRNA
|
CTD |
PMID:19854247 |
|
NCBI chr10:101,156,673...101,161,926
Ensembl chr10:100,657,708...100,663,479
|
|
G
|
Baat
|
bile acid CoA:amino acid N-acyltransferase
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of BAAT mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:63,850,705...63,860,685
|
|
G
|
Bdh2
|
3-hydroxybutyrate dehydrogenase 2
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of BDH2 mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr 2:226,376,346...226,397,010
Ensembl chr 2:223,702,412...223,723,072
|
|
G
|
Ccnd1
|
cyclin D1
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of CCND1 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
|
|
G
|
Cd36
|
CD36 molecule
|
increases expression increases uptake
|
EXP ISO
|
perfluorododecanoic acid results in increased expression of CD36 mRNA CD36 protein results in increased uptake of perfluorododecanoic acid
|
CTD |
PMID:23353032 PMID:35380827 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
|
|
G
|
Cdh5
|
cadherin 5
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of CDH5 protein
|
CTD |
PMID:33677611 |
|
NCBI chr19:821,875...860,931
Ensembl chr19:815,411...854,368
|
|
G
|
Cops4
|
COP9 signalosome subunit 4
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of COPS4 protein
|
CTD |
PMID:26168851 |
|
NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887
|
|
G
|
Cops8
|
COP9 signalosome subunit 8
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of COPS8 protein
|
CTD |
PMID:19854247 |
|
NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258
|
|
G
|
Cox5a
|
cytochrome c oxidase subunit 5A
|
decreases expression increases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of COX5A protein perfluorododecanoic acid results in increased expression of COX5A mRNA
|
CTD |
PMID:19854247 |
|
NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:57,922,290...57,933,781
|
|
G
|
Cox5b
|
cytochrome c oxidase subunit 5B
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of COX5B mRNA
|
CTD |
PMID:19854247 |
|
NCBI chr 9:46,417,735...46,419,664
Ensembl chr 9:38,921,967...38,925,052
|
|
G
|
Cps1
|
carbamoyl-phosphate synthase 1
|
decreases expression multiple interactions
|
EXP
|
perfluorododecanoic acid results in decreased expression of CPS1 mRNA; perfluorododecanoic acid results in decreased expression of CPS1 protein PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in decreased expression of CPS1 mRNA]
|
CTD |
PMID:26168851 |
|
NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
|
|
G
|
Cpt1a
|
carnitine palmitoyltransferase 1A
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of CPT1A mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
|
|
G
|
Crym
|
crystallin, mu
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of CRYM protein
|
CTD |
PMID:26168851 |
|
NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
|
|
G
|
Csk
|
C-terminal Src kinase
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of CSK mRNA; perfluorododecanoic acid results in decreased expression of CSK protein
|
CTD |
PMID:19854247 |
|
NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:58,029,749...58,048,292
|
|
G
|
Ctsa
|
cathepsin A
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of CTSA protein
|
CTD |
PMID:26168851 |
|
NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215
|
|
G
|
Cuta
|
cutA divalent cation tolerance homolog
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of CUTA protein
|
CTD |
PMID:19854247 |
|
NCBI chr20:5,022,956...5,024,580
Ensembl chr20:5,022,956...5,024,552
|
|
G
|
Cyp11a1
|
cytochrome P450, family 11, subfamily a, polypeptide 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of CYP11A1 mRNA; perfluorododecanoic acid results in decreased expression of CYP11A1 protein
|
CTD |
PMID:17400581 PMID:19397962 PMID:19429406 PMID:30489073 PMID:33774092 |
|
NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
|
|
G
|
Cyp17a1
|
cytochrome P450, family 17, subfamily a, polypeptide 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of CYP17A1 mRNA; perfluorododecanoic acid results in decreased expression of CYP17A1 protein
|
CTD |
PMID:17400581 PMID:30489073 PMID:33774092 |
|
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of CYP1A1 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
|
|
G
|
Cyp2b3
|
cytochrome P450, family 2, subfamily b, polypeptide 3
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of CYP2B10 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
|
|
G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of CYP3A4 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
|
|
G
|
Cyp4a1
|
cytochrome P450, family 4, subfamily a, polypeptide 1
|
multiple interactions increases expression
