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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ruthenium atom
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Accession:CHEBI:30682 term browser browse the term
Definition:An iron group element atom that has formula Ru.
Synonyms:related_synonym: 44Ru;   Formula=Ru;   InChI=1S/Ru;   InChIKey=KJTLSVCANCCWHF-UHFFFAOYSA-N;   Ru;   SMILES=[Ru];   rutenio;   ruthenium
 xref: CAS:7440-18-8
 xref_mesh: MESH:D012428
 xref: WebElements:Ru



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ruthenium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa5 annexin A5 increases expression ISO Ruthenium results in increased expression of ANXA5 protein CTD PMID:17210701 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation ISO Ruthenium results in decreased phosphorylation of BAD protein CTD PMID:17210701 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Ruthenium results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:17210701 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ruthenium results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:17210701 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ckb creatine kinase B decreases activity
increases activity
EXP Ruthenium results in decreased activity of CKB protein
Ruthenium results in increased activity of CKB protein
CTD PMID:17109965 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type decreases activity EXP Ruthenium results in decreased activity of CKM protein CTD PMID:17109965 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases activity ISO Ruthenium results in decreased activity of GSK3A protein CTD PMID:17210701 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO Ruthenium results in decreased activity of GSK3B protein CTD PMID:17210701 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO Ruthenium results in decreased expression of MDM2 protein CTD PMID:17210701 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mdm4 MDM4 regulator of p53 decreases expression ISO Ruthenium results in decreased expression of MDM4 protein CTD PMID:17210701 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) promotes the reaction [Ruthenium binds to PARP1 protein]; RAPTA-T promotes the reaction [Ruthenium binds to PARP1 protein] CTD PMID:21370912 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Ruthenium results in increased expression of PMAIP1 protein CTD PMID:17210701 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Ruthenium results in increased expression of TP53 protein CTD PMID:17210701 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
ruthenium red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA] CTD PMID:32652086 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein] CTD PMID:32652086 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agrp agouti related neuropeptide multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA] CTD PMID:32652086 NCBI chr19:33,447,992...33,523,068
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA] CTD PMID:32652086 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Ruthenium Red inhibits the reaction [APP protein modified form results in increased uptake of Calcium] CTD PMID:24457011 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Ruthenium Red inhibits the reaction [Dronabinol affects the secretion of CALCA protein] CTD PMID:17828286 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:19631781 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein] CTD PMID:19631781 PMID:23219522 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cck cholecystokinin multiple interactions ISO [N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of CCK protein] CTD PMID:26979077 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Ghsr growth hormone secretagogue receptor multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA] CTD PMID:32652086 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] CTD PMID:14622174 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] CTD PMID:20539001 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
CTD PMID:16173059 PMID:32652086 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Ruthenium Red inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Lep leptin multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK1 protein]
CTD PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein]
Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein] CTD PMID:20886221 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression
multiple interactions
ISO Ruthenium Red affects the expression of MMP1 mRNA; Ruthenium Red affects the expression of MMP1 protein
Ruthenium Red inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein]
CTD PMID:17508023 PMID:21245013 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]; Ruthenium Red inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21466812 PMID:22882778 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA] CTD PMID:32652086 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:20886221 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Npy neuropeptide Y multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA] CTD PMID:32652086 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] CTD PMID:32652086 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA] CTD PMID:32652086 NCBI chr 4:10,010,574...10,252,152
Ensembl chr 4:10,010,890...10,252,142
JBrowse link
G Pyy peptide YY multiple interactions ISO [Ruthenium Red co-treated with N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine] inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form] CTD PMID:26979077 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein] CTD PMID:32652086 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
decreases activity
ISO Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]
Ruthenium Red inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]
Ruthenium Red results in decreased activity of TRPA1 protein
CTD PMID:15046718 PMID:15843607 PMID:17684094 PMID:23994502 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects binding
ISO
EXP
Ruthenium Red inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; Ruthenium Red inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]]
Ruthenium Red binds to TRPV1 protein
Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]
Ruthenium Red binds to and results in decreased activity of TRPV1 protein; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]
CTD PMID:11140687 PMID:18172555 PMID:18230619 PMID:23747933 PMID:30496739 More... NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions EXP
ISO
Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA]
CTD PMID:20086034 PMID:32652086 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions
decreases activity
EXP [Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine CTD PMID:20064552 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] CTD PMID:20539001 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      atom 20054
        metal atom 17583
          d-block element atom 16947
            iron group element atom 882
              ruthenium atom 47
                ruthenium molecular entity + 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  metal atom 17583
                    transition element atom 16956
                      d-block element atom 16947
                        iron group element atom 882
                          ruthenium atom 47
                            ruthenium molecular entity + 35
paths to the root