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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aflatoxin B1 exo-8,9-epoxide
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Accession:CHEBI:30725 term browser browse the term
Definition:An aflatoxin that has formula C17H12O7.
Synonyms:exact_synonym: (6aS,7aS,8aR,8bR)-4-methoxy-2,3,6a,7a,8a,8b-hexahydrocyclopenta[c]oxireno[4',5']furo[3',2':4,5]furo[2,3-h]chromene-1,10-dione
 related_synonym: 2,3-Epoxyaflatoxin B1;   Aflatoxin B1 2,3-epoxide;   Aflatoxin B1 8,9-epoxide;   Aflatoxin B1 exo-8,9-oxide;   Aflatoxin B1-2,3-oxide;   Formula=C17H12O7;   InChI=1S/C17H12O7/c1-20-7-4-8-11(12-14-17(23-14)24-16(12)21-8)13-10(7)5-2-3-6(18)9(5)15(19)22-13/h4,12,14,16-17H,2-3H2,1H3/t12-,14-,16+,17+/m1/s1;   InChIKey=KHBXRZGALJGBPA-IRWJRLHMSA-N;   SMILES=[H][C@@]12Oc3cc(OC)c4c5CCC(=O)c5c(=O)oc4c3[C@]1([H])[C@@]1([H])O[C@@]1([H])O2
 xref: CAS:42583-46-0;   KEGG:C19586
 xref_mesh: MESH:C006426



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aflatoxin B1 exo-8,9-epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide CTD PMID:20707407 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide CTD PMID:20707407 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP [GSTA3 protein binds to GSTA5 protein] which affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide CTD PMID:8051171 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects metabolic processing
increases metabolic processing
increases glutathionylation
ISO GSTA3 protein affects the metabolism of aflatoxin B1-2,3-oxide
GSTA3 protein results in increased metabolism of aflatoxin B1-2,3-oxide
GSTA3 protein results in increased glutathionylation of aflatoxin B1-2,3-oxide
CTD PMID:1637297 PMID:12388831 PMID:14573750 PMID:21876218 PMID:23613737 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
affects metabolic processing
EXP [GSTA3 protein binds to GSTA5 protein] which affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide; Butylated Hydroxyanisole promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Butylated Hydroxytoluene promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Ethoxyquin promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; GSTA5 protein affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide; GSTA5 protein binds to and affects the metabolism of aflatoxin B1-2,3-oxide; Phenobarbital promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide] CTD PMID:1637297 PMID:8051171 PMID:8198522 PMID:8625305 PMID:8761455 More... NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP GSTM1 protein affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide CTD PMID:1638515 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing EXP GSTP1 protein affects the metabolism of aflatoxin B1-2,3-oxide CTD PMID:1638515 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        poison 18479
          toxin 15299
            mycotoxin 11908
              aflatoxin 11099
                aflatoxin B1 exo-8,9-epoxide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                organic heterocyclic compound 18804
                                  organic heteropolycyclic compound 18274
                                    organic heteropentacyclic compound 13411
                                      cyclopentafurofurochromene 11099
                                        aflatoxin 11099
                                          aflatoxin B1 exo-8,9-epoxide 7
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