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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hexanoic acid
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Accession:CHEBI:30776 term browser browse the term
Definition:A C6, straight-chain saturated fatty acid.
Synonyms:related_synonym: 1-hexanoic acid;   1-pentanecarboxylic acid;   6:0;   C6:0;   CH3-[CH2]4-COOH;   Formula=C6H12O2;   Hexanoate;   Hexylic acid;   InChI=1S/C6H12O2/c1-2-3-4-5-6(7)8/h2-5H2,1H3,(H,7,8);   InChIKey=FUZZWVXGSFPDMH-UHFFFAOYSA-N;   Pentanecarboxylic acid;   SMILES=CCCCCC(O)=O;   butylacetic acid;   caproic acid;   capronic acid;   hexoic acid;   n-Caproic acid;   n-hexanoic acid;   n-hexoic acid;   n-hexylic acid;   pentiformic acid;   pentylformic acid
 alt_id: CHEBI:24571;   CHEBI:40213;   CHEBI:5702
 xref: Beilstein:773837;   CAS:142-62-1;   ECMDB:ECMDB21229;   Gmelin:185066;   HMDB:HMDB0000535;   KEGG:C01585;   KNApSAcK:C00001218;   LIPID_MAPS_instance:LMFA01010006
 xref_mesh: MESH:C037652
 xref: MetaCyc:HEXANOATE;   PDBeChem:6NA;   PMID:10685018;   PMID:1556177;   PMID:24357269;   PMID:24924750;   Reaxys:773837;   Wikipedia:Hexanoic_acid;   YMDB:YMDB01424
 cyclic_relationship: is_conjugate_acid_of CHEBI:17120

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hexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions ISO hexanoic acid inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl] CTD PMID:28595002 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of hexanoic acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
6-aminohexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Aminocaproic Acid results in decreased expression of A2M protein CTD PMID:11304663 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137 		JBrowse link
G Folh1 folate hydrolase 1 multiple interactions ISO [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein] CTD PMID:24508213 NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415 		JBrowse link
G Grpr gastrin releasing peptide receptor multiple interactions ISO [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein] CTD PMID:24508213 NCBI chr  X:32,746,259...32,786,266
Ensembl chr  X:32,745,873...32,786,359 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein] CTD PMID:17482686 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Plg plasminogen multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]; Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Aminocaproic Acid results in increased expression of SERPINC1 protein CTD PMID:11304663 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192 		JBrowse link
hexanoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO [hexanoyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536 		JBrowse link
L-lysine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor multiple interactions EXP [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine] CTD PMID:22689575 NCBI chr 2:68,820,616...68,895,537 JBrowse link
lisinopril dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity ISO Lisinopril analog results in decreased activity of ACE protein CTD PMID:22200082 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression
increases activity		 EXP Lisinopril results in increased expression of ACE2 mRNA
Lisinopril results in increased activity of ACE2 protein		 CTD PMID:15897343, PMID:16221218 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO
EXP		 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Lisinopril inhibits the reaction [Sodium Fluoride results in decreased activity of ACHE protein]		 CTD PMID:23060470, PMID:31710167 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
decreases secretion
increases secretion
affects response to substance
increases expression		 ISO
EXP		 Lisinopril results in decreased expression of AGT protein
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA
Lisinopril results in decreased secretion of AGT protein
Lisinopril results in increased secretion of AGT protein alternative form
AGT gene alternative form affects the susceptibility to Lisinopril
Lisinopril results in increased expression of AGT mRNA		 CTD PMID:8393685, PMID:8915971, PMID:15897343, PMID:16221218, PMID:16685205 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Lisinopril results in decreased expression of BCL2 CTD PMID:10075388 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] CTD PMID:16636307 NCBI chr 9:20,794,680...20,858,438
Ensembl chr 9:20,765,296...20,858,504 		JBrowse link
G Edn1 endothelin 1 decreases secretion ISO Lisinopril results in decreased secretion of EDN1 protein CTD PMID:19079593 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] CTD PMID:20051877 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:19225054 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379 		JBrowse link
G Hpse heparanase multiple interactions EXP [Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] CTD PMID:19429930 NCBI chr14:10,534,358...10,576,686
