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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethylene glycol
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Accession:CHEBI:30742 term browser browse the term
Definition:A 1,2-glycol compound produced via reaction of ethylene oxide with water.
Synonyms:related_synonym: 1,2-Dihydroxyethane;   1,2-ETHANEDIOL;   2-Hydroxyethanol;   Ethane-1,2-diol;   Ethanediol;   Formula=C2H6O2;   Glycol;   HO-CH2-CH2-OH;   InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2;   InChIKey=LYCAIKOWRPUZTN-UHFFFAOYSA-N;   Monoethylene glycol;   SMILES=OCCO
 alt_id: CHEBI:21317;   CHEBI:42277;   CHEBI:5473
 xref: Beilstein:505945;   CAS:107-21-1;   Gmelin:943;   KEGG:C01380;   KEGG:C15588;   KNApSAcK:C00007409
 xref_mesh: MESH:D019855
 xref: MetaCyc:GLYCOL;   PDBeChem:EDO;   PMID:10349109;   PMID:15716482;   PMID:16901854;   PMID:17186009;   PMID:17336832;   PMID:17439666;   PMID:17979222;   PMID:18612987;   PMID:23764541;   PMID:23827374;   PMID:24045699;   PMID:24643482;   PMID:25108762;   PMID:9463526;   PPDB:1310;   Reaxys:505945;   UM-BBD_compID:c0542;   Wikipedia:Ethylene_Glycol


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ethylene glycol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) increases oxidation ISO ADH1C protein results in increased oxidation of Ethylene Glycol CTD PMID:21167143 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide increases oxidation ISO ADH4 protein results in increased oxidation of Ethylene Glycol CTD PMID:21167143 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases oxidation ISO ADH7 protein results in increased oxidation of Ethylene Glycol CTD PMID:21167143 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Ethylene Glycol results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G C5 complement C5 multiple interactions ISO [Ethylene Glycol co-treated with Asbestos, Crocidolite] results in increased cleavage of C5 protein; [Ethylene Glycol co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein CTD PMID:10777245 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Cat catalase decreases activity
increases activity
multiple interactions
EXP Ethylene Glycol results in decreased activity of CAT protein
Ethylene Glycol results in increased activity of CAT protein
acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased activity of CAT protein]
CTD PMID:24145091, PMID:27018375 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO
EXP
Ethylene Glycol results in increased expression of CCL2 mRNA
Ethylene Glycol results in increased expression of CCL2 mRNA; Ethylene Glycol results in increased expression of CCL2 protein
acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 mRNA]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]
CTD PMID:16284884, PMID:21907259, PMID:27018375 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression
multiple interactions
EXP Ethylene Glycol results in increased expression of CCL5 protein
benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]; PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]
CTD PMID:16284884 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Ethylene Glycol results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Ethylene Glycol results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081
JBrowse link
G Gh1 growth hormone 1 affects folding ISO Ethylene Glycol affects the folding of GH1 protein CTD PMID:11064379 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO
EXP
Ethylene Glycol results in increased expression of HAVCR1 mRNA CTD PMID:21907259 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hoxb7 homeo box B7 increases expression ISO Ethylene Glycol results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:84,135,224...84,138,642
Ensembl chr10:84,135,116...84,138,637
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP Ethylene Glycol results in increased expression of IL6 mRNA; Ethylene Glycol results in increased expression of IL6 protein
[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of IL6 mRNA]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]
CTD PMID:16284884, PMID:27018375, PMID:27241030 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Ethylene Glycol results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Nefh neurofilament heavy affects expression EXP Ethylene Glycol affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Ethylene Glycol results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]; PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Ethylene Glycol results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835
JBrowse link
G Pax3 paired box 3 decreases expression ISO Ethylene Glycol results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
