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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aflatoxin B1 exo-8,9-epoxide
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Accession:CHEBI:30725 term browser browse the term
Definition:An aflatoxin that has formula C17H12O7.
Synonyms:exact_synonym: (6aS,7aS,8aR,8bR)-4-methoxy-2,3,6a,7a,8a,8b-hexahydrocyclopenta[c]oxireno[4',5']furo[3',2':4,5]furo[2,3-h]chromene-1,10-dione
 related_synonym: 2,3-Epoxyaflatoxin B1;   Aflatoxin B1 2,3-epoxide;   Aflatoxin B1 8,9-epoxide;   Aflatoxin B1 exo-8,9-oxide;   Aflatoxin B1-2,3-oxide;   Formula=C17H12O7;   InChI=1S/C17H12O7/c1-20-7-4-8-11(12-14-17(23-14)24-16(12)21-8)13-10(7)5-2-3-6(18)9(5)15(19)22-13/h4,12,14,16-17H,2-3H2,1H3/t12-,14-,16+,17+/m1/s1;   InChIKey=KHBXRZGALJGBPA-IRWJRLHMSA-N;   SMILES=[H][C@@]12Oc3cc(OC)c4c5CCC(=O)c5c(=O)oc4c3[C@]1([H])[C@@]1([H])O[C@@]1([H])O2
 xref: CAS:42583-46-0;   KEGG:C19586
 xref_mesh: MESH:C006426


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aflatoxin B1 exo-8,9-epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide CTD PMID:20707407 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2,3-oxide CTD PMID:20707407 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP [GSTA3 protein binds to GSTA5 protein] which affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide CTD PMID:8051171 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects metabolic processing
increases metabolic processing
increases glutathionylation
ISO GSTA3 protein affects the metabolism of aflatoxin B1-2,3-oxide
GSTA3 protein results in increased metabolism of aflatoxin B1-2,3-oxide
GSTA3 protein results in increased glutathionylation of aflatoxin B1-2,3-oxide
CTD PMID:1637297 PMID:12388831 PMID:14573750 PMID:21876218 PMID:23613737 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
affects metabolic processing
EXP [GSTA3 protein binds to GSTA5 protein] which affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide; Butylated Hydroxyanisole promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Butylated Hydroxytoluene promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Ethoxyquin promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; GSTA5 protein affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide; GSTA5 protein binds to and affects the metabolism of aflatoxin B1-2,3-oxide; Phenobarbital promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide] CTD PMID:1637297 PMID:8051171 PMID:8198522 PMID:8625305 PMID:8761455 PMID:10085232 PMID:12388831 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP GSTM1 protein affects the metabolism of and results in decreased activity of aflatoxin B1-2,3-oxide CTD PMID:1638515 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing EXP GSTP1 protein affects the metabolism of aflatoxin B1-2,3-oxide CTD PMID:1638515 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      biological role 19804
        poison 18122
          toxin 14246
            mycotoxin 12066
              aflatoxin 11294
                aflatoxin B1 exo-8,9-epoxide 7
Path 2
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  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  organic heteropolycyclic compound 17883
                                    organic heteropentacyclic compound 13241
                                      cyclopentafurofurochromene 11294
                                        aflatoxin 11294
                                          aflatoxin B1 exo-8,9-epoxide 7
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