Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hexanoic acid
go back to main search page
Accession:CHEBI:30776 term browser browse the term
Definition:A C6, straight-chain saturated fatty acid.
Synonyms:related_synonym: 1-hexanoic acid;   1-pentanecarboxylic acid;   6:0;   C6:0;   CH3-[CH2]4-COOH;   Formula=C6H12O2;   Hexanoate;   Hexylic acid;   InChI=1S/C6H12O2/c1-2-3-4-5-6(7)8/h2-5H2,1H3,(H,7,8);   InChIKey=FUZZWVXGSFPDMH-UHFFFAOYSA-N;   Pentanecarboxylic acid;   SMILES=CCCCCC(O)=O;   butylacetic acid;   caproic acid;   capronic acid;   hexoic acid;   n-Caproic acid;   n-hexanoic acid;   n-hexoic acid;   n-hexylic acid;   pentiformic acid;   pentylformic acid
 alt_id: CHEBI:24571;   CHEBI:40213;   CHEBI:5702
 xref: Beilstein:773837;   CAS:142-62-1;   ECMDB:ECMDB21229;   Gmelin:185066;   HMDB:HMDB0000535;   KEGG:C01585;   KNApSAcK:C00001218;   LIPID_MAPS_instance:LMFA01010006
 xref_mesh: MESH:C037652
 xref: MetaCyc:HEXANOATE;   PDBeChem:6NA;   PMID:10685018;   PMID:1556177;   PMID:24357269;   PMID:24924750;   Reaxys:773837;   Wikipedia:Hexanoic_acid;   YMDB:YMDB01424
 cyclic_relationship: is_conjugate_acid_of CHEBI:17120


show annotations for term's descendants           Sort by:
 
hexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions ISO hexanoic acid inhibits the reaction [[DCXR protein co-treated with NADP] results in increased reduction of Diacetyl] CTD PMID:28595002 NCBI chr10:106,006,404...106,008,294 JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of hexanoic acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
6-aminohexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Aminocaproic Acid results in decreased expression of A2M protein CTD PMID:11304663 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Folh1 folate hydrolase 1 multiple interactions ISO [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein] CTD PMID:24508213 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379 		JBrowse link
G Grpr gastrin releasing peptide receptor multiple interactions ISO [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein] CTD PMID:24508213 NCBI chr  X:30,998,425...31,038,442
Ensembl chr  X:30,998,416...31,038,442 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein] CTD PMID:17482686 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Plg plasminogen multiple interactions ISO Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]; Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Aminocaproic Acid results in increased expression of SERPINC1 protein CTD PMID:11304663 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
hexanoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pecr peroxisomal trans-2-enoyl-CoA reductase multiple interactions ISO [hexanoyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511 		JBrowse link
L-homoarginine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco4c1 solute carrier organic anion transporter family, member 4C1 increases export ISO SLCO4C1 protein results in increased export of Homoarginine CTD PMID:30865704 NCBI chr 9:97,180,162...97,229,135
Ensembl chr 9:97,178,861...97,229,715 		JBrowse link
L-lysine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor multiple interactions EXP [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine] CTD PMID:22689575 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
lisinopril dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity ISO Lisinopril analog results in decreased activity of ACE protein CTD PMID:22200082 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression
multiple interactions
increases activity		 EXP
ISO		 Lisinopril results in increased expression of ACE2 mRNA
ACE2 protein affects the reaction [[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7)]
Lisinopril results in increased activity of ACE2 protein		 CTD PMID:15897343 PMID:16221218 PMID:27649628 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO
EXP		 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Lisinopril inhibits the reaction [Sodium Fluoride results in decreased activity of ACHE protein]		 CTD PMID:23060470 PMID:31710167 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
affects metabolic processing
decreases secretion
increases secretion
affects response to substance
increases expression		 ISO
EXP		 Lisinopril results in decreased expression of AGT protein
[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [[Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in increased abundance of angiotensin I (1-7); [Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein; ACE2 protein affects the reaction [[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7)]; Thiorphan inhibits the reaction [[Lisinopril affects the metabolism of AGT protein] which results in increased abundance of angiotensin I (1-7)]
[[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [[Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA
Lisinopril results in decreased secretion of AGT protein
Lisinopril results in increased secretion of AGT protein alternative form
AGT gene alternative form affects the susceptibility to Lisinopril
