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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases abundance |
EXP |
ABCC2 results in decreased abundance of Thyroxine |
CTD |
PMID:19211616 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
AHR affects the reaction [2,4,6-triphenyl-1-hexene results in increased abundance of Thyroxine] |
CTD |
PMID:18560529 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Alb |
albumin |
affects binding multiple interactions |
ISO |
Thyroxine binds to ALB protein 2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to ALB protein]; Flame Retardants analog inhibits the reaction [Thyroxine binds to ALB protein] |
CTD |
PMID:20039755 PMID:21517007 PMID:29283575 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Amh |
anti-Mullerian hormone |
multiple interactions |
EXP |
Thyroxine affects the reaction [Propylthiouracil affects the expression of AMH mRNA] |
CTD |
PMID:7819453 |
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NCBI chr 7:8,906,776...8,909,184
Ensembl chr 7:8,906,836...8,909,282
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G |
App |
amyloid beta precursor protein |
decreases cleavage decreases expression |
ISO |
Thyroxine results in decreased cleavage of APP protein Thyroxine results in decreased expression of APP mRNA; Thyroxine results in decreased expression of APP protein |
CTD |
PMID:17199430 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions decreases expression |
ISO |
[nano-diamino-tetrac co-treated with Resveratrol] inhibits the reaction [Thyroxine results in decreased expression of BAD mRNA]; Resveratrol inhibits the reaction [Thyroxine results in decreased expression of BAD mRNA]; Thyroxine inhibits the reaction [Resveratrol results in increased expression of BAD mRNA] |
CTD |
PMID:31336132 PMID:31883986 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Cat |
catalase |
multiple interactions decreases activity decreases expression |
EXP |
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; arotinolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Atenolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]; Thyroxine inhibits the reaction [Propylthiouracil results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of CAT protein] Thyroxine results in decreased expression of CAT mRNA; Thyroxine results in decreased expression of CAT protein |
CTD |
PMID:2575990 PMID:18723006 PMID:19914224 PMID:34047416 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccnd1 |
cyclin D1 |
increases expression multiple interactions |
ISO |
Thyroxine results in increased expression of CCND1 mRNA [Resveratrol co-treated with nano-diamino-tetrac] inhibits the reaction [Thyroxine results in increased expression of CCND1 mRNA]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of CCND1 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of CCND1 mRNA] |
CTD |
PMID:31336132 PMID:31883986 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cd274 |
CD274 molecule |
increases expression multiple interactions |
ISO |
Thyroxine results in increased expression of CD274 mRNA; Thyroxine results in increased expression of CD274 protein; Thyroxine results in increased expression of PDL1 mRNA; Thyroxine results in increased expression of PDL1 protein [Resveratrol co-treated with nano-diamino-tetrac] inhibits the reaction [Thyroxine results in increased expression of PDL1 mRNA]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of CD274 mRNA]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of CD274 protein]; nano-diamino-tetrac inhibits the reaction [Thyroxine results in increased expression of PDL1 mRNA]; NSC 74859 inhibits the reaction [Thyroxine results in increased expression of PDL1 protein]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of PDL1 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of PDL1 protein] |
CTD |
PMID:29960019 PMID:31336132 PMID:31883986 |
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NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
Thyroxine inhibits the reaction [resveratrol results in increased expression of CDKN1A mRNA] |
CTD |
PMID:17174366 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cidea |
cell death-inducing DFFA-like effector a |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA |
CTD |
PMID:34323617 |
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NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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G |
Cidec |
cell death-inducing DFFA-like effector c |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA |
CTD |
PMID:34323617 |
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NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
Thyroxine results in decreased activity of CYP2C8 protein |
CTD |
PMID:15601807 |
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[Thyroxine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:25455453 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp8b1 |
cytochrome P450 family 8 subfamily B member 1 |
decreases expression |
EXP |
Thyroxine results in decreased expression of CYP8B1 mRNA |
CTD |
PMID:10393316 |
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NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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G |
Dcn |
decorin |
decreases expression |
ISO |
Thyroxine results in decreased expression of DCN mRNA |
CTD |
PMID:23935926 |
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NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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G |
Dio1 |
iodothyronine deiodinase 1 |
affects abundance increases metabolic processing multiple interactions affects metabolic processing increases expression |
ISO EXP |
DIO1 gene SNP affects the abundance of Thyroxine DIO1 protein results in increased metabolism of Thyroxine [DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine; Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Thyroxine] which results in increased abundance of Triiodothyronine] DIO1 protein affects the metabolism of Thyroxine Thyroxine results in increased expression of DIO1 mRNA 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine results in increased expression of DIO1 mRNA] |
CTD |
PMID:15254343 PMID:17105838 PMID:21565810 PMID:27420076 |
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NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Dio2 |
iodothyronine deiodinase 2 |
multiple interactions affects metabolic processing increases metabolic processing decreases activity decreases expression |
ISO EXP |
2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; [DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; lactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; Thyroxine results in decreased expression of and results in decreased activity of DIO2 protein DIO2 protein mutant form affects the metabolism of Thyroxine Thyroxine results in decreased expression of DIO2 mRNA 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine results in decreased expression of DIO2 mRNA] |
CTD |
PMID:11108274 PMID:11425850 PMID:16728495 PMID:17615150 PMID:26004626 PMID:27420076 More...