|
EXP
|
perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of CYP4A1 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of CYP4A1 mRNA] perfluorododecanoic acid results in increased expression of CYP4A1 mRNA
|
CTD |
PMID:26168851 |
|
NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:129,123,336...129,137,464
|
|
G
|
Cyp7a1
|
cytochrome P450 family 7 subfamily A member 1
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of CYP7A1 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
|
|
G
|
Ddah1
|
dimethylarginine dimethylaminohydrolase 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of DDAH1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of DDIT3 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
|
|
G
|
Ddt
|
D-dopachrome tautomerase
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of DDT protein
|
CTD |
PMID:19854247 |
|
NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482
|
|
G
|
Dhh
|
desert hedgehog signaling molecule
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of DHH mRNA; perfluorododecanoic acid results in decreased expression of DHH protein
|
CTD |
PMID:33774092 |
|
NCBI chr 7:131,929,857...131,935,352
Ensembl chr 7:130,050,910...130,056,406
|
|
G
|
Dlat
|
dihydrolipoamide S-acetyltransferase
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of DLAT protein
|
CTD |
PMID:26168851 |
|
NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479 Ensembl chr 1:50,978,051...51,004,479
|
|
G
|
Drd2
|
dopamine receptor D2
|
multiple interactions
|
ISO
|
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in increased expression of DRD2 mRNA
|
CTD |
PMID:34371090 |
|
NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
|
|
G
|
Ech1
|
enoyl-CoA hydratase 1
|
increases expression multiple interactions
|
EXP
|
perfluorododecanoic acid results in increased expression of ECH1 mRNA; perfluorododecanoic acid results in increased expression of ECH1 protein PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ECH1 mRNA]
|
CTD |
PMID:26168851 |
|
NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
|
|
G
|
Efhd2
|
EF-hand domain family, member D2
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of EFHD2 protein
|
CTD |
PMID:19854247 |
|
NCBI chr 5:154,160,945...154,176,980
Ensembl chr 5:154,160,946...154,176,980
|
|
G
|
Ehhadh
|
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of EHHADH mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr11:92,746,409...92,779,647
Ensembl chr11:79,241,938...79,275,188
|
|
G
|
Esr1
|
estrogen receptor 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of ESR1 mRNA
|
CTD |
PMID:19429406 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
|
|
G
|
Esr2
|
estrogen receptor 2
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of ESR2 mRNA
|
CTD |
PMID:19429406 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
|
|
G
|
Ethe1
|
ETHE1, persulfide dioxygenase
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of ETHE1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 1:89,311,948...89,327,000
Ensembl chr 1:80,183,894...80,199,052
|
|
G
|
Fabp1
|
fatty acid binding protein 1
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of FABP1 mRNA
|
CTD |
PMID:23567314 PMID:35337807 |
|
NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
|
|
G
|
Fasn
|
fatty acid synthase
|
decreases expression affects expression
|
EXP ISO
|
perfluorododecanoic acid results in decreased expression of FASN mRNA perfluorododecanoic acid affects the expression of FASN mRNA
|
CTD |
PMID:23353032 PMID:35337807 |
|
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
|
|
G
|
Fdft1
|
farnesyl diphosphate farnesyl transferase 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of FDFT1 mRNA
|
CTD |
PMID:22071372 |
|
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
|
|
G
|
Fhit
|
fragile histidine triad diadenosine triphosphatase
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of FHIT protein
|
CTD |
PMID:19854247 |
|
NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
|
|
G
|
Fshb
|
follicle stimulating hormone subunit beta
|
decreases expression decreases secretion
|
EXP
|
perfluorododecanoic acid results in decreased expression of FSHB mRNA; perfluorododecanoic acid results in decreased expression of FSHB protein perfluorododecanoic acid results in decreased secretion of FSHB protein
|
CTD |
PMID:19397962 PMID:30489073 PMID:33774092 |
|
NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
|
|
G
|
Fshr
|
follicle stimulating hormone receptor
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of FSHR mRNA; perfluorododecanoic acid results in decreased expression of FSHR protein
|
CTD |
PMID:33774092 |
|