Lisinopril results in increased expression of AGT mRNA		 CTD PMID:8393685 PMID:8915971 PMID:15897343 PMID:16221218 PMID:16685205 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Lisinopril results in decreased expression of BCL2 CTD PMID:10075388 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] CTD PMID:16636307 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Edn1 endothelin 1 decreases secretion ISO Lisinopril results in decreased secretion of EDN1 protein CTD PMID:19079593 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] CTD PMID:20051877 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:19225054 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hpse heparanase multiple interactions EXP [Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] CTD PMID:19429930 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Lisinopril results in increased expression of IGFBP1 protein CTD PMID:9663927 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:20051877 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein] CTD PMID:23060470 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] CTD PMID:20051877 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in decreased phosphorylation of NPHS1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NPHS1 protein] CTD PMID:16636307 PMID:19293598 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 mRNA]; Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 protein] CTD PMID:16636307 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Lisinopril results in decreased expression of NPPA protein CTD PMID:8393685 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Ren renin increases expression
multiple interactions		 ISO
EXP		 Lisinopril results in increased expression of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA
Lisinopril results in increased expression of REN mRNA		 CTD PMID:2550029 PMID:8915971 PMID:16221218 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Lisinopril affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein] CTD PMID:20051877 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of VEGFA protein] CTD PMID:19293598 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
perfluorohexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot1 acyl-CoA thioesterase 1 increases expression EXP perfluorohexanoic acid results in increased expression of ACOT1 mRNA CTD PMID:19407336 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO perfluorohexanoic acid results in increased expression of ACSL1 mRNA CTD PMID:23567314 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO perfluorohexanoic acid results in increased expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Apoa2 apolipoprotein A2 increases expression ISO perfluorohexanoic acid results in increased expression of APOA2 mRNA CTD PMID:23567314 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apoa4 apolipoprotein A4 increases expression EXP perfluorohexanoic acid results in increased expression of APOA4 mRNA CTD PMID:22071372 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apoa5 apolipoprotein A5 increases expression ISO perfluorohexanoic acid results in increased expression of APOA5 mRNA CTD PMID:23567314 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816 		JBrowse link
G Ar androgen receptor multiple interactions ISO perfluorohexanoic acid promotes the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:29601859 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO perfluorohexanoic acid results in decreased expression of CCND1 mRNA CTD PMID:23567314 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO perfluorohexanoic acid results in increased expression of CPT1A mRNA CTD PMID:23567314 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO perfluorohexanoic acid results in increased expression of CPT1B mRNA CTD PMID:23567314 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO perfluorohexanoic acid results in increased expression of CYP2B6 mRNA CTD PMID:23567314 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP perfluorohexanoic acid results in increased expression of CYP4A1 mRNA CTD PMID:19407336 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO perfluorohexanoic acid results in decreased expression of CYP7A1 mRNA CTD PMID:23567314 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO perfluorohexanoic acid results in increased expression of EHHADH mRNA CTD PMID:23567314 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO perfluorohexanoic acid results in increased expression of FABP1 mRNA CTD PMID:23567314 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP perfluorohexanoic acid results in increased expression of FDFT1 mRNA CTD PMID:22071372 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
decreases expression		 ISO
EXP		 perfluorohexanoic acid results in increased expression of HADHA mRNA
perfluorohexanoic acid results in decreased expression of HADHA mRNA		 CTD PMID:22071372 PMID:23567314 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP perfluorohexanoic acid results in increased expression of HADHB mRNA CTD PMID:22071372 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Hhex hematopoietically expressed homeobox increases expression EXP perfluorohexanoic acid results in increased expression of HHEX mRNA CTD PMID:22071372 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042 		JBrowse link
G Mbl2 mannose binding lectin 2 increases expression ISO perfluorohexanoic acid results in increased expression of MBL2 mRNA CTD PMID:23567314 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 increases expression ISO perfluorohexanoic acid results in increased expression of MOGAT1 mRNA CTD PMID:23567314 NCBI chr 9:79,980,963...79,988,513
Ensembl chr 9:79,956,649...79,988,513 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO perfluorohexanoic acid results in increased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO perfluorohexanoic acid results in increased activity of NR1I2 protein CTD PMID:28115241 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pax8 paired box 8 increases expression EXP perfluorohexanoic acid results in increased expression of PAX8 mRNA CTD PMID:22071372 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO perfluorohexanoic acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Plin2 perilipin 2 increases expression ISO perfluorohexanoic acid results in increased expression of PLIN2 mRNA CTD PMID:23567314 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO perfluorohexanoic acid results in increased expression of POR mRNA CTD PMID:23567314 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