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NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Dio3 |
iodothyronine deiodinase 3 |
increases activity multiple interactions |
EXP |
Thyroxine results in increased activity of DIO3 protein Hydrogen Peroxide promotes the reaction [Thyroxine results in increased activity of DIO3 protein] |
CTD |
PMID:18420745 |
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NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
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G |
Dmp1 |
dentin matrix acidic phosphoprotein 1 |
increases expression |
ISO |
Thyroxine results in increased expression of DMP1 mRNA |
CTD |
PMID:23935926 |
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NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323
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G |
Duox1 |
dual oxidase 1 |
decreases expression |
ISO |
Thyroxine results in decreased expression of DUOX1 protein |
CTD |
PMID:17332529 |
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NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
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G |
Duox2 |
dual oxidase 2 |
decreases expression |
ISO |
Thyroxine results in decreased expression of DUOX2 protein |
CTD |
PMID:17332529 |
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NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
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G |
Fgf1 |
fibroblast growth factor 1 |
increases expression |
ISO |
Thyroxine results in increased expression of FGF1 mRNA |
CTD |
PMID:23935926 |
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NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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G |
Fgf2 |
fibroblast growth factor 2 |
increases expression |
ISO |
Thyroxine results in increased expression of FGF2 mRNA |
CTD |
PMID:23935926 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Thyroxine inhibits the reaction [resveratrol results in increased expression of FOS mRNA] |
CTD |
PMID:17174366 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gap43 |
growth associated protein 43 |
increases expression multiple interactions |
EXP |
Thyroxine results in increased expression of GAP43 mRNA Thyroxine inhibits the reaction [Ethanol results in decreased expression of GAP43 mRNA] |
CTD |
PMID:15940294 |
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NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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G |
Gh1 |
growth hormone 1 |
decreases abundance multiple interactions |
ISO |
GH1 protein results in decreased abundance of Thyroxine [2,2',4,4'-tetrabromodiphenyl ether co-treated with Thyroxine] results in increased expression of GH mRNA |
CTD |
PMID:17311540 PMID:17324600 PMID:27420076 |
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NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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G |
Gpd2 |
glycerol-3-phosphate dehydrogenase 2 |
multiple interactions |
EXP |
Ipodate inhibits the reaction [Thyroxine results in increased activity of GPD2 protein]; Propylthiouracil inhibits the reaction [Thyroxine results in increased activity of GPD2 protein] |
CTD |
PMID:6723573 |
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NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Thyroxine inhibits the reaction [Propylthiouracil results in increased expression of GPT protein] |
CTD |
PMID:34047416 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions decreases expression increases expression decreases activity increases activity |
EXP |
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA] Thyroxine results in decreased activity of GPX1 protein Thyroxine results in increased activity of GPX1 protein |
CTD |
PMID:19914224 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases expression decreases activity |
EXP |
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA] Thyroxine results in decreased expression of GSR mRNA; Thyroxine results in decreased expression of GSR protein Thyroxine results in decreased activity of GSR protein |
CTD |
PMID:19914224 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions |
EXP |
[Propylthiouracil results in increased abundance of Thyroxine] which results in increased expression of HES1 mRNA |
CTD |
PMID:15862623 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hes5 |
hes family bHLH transcription factor 5 |
multiple interactions |
EXP |
[Propylthiouracil results in increased abundance of Thyroxine] which results in increased expression of HES5 mRNA |
CTD |
PMID:15862623 |
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NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001
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G |
Hr |
HR, lysine demethylase and nuclear receptor corepressor |
increases expression |
EXP |
Thyroxine results in increased expression of HR mRNA |
CTD |
PMID:29901742 |
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NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313
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G |
Htra1 |
HtrA serine peptidase 1 |
increases expression |
