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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thyroxine
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Accession:CHEBI:30660 term browser browse the term
Definition:An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Synonyms:related_synonym: 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid;   DL-Thyroxine;   Formula=C15H11I4NO4;   InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23);   InChIKey=XUIIKFGFIJCVMT-UHFFFAOYSA-N;   O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-DL-tyrosine;   SMILES=NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O;   Thx
 xref: Beilstein:2228514;   CAS:300-30-1
 xref_mesh: MESH:D013974
 xref: PMID:15206581;   PMID:24375501;   PMID:9824273
 cyclic_relationship: is_tautomer_of CHEBI:305790

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thyroxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases abundance EXP ABCC2 results in decreased abundance of Thyroxine CTD PMID:19211616 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR affects the reaction [2,4,6-triphenyl-1-hexene results in increased abundance of Thyroxine] CTD PMID:18560529 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO Thyroxine binds to ALB protein
2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to ALB protein]; Flame Retardants analog inhibits the reaction [Thyroxine binds to ALB protein]		 CTD PMID:20039755 PMID:21517007 PMID:29283575 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Amh anti-Mullerian hormone multiple interactions EXP Thyroxine affects the reaction [Propylthiouracil affects the expression of AMH mRNA] CTD PMID:7819453 NCBI chr 7:8,906,776...8,909,184
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G App amyloid beta precursor protein decreases cleavage
decreases expression		 ISO Thyroxine results in decreased cleavage of APP protein
Thyroxine results in decreased expression of APP mRNA; Thyroxine results in decreased expression of APP protein		 CTD PMID:17199430 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases expression		 ISO [nano-diamino-tetrac co-treated with Resveratrol] inhibits the reaction [Thyroxine results in decreased expression of BAD mRNA]; Resveratrol inhibits the reaction [Thyroxine results in decreased expression of BAD mRNA]; Thyroxine inhibits the reaction [Resveratrol results in increased expression of BAD mRNA] CTD PMID:31336132 PMID:31883986 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity		 EXP [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; arotinolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Atenolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of CAT protein]
Thyroxine results in decreased expression of CAT mRNA; Thyroxine results in decreased expression of CAT protein		 CTD PMID:2575990 PMID:18723006 PMID:19914224 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 ISO Thyroxine results in increased expression of CCND1 mRNA
[Resveratrol co-treated with nano-diamino-tetrac] inhibits the reaction [Thyroxine results in increased expression of CCND1 mRNA]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of CCND1 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of CCND1 mRNA]		 CTD PMID:31336132 PMID:31883986 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd274 CD274 molecule increases expression
multiple interactions		 ISO Thyroxine results in increased expression of CD274 mRNA; Thyroxine results in increased expression of CD274 protein; Thyroxine results in increased expression of PDL1 mRNA; Thyroxine results in increased expression of PDL1 protein
[Resveratrol co-treated with nano-diamino-tetrac] inhibits the reaction [Thyroxine results in increased expression of PDL1 mRNA]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of CD274 mRNA]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of CD274 protein]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of PDL1 mRNA]; NSC 74859 inhibits the reaction [Thyroxine results in increased expression of PDL1 protein]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of PDL1 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of PDL1 protein]		 CTD PMID:29960019 PMID:31336132 PMID:31883986 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Thyroxine inhibits the reaction [resveratrol results in increased expression of CDKN1A mRNA] CTD PMID:17174366 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Thyroxine results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Thyroxine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Thyroxine results in decreased expression of CYP8B1 mRNA CTD PMID:10393316 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Dcn decorin decreases expression ISO Thyroxine results in decreased expression of DCN mRNA CTD PMID:23935926 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Dio1 iodothyronine deiodinase 1 affects abundance
multiple interactions
increases expression
affects metabolic processing
increases metabolic processing		 ISO
EXP		 DIO1 gene SNP affects the abundance of Thyroxine
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine results in increased expression of DIO1 mRNA]
DIO1 protein affects the metabolism of Thyroxine
[DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine]		 CTD PMID:15254343 PMID:17105838 PMID:21565810 PMID:27420076 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions
decreases expression
decreases activity
increases metabolic processing
affects metabolic processing		 ISO
EXP		 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; [DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; lactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; Thyroxine results in decreased expression of and results in decreased activity of DIO2 protein
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine results in decreased expression of DIO2 mRNA]
DIO2 protein mutant form affects the metabolism of Thyroxine		 CTD PMID:11108274 PMID:11425850 PMID:16728495 PMID:17615150 PMID:26004626 More... NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity
multiple interactions		 EXP Thyroxine results in increased activity of DIO3 protein
Hydrogen Peroxide promotes the reaction [Thyroxine results in increased activity of DIO3 protein]		 CTD PMID:18420745 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 increases expression ISO Thyroxine results in increased expression of DMP1 mRNA CTD PMID:23935926 NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323 		JBrowse link
G Duox1 dual oxidase 1 decreases expression ISO Thyroxine results in decreased expression of DUOX1 protein CTD PMID:17332529 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 decreases expression ISO Thyroxine results in decreased expression of DUOX2 protein CTD PMID:17332529 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Thyroxine results in increased expression of FGF1 mRNA CTD PMID:23935926 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Thyroxine results in increased expression of FGF2 mRNA CTD PMID:23935926 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thyroxine inhibits the reaction [resveratrol results in increased expression of FOS mRNA] CTD PMID:17174366 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gap43 growth associated protein 43 increases expression
multiple interactions		 EXP Thyroxine results in increased expression of GAP43 mRNA
Thyroxine inhibits the reaction [Ethanol results in decreased expression of GAP43 mRNA]		 CTD PMID:15940294 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gh1 growth hormone 1 decreases abundance
multiple interactions		 ISO GH1 protein results in decreased abundance of Thyroxine
[2,2',4,4'-tetrabromodiphenyl ether co-treated with Thyroxine] results in increased expression of GH mRNA		 CTD PMID:17311540 PMID:17324600 PMID:27420076 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions EXP Ipodate inhibits the reaction [Thyroxine results in increased activity of GPD2 protein]; Propylthiouracil inhibits the reaction [Thyroxine results in increased activity of GPD2 protein] CTD PMID:6723573 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity
decreases activity
increases expression
decreases expression		 EXP [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]
Thyroxine results in increased activity of GPX1 protein
Thyroxine results in decreased activity of GPX1 protein		 CTD PMID:19914224 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
decreases expression		 EXP [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]
Thyroxine results in decreased activity of GSR protein
Thyroxine results in decreased expression of GSR mRNA; Thyroxine results in decreased expression of GSR protein		 CTD PMID:19914224 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP [Propylthiouracil results in increased abundance of Thyroxine] which results in increased expression of HES1 mRNA CTD PMID:15862623 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hes5 hes family bHLH transcription factor 5 multiple interactions EXP [Propylthiouracil results in increased abundance of Thyroxine] which results in increased expression of HES5 mRNA CTD PMID:15862623 NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001 		JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor increases expression EXP Thyroxine results in increased expression of HR mRNA CTD PMID:29901742 NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313 		JBrowse link
G Htra1 HtrA serine peptidase 1 increases expression ISO Thyroxine results in increased expression of HTRA1 mRNA CTD PMID:23935926 NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Thyroxine results in increased expression of IGF1 mRNA CTD PMID:23935926 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases expression		 EXP Vitamin E inhibits the reaction [Thyroxine results in increased expression of IGF1R protein] CTD PMID:17447016 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO NSC 74859 inhibits the reaction [Thyroxine results in increased expression of IL1B mRNA] CTD PMID:31336132 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thyroxine inhibits the reaction [resveratrol results in increased expression of JUN mRNA] CTD PMID:17174366 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects localization		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; NSC 74859 inhibits the reaction [Thyroxine results in increased phosphorylation of MAPK1 protein]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Thyroxine affects the localization of MAPK1 protein
