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ONTOLOGY REPORT - ANNOTATIONS


Term:citric acid
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Accession:CHEBI:30769 term browser browse the term
Definition:A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.
Synonyms:related_synonym: 2-Hydroxy-1,2,3-propanetricarboxylic acid;   2-Hydroxytricarballylic acid;   2-hydroxypropane-1,2,3-tricarboxylic acid;   3-Carboxy-3-hydroxypentane-1,5-dioic acid;   Citronensaeure;   E330;   Formula=C6H8O7;   H3cit;   InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);   InChIKey=KRKNYBCHXYNGOX-UHFFFAOYSA-N;   SMILES=OC(=O)CC(O)(CC(O)=O)C(O)=O
 alt_id: CHEBI:23322;   CHEBI:3727;   CHEBI:41523
 xref: BPDB:1359;   Beilstein:782061 "Beilstein";   CAS:77-92-9 "ChemIDplus";   CAS:77-92-9 "KEGG COMPOUND";   CAS:77-92-9 "NIST Chemistry WebBook";   DrugBank:DB04272;   Drug_Central:666 "DrugCentral";   Gmelin:4240 "Gmelin";   HMDB:HMDB0000094;   KEGG:C00158;   KEGG:D00037;   KNApSAcK:C00007619
 xref_mesh: MESH:D019343
 xref: MetaCyc:CIT;   PDBeChem:CIT;   PMID:11762832 "Europe PMC";   PMID:11782123 "Europe PMC";   PMID:11857437 "Europe PMC";   PMID:14537820 "Europe PMC";   PMID:15311880 "Europe PMC";   PMID:15934243 "Europe PMC";   PMID:16232627 "Europe PMC";   PMID:17190852 "Europe PMC";   PMID:17357118 "Europe PMC";   PMID:17604395 "Europe PMC";   PMID:18298573 "Europe PMC";   PMID:18960216 "Europe PMC";   PMID:19288211 "Europe PMC";   PMID:22115968 "Europe PMC";   PMID:22192423 "Europe PMC";   PMID:22264346 "Europe PMC";   PMID:22373571 "Europe PMC";   PMID:22509852 "Europe PMC";   Reaxys:782061 "Reaxys";   Wikipedia:Citric_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:133748;   is_conjugate_acid_of CHEBI:35804


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citric acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aco2 aconitase 2 JBrowse link 7 123,102,493 123,145,608 RGD:6480464
G Angptl3 angiopoietin-like 3 JBrowse link 5 117,698,590 117,706,729 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Dlg4 discs large MAGUK scaffold protein 4 JBrowse link 10 56,625,845 56,655,543 RGD:6480464
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:6480464
G Glud1 glutamate dehydrogenase 1 JBrowse link 16 10,661,486 10,695,557 RGD:6480464
G Hlcs holocarboxylase synthetase JBrowse link 11 34,357,372 34,537,798 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Klk5 kallikrein related-peptidase 5 JBrowse link 1 99,781,291 99,793,745 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Pfkm phosphofructokinase, muscle JBrowse link 7 139,702,066 139,722,132 RGD:6480464
G Slc13a2 solute carrier family 13 member 2 JBrowse link 10 65,664,665 65,692,046 RGD:6480464
G Slc13a5 solute carrier family 13 member 5 JBrowse link 10 58,806,581 58,835,549 RGD:6480464
G Slco1a4 solute carrier organic anion transporter family, member 1a4 JBrowse link 4 175,969,549 176,026,227 RGD:6480464
G Syn1 synapsin I JBrowse link X 1,321,315 1,379,202 RGD:6480464
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:6480464
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6480464
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:6480464
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 JBrowse link 10 59,799,123 59,824,208 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        antimicrobial agent 17158
          citric acid 34
            (3S)-citryl-CoA 0
            2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate(2-) 0
            2-methylcitric acid + 0
            Anaerocult(TM) 0
            N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine 0
            beta-citryl-Glu-Glu 0
            beta-citrylglutamic acid 0
            iron(III) dicitrate(3-) 0
            rhizobactin 1021 0
            schizokinen 0
            staphyloferrin A + 0
            staphyloferrin B 0
            vibrioferrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic group 18351
                              organic divalent group 18340
                                organodiyl group 18340
                                  carbonyl group 18225
                                    carbonyl compound 18225
                                      carboxylic acid 17930
                                        tricarboxylic acid 2432
                                          citric acid 34
                                            (3S)-citryl-CoA 0
                                            2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate(2-) 0
                                            2-methylcitric acid + 0
                                            Anaerocult(TM) 0
                                            N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine 0
                                            beta-citryl-Glu-Glu 0
                                            beta-citrylglutamic acid 0
                                            iron(III) dicitrate(3-) 0
                                            rhizobactin 1021 0
                                            schizokinen 0
                                            staphyloferrin A + 0
                                            staphyloferrin B 0
                                            vibrioferrin 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.