ISO |
Thyroxine results in increased expression of HTRA1 mRNA |
CTD |
PMID:23935926 |
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NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
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G |
Igf1 |
insulin-like growth factor 1 |
increases expression |
ISO |
Thyroxine results in increased expression of IGF1 mRNA |
CTD |
PMID:23935926 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
multiple interactions increases expression |
EXP |
Vitamin E inhibits the reaction [Thyroxine results in increased expression of IGF1R protein] |
CTD |
PMID:17447016 |
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NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
NSC 74859 inhibits the reaction [Thyroxine results in increased expression of IL1B mRNA] |
CTD |
PMID:31336132 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Thyroxine inhibits the reaction [Propylthiouracil results in increased expression of IL6 protein] |
CTD |
PMID:34047416 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA |
CTD |
PMID:34323617 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Itgav |
integrin subunit alpha V |
multiple interactions |
EXP |
[Methamphetamine co-treated with Thyroxine] results in increased expression of ITGAV protein |
CTD |
PMID:35301009 |
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NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
ISO |
ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] |
CTD |
PMID:22227104 |
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NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Thyroxine inhibits the reaction [resveratrol results in increased expression of JUN mRNA] |
CTD |
PMID:17174366 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions affects localization increases phosphorylation |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; NSC 74859 inhibits the reaction [Thyroxine results in increased phosphorylation of MAPK1 protein]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Thyroxine results in increased phosphorylation of and results in increased activity of MAPK1 protein tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK1 protein] |
CTD |
PMID:17174366 PMID:17984113 PMID:31336132 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions affects localization increases phosphorylation |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; NSC 74859 inhibits the reaction [Thyroxine results in increased phosphorylation of MAPK3 protein]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Thyroxine results in increased phosphorylation of and results in increased activity of MAPK3 protein tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of MAPK3 protein] |
CTD |
PMID:17174366 PMID:17984113 PMID:31336132 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
ISO |
Thyroxine results in increased expression of MMP9 mRNA |
CTD |
PMID:23935926 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions |
ISO |
Thyroxine promotes the reaction [THRA protein binds to NCOA2 protein]; Thyroxine promotes the reaction [THRB protein binds to NCOA2 protein] |
CTD |
PMID:31566444 |
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NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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G |
Ncor1 |
nuclear receptor co-repressor 1 |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein] |
CTD |
PMID:22227104 |
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NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
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G |
Ncor2 |
nuclear receptor co-repressor 2 |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein] |
CTD |
PMID:22227104 |
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NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity multiple interactions |
ISO |
Thyroxine results in increased activity of NR1I2 protein [Thyroxine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:25455453 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
affects metabolic processing |
ISO |
NR1I3 protein affects the metabolism of Thyroxine |
CTD |
PMID:15004031 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions increases expression |
EXP |
Thyroxine inhibits the reaction [Ethanol results in decreased expression of NR3C1 mRNA] Thyroxine results in increased expression of NR3C1 mRNA |
CTD |
PMID:15940294 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Odc1 |
ornithine decarboxylase 1 |
multiple interactions |
EXP |
Ipodate inhibits the reaction [Thyroxine results in increased activity of ODC1 protein]; Propylthiouracil inhibits the reaction [Thyroxine results in increased activity of ODC1 protein] |
CTD |
PMID:6723573 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine results in increased expression of PCNA protein] |
CTD |
PMID:17174366 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcsk2 |
proprotein convertase subtilisin/kexin type 2 |
decreases expression |
EXP |
Thyroxine results in decreased expression of PCSK2 mRNA |
CTD |
PMID:15585599 |
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NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
