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G |
Gap43 |
growth associated protein 43 |
increases expression multiple interactions |
ISO |
isophthalate analog results in increased expression of GAP43 mRNA; isophthalate analog results in increased expression of GAP43 protein Go 6976 inhibits the reaction [isophthalate analog results in increased expression of GAP43 protein] |
CTD |
PMID:23643828 |
|
NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
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G |
Prkca |
protein kinase C, alpha |
multiple interactions affects localization |
ISO |
Go 6976 inhibits the reaction [isophthalate analog affects the localization of PRKCA protein] |
CTD |
PMID:23643828 |
|
NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
tetrachloroisophthalonitrile binds to and results in increased activity of AHR protein |
CTD |
PMID:14636698 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
tetrachloroisophthalonitrile results in increased expression of BAX protein |
CTD |
PMID:30586609 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of BCL2 protein |
CTD |
PMID:30586609 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bmp15 |
bone morphogenetic protein 15 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of BMP15 protein |
CTD |
PMID:30586609 |
|
NCBI chr X:17,016,831...17,021,894
Ensembl chr X:17,016,778...17,023,418
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of CYP11A1 protein |
CTD |
PMID:30586609 |
|
NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
tetrachloroisophthalonitrile results in decreased activity of DIO1 protein |
CTD |
PMID:29228274 PMID:30561685 |
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NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
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G |
Dio2 |
iodothyronine deiodinase 2 |
decreases activity |
ISO |
tetrachloroisophthalonitrile results in decreased activity of DIO2 protein |
CTD |
PMID:30561685 |
|
NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
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G |
Dio3 |
iodothyronine deiodinase 3 |
decreases activity |
ISO |
tetrachloroisophthalonitrile results in decreased activity of DIO3 protein |
CTD |
PMID:30561685 |
|
NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
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G |
Egfr |
epidermal growth factor receptor |
decreases phosphorylation |
ISO |
tetrachloroisophthalonitrile results in decreased phosphorylation of EGFR protein |
CTD |
PMID:28426875 |
|
NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
increases activity |
ISO |
tetrachloroisophthalonitrile results in increased activity of ERBB2 protein |
CTD |
PMID:11222871 |
|
NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
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G |
Fshr |
follicle stimulating hormone receptor |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of FSHR protein |
CTD |
PMID:30586609 |
|
NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
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G |
Gdf9 |
growth differentiation factor 9 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of GDF9 protein |
CTD |
PMID:30586609 |
|
NCBI chr10:38,782,519...38,793,238
Ensembl chr10:38,788,992...38,792,940
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G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of GJA1 protein |
CTD |
PMID:30586609 |
|
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of HSD17B4 protein |
CTD |
PMID:30586609 |
|
NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
ISO |
tetrachloroisophthalonitrile results in decreased expression of HSD3B1 protein |
CTD |
PMID:30586609 |
|
|
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:28426875 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
tetrachloroisophthalonitrile results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:28426875 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
tetrachloroisophthalonitrile results in increased activity of NR1I2 protein |
CTD |
PMID:20143881 |
|
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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G |
Rad51 |
RAD51 recombinase |
increases expression |
ISO |
tetrachloroisophthalonitrile results in increased expression of RAD51 protein |
CTD |
PMID:30586609 |
|
NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases activity |
ISO |
tetrachloroisophthalonitrile results in decreased activity of TGFB1 protein |
CTD |
PMID:31652400 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
di-n-hexyl phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; di-n-hexyl phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] |
CTD |
PMID:15840436 PMID:28571686 |
|
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of CYP11A1 mRNA; di-n-hexyl phthalate results in decreased expression of CYP11A1 protein |
CTD |
PMID:22112501 PMID:23754470 PMID:26934186 |
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NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
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G |
Cyp11b2 |
cytochrome P450, family 11, subfamily b, polypeptide 2 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of CYP11B1 mRNA |
CTD |
PMID:22112501 |
|
NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of CYP17A1 mRNA; di-n-hexyl phthalate results in decreased expression of CYP17A1 protein |
CTD |
PMID:22112501 PMID:23754470 PMID:26934186 |
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NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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G |
Dhh |
desert hedgehog signaling molecule |
increases expression |
EXP |
di-n-hexyl phthalate results in increased expression of DHH mRNA; di-n-hexyl phthalate results in increased expression of DHH protein |
CTD |
PMID:32693021 |
|
NCBI chr 7:140,575,288...140,580,783
Ensembl chr 7:140,575,288...140,580,783
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G |
Esr1 |
estrogen receptor 1 |
affects binding increases expression multiple interactions |
ISO EXP |
di-n-hexyl phthalate analog binds to ESR1 protein di-n-hexyl phthalate results in increased expression of ESR1 mRNA di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [di-n-hexyl phthalate binds to and results in increased activity of ESR1 protein] |
CTD |
PMID:15464722 PMID:15840436 PMID:22112501 PMID:28571686 |
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NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects binding |
ISO |