Ensembl chr14:10,534,423...10,575,224 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Lisinopril results in increased expression of IGFBP1 protein CTD PMID:9663927 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:20051877 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein] CTD PMID:23060470 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] CTD PMID:20051877 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in decreased phosphorylation of NPHS1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NPHS1 protein] CTD PMID:16636307, PMID:19293598 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 mRNA]; Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 protein] CTD PMID:16636307 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522 		JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Lisinopril results in decreased expression of NPPA protein CTD PMID:8393685 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Ren renin increases expression
multiple interactions		 ISO
EXP		 Lisinopril results in increased expression of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA
Lisinopril results in increased expression of REN mRNA		 CTD PMID:2550029, PMID:8915971, PMID:16221218 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein] CTD PMID:20051877 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of VEGFA protein] CTD PMID:19293598 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
perfluorohexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot1 acyl-CoA thioesterase 1 increases expression EXP perfluorohexanoic acid results in increased expression of ACOT1 mRNA CTD PMID:19407336 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO perfluorohexanoic acid results in increased expression of ACSL1 mRNA CTD PMID:23567314 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO perfluorohexanoic acid results in increased expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079 		JBrowse link
G Apoa2 apolipoprotein A2 increases expression ISO perfluorohexanoic acid results in increased expression of APOA2 mRNA CTD PMID:23567314 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802 		JBrowse link
G Apoa4 apolipoprotein A4 increases expression EXP perfluorohexanoic acid results in increased expression of APOA4 mRNA CTD PMID:22071372 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376 		JBrowse link
G Apoa5 apolipoprotein A5 increases expression ISO perfluorohexanoic acid results in increased expression of APOA5 mRNA CTD PMID:23567314 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736 		JBrowse link
G Ar androgen receptor multiple interactions ISO perfluorohexanoic acid promotes the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:29601859 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO perfluorohexanoic acid results in decreased expression of CCND1 mRNA CTD PMID:23567314 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO perfluorohexanoic acid results in increased expression of CPT1A mRNA CTD PMID:23567314 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO perfluorohexanoic acid results in increased expression of CPT1B mRNA CTD PMID:23567314 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO perfluorohexanoic acid results in increased expression of CYP2B6 mRNA CTD PMID:23567314 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP perfluorohexanoic acid results in increased expression of CYP4A1 mRNA CTD PMID:19407336 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO perfluorohexanoic acid results in decreased expression of CYP7A1 mRNA CTD PMID:23567314 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO perfluorohexanoic acid results in increased expression of EHHADH mRNA CTD PMID:23567314 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO perfluorohexanoic acid results in increased expression of FABP1 mRNA CTD PMID:23567314 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP perfluorohexanoic acid results in increased expression of FDFT1 mRNA CTD PMID:22071372 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
decreases expression		 ISO
EXP		 perfluorohexanoic acid results in increased expression of HADHA mRNA
perfluorohexanoic acid results in decreased expression of HADHA mRNA		 CTD PMID:22071372, PMID:23567314 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP perfluorohexanoic acid results in increased expression of HADHB mRNA CTD PMID:22071372 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995 		JBrowse link
G Hhex hematopoietically expressed homeobox increases expression EXP perfluorohexanoic acid results in increased expression of HHEX mRNA CTD PMID:22071372 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649 		JBrowse link
G Mbl2 mannose binding lectin 2 increases expression ISO perfluorohexanoic acid results in increased expression of MBL2 mRNA CTD PMID:23567314 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962 		JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 increases expression ISO perfluorohexanoic acid results in increased expression of MOGAT1 mRNA CTD PMID:23567314 NCBI chr 9:84,405,481...84,418,657
Ensembl chr 9:84,405,477...84,418,591 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO perfluorohexanoic acid results in increased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO perfluorohexanoic acid results in increased activity of NR1I2 protein CTD PMID:28115241 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Pax8 paired box 8 increases expression EXP perfluorohexanoic acid results in increased expression of PAX8 mRNA CTD PMID:22071372 NCBI chr 3:1,527,316...1,586,019
Ensembl chr 3:1,527,279...1,584,946 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO perfluorohexanoic acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814 		JBrowse link