EXP acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of RELA mRNA] CTD PMID:27018375 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc26a1 solute carrier family 26 member 1 increases expression EXP Ethylene Glycol results in increased expression of SLC26A1 protein CTD PMID:26526882 NCBI chr14:2,050,805...2,056,091
Ensembl chr14:2,050,483...2,056,089
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
EXP [Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein] CTD PMID:24145091, PMID:27018375, PMID:27241030 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Ethylene Glycol results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504
JBrowse link
G Tf transferrin multiple interactions
increases expression
EXP [Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of TF protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of TF protein] CTD PMID:27018375, PMID:27241030 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP Ethylene Glycol results in increased expression of TNF mRNA; Ethylene Glycol results in increased expression of TNF protein
[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of TNF protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of TNF mRNA]
CTD PMID:27018375, PMID:27241030 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Umod uromodulin multiple interactions
increases expression
EXP [Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of UMOD protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of and affects the localization of UMOD protein]; Ethylene Glycol results in increased expression of and affects the localization of UMOD protein CTD PMID:27018375, PMID:27241030 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link
G Uncx UNC homeobox decreases expression ISO Ethylene Glycol results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:17,182,158...17,186,679
Ensembl chr12:17,182,163...17,186,679
JBrowse link
G Vnn1 vanin 1 increases expression EXP
ISO
Ethylene Glycol results in increased expression of VNN1 mRNA; Ethylene Glycol results in increased expression of VNN1 protein CTD PMID:21907259 NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204
JBrowse link
2-ethoxyethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 AKT serine/threonine kinase 2 increases expression EXP 2-ethoxyethanol results in increased expression of AKT2 mRNA CTD PMID:19643169 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 increases expression EXP 2-ethoxyethanol results in increased expression of AKT3 mRNA CTD PMID:19643169 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases reaction ISO ALDH2 protein promotes the reaction 2-ethoxyethanol CTD PMID:17878629 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G App amyloid beta precursor protein increases expression EXP 2-ethoxyethanol results in increased expression of APP mRNA CTD PMID:19643169 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arf3 ADP-ribosylation factor 3 increases expression EXP 2-ethoxyethanol results in increased expression of ARF3 mRNA CTD PMID:19643169 NCBI chr 7:140,412,463...140,438,751
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Atf2 activating transcription factor 2 increases expression EXP 2-ethoxyethanol results in increased expression of ATF2 mRNA CTD PMID:19643169 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bag6 BAG cochaperone 6 increases expression EXP 2-ethoxyethanol results in increased expression of BAG6 mRNA CTD PMID:19643169 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP 2-ethoxyethanol results in increased expression of BCL2L1 mRNA CTD PMID:19643169 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Cat catalase decreases activity EXP 2-ethoxyethanol results in decreased activity of CAT protein CTD PMID:20172899 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 increases expression EXP 2-ethoxyethanol results in increased expression of CAV mRNA CTD PMID:19643169 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression EXP 2-ethoxyethanol results in increased expression of CEBPG mRNA CTD PMID:19643169 NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656
JBrowse link
G Cel carboxyl ester lipase increases expression EXP 2-ethoxyethanol results in increased expression of CEL mRNA CTD PMID:19643169 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 increases expression EXP 2-ethoxyethanol results in increased expression of CHP1 mRNA CTD PMID:19643169 NCBI chr 3:111,354,506...111,389,998
Ensembl chr 3:111,354,506...111,389,989
JBrowse link
G Cltc clathrin heavy chain increases expression EXP 2-ethoxyethanol results in increased expression of CLTC mRNA CTD PMID:19643169 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 increases expression EXP 2-ethoxyethanol results in increased expression of CSNK1A1 mRNA CTD PMID:19643169 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
JBrowse link
