Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bepridil
go back to main search page
Accession:CHEBI:3061 term browser browse the term
Definition:A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Synonyms:exact_synonym: N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline
 related_synonym: Bepadin;   Formula=C24H34N2O;   InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;   InChIKey=UIEATEWHFDRYRU-UHFFFAOYSA-N;   SMILES=CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
 xref: Beilstein:5993674;   CAS:64706-54-3;   DrugBank:DB01244;   Drug_Central:342;   KEGG:C06847;   KEGG:D07520;   LINCS:LSM-1898
 xref_mesh: MESH:D015764
 xref: Wikipedia:Bepridil


show annotations for term's descendants           Sort by:
 
bepridil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Bepridil results in increased expression of ATF4 protein CTD PMID:21292685 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Bepridil results in increased expression of DDIT3 protein CTD PMID:21292685 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Bepridil results in increased phosphorylation of EIF2A protein CTD PMID:21292685 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Bepridil results in decreased activity of KCNA5 protein CTD PMID:11711026 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Bepridil binds to and results in decreased activity of KCNH2 protein; Bepridil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Bepridil results in decreased activity of KCNH2 protein
CTD PMID:15272206, PMID:15671647, PMID:21158687, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)] CTD PMID:16009740 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO Bepridil results in increased susceptibility to TNFSF10 protein CTD PMID:21292685 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            cardiovascular drug 7613
              vasodilator agent 5729
                bepridil 8
                  bepridil hydrochloride 0
                  bepridil hydrochloride monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          tertiary amine 616
                                            bepridil 8
                                              bepridil hydrochloride 0
                                              bepridil hydrochloride monohydrate 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.