G Plin2 perilipin 2 increases expression ISO perfluorohexanoic acid results in increased expression of PLIN2 mRNA CTD PMID:23567314 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857 		JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO perfluorohexanoic acid results in increased expression of POR mRNA CTD PMID:23567314 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
multiple interactions
increases expression		 ISO perfluorohexanoic acid results in increased activity of PPARA protein
[perfluorooctanoic acid co-treated with perfluorohexanoic acid] results in increased expression of PPARA mRNA
perfluorohexanoic acid results in increased expression of PPARA mRNA		 CTD PMID:23391484, PMID:24374136, PMID:28857218 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO perfluorohexanoic acid results in increased expression of PPARD mRNA CTD PMID:23567314 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO perfluorohexanoic acid results in increased activity of PPARG protein CTD PMID:23391484 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorohexanoic acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO perfluorohexanoic acid results in increased expression of SCD mRNA CTD PMID:23567314 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP perfluorohexanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid] CTD PMID:19915082 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc25a34 solute carrier family 25, member 34 increases expression ISO perfluorohexanoic acid results in increased expression of SLC25A34 mRNA CTD PMID:23567314 NCBI chr 5:160,175,206...160,179,978
Ensembl chr 5:160,176,124...160,179,978 		JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorohexanoic acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO perfluorohexanoic acid results in increased expression of TXNIP mRNA CTD PMID:23567314 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] CTD PMID:30896085 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] CTD PMID:30896085 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]		 CTD PMID:20369241, PMID:30896085 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein		 CTD PMID:15946813, PMID:17287592 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813, PMID:17287592 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP		 royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813, PMID:17287592 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            eukaryotic metabolite 18908
              plant metabolite 17360
                hexanoic acid 72
                  (3R)-3,6-diaminohexanoic acid 0
                  (3S)-3,6-diaminohexanoic acid 0
                  (3S,5S)-3,5-diaminohexanoic acid 0
                  (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid 0
                  (5R)-5-hydroxyhexanoic acid + 0
                  (5S)-5-amino-3-oxohexanoic acid 0
                  (9R,13R)-1a,1b-dinor-10,11-dihydro-12-oxo-15-phytoenoic acid 0
                  (R)-3-hydroxyhexanoyl-CoA 0
                  (S)-(+)-4-(5-carboxypentyl)methamphetamine 0
                  1,2-dihexanoyl-sn-glycero-3-phosphocholine 0
                  1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine 0
                  1,2-dihexanoyl-sn-glycerol 0
                  1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine 0
                  1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine 0
                  1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine 0
                  1-hexanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine 0
                  1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine 0
                  2,5-diaminohexanoic acid 0
                  2,6-dioxo-6-phenylhexanoic acid 0
                  2-amino-5-oxohexanoic acid 0
                  2-aminohexanoic acid + 0
                  2-hydroxyhexanoic acid + 0
                  2-oxohexanoic acid 0
                  3-deoxy-D-glycero-hexo-2,5-diulosonic acid 0
                  3-hydroxy-5-oxohexanoic acid + 0
                  3-oxohexanoic acid + 0
                  4-hydroxy-2-oxohexanoic acid + 0
                  5-hydroxyhexanoic acid 0
                  5-oxohexanoic acid 0
                  6-\{4-[hydroxy-(4-nitrophenoxy)phosphoryl]butyrylamino\}hexanoic acid 0
                  6-acetamido-3-aminohexanoic acid + 0
                  6-amino-2-oxohexanoic acid + 0
                  6-aminohexanoic acid + 7
                  6-bromohexanoic acid + 0
                  6-hydroxy-2-oxohexanoic acid 0
                  6-hydroxyhexanoic acid + 0
                  6-oxohexanoic acid 0
                  N-(6-aminohexanoyl)-6-aminohexanoic acid 0
                  N-(hexanoyl)ethanolamine 0
                  N-caproyl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  N-hexanoyl-(2S)-hydroxyglycine 0
                  N-hexanoyl-beta-D-galactosylsphinganine 0
                  N-hexanoyldihydroceramide 0
                  N-hexanoylphytosphingosine 0
                  N-hexanoylphytosphingosine 1-phosphate 0
                  N-hexanoylsphingosine 1-phosphate 0
                  N-hexanoylsphingosine-1-phosphocholine + 0
                  N-hexanoylsphingosine-1-phosphoethanolamine 0
                  S-hexanoyl-4'-phosphopantetheine 0
                  caproylcholine 0
                  dethiobiotin + 0
                  hexanamide 0
                  hexanoate ester + 0
                  hexanoyl group 0
                  hexanoyl-CoA + 1
