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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Berbamine
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Accession:CHEBI:3063 term browser browse the term
Definition:A bisbenzylisoquinoline alkaloid that has formula C37H40N2O6.
Synonyms:related_synonym: Formula=C37H40N2O6;   InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1;   InChIKey=DFOCUWZXJBAUSQ-URLMMPGGSA-N;   SMILES=COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5cc(C[C@H]6N(C)CCc7cc(OC)c(OC)c(Oc1cc23)c67)ccc5O)cc4
 xref: CAS:478-61-5;   KEGG:C09357;   KNApSAcK:C00001817
 xref_mesh: MESH:C027870


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Berbamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 decreases expression ISO berbamine results in decreased expression of BCL2L1 protein CTD PMID:19960011 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO berbamine results in decreased expression of BID protein CTD PMID:19960011 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
affects binding
ISO berbamine results in decreased expression of BIRC5 mRNA; berbamine results in decreased expression of BIRC5 protein
berbamine binds to BIRC5 promoter
CTD PMID:17531122 PMID:17968851 PMID:19960011 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 increases activity ISO berbamine results in increased activity of CASP3 protein CTD PMID:17531122 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO berbamine results in decreased expression of CCND1 protein CTD PMID:19960011 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO berbamine results in decreased expression of CHUK protein CTD PMID:19960011 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO berbamine results in decreased phosphorylation of NFKBIA protein CTD PMID:19960011 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO berbamine affects the localization of RELA protein CTD PMID:19960011 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO berbamine results in increased expression of TNFAIP3 protein CTD PMID:19960011 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        biochemical role 19310
          metabolite 19292
            alkaloid 5625
              isoquinoline alkaloid 1135
                benzylisoquinoline alkaloid 216
                  bisbenzylisoquinoline alkaloid 115
                    Berbamine 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            heteroorganic entity 19206
                              organonitrogen compound 18370
                                alkaloid 5625
                                  isoquinoline alkaloid 1135
                                    benzylisoquinoline alkaloid 216
                                      bisbenzylisoquinoline alkaloid 115
                                        Berbamine 9
paths to the root