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
|
|
G
|
Fth1
|
ferritin heavy chain 1
|
decreases expression increases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of FTH1 protein perfluorododecanoic acid results in increased expression of FTH1 mRNA
|
CTD |
PMID:19854247 |
|
NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
|
|
G
|
Gadd45b
|
growth arrest and DNA-damage-inducible, beta
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of GADD45B mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:8,778,007...8,780,046
|
|
G
|
Gc
|
GC, vitamin D binding protein
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of GC protein
|
CTD |
PMID:26168851 |
|
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
|
|
G
|
Gk
|
glycerol kinase
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of GK mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
|
|
G
|
Glod4
|
glyoxalase domain containing 4
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of GLOD4 protein
|
CTD |
PMID:19854247 |
|
NCBI chr10:61,077,535...61,095,876
Ensembl chr10:61,066,421...61,095,898
|
|
G
|
Gmfb
|
glia maturation factor, beta
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of GMFB protein
|
CTD |
PMID:26168851 |
|
NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331
|
|
G
|
Gmfg
|
glia maturation factor, gamma
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of GMFG protein
|
CTD |
PMID:19854247 |
|
NCBI chr 1:83,728,797...83,739,189
Ensembl chr 1:83,728,776...83,739,183
|
|
G
|
Gnrhr
|
gonadotropin releasing hormone receptor
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of GNRHR mRNA
|
CTD |
PMID:19397962 |
|
NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
|
|
G
|
Gpam
|
glycerol-3-phosphate acyltransferase, mitochondrial
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of GPAM mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
|
|
G
|
Gpd1
|
glycerol-3-phosphate dehydrogenase 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of GPD1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
|
|
G
|
Gsk3a
|
glycogen synthase kinase 3 alpha
|
decreases expression affects response to substance
|
EXP
|
perfluorododecanoic acid results in decreased expression of GSK3A protein; perfluorododecanoic acid results in decreased expression of GSK3A protein modified form GSK3A protein affects the susceptibility to perfluorododecanoic acid
|
CTD |
PMID:23353032 |
|
NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
affects response to substance decreases expression
|
EXP
|
GSK3B protein affects the susceptibility to perfluorododecanoic acid perfluorododecanoic acid results in decreased expression of GSK3B protein; perfluorododecanoic acid results in decreased expression of GSK3B protein modified form
|
CTD |
PMID:23353032 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
|
|
G
|
Gsta1
|
glutathione S-transferase alpha 1
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of GSTA1 mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121
|
|
G
|
Haao
|
3-hydroxyanthranilate 3,4-dioxygenase
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of HAAO protein
|
CTD |
PMID:26168851 |
|
NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877
|
|
G
|
Hadha
|
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
|
affects expression increases expression multiple interactions
|
ISO EXP
|
perfluorododecanoic acid affects the expression of HADHA mRNA perfluorododecanoic acid results in increased expression of HADHA mRNA; perfluorododecanoic acid results in increased expression of HADHA protein PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of HADHA mRNA]
|
CTD |
PMID:22071372 PMID:23567314 PMID:26168851 |
|
NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:26,187,956...26,227,869
|
|
G
|
Hadhb
|
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of HADHB mRNA
|
CTD |
PMID:22071372 |
|
NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:26,153,578...26,184,869
|
|
G
|
Hhex
|
hematopoietically expressed homeobox
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of HHEX mRNA
|
CTD |
PMID:22071372 |
|
NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:235,190,455...235,196,042
|
|
G
|
Hmgcs1
|
3-hydroxy-3-methylglutaryl-CoA synthase 1
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of HMGCS1 mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100
|
|
G
|
Hmgcs2
|
3-hydroxy-3-methylglutaryl-CoA synthase 2
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of HMGCS2 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:185,875,616...185,902,130
|
|
G
|
Hmox1
|
heme oxygenase 1
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of HMOX1 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Hpx