                  lysine + 27
                  lysophosphatidylcholine 6:0 + 0
                  perfluorohexanoic acid 36
                  pescaprein XXIX 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            saturated fatty acid 15812
                                              straight-chain saturated fatty acid 15227
                                                hexanoic acid 72
                                                  (3R)-3,6-diaminohexanoic acid 0
                                                  (3S)-3,6-diaminohexanoic acid 0
                                                  (3S,5S)-3,5-diaminohexanoic acid 0
                                                  (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid 0
                                                  (5R)-5-hydroxyhexanoic acid + 0
                                                  (5S)-5-amino-3-oxohexanoic acid 0
                                                  (9R,13R)-1a,1b-dinor-10,11-dihydro-12-oxo-15-phytoenoic acid 0
                                                  (R)-3-hydroxyhexanoyl-CoA 0
                                                  (S)-(+)-4-(5-carboxypentyl)methamphetamine 0
                                                  1,2-dihexanoyl-sn-glycero-3-phosphocholine 0
                                                  1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine 0
                                                  1,2-dihexanoyl-sn-glycerol 0
                                                  1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine 0
                                                  1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine 0
                                                  1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine 0
                                                  1-hexanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine 0
                                                  1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine 0
                                                  2,5-diaminohexanoic acid 0
                                                  2,6-dioxo-6-phenylhexanoic acid 0
                                                  2-amino-5-oxohexanoic acid 0
                                                  2-aminohexanoic acid + 0
                                                  2-hydroxyhexanoic acid + 0
                                                  2-oxohexanoic acid 0
                                                  3-deoxy-D-glycero-hexo-2,5-diulosonic acid 0
                                                  3-hydroxy-5-oxohexanoic acid + 0
                                                  3-oxohexanoic acid + 0
                                                  4-hydroxy-2-oxohexanoic acid + 0
                                                  5-hydroxyhexanoic acid 0
                                                  5-oxohexanoic acid 0
                                                  6-\{4-[hydroxy-(4-nitrophenoxy)phosphoryl]butyrylamino\}hexanoic acid 0
                                                  6-acetamido-3-aminohexanoic acid + 0
                                                  6-amino-2-oxohexanoic acid + 0
                                                  6-aminohexanoic acid + 7
                                                  6-bromohexanoic acid + 0
                                                  6-hydroxy-2-oxohexanoic acid 0
                                                  6-hydroxyhexanoic acid + 0
                                                  6-oxohexanoic acid 0
                                                  N-(6-aminohexanoyl)-6-aminohexanoic acid 0
                                                  N-(hexanoyl)ethanolamine 0
                                                  N-caproyl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                  N-hexanoyl-(2S)-hydroxyglycine 0
                                                  N-hexanoyl-beta-D-galactosylsphinganine 0
                                                  N-hexanoyldihydroceramide 0
                                                  N-hexanoylphytosphingosine 0
                                                  N-hexanoylphytosphingosine 1-phosphate 0
                                                  N-hexanoylsphingosine 1-phosphate 0
                                                  N-hexanoylsphingosine-1-phosphocholine + 0
                                                  N-hexanoylsphingosine-1-phosphoethanolamine 0
                                                  S-hexanoyl-4'-phosphopantetheine 0
                                                  caproylcholine 0
                                                  dethiobiotin + 0
                                                  hexanamide 0
                                                  hexanoate ester + 0
                                                  hexanoyl group 0
                                                  hexanoyl-CoA + 1
                                                  lysine + 27
                                                  lysophosphatidylcholine 6:0 + 0
                                                  perfluorohexanoic acid 36
                                                  pescaprein XXIX 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.