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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:malonic acid
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Accession:CHEBI:30794 term browser browse the term
Definition:An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
Synonyms:related_synonym: Formula=C3H4O4;   H2malo;   HOOC-CH2-COOH;   InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7);   InChIKey=OFOBLEOULBTSOW-UHFFFAOYSA-N;   Propanedioic acid;   SMILES=OC(=O)CC(O)=O
 alt_id: CHEBI:25132;   CHEBI:44060;   CHEBI:6660
 xref: Beilstein:1751370;   CAS:141-82-2;   DrugBank:DB02175;   Gmelin:2550;   HMDB:HMDB0000691;   KEGG:C00383;   KNApSAcK:C00001193;   LIPID_MAPS_instance:LMFA01170041
 xref_mesh: MESH:C030290
 xref: MetaCyc:MALONATE;   PDBeChem:MLA;   PMID:22770225;   Reaxys:1751370;   Wikipedia:Malonic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30795


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malonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression EXP malonic acid results in decreased expression of BCL2 mRNA CTD PMID:16242643 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions EXP malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP3 protein] CTD PMID:21664962 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions EXP malonic acid inhibits the reaction [chelerythrine results in increased activity of CASP9 protein] CTD PMID:21664962 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects expression EXP malonic acid affects the expression of HIF1A protein CTD PMID:16034640 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of malonic acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO malonic acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Slc25a10 solute carrier family 25 member 10 increases uptake EXP SLC25A10 protein results in increased uptake of malonic acid CTD PMID:12388626 NCBI chr10:109,665,682...109,674,782
Ensembl chr10:109,665,682...109,673,143
JBrowse link
aminomalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmr1 FMRP translational regulator 1 increases abundance ISO FMR1 5' UTR mutant form results in increased abundance of aminomalonic acid CTD PMID:27385396 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
elesclomol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag3 BAG cochaperone 3 increases expression
multiple interactions
ISO elesclomol results in increased expression of BAG3 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of BAG3 mRNA]
CTD PMID:18723479 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO elesclomol results in increased expression of CHORDC1 mRNA CTD PMID:18723479 NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165
JBrowse link
G Clk1 CDC-like kinase 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of CLK1 mRNA] CTD PMID:18723479 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Cryab crystallin, alpha B increases expression ISO elesclomol results in increased expression of CRYAB mRNA CTD PMID:18723479 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB1 mRNA] CTD PMID:18723479 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB4 mRNA] CTD PMID:18723479 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO elesclomol results in increased expression of DNAJB9 mRNA CTD PMID:18723479 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO elesclomol results in increased expression of FTL mRNA CTD PMID:18723479 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of GCLM mRNA] CTD PMID:18723479 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gla galactosidase, alpha increases expression ISO elesclomol results in increased expression of GLA mRNA CTD PMID:18723479 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression
multiple interactions
ISO elesclomol results in increased expression of HERPUD1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HERPUD1 mRNA]
CTD PMID:18723479 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HMOX1 mRNA] CTD PMID:18723479 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1A mRNA] CTD PMID:18723479 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1B mRNA] CTD PMID:18723479 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO elesclomol results in increased expression of HSPH1 mRNA CTD PMID:18723479 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ier5 immediate early response 5 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IER5 mRNA] CTD PMID:18723479 NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IFRD1 mRNA] CTD PMID:18723479 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Oser1 oxidative stress responsive serine-rich 1 increases expression
multiple interactions
ISO elesclomol results in increased expression of OSER1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of OSER1 mRNA]
CTD PMID:18723479 NCBI chr 3:159,784,131...159,802,923
Ensembl chr 3:159,784,128...159,802,952
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of PMAIP1 mRNA] CTD PMID:18723479 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO elesclomol results in increased expression of PPP1R15A mRNA CTD PMID:18723479 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 increases expression ISO elesclomol results in increased expression of PSMC1 mRNA CTD PMID:18723479 NCBI chr 6:124,123,283...124,135,644
Ensembl chr 6:124,123,228...124,135,658
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression ISO elesclomol results in increased expression of PSMC4 mRNA CTD PMID:18723479 NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression ISO elesclomol results in increased expression of PSMC6 mRNA CTD PMID:18723479 NCBI chr15:19,667,453...19,688,916
Ensembl chr15:19,667,453...19,688,914
JBrowse link
G Psmd1 proteasome 26S subunit, non-ATPase 1 increases expression ISO elesclomol results in increased expression of PSMD1 mRNA CTD PMID:18723479 NCBI chr 9:93,080,618...93,155,033
Ensembl chr 9:93,080,615...93,155,027
JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 increases expression ISO elesclomol results in increased expression of PSMD12 mRNA CTD PMID:18723479 NCBI chr10:95,706,808...95,725,452
Ensembl chr10:95,706,685...95,725,812
JBrowse link
G Psmd2 proteasome 26S subunit, non-ATPase 2 increases expression ISO elesclomol results in increased expression of PSMD2 mRNA CTD PMID:18723479 NCBI chr11:83,934,098...83,944,725
Ensembl chr11:83,934,087...83,944,763
JBrowse link
G Psme4 proteasome activator subunit 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of PSME4 mRNA] CTD PMID:18723479 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 increases expression ISO elesclomol results in increased expression of RB1CC1 mRNA CTD PMID:18723479 NCBI chr 5:13,033,918...13,097,369
Ensembl chr 5:13,033,918...13,097,341