|
hemopexin
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of HPX protein
|
CTD |
PMID:26168851 |
|
NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328
|
|
G
|
Hsd11b1
|
hydroxysteroid 11-beta dehydrogenase 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of HSD11B1 mRNA; perfluorododecanoic acid results in decreased expression of HSD11B1 protein
|
CTD |
PMID:30489073 PMID:33774092 |
|
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
|
|
G
|
Hsd11b2
|
hydroxysteroid 11-beta dehydrogenase 2
|
decreases activity
|
ISO
|
perfluorododecanoic acid results in decreased activity of HSD11B2 protein
|
CTD |
PMID:36878351 |
|
NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
|
|
G
|
Hsd17b1
|
hydroxysteroid (17-beta) dehydrogenase 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of HSD17B1 mRNA
|
CTD |
PMID:19429406 |
|
NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,009,728...86,011,927
|
|
G
|
Hsd17b2
|
hydroxysteroid (17-beta) dehydrogenase 2
|
affects expression
|
EXP
|
perfluorododecanoic acid affects the expression of HSD17B2 mRNA
|
CTD |
PMID:33774092 |
|
NCBI chr19:62,662,320...62,733,944
Ensembl chr19:45,753,574...45,825,202
|
|
G
|
Hsd17b3
|
hydroxysteroid (17-beta) dehydrogenase 3
|
decreases expression affects expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of HSD17B3 mRNA perfluorododecanoic acid affects the expression of HSD17B3 protein
|
CTD |
PMID:17400581 PMID:33774092 |
|
NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,027,229...1,058,554
|
|
G
|
Hsd3b1
|
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
|
decreases expression affects expression decreases activity
|
EXP ISO
|
perfluorododecanoic acid results in decreased expression of HSD3B1 mRNA; perfluorododecanoic acid results in decreased expression of HSD3B1 protein perfluorododecanoic acid affects the expression of HSD3B1 mRNA; perfluorododecanoic acid affects the expression of HSD3B1 protein perfluorododecanoic acid results in decreased activity of HSD3B1 protein
|
CTD |
PMID:17400581 PMID:33774092 PMID:36122607 |
|
NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999
|
|
G
|
Hspa5
|
heat shock protein family A (Hsp70) member 5
|
affects expression
|
EXP
|
perfluorododecanoic acid affects the expression of HSPA5 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
|
|
G
|
Hspa8
|
heat shock protein family A (Hsp70) member 8
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of HSPA8 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
|
|
G
|
Hspa9
|
heat shock protein family A (Hsp70) member 9
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of HSPA9 protein
|
CTD |
PMID:26168851 |
|
NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292
|
|
G
|
Hspd1
|
heat shock protein family D (Hsp60) member 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of HSPD1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662
|
|
G
|
Idh3a
|
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of IDH3A protein
|
CTD |
PMID:26168851 |
|
NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:54,971,740...54,991,084
|
|
G
|
Ido1
|
indoleamine 2,3-dioxygenase 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of IDO1 protein
|
CTD |
PMID:19854247 |
|
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
|
|
G
|
Ift20
|
intraflagellar transport 20
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of IFT20 protein
|
CTD |
PMID:19854247 |
|
NCBI chr10:63,432,597...63,438,125
Ensembl chr10:63,432,633...63,438,124
|
|
G
|
Igf1
|
insulin-like growth factor 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of IGF1 mRNA
|
CTD |
PMID:19397962 |
|
NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
|
|
G
|
Igf1r
|
insulin-like growth factor 1 receptor
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of IGF1R mRNA
|
CTD |
PMID:19397962 |
|
NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777
|
|
G
|
Il1a
|
interleukin 1 alpha
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of IL1A mRNA
|
CTD |
PMID:19397962 |
|
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
|
|
G
|
Impa1
|
inositol monophosphatase 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of IMPA1 protein
|
CTD |
PMID:19854247 |
|
NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313
|
|
G
|
Irs1
|
insulin receptor substrate 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of IRS1 protein modified form
|
CTD |
PMID:23353032 |
|
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
|
|
G
|
Itga1
|
integrin subunit alpha 1
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of ITGA1 protein
|
CTD |
PMID:33677611 |
|
NCBI chr 2:48,379,181...48,545,336
Ensembl chr 2:46,653,193...46,812,238
|
|
G
|
Itpa
|