G Csnk1d casein kinase 1, delta increases expression EXP 2-ethoxyethanol results in increased expression of CSNK1D mRNA CTD PMID:19643169 NCBI chr10:110,147,786...110,182,413
Ensembl chr10:110,148,600...110,182,408
JBrowse link
G Csnk1g3 casein kinase 1, gamma 3 increases expression EXP 2-ethoxyethanol results in increased expression of CSNK1G3 mRNA CTD PMID:19643169 NCBI chr18:48,831,209...48,913,341
Ensembl chr18:48,853,418...48,911,122
JBrowse link
G Cttn cortactin increases expression EXP 2-ethoxyethanol results in increased expression of CTTN mRNA CTD PMID:19643169 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP 2-ethoxyethanol results in increased expression of DHCR7 mRNA CTD PMID:19643169 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 decreases expression EXP 2-ethoxyethanol results in decreased expression of DYNC1LI1 mRNA CTD PMID:19643169 NCBI chr 8:122,743,274...122,776,801
Ensembl chr 8:122,743,189...122,776,806
JBrowse link
G Eloa elongin A increases expression EXP 2-ethoxyethanol results in increased expression of ELOA mRNA CTD PMID:19643169 NCBI chr 5:154,348,167...154,363,324
Ensembl chr 5:154,347,391...154,363,329
JBrowse link
G Eno2 enolase 2 increases expression EXP 2-ethoxyethanol results in increased expression of ENO2 mRNA CTD PMID:19643169 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Epn2 epsin 2 increases expression EXP 2-ethoxyethanol results in increased expression of EPN2 mRNA CTD PMID:19643169 NCBI chr10:47,795,496...47,857,373
Ensembl chr10:47,795,524...47,857,326
JBrowse link
G Gata4 GATA binding protein 4 increases expression EXP 2-ethoxyethanol results in increased expression of GATA4 mRNA CTD PMID:19643169 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gata6 GATA binding protein 6 increases expression EXP 2-ethoxyethanol results in increased expression of GATA6 mRNA CTD PMID:19643169 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression EXP 2-ethoxyethanol results in increased expression of GDI2 mRNA CTD PMID:19643169 NCBI chr17:70,299,177...70,325,864
Ensembl chr17:70,299,183...70,325,855
JBrowse link
G Hk1 hexokinase 1 increases expression EXP 2-ethoxyethanol results in increased expression of HK1 mRNA CTD PMID:19643169 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649
JBrowse link
G Hk2 hexokinase 2 increases expression EXP 2-ethoxyethanol results in increased expression of HK2 mRNA CTD PMID:19643169 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP 2-ethoxyethanol results in increased expression of IGF2 mRNA CTD PMID:19643169 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Jak2 Janus kinase 2 increases expression EXP 2-ethoxyethanol results in increased expression of JAK2 mRNA CTD PMID:19643169 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase increases expression EXP 2-ethoxyethanol results in increased expression of LYN mRNA CTD PMID:19643169 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 decreases expression EXP 2-ethoxyethanol results in decreased expression of MAP3K12 mRNA CTD PMID:19643169 NCBI chr 7:144,102,275...144,120,306
Ensembl chr 7:144,102,680...144,109,116
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP 2-ethoxyethanol results in increased expression of MAPK1 mRNA CTD PMID:19643169 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression EXP 2-ethoxyethanol results in increased expression of MAPK10 mRNA CTD PMID:19643169 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression EXP 2-ethoxyethanol results in increased expression of MXI1 mRNA CTD PMID:19643169 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071
JBrowse link
G Nab1 Ngfi-A binding protein 1 increases expression EXP 2-ethoxyethanol results in increased expression of NAB1 mRNA CTD PMID:19643169 NCBI chr 9:53,906,073...53,945,474
Ensembl chr 9:53,906,073...53,945,473
JBrowse link
G Nfia nuclear factor I/A increases expression EXP 2-ethoxyethanol results in increased expression of NFIA mRNA CTD PMID:19643169 NCBI chr 5:116,421,895...116,750,381
Ensembl chr 5:116,420,690...116,751,416
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 increases expression EXP 2-ethoxyethanol results in increased expression of NR2F2 mRNA CTD PMID:19643169 NCBI chr 1:131,447,671...131,465,749
Ensembl chr 1:131,448,447...131,460,473
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 increases expression EXP 2-ethoxyethanol results in increased expression of PAK2 mRNA CTD PMID:19643169 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 increases expression EXP 2-ethoxyethanol results in increased expression of PFKFB2 mRNA CTD PMID:19643169 NCBI chr13:47,413,453...47,440,682
Ensembl chr13:47,413,458...47,440,682