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G |
Phex |
phosphate regulating endopeptidase X-linked |
increases expression |
ISO |
Thyroxine results in increased expression of PHEX mRNA |
CTD |
PMID:23935926 |
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NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469
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G |
Pmp22 |
peripheral myelin protein 22 |
increases expression |
ISO EXP |
Thyroxine results in increased expression of PMP22 mRNA |
CTD |
PMID:29901742 |
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NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
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G |
Por |
cytochrome p450 oxidoreductase |
increases expression |
ISO |
Thyroxine results in increased expression of POR mRNA |
CTD |
PMID:23935926 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
Thyroxine inhibits the reaction [Triclosan results in decreased expression of PPARG protein] |
CTD |
PMID:28973666 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases expression |
EXP ISO |
Thyroxine inhibits the reaction [resveratrol affects the localization of PTGS2 protein] [Resveratrol co-treated with nano-diamino-tetrac] promotes the reaction [Thyroxine results in decreased expression of PTGS2 mRNA]; nano-diamino-tetrac promotes the reaction [Thyroxine results in decreased expression of PTGS2 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in decreased expression of PTGS2 mRNA]; Thyroxine inhibits the reaction [Resveratrol affects the localization of PTGS2 protein]; Thyroxine inhibits the reaction [Resveratrol results in increased expression of PTGS2 mRNA] |
CTD |
PMID:17984113 PMID:31336132 PMID:31883986 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Rxra |
retinoid X receptor alpha |
affects binding |
ISO |
Thyroxine binds to RXRA protein |
CTD |
PMID:31566444 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Sdha |
succinate dehydrogenase complex flavoprotein subunit A |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein |
CTD |
PMID:34323617 |
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NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
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G |
Sema7a |
semaphorin 7A (John Milton Hagen blood group) |
increases expression |
EXP |
Thyroxine results in increased expression of SEMA7A mRNA |
CTD |
PMID:29901742 |
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NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536
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G |
Serpina7 |
serpin family A member 7 |
multiple interactions affects binding |
ISO |
3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to SERPINA7 protein]; bisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]; tetrabromobisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]; tetrachlorodian inhibits the reaction [Thyroxine binds to SERPINA7 protein] |
CTD |
PMID:16478101 PMID:20804816 PMID:21517007 PMID:27528273 |
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NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
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G |
Shh |
sonic hedgehog signaling molecule |
increases expression |
EXP |
Thyroxine results in increased expression of SHH mRNA |
CTD |
PMID:29901742 |
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NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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G |
Sirt1 |
sirtuin 1 |
increases expression |
ISO |
Thyroxine results in increased expression of SIRT1 protein |
CTD |
PMID:18204789 |
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NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
Thyroxine inhibits the reaction [Triclosan results in decreased expression of SLC2A4 protein] |
CTD |
PMID:28973666 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Slc30a10 |
solute carrier family 30, member 10 |
decreases chemical synthesis |
ISO |
SLC30A10 gene mutant form results in decreased chemical synthesis of Thyroxine |
CTD |
PMID:28860195 |
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NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
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G |
Slc5a5 |
solute carrier family 5 member 5 |
decreases expression |
ISO |
Thyroxine results in decreased expression of SLC5A5 protein |
CTD |
PMID:17332529 |
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NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions decreases expression decreases activity increases activity increases expression |
EXP |
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; [Curcumin co-treated with Vitamin E] promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Atenolol promotes the reaction [Thyroxine results in decreased expression of SOD1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Curcumin promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Thyroxine inhibits the reaction [Zinc deficiency results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD1 protein]; Vitamin E inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Thyroxine results in increased expression of SOD1 protein]; Vitamin E promotes the reaction [Thyroxine results in decreased activity of SOD1 protein] Thyroxine results in decreased expression of SOD1 mRNA; Thyroxine results in decreased expression of SOD1 protein |
