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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isophthalic acid
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Accession:CHEBI:30802 term browser browse the term
Definition:A benzenedicarboxylic acid that is benzene substituted by carboxy groups at position 1 and 3. One of three possible isomers of benzenedicarboxylic acid, the others being phthalic and terephthalic acids.
Synonyms:exact_synonym: benzene-1,3-dicarboxylic acid
 related_synonym: Formula=C8H6O4;   IPA;   InChI=1S/C8H6O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H,9,10)(H,11,12);   InChIKey=QQVIHTHCMHWDBS-UHFFFAOYSA-N;   SMILES=OC(=O)c1cccc(c1)C(O)=O;   m-benzenedicarboxylic acid;   meta-benzenedicarboxylic acid
 xref: Beilstein:1909332;   CAS:121-91-5;   Gmelin:27618
 xref_mesh: MESH:C059768
 xref: MetaCyc:CPD0-1267;   PMID:24101250;   Reaxys:1909332;   Wikipedia:Isophthalic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30804


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isophthalic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gap43 growth associated protein 43 increases expression
multiple interactions
ISO isophthalate analog results in increased expression of GAP43 mRNA; isophthalate analog results in increased expression of GAP43 protein
Go 6976 inhibits the reaction [isophthalate analog results in increased expression of GAP43 protein]
CTD PMID:23643828 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
affects localization
ISO Go 6976 inhibits the reaction [isophthalate analog affects the localization of PRKCA protein] CTD PMID:23643828 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
chlorothalonil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP tetrachloroisophthalonitrile binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrachloroisophthalonitrile results in increased expression of BAX protein CTD PMID:30586609 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BCL2 protein CTD PMID:30586609 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bmp15 bone morphogenetic protein 15 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of BMP15 protein CTD PMID:30586609 NCBI chr  X:17,016,831...17,021,894
Ensembl chr  X:17,016,778...17,023,418
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of CYP11A1 protein CTD PMID:30586609 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO1 protein CTD PMID:29228274 PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of EGFR protein CTD PMID:28426875 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of ERBB2 protein CTD PMID:11222871 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of FSHR protein CTD PMID:30586609 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Gdf9 growth differentiation factor 9 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GDF9 protein CTD PMID:30586609 NCBI chr10:38,782,519...38,793,238
Ensembl chr10:38,788,992...38,792,940
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of GJA1 protein CTD PMID:30586609 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD17B4 protein CTD PMID:30586609 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO tetrachloroisophthalonitrile results in decreased expression of HSD3B1 protein CTD PMID:30586609
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK1 protein CTD PMID:28426875 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK3 protein CTD PMID:28426875 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tetrachloroisophthalonitrile results in increased activity of NR1I2 protein CTD PMID:20143881 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Rad51 RAD51 recombinase increases expression ISO tetrachloroisophthalonitrile results in increased expression of RAD51 protein CTD PMID:30586609 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO tetrachloroisophthalonitrile results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
Di-n-hexyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO di-n-hexyl phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; di-n-hexyl phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:15840436 PMID:28571686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP11A1 mRNA; di-n-hexyl phthalate results in decreased expression of CYP11A1 protein CTD PMID:22112501 PMID:23754470 PMID:26934186 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP11B1 mRNA CTD PMID:22112501 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of CYP17A1 mRNA; di-n-hexyl phthalate results in decreased expression of CYP17A1 protein CTD PMID:22112501 PMID:23754470 PMID:26934186 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Dhh desert hedgehog signaling molecule increases expression EXP di-n-hexyl phthalate results in increased expression of DHH mRNA; di-n-hexyl phthalate results in increased expression of DHH protein CTD PMID:32693021 NCBI chr 7:140,575,288...140,580,783
Ensembl chr 7:140,575,288...140,580,783
JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases expression
multiple interactions
ISO
EXP
di-n-hexyl phthalate analog binds to ESR1 protein
di-n-hexyl phthalate results in increased expression of ESR1 mRNA
di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein]
CTD PMID:15464722 PMID:15840436 PMID:22112501 PMID:28571686 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO di-n-hexyl phthalate binds to and results in decreased activity of ESR2 protein; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
di-n-hexyl phthalate analog binds to ESR2 protein