inosine triphosphatase
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of ITPA protein
|
CTD |
PMID:26168851 |
|
NCBI chr 3:138,338,549...138,350,329
Ensembl chr 3:117,885,099...117,897,249
|
|
G
|
Ivd
|
isovaleryl-CoA dehydrogenase
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of IVD protein
|
CTD |
PMID:26168851 |
|
NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575
|
|
G
|
Krt10
|
keratin 10
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of KRT10 protein
|
CTD |
PMID:19854247 |
|
NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
|
|
G
|
Krt14
|
keratin 14
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of KRT14 protein
|
CTD |
PMID:19854247 |
|
NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799
|
|
G
|
Krt16
|
keratin 16
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of KRT16 protein
|
CTD |
PMID:19854247 |
|
NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799
|
|
G
|
Krt8
|
keratin 8
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of KRT8 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
|
|
G
|
Lhb
|
luteinizing hormone subunit beta
|
decreases expression decreases secretion
|
EXP
|
perfluorododecanoic acid results in decreased expression of LHB mRNA; perfluorododecanoic acid results in decreased expression of LHB protein perfluorododecanoic acid results in decreased secretion of LHB protein
|
CTD |
PMID:17400581 PMID:19397962 PMID:30489073 PMID:33774092 |
|
NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
|
|
G
|
Lhcgr
|
luteinizing hormone/choriogonadotropin receptor
|
decreases expression affects expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of LHCGR mRNA; perfluorododecanoic acid results in decreased expression of LHCGR protein perfluorododecanoic acid affects the expression of LHCGR mRNA; perfluorododecanoic acid affects the expression of LHCGR protein
|
CTD |
PMID:19429406 PMID:30489073 PMID:33774092 |
|
NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521
|
|
G
|
Lhpp
|
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of LHPP protein
|
CTD |
PMID:26168851 |
|
NCBI chr 1:196,833,516...196,924,687
Ensembl chr 1:187,403,433...187,494,578
|
|
G
|
Mbl2
|
mannose binding lectin 2
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of MBL2 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 1:237,429,873...237,465,567
|
|
G
|
Mdh1
|
malate dehydrogenase 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of MDH1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
|
|
G
|
Mttp
|
microsomal triglyceride transfer protein
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of MTTP mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
|
|
G
|
Mug2
|
murinoglobulin 2
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of PZP protein
|
CTD |
PMID:26168851 |
|
NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475
|
|
G
|
Ndufv2
|
NADH:ubiquinone oxidoreductase core subunit V2
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of NDUFV2 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:105,690,455...105,710,713
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of NOS2 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
increases activity
|
ISO
|
perfluorododecanoic acid results in increased activity of NR1I2 protein
|
CTD |
PMID:28115241 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
|
|
G
|
Nr1i3
|
nuclear receptor subfamily 1, group I, member 3
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of NR1I3 mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
|
|
G
|
Ntan1
|
N-terminal asparagine amidase
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of NTAN1 protein
|
CTD |
PMID:19854247 |
|
NCBI chr10:2,111,090...2,126,119
|
|
G
|
P4hb
|
prolyl 4-hydroxylase subunit beta
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of P4HB protein
|
CTD |
PMID:26168851 |
|
NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
|
|
G
|
Park7
|
Parkinsonism associated deglycase
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of PARK7 protein
|
CTD |
PMID:19854247 |
|
NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
|
|
G
|
Pax8
|
paired box 8
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of PAX8 mRNA
|
CTD |
PMID:22071372 |
|
NCBI chr 3:27,584,000...27,641,094
Ensembl chr 3:7,185,723...7,242,363
|
|
G
|
Pbld1
|
phenazine biosynthesis-like protein domain containing 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of PBLD1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
|
|
G
|
Pck2
|
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of PCK2 mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr15:32,997,853...33,006,691
Ensembl chr15:29,027,894...29,037,283
|
|
G
|
Pdhb
|