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK1 protein]		 CTD PMID:17174366 PMID:17984113 PMID:31336132 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
affects localization		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; NSC 74859 inhibits the reaction [Thyroxine results in increased phosphorylation of MAPK3 protein]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Thyroxine affects the localization of MAPK3 protein
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK3 protein]		 CTD PMID:17174366 PMID:17984113 PMID:31336132 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Thyroxine results in increased expression of MMP9 mRNA CTD PMID:23935926 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Thyroxine promotes the reaction [THRA protein binds to NCOA2 protein]; Thyroxine promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein] CTD PMID:22227104 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein] CTD PMID:22227104 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Thyroxine results in increased activity of NR1I2 protein
[Thyroxine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects metabolic processing ISO NR1I3 protein affects the metabolism of Thyroxine CTD PMID:15004031 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases expression		 EXP Thyroxine inhibits the reaction [Ethanol results in decreased expression of NR3C1 mRNA]
Thyroxine results in increased expression of NR3C1 mRNA		 CTD PMID:15940294 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions EXP Ipodate inhibits the reaction [Thyroxine results in increased activity of ODC1 protein]; Propylthiouracil inhibits the reaction [Thyroxine results in increased activity of ODC1 protein] CTD PMID:6723573 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine results in increased expression of PCNA protein] CTD PMID:17174366 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 decreases expression EXP Thyroxine results in decreased expression of PCSK2 mRNA CTD PMID:15585599 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127 		JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO Thyroxine results in increased expression of PHEX mRNA CTD PMID:23935926 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO
EXP		 Thyroxine results in increased expression of PMP22 mRNA CTD PMID:29901742 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO Thyroxine results in increased expression of POR mRNA CTD PMID:23935926 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Thyroxine inhibits the reaction [Triclosan results in decreased expression of PPARG protein] CTD PMID:28973666 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 EXP
ISO		 Thyroxine inhibits the reaction [resveratrol affects the localization of PTGS2 protein]
Thyroxine results in decreased expression of PTGS2 mRNA
[Resveratrol co-treated with nano-diamino-tetrac] promotes the reaction [Thyroxine results in decreased expression of PTGS2 mRNA]; nano-diamino-tetrac promotes the reaction [Thyroxine results in decreased expression of PTGS2 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in decreased expression of PTGS2 mRNA]; Thyroxine inhibits the reaction [Resveratrol affects the localization of PTGS2 protein]; Thyroxine inhibits the reaction [Resveratrol results in increased expression of PTGS2 mRNA]		 CTD PMID:17984113 PMID:31336132 PMID:31883986 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO Thyroxine binds to RXRA protein CTD PMID:31566444 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sema7a semaphorin 7A (John Milton Hagen blood group) increases expression EXP Thyroxine results in increased expression of SEMA7A mRNA CTD PMID:29901742 NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536 		JBrowse link
G Serpina7 serpin family A member 7 multiple interactions
affects binding		 ISO 3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to SERPINA7 protein]; bisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]; tetrabromobisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]; tetrachlorodian inhibits the reaction [Thyroxine binds to SERPINA7 protein] CTD PMID:16478101 PMID:20804816 PMID:21517007 PMID:27528273 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Shh sonic hedgehog signaling molecule increases expression EXP Thyroxine results in increased expression of SHH mRNA CTD PMID:29901742 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Sirt1 sirtuin 1 increases expression ISO Thyroxine results in increased expression of SIRT1 protein CTD PMID:18204789 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Thyroxine inhibits the reaction [Triclosan results in decreased expression of SLC2A4 protein] CTD PMID:28973666 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 decreases chemical synthesis ISO SLC30A10 gene mutant form results in decreased chemical synthesis of Thyroxine CTD PMID:28860195 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 decreases expression ISO Thyroxine results in decreased expression of SLC5A5 protein CTD PMID:17332529 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
increases activity
decreases activity
