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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bepridil
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Accession:CHEBI:3061 term browser browse the term
Definition:A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Synonyms:exact_synonym: N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline
 related_synonym: Bepadin;   Formula=C24H34N2O;   InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;   InChIKey=UIEATEWHFDRYRU-UHFFFAOYSA-N;   SMILES=CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
 xref: Beilstein:5993674;   CAS:64706-54-3;   DrugBank:DB01244;   Drug_Central:342;   KEGG:C06847;   KEGG:D07520;   LINCS:LSM-1898
 xref_mesh: MESH:D015764
 xref: Wikipedia:Bepridil


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bepridil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Bepridil results in increased expression of ATF4 protein CTD PMID:21292685 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Bepridil CTD PMID:15286053 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Bepridil results in increased expression of DDIT3 protein CTD PMID:21292685 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Bepridil results in increased phosphorylation of EIF2A protein CTD PMID:21292685 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Bepridil results in decreased activity of KCNA5 protein CTD PMID:11711026 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Bepridil binds to and results in decreased activity of KCNH2 protein; Bepridil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Bepridil results in decreased activity of KCNH2 protein
CTD PMID:15272206 PMID:15671647 PMID:21158687 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)] CTD PMID:16009740 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO Bepridil results in increased susceptibility to TNFSF10 protein CTD PMID:21292685 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            cardiovascular drug 7679
              vasodilator agent 5820
                bepridil 9
                  bepridil hydrochloride 0
                  bepridil hydrochloride monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8677
                                          tertiary amine 619
                                            bepridil 9
                                              bepridil hydrochloride 0
                                              bepridil hydrochloride monohydrate 0
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