multiple interactions
increases expression		 ISO perfluorohexanoic acid results in increased activity of PPARA protein
[perfluorooctanoic acid co-treated with perfluorohexanoic acid] results in increased expression of PPARA mRNA
perfluorohexanoic acid results in increased expression of PPARA mRNA		 CTD PMID:23391484 PMID:24374136 PMID:28857218 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO perfluorohexanoic acid results in increased expression of PPARD mRNA CTD PMID:23567314 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO perfluorohexanoic acid results in increased activity of PPARG protein CTD PMID:23391484 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorohexanoic acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO perfluorohexanoic acid results in increased expression of SCD mRNA CTD PMID:23567314 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP perfluorohexanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid] CTD PMID:19915082 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc25a34 solute carrier family 25, member 34 increases expression ISO perfluorohexanoic acid results in increased expression of SLC25A34 mRNA CTD PMID:23567314 NCBI chr 5:153,932,081...153,936,854 JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorohexanoic acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO perfluorohexanoic acid results in increased expression of TXNIP mRNA CTD PMID:23567314 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
royal jelly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] CTD PMID:30896085 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] CTD PMID:30896085 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]		 CTD PMID:20369241 PMID:30896085 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein		 CTD PMID:15946813 PMID:17287592 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 ISO Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein] CTD PMID:15946813 PMID:17287592 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein] CTD PMID:30896085 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO royal jelly results in increased expression of TFF1 mRNA CTD PMID:15946813 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] CTD PMID:30896085 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP		 royal jelly results in increased expression of VEGFA mRNA CTD PMID:15946813 PMID:17287592 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            eukaryotic metabolite 19358
              plant metabolite 17795
                hexanoic acid 74
                  (3R)-3,6-diaminohexanoic acid 0
                  (3S)-3,6-diaminohexanoic acid 0
                  (3S,5S)-3,5-diaminohexanoic acid 0
                  (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid 0
                  (5R)-5-hydroxyhexanoic acid + 0
                  (5S)-5-amino-3-oxohexanoic acid 0
                  (9R,13R)-1a,1b-dinor-10,11-dihydro-12-oxo-15-phytoenoic acid 0
                  (R)-3-hydroxyhexanoyl-CoA 0
                  (S)-(+)-4-(5-carboxypentyl)methamphetamine 0
                  1,2-dihexanoyl-sn-glycero-3-phosphocholine 0
                  1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine 0
                  1,2-dihexanoyl-sn-glycerol 0
                  1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine 0
                  1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine 0
                  1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine 0
                  1-hexanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine 0
                  1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine 0
                  2,5-diaminohexanoic acid 0
                  2,6-dioxo-6-phenylhexanoic acid 0
                  2-amino-5-oxohexanoic acid 0
                  2-aminohexanoic acid + 0
                  2-hydroxyhexanoic acid + 0
                  2-oxohexanoic acid 0
                  3-deoxy-D-glycero-hexo-2,5-diulosonic acid 0
                  3-hydroxy-5-oxohexanoic acid + 0
                  3-oxohexanoic acid + 0
                  4-hydroxy-2-oxohexanoic acid + 0
                  5-hydroxyhexanoic acid 0
                  5-oxohexanoic acid 0
                  6-\{4-[hydroxy-(4-nitrophenoxy)phosphoryl]butyrylamino\}hexanoic acid 0
                  6-acetamido-3-aminohexanoic acid + 0
                  6-amino-2-oxohexanoic acid + 0
                  6-aminohexanoic acid + 7
                  6-bromohexanoic acid + 0
                  6-hydroxy-2-oxohexanoic acid 0
                  6-hydroxyhexanoic acid + 0
                  6-oxohexanoic acid 0
                  N-(6-aminohexanoyl)-6-aminohexanoic acid 0
                  N-(hexanoyl)ethanolamine 0
                  N-caproyl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                  N-hexanoyl-(2S)-hydroxyglycine 0
                  N-hexanoyl-beta-D-galactosylsphinganine 0
                  N-hexanoyldihydroceramide 0
                  N-hexanoylphytosphingosine 0
                  N-hexanoylphytosphingosine 1-phosphate 0
                  N-hexanoylsphingosine 1-phosphate 0
                  N-hexanoylsphingosine-1-phosphocholine + 0
                  N-hexanoylsphingosine-1-phosphoethanolamine 0
                  S-hexanoyl-4'-phosphopantetheine 0
                  caproylcholine 0
                  dethiobiotin + 0