decreases expression		 EXP [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; [Curcumin co-treated with Vitamin E] promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Atenolol promotes the reaction [Thyroxine results in decreased expression of SOD1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Curcumin promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Thyroxine inhibits the reaction [Zinc deficiency results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD1 protein]; Vitamin E inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Thyroxine results in increased expression of SOD1 protein]; Vitamin E promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]
Thyroxine results in decreased expression of SOD1 mRNA; Thyroxine results in decreased expression of SOD1 protein		 CTD PMID:2575990 PMID:10381190 PMID:17447016 PMID:19914224 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases activity
decreases expression
increases expression		 EXP [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Atenolol inhibits the reaction [Thyroxine results in increased expression of SOD2 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased activity of SOD2 protein]; Curcumin promotes the reaction [Thyroxine results in increased expression of SOD2 protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Vitamin E promotes the reaction [Thyroxine results in increased expression of SOD2 protein] CTD PMID:2575990 PMID:19914224 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] CTD PMID:22227104 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation		 ISO NSC 74859 inhibits the reaction [Thyroxine results in increased phosphorylation of STAT3 protein] CTD PMID:31336132 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects sulfation
multiple interactions
increases sulfation		 ISO SULT1A1 gene polymorphism affects the sulfation of Thyroxine
Thyroxine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]
SULT1A1 protein results in increased sulfation of Thyroxine		 CTD PMID:11739018 PMID:15531517 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO SULT4A1 protein results in increased metabolism of Thyroxine CTD PMID:12039030 NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085 		JBrowse link
G Syn1 synapsin I multiple interactions ISO Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA] CTD PMID:27413119 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Syp synaptophysin multiple interactions ISO Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA] CTD PMID:27413119 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO NSC 74859 inhibits the reaction [Thyroxine results in increased expression of TGFB1 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of TGFB1 mRNA] CTD PMID:31336132 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thra thyroid hormone receptor alpha affects binding
multiple interactions
increases expression		 ISO
EXP		 Thyroxine binds to THRA protein
Thyroxine promotes the reaction [THRA protein binds to NCOA2 protein]
Thyroxine results in increased expression of THRA mRNA
[bisphenol A co-treated with Estradiol co-treated with Thyroxine] results in increased expression of THRA mRNA; [bisphenol A co-treated with Thyroxine] results in increased expression of THRA mRNA		 CTD PMID:23112079 PMID:23402801 PMID:27993100 PMID:31566444 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions
decreases expression
increases expression
increases activity
affects binding		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]; Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]; Thyroxine inhibits the reaction [Triiodothyronine binds to THRB protein]; Thyroxine promotes the reaction [THRB protein binds to NCOA2 protein]
Thyroxine results in decreased expression of THRB mRNA
Thyroxine results in increased expression of THRB mRNA
[bisphenol A co-treated with Estradiol co-treated with Thyroxine] results in increased expression of THRB mRNA; [bisphenol A co-treated with Thyroxine] results in increased expression of THRB mRNA
Thyroxine results in increased activity of THRB protein
Thyroxine binds to THRB protein		 CTD PMID:18584933 PMID:19457453 PMID:22227104 PMID:23112079 PMID:23402801 More... NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Thyroxine results in increased expression of TNF mRNA CTD PMID:23935926 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects localization		 ISO
EXP		 Thyroxine inhibits the reaction [resveratrol results in increased activity of TP53 protein]
tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of TP53 protein modified form]		 CTD PMID:17174366 PMID:17984113 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpo thyroid peroxidase multiple interactions EXP [Propylthiouracil results in decreased activity of TPO protein] which results in decreased chemical synthesis of and results in decreased abundance of Thyroxine CTD PMID:28973696 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 decreases abundance ISO TRPM7 gene mutant form results in decreased abundance of Thyroxine CTD PMID:30770447 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
decreases expression		 EXP
ISO		 Clofibrate inhibits the reaction [Thyroxine results in decreased expression of TSHB protein]; Thyroxine inhibits the reaction [lead acetate results in decreased expression of TSHB protein]; Thyroxine inhibits the reaction [pexacerfont results in increased expression of TSHB protein]
