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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxaloacetic acid
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Accession:CHEBI:30744 term browser browse the term
Definition:An oxodicarboxylic acid that is succinic acid bearing a single oxo group.
Synonyms:related_synonym: 2-Oxobutanedioic acid;   2-oxosuccinic acid;   3-carboxy-3-oxopropanoic acid;   Formula=C4H4O5;   InChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9);   InChIKey=KHPXUQMNIQBQEV-UHFFFAOYSA-N;   OAA;   Oxalacetic acid;   Oxosuccinic acid;   SMILES=OC(=O)CC(=O)C(O)=O;   keto-succinic acid;   ketosuccinic acid;   oxobutanedioic acid
 alt_id: CHEBI:24959;   CHEBI:25734;   CHEBI:7812
 xref: Beilstein:1705475;   CAS:328-42-7;   Gmelin:1042886;   HMDB:HMDB0000223;   KEGG:C00036;   KNApSAcK:C00001197;   LIPID_MAPS_instance:LMFA01170061
 xref_mesh: MESH:D062907
 xref: MetaCyc:OXALACETIC_ACID;   PDBeChem:OAA;   PMID:15710237;   PMID:17190852;   PMID:21825143;   PMID:22451473;   PMID:28322963;   PMID:4014670;   PMID:8422384;   Patent:US2011064679;   Reaxys:1705475;   Wikipedia:Oxaloacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:16452


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oxaloacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Oxaloacetic Acid results in increased expression of GOT1 mRNA CTD PMID:26811028 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO Oxaloacetic Acid results in increased expression of MDH1 protein CTD PMID:26811028 NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II increases expression ISO Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein CTD PMID:26811028 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein CTD PMID:23056435, PMID:26811028 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1B protein CTD PMID:26811028 NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
JBrowse link
G Pprc1 PPARG related coactivator 1 increases expression ISO Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein CTD PMID:26811028 NCBI chr 1:265,809,892...265,826,319
Ensembl chr 1:265,809,754...265,826,306
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Oxaloacetic Acid results in increased expression of TFAM mRNA CTD PMID:26811028 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            oxaloacetic acid 8
              oxaloacetic acid 4-methyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      dicarboxylic acids and O-substituted derivatives 10271
                                        dicarboxylic acid 10264
                                          alpha,omega-dicarboxylic acid 2773
                                            succinic acid 216
                                              oxaloacetic acid 8
                                                oxaloacetic acid 4-methyl ester 0
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