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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethylene glycol bis(2-aminoethyl)tetraacetic acid
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Accession:CHEBI:30740 term browser browse the term
Definition:A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.
Synonyms:exact_synonym: 2,2',2'',2'''-[ethane-1,2-diylbis(oxyethane-2,1-diylnitrilo)]tetraacetic acid
 related_synonym: 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid;   EGTA;   Egtazic acid;   Formula=C14H24N2O10;   H4egta;   InChI=1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24);   InChIKey=DEFVIWRASFVYLL-UHFFFAOYSA-N;   SMILES=OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O;   [ethylenebis(oxyethylenenitrilo)]tetraacetic acid;   ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid;   ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid
 xref: Beilstein:1717370;   CAS:67-42-5;   Gmelin:234970
 xref_mesh: MESH:D004533
 xref: PMID:11034152;   PMID:18804143;   Reaxys:1717370;   Wikipedia:EGTA_(chemical)


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ethylene glycol bis(2-aminoethyl)tetraacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP [Egtazic Acid co-treated with Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone] inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species] CTD PMID:18854758 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:21544200 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of ATG7 protein] CTD PMID:30266318 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of BECN1 protein] CTD PMID:30266318 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G C5 complement C5 multiple interactions ISO [Egtazic Acid co-treated with Asbestos, Crocidolite] results in increased cleavage of C5 protein; [Egtazic Acid co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein CTD PMID:10777245 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Egtazic Acid inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] CTD PMID:11073891 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Egtazic Acid inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Egtazic Acid promotes the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
[1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]
CTD PMID:19837105 PMID:20020783 PMID:21544200 PMID:29111403 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cck cholecystokinin multiple interactions ISO Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein] CTD PMID:25787141 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased secretion of CCL5 protein] CTD PMID:21245013 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cfl1 cofilin 1 multiple interactions ISO Egtazic Acid inhibits the reaction [Capsaicin results in decreased phosphorylation of and results in increased activity of CFL1 protein]; Egtazic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of and results in increased activity of CFL1 protein] CTD PMID:17303079 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions EXP
ISO
[Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester] inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]
Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of CGA mRNA]
CTD PMID:27554787 PMID:28731686 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
JBrowse link
G Col6a3 collagen type VI alpha 3 chain multiple interactions ISO [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]; [Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] CTD PMID:18435905 NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation ISO Egtazic Acid results in decreased phosphorylation of CREB1 protein CTD PMID:21443188 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]] CTD PMID:21443188 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions EXP Egtazic Acid inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein] CTD PMID:16187300 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Egtazic Acid inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Egtazic Acid inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased secretion of CXCL10 protein] CTD PMID:21245013 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of CYP11A1 mRNA] CTD PMID:28731686 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Egtazic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Egtazic Acid inhibits the reaction [Amiodarone results in increased expression of DDIT3]
[Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]
CTD PMID:21292685 PMID:29111403 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of EGR1 protein] CTD PMID:29149324 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:21544200 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of FOS protein] CTD PMID:29149324 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of FSHB mRNA]; Egtazic Acid inhibits the reaction [cypermethrin results in increased secretion of FSHB protein] CTD PMID:28731686 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO Egtazic Acid inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Gcg glucagon multiple interactions ISO Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form] CTD PMID:25787141 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gnal G protein subunit alpha L multiple interactions ISO Egtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to azelaic acid] which results in increased activity of OLFR544 protein]; Egtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein]; Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to azelaic acid]; Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to citronellal]; Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to Isoproterenol] CTD PMID:15598656 NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO Egtazic Acid inhibits the reaction [[GNAS protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein]; Egtazic Acid inhibits the reaction [GNAS protein results in increased susceptibility to citronellal]; Egtazic Acid inhibits the reaction [GNAS protein results in increased susceptibility to Isoproterenol] CTD PMID:15598656 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; Egtazic Acid inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] CTD PMID:18357586 PMID:21443188 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO Egtazic Acid results in decreased susceptibility to IGF1 protein CTD PMID:16485066 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf2 insulin-like growth factor 2 decreases response to substance ISO Egtazic Acid results in decreased susceptibility to IGF2 protein CTD PMID:16485066 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Egtazic Acid inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA] CTD PMID:16173059 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of JUN protein] CTD PMID:29149324 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Egtazic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Kif5a kinesin family member 5A multiple interactions ISO Egtazic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [KIF5A protein results in increased hydrolysis of Adenosine Triphosphate]]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of KIF5A protein]; Egtazic Acid inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein] CTD PMID:24239783 PMID:24853401 NCBI chr 7:63,051,894...63,089,024