CTD PMID:15464722 PMID:15840436 PMID:28571686 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP di-n-hexyl phthalate results in increased phosphorylation of GSK3B protein CTD PMID:32693021 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP di-n-hexyl phthalate results in decreased expression of HMGCR mRNA CTD PMID:26934186 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HMGCS1 mRNA CTD PMID:26934186 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HSD11B1 protein CTD PMID:32693021 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 increases expression EXP di-n-hexyl phthalate results in increased expression of HSD17B3 mRNA CTD PMID:26934186 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HSD3B1 mRNA; di-n-hexyl phthalate results in decreased expression of HSD3B1 protein CTD PMID:26934186 PMID:32693021
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 decreases expression EXP di-n-hexyl phthalate results in decreased expression of HSD3B3 mRNA; di-n-hexyl phthalate results in decreased expression of HSD3B3 protein CTD PMID:32693021 NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492
JBrowse link
G Inha inhibin subunit alpha decreases expression EXP di-n-hexyl phthalate results in decreased expression of INHA mRNA CTD PMID:22112501 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
JBrowse link
G Insl3 insulin-like 3 decreases expression EXP di-n-hexyl phthalate results in decreased expression of INSL3 mRNA CTD PMID:22112501 NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP di-n-hexyl phthalate results in increased expression of LHB protein CTD PMID:32693021 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP di-n-hexyl phthalate results in decreased expression of LHCGR mRNA; di-n-hexyl phthalate results in decreased expression of LHCGR protein CTD PMID:32693021 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP di-n-hexyl phthalate results in increased phosphorylation of MAPK1 protein CTD PMID:32693021 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP di-n-hexyl phthalate results in increased phosphorylation of MAPK3 protein CTD PMID:32693021 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects binding
increases activity
ISO di-n-hexyl phthalate binds to NR1I3 protein
di-n-hexyl phthalate results in increased activity of NR1I3 protein
CTD PMID:25938866 PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects binding ISO di-n-hexyl phthalate binds to PPARA protein CTD PMID:23843199 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding ISO di-n-hexyl phthalate binds to PPARB protein CTD PMID:23843199 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO di-n-hexyl phthalate binds to PPARG protein CTD PMID:23843199 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression EXP di-n-hexyl phthalate results in decreased expression of PPARGC1A protein CTD PMID:32693021 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rhox10 reproductive homeobox 10 decreases expression EXP di-n-hexyl phthalate results in decreased expression of RHOX10 mRNA CTD PMID:22112501 NCBI chr  X:124,207,017...124,211,455
Ensembl chr  X:124,207,017...124,211,455
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO di-n-hexyl phthalate binds to RXRA protein CTD PMID:23843199 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrb retinoid X receptor beta affects binding ISO di-n-hexyl phthalate binds to RXRB protein CTD PMID:23843199 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Rxrg retinoid X receptor gamma affects binding ISO di-n-hexyl phthalate binds to RXRG protein CTD PMID:23843199 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of SCARB1 mRNA CTD PMID:22112501 PMID:23754470 PMID:26934186 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Sirt1 sirtuin 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of SIRT1 protein CTD PMID:32693021 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP di-n-hexyl phthalate results in decreased expression of STAR mRNA CTD PMID:22112501 PMID:23754470 PMID:26934186 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP di-n-hexyl phthalate results in decreased expression of TGFB1 mRNA CTD PMID:22112501 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Wnt7a Wnt family member 7A decreases expression EXP di-n-hexyl phthalate results in decreased expression of WNT7A mRNA CTD PMID:22112501 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link
iopromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 increases expression EXP iopromide results in increased expression of EDN1 protein CTD PMID:21354280 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO iopromide affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP iopromide results in decreased expression of NOS2 protein CTD PMID:21354280 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G RT1-Da RT1 class II, locus Da affects expression ISO iopromide affects the expression of HLA-DRA mRNA CTD PMID:25811541 NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      group 19787
        inorganic group 19219
          oxo group 18468
            organic oxo compound 18468
              carbonyl compound 18468
                dicarboxylic acids and O-substituted derivatives 10300
                  dicarboxylic acid 10292
                    benzenedicarboxylic acid 7693
                      isophthalic acid 55
                        2-hydroxyisophthalic acid + 34
                        isophthalamide + 4
                        isophthalonitrile + 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        aromatic carboxylic acid 10919
                                          benzoic acids 10888
                                            benzenedicarboxylic acid 7693
                                              isophthalic acid 55
                                                2-hydroxyisophthalic acid + 34
                                                isophthalamide + 4
                                                isophthalonitrile + 20
paths to the root