CTD |
PMID:2575990 PMID:10381190 PMID:17447016 PMID:19914224 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions increases expression decreases expression decreases activity |
EXP |
[Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Atenolol inhibits the reaction [Thyroxine results in increased expression of SOD2 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased activity of SOD2 protein]; Curcumin promotes the reaction [Thyroxine results in increased expression of SOD2 protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Vitamin E promotes the reaction [Thyroxine results in increased expression of SOD2 protein] |
CTD |
PMID:2575990 PMID:19914224 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]] |
CTD |
PMID:22227104 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions increases phosphorylation |
ISO |
NSC 74859 inhibits the reaction [Thyroxine results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:31336132 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
affects sulfation increases sulfation multiple interactions |
ISO |
SULT1A1 gene polymorphism affects the sulfation of Thyroxine SULT1A1 protein results in increased sulfation of Thyroxine Thyroxine inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] |
CTD |
PMID:11739018 PMID:15531517 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Sult4a1 |
sulfotransferase family 4A, member 1 |
increases metabolic processing |
ISO |
SULT4A1 protein results in increased metabolism of Thyroxine |
CTD |
PMID:12039030 |
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NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085
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G |
Syn1 |
synapsin I |
multiple interactions |
ISO |
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA] |
CTD |
PMID:27413119 |
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NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
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G |
Syp |
synaptophysin |
multiple interactions |
ISO |
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA] |
CTD |
PMID:27413119 |
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NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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G |
Tf |
transferrin |
multiple interactions |
ISO |
[acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of CIDEA mRNA; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [acetyl methyl tetramethyl tetralin co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in decreased expression of SDHA protein; [quinoxyfen co-treated with Biotin co-treated with Pantothenic Acid co-treated with Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Thyroxine co-treated with TF protein] results in increased expression of CIDEC mRNA |
CTD |
PMID:34323617 |
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NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions increases expression |
ISO |
NSC 74859 inhibits the reaction [Thyroxine results in increased expression of TGFB1 mRNA]; Resveratrol inhibits the reaction [Thyroxine results in increased expression of TGFB1 mRNA] |
CTD |
PMID:31336132 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Thra |
thyroid hormone receptor alpha |
affects binding multiple interactions increases expression |
ISO EXP |
Thyroxine binds to THRA protein [bisphenol A co-treated with Estradiol co-treated with Thyroxine] results in increased expression of THRA mRNA; [bisphenol A co-treated with Thyroxine] results in increased expression of THRA mRNA Thyroxine results in increased expression of THRA mRNA Thyroxine promotes the reaction [THRA protein binds to NCOA2 protein] |
CTD |
PMID:23112079 PMID:23402801 PMID:27993100 PMID:31566444 |
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NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Thrb |
thyroid hormone receptor beta |
multiple interactions affects binding increases activity increases expression decreases expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]]; SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]]; tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]; Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]; Thyroxine inhibits the reaction [THRB protein binds to NCOR1 protein]; Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]; Thyroxine inhibits the reaction [Triiodothyronine binds to THRB protein]; Thyroxine promotes the reaction [THRB protein binds to NCOA2 protein] Thyroxine binds to THRB protein Thyroxine results in increased activity of THRB protein [bisphenol A co-treated with Estradiol co-treated with Thyroxine] results in increased expression of THRB mRNA; [bisphenol A co-treated with Thyroxine] results in increased expression of THRB mRNA Thyroxine results in increased expression of THRB mRNA Thyroxine results in decreased expression of THRB mRNA |
CTD |
PMID:18584933 PMID:19457453 PMID:22227104 PMID:23112079 PMID:23402801 PMID:27420076 PMID:27993100 PMID:29409039 PMID:31077750 PMID:31566444 More...