Ensembl chr 7:63,049,424...63,092,858
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of LHB mRNA]; Egtazic Acid inhibits the reaction [cypermethrin results in increased secretion of LHB protein] CTD PMID:28731686 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions EXP Egtazic Acid inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] CTD PMID:11073891 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [Calcimycin results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [Thapsigargin results in increased activity of MAPK1 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased localization of MAPK1 protein modified form]
CTD PMID:11914123 PMID:11981161 PMID:19576918 PMID:21245013 PMID:21544200 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK14 protein] CTD PMID:21544200 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Egtazic Acid inhibits the reaction [Calcimycin results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [Thapsigargin results in increased activity of MAPK3 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Egtazic Acid inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased localization of MAPK3 protein modified form]
CTD PMID:11914123 PMID:11981161 PMID:19576918 PMID:21245013 PMID:21544200 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]
CTD PMID:11981161 PMID:15254339 PMID:21544200 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]
CTD PMID:11981161 PMID:15254339 PMID:21544200 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]; Egtazic Acid inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein] CTD PMID:21245013 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein] CTD PMID:21544200 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain multiple interactions EXP [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] CTD PMID:21443188 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
ISO Egtazic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of NOS1 protein alternative form]
Egtazic Acid results in decreased expression of NOS1 protein alternative form
CTD PMID:16791854 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO Egtazic Acid results in decreased expression of NOS3; Egtazic Acid results in decreased expression of NOS3 mRNA CTD PMID:19837105 PMID:20020783 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Olr1646 olfactory receptor 1646 multiple interactions ISO Egtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein]; Egtazic Acid inhibits the reaction [[GNAS protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein] CTD PMID:15598656 NCBI chr15:27,733,881...27,734,825
Ensembl chr15:27,729,827...27,736,945
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]
[1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Egtazic Acid inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
CTD PMID:21544200 PMID:29111403 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Egtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:19576918 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pla2g1b phospholipase A2 group IB decreases activity ISO Egtazic Acid results in decreased activity of PLA2G1B protein CTD PMID:15528384 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
ISO
EXP
Egtazic Acid results in decreased activity of PON1 protein
[Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate; [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to methylparaoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Paraoxon
[Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to methylparaoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Paraoxon
CTD PMID:27132127 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions EXP [Egtazic Acid co-treated with Calcium deficiency] results in increased expression of PPP1R15A mRNA CTD PMID:9878749 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Egtazic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein] CTD PMID:20172950 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP Egtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] CTD PMID:16877402 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Egtazic Acid inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of RAF1 protein] CTD PMID:29149324 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6 protein] CTD PMID:21544200 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP
ISO
Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
Egtazic Acid inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:14516795 PMID:21544200 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Egtazic Acid inhibits the reaction [Potassium Chloride results in increased secretion of SOD1 protein] CTD PMID:28085149 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Srr serine racemase multiple interactions ISO
EXP
[methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein CTD PMID:24012499 NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO
EXP
Egtazic Acid inhibits the reaction [cypermethrin results in increased expression of STAR mRNA]; Egtazic Acid inhibits the reaction [Quercetin results in increased expression of STAR mRNA]
[Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester] inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]
CTD PMID:17332522 PMID:27554787 PMID:28731686 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Egtazic Acid inhibits the reaction [TNF protein results in increased transport of Chlorides]; Egtazic Acid inhibits the reaction [TNF protein results in increased transport of Potassium] CTD PMID:10783394 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Egtazic Acid inhibits the reaction [Capsaicin results in increased expression of TNFSF10 mRNA] CTD PMID:22200406 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Egtazic Acid inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Egtazic Acid inhibits the reaction [Capsaicin binds to and results in increased activity of TRPV1 protein]; Egtazic Acid inhibits the reaction [N-(4-hydroxyphenyl)arachidonylamide binds to and results in increased activity of TRPV1 protein] CTD PMID:11278420 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Vim vimentin multiple interactions EXP [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      chemical role 19332
        ligand 5818
          chelator 5804
            ethylene glycol bis(2-aminoethyl)tetraacetic acid 71
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic acid 18361
                                        tetracarboxylic acid 494
                                          ethylene glycol bis(2-aminoethyl)tetraacetic acid 71
paths to the root