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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flavin
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Accession:CHEBI:30527 term browser browse the term
Definition:A derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.
Synonyms:exact_synonym: flavins
 related_synonym: Formula=C12H9N4O2R;   SMILES=Cc1cc2nc3c(nc(=O)[nH]c3=O)n([*])c2cc1C
 alt_id: CHEBI:24042;   CHEBI:5073
 xref: KEGG:C00176
 cyclic_relationship: is_conjugate_acid_of CHEBI:60531


show annotations for term's descendants           Sort by:
FAD term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions ISO Flavin-Adenine Dinucleotide binds to and results in increased activity of NDUFA9 protein CTD PMID:25526675 NCBI chr 6:126,798,826...126,826,107
Ensembl chr 6:126,798,684...126,826,099 		JBrowse link
G Rfk riboflavin kinase increases abundance ISO RFK protein results in increased abundance of Flavin-Adenine Dinucleotide CTD PMID:21308351 NCBI chr19:17,371,407...17,378,713
Ensembl chr19:17,371,407...17,378,713 		JBrowse link
G Slc52a3 solute carrier protein family 52, member 3 multiple interactions ISO Flavin-Adenine Dinucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin] CTD PMID:19122205 NCBI chr 2:151,838,431...151,851,178
Ensembl chr 2:151,838,431...151,851,178 		JBrowse link
FMN term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance		 EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Flavin Mononucleotide] CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Rfk riboflavin kinase increases abundance ISO RFK protein results in increased abundance of Flavin Mononucleotide CTD PMID:21308351 NCBI chr19:17,371,407...17,378,713
Ensembl chr19:17,371,407...17,378,713 		JBrowse link
G Slc52a3 solute carrier protein family 52, member 3 multiple interactions ISO Flavin Mononucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin] CTD PMID:19122205 NCBI chr 2:151,838,431...151,851,178
Ensembl chr 2:151,838,431...151,851,178 		JBrowse link
lumiflavin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc52a3 solute carrier protein family 52, member 3 multiple interactions ISO lumiflavin inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin] CTD PMID:19122205 NCBI chr 2:151,838,431...151,851,178
Ensembl chr 2:151,838,431...151,851,178 		JBrowse link
riboflavin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation EXP Riboflavin analog results in increased phosphorylation of AKT1 protein; Riboflavin results in increased phosphorylation of AKT1 protein CTD PMID:20688149 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aspm abnormal spindle microtubule assembly affects expression ISO Riboflavin affects the expression of ASPM CTD PMID:20848206 NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO Riboflavin results in increased expression of BAX protein CTD PMID:12654180 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Riboflavin results in decreased expression of BCL2 protein CTD PMID:12654180 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression ISO Riboflavin affects the expression of BIRC5 CTD PMID:20848206 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Casp3 caspase 3 increases activity EXP Riboflavin analog results in increased activity of CASP3 protein CTD PMID:20688149 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 increases activity EXP Riboflavin analog results in increased activity of CASP8 protein CTD PMID:20688149 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity EXP Riboflavin analog results in increased activity of CASP9 protein CTD PMID:20688149 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO Riboflavin inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein] CTD PMID:26360969 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccnb1 cyclin B1 affects expression ISO Riboflavin affects the expression of CCNB1 CTD PMID:20848206 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Riboflavin deficiency results in increased expression of CEBPB mRNA; Riboflavin deficiency results in increased expression of CEBPB protein CTD PMID:16856317 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO [Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein; [Vitamin E co-treated with Ascorbic Acid co-treated with Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein CTD PMID:16517955 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression EXP Riboflavin analog results in increased expression of CTNNB1 protein CTD PMID:20688149 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of CXCL8 protein] CTD PMID:17516992 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO Riboflavin affects the expression of DDIT3 CTD PMID:16109485 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Riboflavin inhibits the reaction [Lipopolysaccharides results in decreased activity of GPX1 protein] CTD PMID:26360969 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP Riboflavin analog results in increased phosphorylation of GSK3B protein; Riboflavin results in increased phosphorylation of GSK3B protein CTD PMID:20688149 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gsr glutathione reductase affects expression
multiple interactions		 ISO Riboflavin affects the expression of GSR
Riboflavin inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]		 CTD PMID:16109485 PMID:26360969 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL1B protein] CTD PMID:17516992 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of IL6 protein] CTD PMID:17516992 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Riboflavin inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877 		JBrowse link
G Kif23 kinesin family member 23 affects expression ISO Riboflavin affects the expression of KIF23 CTD PMID:20848206 NCBI chr 9:61,824,559...61,854,078