pyruvate dehydrogenase E1 subunit beta
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of PDHB protein
|
CTD |
PMID:26168851 |
|
NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
|
|
G
|
Pdia6
|
protein disulfide isomerase family A, member 6
|
affects expression
|
EXP
|
perfluorododecanoic acid affects the expression of PDIA6 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
|
|
G
|
Pdk4
|
pyruvate dehydrogenase kinase 4
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of PDK4 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
|
|
G
|
Pdpk1
|
3-phosphoinositide dependent protein kinase-1
|
decreases activity decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased activity of PDPK1 protein perfluorododecanoic acid results in decreased expression of PDPK1 protein; perfluorododecanoic acid results in decreased expression of PDPK1 protein modified form
|
CTD |
PMID:23353032 |
|
NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623
|
|
G
|
Pebp1
|
phosphatidylethanolamine binding protein 1
|
decreases expression increases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of PEBP1 protein perfluorododecanoic acid results in increased expression of PEBP1 mRNA
|
CTD |
PMID:19854247 |
|
NCBI chr12:44,946,307...44,967,890
Ensembl chr12:39,302,840...39,307,862
|
|
G
|
Phb1
|
prohibitin 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of PHB1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
|
|
G
|
Pitpna
|
phosphatidylinositol transfer protein, alpha
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of PITPNA protein
|
CTD |
PMID:19854247 |
|
NCBI chr10:60,430,712...60,473,564
Ensembl chr10:60,430,748...60,471,342
|
|
G
|
Plin2
|
perilipin 2
|
increases expression affects expression
|
ISO
|
perfluorododecanoic acid results in increased expression of PLIN2 mRNA perfluorododecanoic acid affects the expression of PLIN2 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
|
|
G
|
Por
|
cytochrome p450 oxidoreductase
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of POR mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
increases activity multiple interactions increases expression increases response to substance
|
ISO EXP
|
perfluorododecanoic acid results in increased activity of PPARA protein perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of PPARA mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA]; PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in decreased expression of CPS1 mRNA]; PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in increased abundance of Reactive Oxygen Species]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in decreased expression of ALDH2 protein]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT1 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT2 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ECH1 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of HADHA mRNA] perfluorododecanoic acid results in increased expression of PPARA mRNA; perfluorododecanoic acid results in increased expression of PPARA protein PPARA mRNA results in increased susceptibility to perfluorododecanoic acid
|
CTD |
PMID:22107727 PMID:26168851 PMID:28857218 PMID:35337807 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
|
|
G
|
Ppard
|
peroxisome proliferator-activated receptor delta
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of PPARD mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,298,785...6,363,968
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
increases activity increases expression
|
ISO
|
perfluorododecanoic acid results in increased activity of PPARG protein perfluorododecanoic acid results in increased expression of PPARG mRNA
|
CTD |
PMID:23391484 PMID:24998974 PMID:35337807 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of PPARGC1A protein
|
CTD |
PMID:30489073 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
|
|
G
|
Prdx2
|
peroxiredoxin 2
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of PRDX2 protein
|
CTD |
PMID:26168851 |
|
NCBI chr19:40,085,788...40,091,083
Ensembl chr19:23,180,930...23,186,194
|
|
G
|
Prdx4
|
peroxiredoxin 4
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of PRDX4 protein
|
CTD |
PMID:26168851 |
|
NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066
|
|
G
|
Psmf1
|
proteasome inhibitor subunit 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of PSMF1 protein
|
CTD |
PMID:19854247 |
|
NCBI chr 3:140,235,371...140,260,546
Ensembl chr 3:140,235,373...140,260,546
|
|
G
|
Ptpn11
|
protein tyrosine phosphatase, non-receptor type 11
|
multiple interactions
|
ISO
|
perfluorododecanoic acid binds to and results in decreased activity of PTPN11 protein
|
CTD |