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression EXP 2-ethoxyethanol results in increased expression of PLA2G4A mRNA CTD PMID:19643169 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plcb3 phospholipase C beta 3 increases expression EXP 2-ethoxyethanol results in increased expression of PLCB3 mRNA CTD PMID:19643169 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Pou2f3 POU class 2 homeobox 3 increases expression EXP 2-ethoxyethanol results in increased expression of POU2F3 mRNA CTD PMID:19643169 NCBI chr 8:47,412,063...47,495,042
Ensembl chr 8:47,410,220...47,494,982
JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha increases expression EXP 2-ethoxyethanol results in increased expression of PRKAR2A mRNA CTD PMID:19643169 NCBI chr 8:117,486,085...117,548,768
Ensembl chr 8:117,486,083...117,546,370
JBrowse link
G Rab5a RAB5A, member RAS oncogene family increases expression EXP 2-ethoxyethanol results in increased expression of RAB5A mRNA CTD PMID:19643169 NCBI chr 9:5,910...6,065 JBrowse link
G Rnf4 ring finger protein 4 increases expression EXP 2-ethoxyethanol results in increased expression of RNF4 mRNA CTD PMID:19643169 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082
JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase increases expression EXP 2-ethoxyethanol results in increased expression of ROS1 mRNA CTD PMID:19643169 NCBI chr20:33,100,190...33,323,544
Ensembl chr20:33,100,191...33,323,367
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 increases expression EXP 2-ethoxyethanol results in increased expression of SEC14L2 mRNA CTD PMID:19643169 NCBI chr14:84,335,594...84,360,354
Ensembl chr14:84,335,597...84,355,528
JBrowse link
G Sik1 salt-inducible kinase 1 increases expression EXP 2-ethoxyethanol results in increased expression of SIK1 mRNA CTD PMID:19643169 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Snrk SNF related kinase increases expression EXP 2-ethoxyethanol results in increased expression of SNRK mRNA CTD PMID:19643169 NCBI chr 8:130,749,806...130,805,225
Ensembl chr 8:130,749,838...130,803,597
JBrowse link
G Snx16 sorting nexin 16 increases expression EXP 2-ethoxyethanol results in increased expression of SNX16 mRNA CTD PMID:19643169 NCBI chr 2:93,518,796...93,541,056
Ensembl chr 2:93,518,806...93,540,328
JBrowse link
G Soat1 sterol O-acyltransferase 1 increases expression EXP 2-ethoxyethanol results in increased expression of SOAT1 mRNA CTD PMID:19643169 NCBI chr13:74,035,258...74,077,759
Ensembl chr13:74,035,080...74,077,783
JBrowse link
G Stk17b serine/threonine kinase 17b increases expression EXP 2-ethoxyethanol results in increased expression of STK17B mRNA CTD PMID:19643169 NCBI chr 9:60,399,261...60,430,081
Ensembl chr 9:60,399,261...60,430,081
JBrowse link
G Stx2 syntaxin 2 increases expression EXP 2-ethoxyethanol results in increased expression of STX2 mRNA CTD PMID:19643169 NCBI chr12:31,324,203...31,360,249
Ensembl chr12:31,335,372...31,360,254
JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression EXP 2-ethoxyethanol results in increased expression of STXBP1 mRNA CTD PMID:19643169 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Sycp1 synaptonemal complex protein 1 decreases expression EXP 2-ethoxyethanol results in decreased expression of SYCP1 mRNA CTD PMID:19643169 NCBI chr 2:205,274,766...205,426,869
Ensembl chr 2:205,274,769...205,426,869
JBrowse link
G Sycp2 synaptonemal complex protein 2 decreases expression EXP 2-ethoxyethanol results in decreased expression of SYCP2 mRNA CTD PMID:19643169 NCBI chr 3:173,884,559...173,948,304
Ensembl chr 3:173,884,287...173,947,018
JBrowse link
G Sycp3 synaptonemal complex protein 3 decreases expression EXP 2-ethoxyethanol results in decreased expression of SYCP3 mRNA CTD PMID:19643169 NCBI chr 7:29,029,887...29,044,344
Ensembl chr 7:29,029,263...29,044,251
JBrowse link
G Tle4 TLE family member 4, transcriptional corepressor increases expression EXP 2-ethoxyethanol results in increased expression of TLE4 mRNA CTD PMID:19643169 NCBI chr 1:231,394,606...231,531,396
Ensembl chr 1:231,393,379...231,530,786
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 increases expression EXP 2-ethoxyethanol results in increased expression of TMED2 mRNA CTD PMID:19643169 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
G Wt1 WT1 transcription factor increases expression EXP 2-ethoxyethanol results in increased expression of WT1 mRNA CTD PMID:19643169 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link
G Yy1 YY1 transcription factor increases expression EXP 2-ethoxyethanol results in increased expression of YY1 mRNA CTD PMID:19643169 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link
2-hydroxyethyl methacrylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO hydroxyethyl methacrylate results in increased expression of ADM mRNA CTD PMID:30497689 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C2 mRNA CTD PMID:30497689 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C3 mRNA CTD PMID:30497689 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression ISO hydroxyethyl methacrylate results in increased expression of ALDH3A2 mRNA CTD PMID:30497689 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO hydroxyethyl methacrylate results in increased expression of ATG5 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]