Ensembl chr 9:61,823,187...61,854,056 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity EXP Riboflavin analog results in increased activity of MMP9 protein; Riboflavin results in increased activity of MMP9 protein CTD PMID:20688149 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Riboflavin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:26360969 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to Riboflavin CTD PMID:17303386 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO Riboflavin results in increased expression of MYC protein CTD PMID:12654180 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 Lipopolysaccharides inhibits the reaction [Riboflavin results in increased expression of NOS2]
Riboflavin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]		 CTD PMID:21356098 PMID:26360969 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage		 ISO
EXP		 [Niacin co-treated with Ubiquinone co-treated with Riboflavin] results in increased expression of PARP1 protein
Riboflavin analog results in increased cleavage of PARP1 protein		 CTD PMID:18377693 PMID:20688149 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Plagl1 pleiomorphic adenoma gene-like 1 affects expression ISO Riboflavin affects the expression of PLAGL1 CTD PMID:16109485 NCBI chr10:12,966,576...13,007,438
Ensembl chr10:12,936,248...13,007,438 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO Riboflavin results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Runx2 runt related transcription factor 2 increases expression EXP Riboflavin analog results in increased expression of RUNX2 protein CTD PMID:20688149 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Slc52a3 solute carrier protein family 52, member 3 multiple interactions
increases transport		 ISO Acids promotes the reaction [SLC52A3 protein results in increased transport of Riboflavin]; Amiloride inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]; Flavin Mononucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]; Flavin-Adenine Dinucleotide inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin]; lumiflavin inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin] CTD PMID:19122205 NCBI chr 2:151,838,431...151,851,178
Ensembl chr 2:151,838,431...151,851,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [Ubiquinone co-treated with Niacin co-treated with Riboflavin] promotes the reaction [Tamoxifen results in decreased expression of TNF protein]
Lipopolysaccharides inhibits the reaction [Riboflavin results in increased expression of TNF]		 CTD PMID:17516992 PMID:21356098 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 affects expression EXP Riboflavin analog affects the expression of TNFSF11 protein CTD PMID:20688149 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Riboflavin results in increased expression of TP53 protein CTD PMID:12654180 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      atom 22170
        nonmetal atom 22055
          nitrogen atom 20030
            nitrogen molecular entity 20004
              organonitrogen compound 19809
                organonitrogen heterocyclic compound 19099
                  benzopteridine 39
                    flavin 38
                      1-(a-ribofuranosyl)-lumichrome 0
                      1-methyl-11-hydroxylumichrome 0
                      10H-phenanthro[9,10-g]pteridine-11,13-dione 0
                      6,7-Dimethyl-9-(2-acetoxyethyl)isoalloxazine 0
                      7,10-dimethyl-2,4-dioxo-8-benzo[g]pteridinecarboxaldehyde 0
                      7,8-dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione 0
                      7,8-dimethylisoalloxazine-10-carbaldehyde 0
                      Lampteroflavin 0
                      Ochangoside 0
                      Riboflavin butyrate 0
                      Riboflavine 2',3',4',5'-tetrabutanoate 0
                      Riboflavol 0
                      dihydroriboflavins + 0
                      flavin adenine dinucleotide + 3
                      flavin mononucleotide + 3
                      flavoprotein + 0
                      lumiflavin 1
                      riboflavin + 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteropolycyclic compound 19645
                                    organic heterotricyclic compound 16298
                                      benzopteridine 39
                                        benzo[g]pteridine-2,4-dione 39
                                          isoalloxazine 38
                                            7,8-dimethylisoalloxazine 38
                                              flavin 38
                                                1-(a-ribofuranosyl)-lumichrome 0
                                                1-methyl-11-hydroxylumichrome 0
                                                10H-phenanthro[9,10-g]pteridine-11,13-dione 0
                                                6,7-Dimethyl-9-(2-acetoxyethyl)isoalloxazine 0
                                                7,10-dimethyl-2,4-dioxo-8-benzo[g]pteridinecarboxaldehyde 0
                                                7,8-dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione 0
                                                7,8-dimethylisoalloxazine-10-carbaldehyde 0
                                                Lampteroflavin 0
                                                Ochangoside 0
                                                Riboflavin butyrate 0
                                                Riboflavine 2',3',4',5'-tetrabutanoate 0
                                                Riboflavol 0
                                                dihydroriboflavins + 0
                                                flavin adenine dinucleotide + 3
                                                flavin mononucleotide + 3
                                                flavoprotein + 0
                                                lumiflavin 1
                                                riboflavin + 35
paths to the root