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SAT1 mRNA] CTD PMID:18723479 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Sde2 SDE2 telomere maintenance homolog increases expression ISO elesclomol results in increased expression of SDE2 mRNA CTD PMID:18723479 NCBI chr13:99,136,921...99,153,187
Ensembl chr13:99,136,871...99,153,181
JBrowse link
G Slc19a2 solute carrier family 19 member 2 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC19A2 mRNA] CTD PMID:18723479 NCBI chr13:82,552,586...82,566,586
Ensembl chr13:82,552,550...82,566,586
JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC30A1 mRNA] CTD PMID:18723479 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC7A11 mRNA] CTD PMID:18723479 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of TRIB3 mRNA] CTD PMID:18723479 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO elesclomol results in increased expression of TXNRD1 mRNA CTD PMID:18723479 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ufm1 ubiquitin-fold modifier 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of UFM1 mRNA] CTD PMID:18723479 NCBI chr 2:143,096,268...143,104,412
Ensembl chr 2:143,096,271...143,104,412
JBrowse link
G Uspl1 ubiquitin specific peptidase like 1 increases expression
multiple interactions
ISO elesclomol results in increased expression of USPL1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of USPL1 mRNA]
CTD PMID:18723479 NCBI chr12:6,930,018...6,957,027
Ensembl chr12:6,929,978...6,956,984
JBrowse link
G Yrdc yrdC N(6)-threonylcarbamoyltransferase domain containing increases expression ISO elesclomol results in increased expression of YRDC mRNA CTD PMID:18723479 NCBI chr 5:142,845,265...142,850,110
Ensembl chr 5:142,845,114...142,850,111
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 increases expression ISO elesclomol results in increased expression of ZC3HAV1 mRNA CTD PMID:18723479 NCBI chr 4:66,012,111...66,062,160
Ensembl chr 4:66,011,915...66,062,089
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of ZFAND2A mRNA] CTD PMID:18723479 NCBI chr12:17,252,093...17,263,477
Ensembl chr12:17,252,093...17,263,477
JBrowse link
G Zfp394 zinc finger protein 394 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of ZNF394 mRNA] CTD PMID:18723479 NCBI chr12:11,179,323...11,187,362
Ensembl chr12:11,179,329...11,187,380
JBrowse link
ethylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of AIF1 protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein]
CTD PMID:28223158 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of IL1B protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]
CTD PMID:28223158 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein] CTD PMID:28223158 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of TNF protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]
CTD PMID:28223158 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
isoprothiolane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO isoprothiolane binds to and results in increased activity of ESR1 protein
isoprothiolane results in decreased expression of ESR1 protein
CTD PMID:17904202 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO isoprothiolane binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pgr progesterone receptor increases expression ISO isoprothiolane results in increased expression of PGR mRNA CTD PMID:17904202 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO isoprothiolane results in increased expression of TFF1 mRNA CTD PMID:17904202 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
methylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein] CTD PMID:28223158 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein] CTD PMID:28223158 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of NOS2 protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]
CTD PMID:28223158 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP Methylmalonic Acid results in increased expression of TNF protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]
CTD PMID:28223158 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          metabolite 19218
            eukaryotic metabolite 18842
              animal metabolite 18569
                mammalian metabolite 18558
                  human metabolite 18231
                    malonic acid 58
                      3-(benzyloxy)-3-oxopropanoic acid 0
                      3-oxo-3-ureidopropanoic acid 0
                      N-malonyltryptophan 0
                      O-malonyl-D-carnitine 0
                      O-malonyl-L-carnitine 0
                      O-malonylcarnitine 0
                      S-malonyl-4'-phosphopantetheine 0
                      aminomalonic acid 1
                      bumadizone 0
                      carboxyacetyl group + 0
                      elesclomol + 41
                      ethylmalonic acid + 6
                      heptylmalonic acid 0
                      hydroxymalonic acid 0
                      isoprothiolane + 4
                      malonamide + 0
                      malonate ester + 4
                      malonyl group 0
                      malonyl-CoA methyl ester 0
                      methylmalonic acid + 6
                      oxomalonic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      dicarboxylic acids and O-substituted derivatives 10278
                                        dicarboxylic acid 10271
                                          alpha,omega-dicarboxylic acid 2777
                                            malonic acid 58
                                              3-(benzyloxy)-3-oxopropanoic acid 0
                                              3-oxo-3-ureidopropanoic acid 0
                                              N-malonyltryptophan 0
                                              O-malonyl-D-carnitine 0
                                              O-malonyl-L-carnitine 0
                                              O-malonylcarnitine 0
                                              S-malonyl-4'-phosphopantetheine 0
                                              aminomalonic acid 1
                                              bumadizone 0
                                              carboxyacetyl group + 0
                                              elesclomol + 41
                                              ethylmalonic acid + 6
                                              heptylmalonic acid 0
                                              hydroxymalonic acid 0
                                              isoprothiolane + 4
                                              malonamide + 0
                                              malonate ester + 4
                                              malonyl group 0
                                              malonyl-CoA methyl ester 0
                                              methylmalonic acid + 6
                                              oxomalonic acid 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.