PMID:27572461 |
|
NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925
|
|
G
|
Ranbp1
|
RAN binding protein 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of RANBP1 protein
|
CTD |
PMID:19854247 |
|
NCBI chr11:96,246,912...96,255,145
Ensembl chr11:82,742,600...82,750,838
|
|
G
|
Rbp4
|
retinol binding protein 4
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of RBP4 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399
|
|
G
|
Rgn
|
regucalcin
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of RGN protein
|
CTD |
PMID:26168851 |
|
NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450
|
|
G
|
Scarb1
|
scavenger receptor class B, member 1
|
decreases expression affects expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of SCARB1 mRNA; perfluorododecanoic acid results in decreased expression of SCARB1 protein perfluorododecanoic acid affects the expression of SCARB1 mRNA; perfluorododecanoic acid affects the expression of SCARB1 protein
|
CTD |
PMID:17400581 PMID:30489073 PMID:33774092 |
|
NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647
|
|
G
|
Scd
|
stearoyl-CoA desaturase
|
decreases expression increases expression
|
ISO EXP
|
perfluorododecanoic acid results in decreased expression of SCD mRNA perfluorododecanoic acid results in increased expression of SCD1 mRNA
|
CTD |
PMID:23353032 PMID:23567314 PMID:35337807 |
|
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
|
|
G
|
Serpina3c
|
serine (or cysteine) proteinase inhibitor, clade A, member 3C
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of SERPINA3C protein
|
CTD |
PMID:26168851 |
|
NCBI chr 6:123,240,251...123,250,219
Ensembl chr 6:123,064,804...123,250,202
|
|
G
|
Serpind1
|
serpin family D member 1
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of SERPIND1 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr11:97,168,753...97,179,830
Ensembl chr11:83,664,518...83,675,519
|
|
G
|
Serpinf2
|
serpin family F member 2
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of SERPINF2 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,272,400...60,281,243
|
|
G
|
Sirt1
|
sirtuin 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of SIRT1 protein
|
CTD |
PMID:30489073 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
|
|
G
|
Slc25a20
|
solute carrier family 25 member 20
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of SLC25A20 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:109,365,002...109,386,512
|
|
G
|
Slc27a1
|
solute carrier family 27 member 1
|
increases expression
|
ISO
|
perfluorododecanoic acid results in increased expression of SLC27A1 mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr16:18,311,859...18,337,024
Ensembl chr16:18,278,984...18,296,063
|
|
G
|
Sod1
|
superoxide dismutase 1
|
decreases expression affects expression
|
EXP ISO
|
perfluorododecanoic acid results in decreased expression of SOD1 mRNA perfluorododecanoic acid affects the expression of SOD1 mRNA
|
CTD |
PMID:19854247 PMID:35337807 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
|
|
G
|
Sox9
|
SRY-box transcription factor 9
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of SOX9 mRNA; perfluorododecanoic acid results in decreased expression of SOX9 protein
|
CTD |
PMID:33774092 |
|
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
|
|
G
|
Srd5a1
|
steroid 5 alpha-reductase 1
|
affects expression decreases activity
|
EXP ISO
|
perfluorododecanoic acid affects the expression of SRD5A1 mRNA perfluorododecanoic acid results in decreased activity of SRD5A1 protein
|
CTD |
PMID:33774092 PMID:38574835 |
|
NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:33,686,391...33,720,461
|
|
G
|
Srebf1
|
sterol regulatory element binding transcription factor 1
|
increases expression
|
EXP ISO
|
perfluorododecanoic acid results in increased expression of SREBF1 mRNA
|
CTD |
PMID:23353032 PMID:35337807 |
|
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
|
|
G
|
Star
|
steroidogenic acute regulatory protein
|
multiple interactions decreases expression affects expression
|
ISO EXP
|
Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR mRNA]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR protein]]; perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR mRNA]; perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR protein] perfluorododecanoic acid results in decreased expression of STAR mRNA; perfluorododecanoic acid results in decreased expression of STAR protein perfluorododecanoic acid affects the expression of STAR mRNA; perfluorododecanoic acid affects the expression of STAR protein
|
CTD |
PMID:17400581 PMID:19397962 PMID:19429406 PMID:20100736 PMID:30489073 PMID:33774092 More...