di-n-hexyl phthalate binds to and results in decreased activity of ESR2 protein; di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein] di-n-hexyl phthalate analog binds to ESR2 protein |
CTD |
PMID:15464722 PMID:15840436 PMID:28571686 |
|
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation |
EXP |
di-n-hexyl phthalate results in increased phosphorylation of GSK3B protein |
CTD |
PMID:32693021 |
|
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of HMGCR mRNA |
CTD |
PMID:26934186 |
|
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of HMGCS1 mRNA |
CTD |
PMID:26934186 |
|
NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of HSD11B1 protein |
CTD |
PMID:32693021 |
|
NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
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G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
increases expression |
EXP |
di-n-hexyl phthalate results in increased expression of HSD17B3 mRNA |
CTD |
PMID:26934186 |
|
NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of HSD3B1 mRNA; di-n-hexyl phthalate results in decreased expression of HSD3B1 protein |
CTD |
PMID:26934186 PMID:32693021 |
|
|
|
G |
Hsd3b3 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of HSD3B3 mRNA; di-n-hexyl phthalate results in decreased expression of HSD3B3 protein |
CTD |
PMID:32693021 |
|
NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492
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G |
Inha |
inhibin subunit alpha |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of INHA mRNA |
CTD |
PMID:22112501 |
|
NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
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G |
Insl3 |
insulin-like 3 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of INSL3 mRNA |
CTD |
PMID:22112501 |
|
NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696
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G |
Lhb |
luteinizing hormone subunit beta |
increases expression |
EXP |
di-n-hexyl phthalate results in increased expression of LHB protein |
CTD |
PMID:32693021 |
|
NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
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G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of LHCGR mRNA; di-n-hexyl phthalate results in decreased expression of LHCGR protein |
CTD |
PMID:32693021 |
|
NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
EXP |
di-n-hexyl phthalate results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:32693021 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
EXP |
di-n-hexyl phthalate results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:32693021 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
affects binding increases activity |
ISO |
di-n-hexyl phthalate binds to NR1I3 protein di-n-hexyl phthalate results in increased activity of NR1I3 protein |
CTD |
PMID:25938866 PMID:28927721 |
|
NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
affects binding |
ISO |
di-n-hexyl phthalate binds to PPARA protein |
CTD |
PMID:23843199 |
|
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
affects binding |
ISO |
di-n-hexyl phthalate binds to PPARB protein |
CTD |
PMID:23843199 |
|
NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
affects binding |
ISO |
di-n-hexyl phthalate binds to PPARG protein |
CTD |
PMID:23843199 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of PPARGC1A protein |
CTD |
PMID:32693021 |
|
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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G |
Rhox10 |
reproductive homeobox 10 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of RHOX10 mRNA |
CTD |
PMID:22112501 |
|
NCBI chr X:124,207,017...124,211,455
Ensembl chr X:124,207,017...124,211,455
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G |
Rxra |
retinoid X receptor alpha |
affects binding |
ISO |
di-n-hexyl phthalate binds to RXRA protein |
CTD |
PMID:23843199 |
|
NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
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G |
Rxrb |
retinoid X receptor beta |
affects binding |
ISO |
di-n-hexyl phthalate binds to RXRB protein |
CTD |
PMID:23843199 |
|
NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
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G |
Rxrg |
retinoid X receptor gamma |
affects binding |
ISO |
di-n-hexyl phthalate binds to RXRG protein |
CTD |
PMID:23843199 |
|
NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
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G |
Scarb1 |
scavenger receptor class B, member 1 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of SCARB1 mRNA |
CTD |
PMID:22112501 PMID:23754470 PMID:26934186 |
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NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
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G |
Sirt1 |
sirtuin 1 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of SIRT1 protein |
CTD |
PMID:32693021 |
|
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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G |
Star |
steroidogenic acute regulatory protein |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of STAR mRNA |
CTD |
PMID:22112501 PMID:23754470 PMID:26934186 |
|
NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of TGFB1 mRNA |
CTD |
PMID:22112501 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Wnt7a |
Wnt family member 7A |
decreases expression |
EXP |
di-n-hexyl phthalate results in decreased expression of WNT7A mRNA |
CTD |
PMID:22112501 |
|
NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
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G |
Edn1 |
endothelin 1 |
increases expression |
EXP |
iopromide results in increased expression of EDN1 protein |
CTD |
PMID:21354280 |
|
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Mr1 |
major histocompatibility complex, class I-related |
affects expression |
ISO |
iopromide affects the expression of MR1 mRNA |
CTD |
PMID:25811541 |
|
NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
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G |
Nos2 |
nitric oxide synthase 2 |
decreases expression |
EXP |
iopromide results in decreased expression of NOS2 protein |
CTD |
PMID:21354280 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
RT1-Da |
RT1 class II, locus Da |
affects expression |
ISO |
iopromide affects the expression of HLA-DRA mRNA |
CTD |
PMID:25811541 |
|
NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616
|
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