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions |
ISO EXP |
Thyroxine results in increased expression of TNF mRNA Thyroxine inhibits the reaction [Propylthiouracil results in increased expression of TNF protein] |
CTD |
PMID:23935926 PMID:34047416 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions affects localization |
ISO EXP |
Thyroxine inhibits the reaction [resveratrol results in increased activity of TP53 protein] Thyroxine affects the localization of TP53 protein modified form tetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of TP53 protein modified form] |
CTD |
PMID:17174366 PMID:17984113 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tpo |
thyroid peroxidase |
multiple interactions |
EXP |
[Propylthiouracil results in decreased activity of TPO protein] which results in decreased chemical synthesis of and results in decreased abundance of Thyroxine |
CTD |
PMID:28973696 |
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NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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G |
Trpm7 |
transient receptor potential cation channel, subfamily M, member 7 |
decreases abundance |
ISO |
TRPM7 gene mutant form results in decreased abundance of Thyroxine |
CTD |
PMID:30770447 |
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NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
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G |
Tshb |
thyroid stimulating hormone subunit beta |
multiple interactions decreases expression |
EXP ISO |
Clofibrate inhibits the reaction [Thyroxine results in decreased expression of TSHB protein]; Thyroxine inhibits the reaction [lead acetate results in decreased expression of TSHB protein]; Thyroxine inhibits the reaction [pexacerfont results in increased expression of TSHB protein]; Thyroxine inhibits the reaction [Propylthiouracil results in increased expression of TSHB protein] Thyroxine results in decreased expression of TSHB mRNA |
CTD |
PMID:18219302 PMID:21871911 PMID:27420076 PMID:33340518 PMID:34047416 |
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NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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G |
Tshr |
thyroid stimulating hormone receptor |
decreases activity |
ISO |
Thyroxine results in decreased activity of TSHR protein |
CTD |
PMID:17332529 |
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NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
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G |
Ttr |
transthyretin |
multiple interactions affects binding |
ISO EXP |
2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',3,3',4,4',5-heptachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether analog inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,5'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Thyroxine binds to TTR protein]; 3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to TTR protein]; 4-nonylphenol inhibits the reaction [Thyroxine binds to TTR protein]; bisphenol A inhibits the reaction [Thyroxine binds to TTR protein]; Diethylstilbestrol inhibits the reaction [Thyroxine binds to TTR protein]; Flame Retardants analog inhibits the reaction [Thyroxine binds to TTR protein]; Flame Retardants inhibits the reaction [Thyroxine binds to TTR protein]; Halogenated Diphenyl Ethers analog inhibits the reaction [Thyroxine binds to TTR protein]; PCB 180 inhibits the reaction [Thyroxine binds to TTR protein]; pentabromophenol inhibits the reaction [Thyroxine binds to TTR protein]; Pentachlorophenol inhibits the reaction [Thyroxine binds to TTR protein]; perfluoro-n-heptanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluoro-n-nonanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorobutanesulfonic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorobutyric acid affects the reaction [Thyroxine binds to TTR protein]; perfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorododecanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorohexanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorooctane sulfonic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorooctane sulfonic acid inhibits the reaction [Thyroxine binds to TTR protein]; perfluorooctanoic acid affects the reaction [Thyroxine binds to TTR protein]; perfluorooctanoic acid inhibits the reaction [Thyroxine binds to TTR protein]; perfluoroundecanoic acid affects the reaction [Thyroxine binds to TTR protein]; Polychlorinated Biphenyls analog inhibits the reaction [Thyroxine binds to TTR protein]; T-2 Toxin inhibits the reaction [Thyroxine binds to TTR protein]; tetrabromobisphenol A inhibits the reaction [Thyroxine binds to TTR protein]; tetrachlorodian inhibits the reaction [Thyroxine binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Wastewater inhibits the reaction [Thyroxine binds to TTR protein] 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein] |
CTD |
PMID:10631123 PMID:10869457 PMID:16478101 PMID:16601080 PMID:18161906 PMID:20039755 PMID:20804816 PMID:21357386 PMID:21517007 PMID:23584369 PMID:27528273 PMID:29283575 PMID:31077750 PMID:33095664 More...
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NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
EXP |
Thyroxine promotes the reaction [darglitazone results in increased expression of UCP2 mRNA] |
CTD |
PMID:12588052 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
EXP |
Thyroxine results in increased expression of UGT1A1 mRNA |
CTD |
PMID:17884940 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a3 |
UDP glycosyltransferase 1 family, polypeptide A3 |
increases expression |
EXP |
Thyroxine results in increased expression of UGT1A5 mRNA |
CTD |
PMID:17884940 |
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NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a7c |
UDP glucuronosyltransferase 1 family, polypeptide A7C |
increases expression |
EXP |
Thyroxine results in increased expression of UGT1A7 mRNA |
CTD |
PMID:17884940 |
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NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
multiple interactions |
EXP |
[Clofibrate co-treated with Thyroxine] results in increased activity of UGT1A9 protein |
CTD |
PMID:18219302 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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