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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxaloacetic acid
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Accession:CHEBI:30744 term browser browse the term
Definition:An oxodicarboxylic acid that is succinic acid bearing a single oxo group.
Synonyms:related_synonym: 2-Oxobutanedioic acid;   2-oxosuccinic acid;   3-carboxy-3-oxopropanoic acid;   Formula=C4H4O5;   InChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9);   InChIKey=KHPXUQMNIQBQEV-UHFFFAOYSA-N;   OAA;   Oxalacetic acid;   Oxosuccinic acid;   SMILES=OC(=O)CC(=O)C(O)=O;   keto-succinic acid;   ketosuccinic acid;   oxobutanedioic acid
 alt_id: CHEBI:24959;   CHEBI:25734;   CHEBI:7812
 xref: Beilstein:1705475;   CAS:328-42-7;   Gmelin:1042886;   HMDB:HMDB0000223;   KEGG:C00036;   KNApSAcK:C00001197;   LIPID_MAPS_instance:LMFA01170061
 xref_mesh: MESH:D062907
 xref: MetaCyc:OXALACETIC_ACID;   PDBeChem:OAA;   PMID:15710237;   PMID:17190852;   PMID:21825143;   PMID:22451473;   PMID:28322963;   PMID:4014670;   PMID:8422384;   Patent:US2011064679;   Reaxys:1705475;   Wikipedia:Oxaloacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:16452



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oxaloacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Oxaloacetic Acid results in increased expression of GOT1 mRNA CTD PMID:26811028 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO Oxaloacetic Acid results in increased expression of MDH1 protein CTD PMID:26811028 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II increases expression ISO Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein CTD PMID:26811028 Ensembl chr MT:7,006...7,689 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein CTD PMID:23056435 PMID:26811028 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1B protein CTD PMID:26811028 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
JBrowse link
G Pprc1 PPARG related coactivator 1 increases expression ISO Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein CTD PMID:26811028 NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Oxaloacetic Acid results in increased expression of TFAM mRNA CTD PMID:26811028 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        biochemical role 19377
          metabolite 19352
            oxaloacetic acid 8
              oxaloacetic acid 4-methyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      dicarboxylic acids and O-substituted derivatives 10366
                                        dicarboxylic acid 10359
                                          alpha,omega-dicarboxylic acid 2796
                                            succinic acid 222
                                              oxaloacetic acid 8
                                                oxaloacetic acid 4-methyl ester 0
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