|
|
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
|
|
G
|
Stmn1
|
stathmin 1
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of STMN1 protein
|
CTD |
PMID:19854247 |
|
NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154
|
|
G
|
Suclg2
|
succinate-CoA ligase GDP-forming subunit beta
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of SUCLG2 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
|
|
G
|
Sult1c3
|
sulfotransferase family 1C member 3
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of SULT1C3 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
|
|
G
|
Sult2a1
|
sulfotransferase family 2A member 1
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of SULT2A1 mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr 1:84,582,011...84,639,001
Ensembl chr 1:74,911,100...75,508,134
|
|
G
|
Suox
|
sulfite oxidase
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of SUOX protein
|
CTD |
PMID:26168851 |
|
NCBI chr 7:1,687,666...1,691,759
Ensembl chr 7:1,103,151...1,107,038
|
|
G
|
Th
|
tyrosine hydroxylase
|
multiple interactions
|
ISO
|
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA
|
CTD |
PMID:34371090 |
|
NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
|
|
G
|
Thra
|
thyroid hormone receptor alpha
|
affects binding
|
ISO
|
perfluorododecanoic acid binds to THRA protein
|
CTD |
PMID:24819616 |
|
NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936
|
|
G
|
Tpm1
|
tropomyosin 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of TPM1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
|
|
G
|
Trap1
|
TNF receptor-associated protein 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of TRAP1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981
|
|
G
|
Ttr
|
transthyretin
|
multiple interactions
|
ISO
|
perfluorododecanoic acid affects the reaction [Thyroxine binds to TTR protein]
|
CTD |
PMID:27528273 |
|
NCBI chr18:12,216,684...12,225,972
Ensembl chr18:11,943,789...11,951,008
|
|
G
|
Txnip
|
thioredoxin interacting protein
|
affects expression
|
ISO
|
perfluorododecanoic acid affects the expression of TXNIP mRNA
|
CTD |
PMID:23567314 |
|
NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886
|
|
G
|
Ube2n
|
ubiquitin-conjugating enzyme E2N
|
decreases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of UBE2N protein
|
CTD |
PMID:19854247 |
|
NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
|
|
G
|
Ugt1a1
|
UDP glucuronosyltransferase family 1 member A1
|
decreases expression
|
ISO
|
perfluorododecanoic acid results in decreased expression of UGT1A1 mRNA
|
CTD |
PMID:35337807 |
|
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
|
|
G
|
Uqcrc1
|
ubiquinol-cytochrome c reductase core protein 1
|
increases expression
|
EXP
|
perfluorododecanoic acid results in increased expression of UQCRC1 protein
|
CTD |
PMID:26168851 |
|
NCBI chr 8:118,468,223...118,479,968
Ensembl chr 8:109,589,706...109,601,480
|
|
G
|
Uqcrh
|
ubiquinol-cytochrome c reductase hinge protein
|
decreases expression increases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of UQCRH protein perfluorododecanoic acid results in increased expression of UQCRH mRNA
|
CTD |
PMID:19854247 |
|
NCBI chr 5:134,782,687...134,790,882
Ensembl chr 5:129,545,984...129,554,242
|
|
G
|
Ywhae
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
|
decreases expression increases expression
|
EXP
|
perfluorododecanoic acid results in decreased expression of YWHAE protein perfluorododecanoic acid results in increased expression of YWHAE mRNA
|
CTD |
PMID:19854247 |
|
NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
|
|
|
G
|
Iyd
|
iodotyrosine deiodinase
|
multiple interactions
|
ISO
|
1-monomyristin inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
|
CTD |
PMID:33352258 |
|
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
|
|