Thyroxine results in decreased expression of TSHB mRNA		 CTD PMID:18219302 PMID:21871911 PMID:27420076 PMID:33340518 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Tshr thyroid stimulating hormone receptor decreases activity ISO Thyroxine results in decreased activity of TSHR protein CTD PMID:17332529 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538 		JBrowse link
G Tshr-ps1 thyroid stimulating hormone receptor, pseudogene 1 decreases activity ISO Thyroxine results in decreased activity of TSHR protein CTD PMID:17332529 NCBI chr 4:92,142,656...92,143,138 JBrowse link
G Ttr transthyretin multiple interactions
affects binding		 ISO
EXP		 2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',3,3',4,4',5-heptachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether analog inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]; 3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to TTR protein]; 4-nonylphenol inhibits the reaction [Thyroxine binds to TTR protein]; bisphenol A inhibits the reaction [Thyroxine binds to TTR protein]; Diethylstilbestrol inhibits the reaction [Thyroxine binds to TTR protein]; Flame Retardants analog inhibits the reaction [Thyroxine binds to TTR protein]; Flame Retardants inhibits the reaction [Thyroxine binds to TTR protein]; Halogenated Diphenyl Ethers analog inhibits the reaction [Thyroxine binds to TTR protein]; PCB 180 inhibits the reaction [Thyroxine binds to TTR protein]; pentabromophenol inhibits the reaction [Thyroxine binds to TTR protein]; Pentachlorophenol inhibits the reaction [Thyroxine binds to TTR protein]; perfluorobutanesulfonic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorobutyric acid affects the reaction [Thyroxine binds to TTR protein]; perfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorododecanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluoroheptanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorohexanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorononanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorooctane sulfonic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorooctane sulfonic acid inhibits the reaction [Thyroxine binds to TTR protein]; perfluorooctanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorooctanoic acid inhibits the reaction [Thyroxine binds to TTR protein]; perfluoroundecanoic acid affects the reaction [Thyroxine binds to TTR protein]; Polychlorinated Biphenyls analog inhibits the reaction [Thyroxine binds to TTR protein]; T-2 Toxin inhibits the reaction [Thyroxine binds to TTR protein]; tetrabromobisphenol A inhibits the reaction [Thyroxine binds to TTR protein]; tetrachlorodian inhibits the reaction [Thyroxine binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Waste Water inhibits the reaction [Thyroxine binds to TTR protein]
2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein]		 CTD PMID:10631123 PMID:10869457 PMID:16478101 PMID:16601080 PMID:18161906 More... NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP Thyroxine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA] CTD PMID:12588052 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Thyroxine results in increased expression of UGT1A1 mRNA CTD PMID:17884940 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression EXP Thyroxine results in increased expression of UGT1A5 mRNA CTD PMID:17884940 NCBI chr 9:88,780,328...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases expression EXP Thyroxine results in increased expression of UGT1A7 mRNA CTD PMID:17884940 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions EXP [Clofibrate co-treated with Thyroxine] results in increased activity of UGT1A9 protein CTD PMID:18219302 NCBI chr 9:88,696,981...88,808,465 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        mitogen 3448
          thyroxine 86
            D-thyroxine 0
            L-thyroxine + 0
            thyroxine sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  cyclic hydrocarbon 17078
                                    monocyclic hydrocarbon 5831
                                      annulene 5656
                                        aromatic annulene 5656
                                          benzene 5656
                                            alkylbenzene 3372
                                              methylbenzene 3237
                                                toluene 3103
                                                  benzyl group 2517
                                                    phenylalanine 2517
                                                      phenylalanine derivative 2507
                                                        tyrosine derivative 423
                                                          thyronine 416
                                                            iodothyronine 416
                                                              thyroxine 86
                                                                D-thyroxine 0
                                                                L-thyroxine + 0
                                                                thyroxine sulfate 0
paths to the root