                  hexanamide 0
                  hexanoate ester + 0
                  hexanoyl group 0
                  hexanoyl-CoA + 1
                  lysine + 30
                  lysophosphatidylcholine 6:0 + 0
                  perfluorohexanoic acid 36
                  pescaprein XXIX 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        monocarboxylic acid 17843
                                          fatty acid 16480
                                            saturated fatty acid 16128
                                              straight-chain saturated fatty acid 15570
                                                hexanoic acid 74
                                                  (3R)-3,6-diaminohexanoic acid 0
                                                  (3S)-3,6-diaminohexanoic acid 0
                                                  (3S,5S)-3,5-diaminohexanoic acid 0
                                                  (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid 0
                                                  (5R)-5-hydroxyhexanoic acid + 0
                                                  (5S)-5-amino-3-oxohexanoic acid 0
                                                  (9R,13R)-1a,1b-dinor-10,11-dihydro-12-oxo-15-phytoenoic acid 0
                                                  (R)-3-hydroxyhexanoyl-CoA 0
                                                  (S)-(+)-4-(5-carboxypentyl)methamphetamine 0
                                                  1,2-dihexanoyl-sn-glycero-3-phosphocholine 0
                                                  1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine 0
                                                  1,2-dihexanoyl-sn-glycerol 0
                                                  1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine 0
                                                  1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine 0
                                                  1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine 0
                                                  1-hexanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine 0
                                                  1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine 0
                                                  2,5-diaminohexanoic acid 0
                                                  2,6-dioxo-6-phenylhexanoic acid 0
                                                  2-amino-5-oxohexanoic acid 0
                                                  2-aminohexanoic acid + 0
                                                  2-hydroxyhexanoic acid + 0
                                                  2-oxohexanoic acid 0
                                                  3-deoxy-D-glycero-hexo-2,5-diulosonic acid 0
                                                  3-hydroxy-5-oxohexanoic acid + 0
                                                  3-oxohexanoic acid + 0
                                                  4-hydroxy-2-oxohexanoic acid + 0
                                                  5-hydroxyhexanoic acid 0
                                                  5-oxohexanoic acid 0
                                                  6-\{4-[hydroxy-(4-nitrophenoxy)phosphoryl]butyrylamino\}hexanoic acid 0
                                                  6-acetamido-3-aminohexanoic acid + 0
                                                  6-amino-2-oxohexanoic acid + 0
                                                  6-aminohexanoic acid + 7
                                                  6-bromohexanoic acid + 0
                                                  6-hydroxy-2-oxohexanoic acid 0
                                                  6-hydroxyhexanoic acid + 0
                                                  6-oxohexanoic acid 0
                                                  N-(6-aminohexanoyl)-6-aminohexanoic acid 0
                                                  N-(hexanoyl)ethanolamine 0
                                                  N-caproyl-1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine 0
                                                  N-hexanoyl-(2S)-hydroxyglycine 0
                                                  N-hexanoyl-beta-D-galactosylsphinganine 0
                                                  N-hexanoyldihydroceramide 0
                                                  N-hexanoylphytosphingosine 0
                                                  N-hexanoylphytosphingosine 1-phosphate 0
                                                  N-hexanoylsphingosine 1-phosphate 0
                                                  N-hexanoylsphingosine-1-phosphocholine + 0
                                                  N-hexanoylsphingosine-1-phosphoethanolamine 0
                                                  S-hexanoyl-4'-phosphopantetheine 0
                                                  caproylcholine 0
                                                  dethiobiotin + 0
                                                  hexanamide 0
                                                  hexanoate ester + 0
                                                  hexanoyl group 0
                                                  hexanoyl-CoA + 1
                                                  lysine + 30
                                                  lysophosphatidylcholine 6:0 + 0
                                                  perfluorohexanoic acid 36
                                                  pescaprein XXIX 0
paths to the root