CTD PMID:28184909 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO hydroxyethyl methacrylate results in increased expression of BECN1 mRNA; hydroxyethyl methacrylate results in increased expression of BECN1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]
CTD PMID:28184909 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA] CTD PMID:28184909 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO hydroxyethyl methacrylate results in decreased expression of COL1A1 mRNA; hydroxyethyl methacrylate results in decreased expression of COL1A1 protein CTD PMID:20668299 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO hydroxyethyl methacrylate results in decreased expression of CXCL12 protein CTD PMID:30517439 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO hydroxyethyl methacrylate results in increased expression of DNAJB4 mRNA CTD PMID:30497689 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Fbxo30 F-box protein 30 increases expression ISO hydroxyethyl methacrylate results in increased expression of FBXO30 mRNA CTD PMID:30497689 NCBI chr 1:5,366,119...5,389,774
Ensembl chr 1:5,366,379...5,388,069
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases secretion
ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein] CTD PMID:19176594 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of FTH1 mRNA CTD PMID:30497689 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLC mRNA; hydroxyethyl methacrylate results in increased expression of GCLC protein CTD PMID:30497689 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLM mRNA; hydroxyethyl methacrylate results in increased expression of GCLM protein CTD PMID:30497689 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of HMOX1 mRNA; hydroxyethyl methacrylate results in increased expression of HMOX1 protein CTD PMID:30497689 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1A mRNA CTD PMID:30497689 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1B mRNA CTD PMID:30497689 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Buthionine Sulfoximine promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; hydroxyethyl methacrylate promotes the reaction [triethylene glycol dimethacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; triethylene glycol dimethacrylate promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] CTD PMID:23182953, PMID:28188892 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydroxyethyl methacrylate results in decreased secretion of IL6 protein CTD PMID:19176594 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA; hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein]
CTD PMID:28184909 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 increases expression ISO hydroxyethyl methacrylate results in increased expression of MAP3K14 mRNA CTD PMID:30497689 NCBI chr10:91,303,428...91,353,601
Ensembl chr10:91,303,428...91,353,601
JBrowse link
G Mrpl19 mitochondrial ribosomal protein L19 increases expression ISO hydroxyethyl methacrylate results in increased expression of MRPL19 mRNA CTD PMID:30497689 NCBI chr 4:112,703,041...112,707,270
Ensembl chr 4:112,703,041...112,707,270
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO hydroxyethyl methacrylate results in increased expression of NFE2L2 protein CTD PMID:30497689 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha increases response to substance
multiple interactions
ISO NFKBIA protein results in increased susceptibility to hydroxyethyl methacrylate
NFKBIA protein affects the reaction [Acetylcysteine results in decreased susceptibility to hydroxyethyl methacrylate]
CTD PMID:19176594 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of NQO1 mRNA; hydroxyethyl methacrylate results in increased expression of NQO1 protein CTD PMID:30497689 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of OSGIN1 mRNA CTD PMID:30497689 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased cleavage of PARP1 protein] CTD PMID:28184909 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein]; hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein; hydroxyethyl methacrylate affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein; hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:19176594, PMID:28184909 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SPSB1 mRNA CTD PMID:30497689 NCBI chr 5:166,913,734...166,978,534
Ensembl chr 5:166,913,735...166,926,636
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SQSTM1 mRNA; hydroxyethyl methacrylate results in increased expression of SQSTM1 protein CTD PMID:30497689 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SRXN1 mRNA CTD PMID:30497689 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein]
hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; hydroxyethyl methacrylate promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:19176594, PMID:23182953, PMID:28188892 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of TXNRD1 mRNA CTD PMID:30497689 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO hydroxyethyl methacrylate results in increased expression of UGDH mRNA CTD PMID:30497689 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases secretion
ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein] CTD PMID:19176594 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
ethylene glycol dimethacrylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity ISO ethylene dimethacrylate results in increased activity of AKR1C2 promoter CTD PMID:21195160 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO ethylene dimethacrylate results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO BACH1 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA] CTD PMID:26244607 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Cd86 CD86 molecule increases expression ISO ethylene dimethacrylate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO ethylene dimethacrylate results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO ethylene dimethacrylate results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO ethylene dimethacrylate results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO ethylene dimethacrylate results in increased expression of GPX4 CTD PMID:29107684 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO ethylene dimethacrylate results in increased expression of HMOX1 mRNA
BACH1 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA]
CTD PMID:26244607 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO ethylene dimethacrylate results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA] CTD PMID:26244607 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO ethylene dimethacrylate results in increased expression of SOD2 CTD PMID:29107684 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
macitentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO macitentan results in decreased expression of ABCB1 mRNA CTD PMID:28369585 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO macitentan results in decreased expression of ABCC2 mRNA CTD PMID:28369585 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression ISO macitentan results in decreased expression of ABCC3 mRNA CTD PMID:28369585 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO macitentan results in decreased expression of SLC10A1 mRNA CTD PMID:28369585 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        solvent 16456
          ethylene glycol 135
            1,2-dimethoxyethane 0
            2-ethoxyethanol + 62
            2-hydroxyethyl hexadecanoate 0
            2-hydroxyethyl methacrylate 36
            2-hydroxyethyl salicylate 0
            2-hydroxyethyl sulfonate 0
            4-[(2-hydroxyethoxy)carbonyl]benzoic acid 0
            6-(2-hydroxyethoxy)-6-oxohexanoic acid 0
            ACT-132577 + 4
            TCA-ethadyl 0
            ethylene glycol bis(2-aminoethyl)tetraacetate 0
            ethylene glycol dimethacrylate 12
            ethylene glycol monododecyl ether 0
            ethylene glycol monophosphate 0
            macitentan 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              organic hydroxy compound 18630
                                polyol 7802
                                  diol 2718
                                    glycol 2449
                                      ethylene glycol 135
                                        1,2-dimethoxyethane 0
                                        2-ethoxyethanol + 62
                                        2-hydroxyethyl hexadecanoate 0
                                        2-hydroxyethyl methacrylate 36
                                        2-hydroxyethyl salicylate 0
                                        2-hydroxyethyl sulfonate 0
                                        4-[(2-hydroxyethoxy)carbonyl]benzoic acid 0
                                        6-(2-hydroxyethoxy)-6-oxohexanoic acid 0
                                        ACT-132577 + 4
                                        TCA-ethadyl 0
                                        ethylene glycol bis(2-aminoethyl)tetraacetate 0
                                        ethylene glycol dimethacrylate 12
                                        ethylene glycol monododecyl ether 0
                                        ethylene glycol monophosphate 0
                                        macitentan 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.