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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beryllium(2+)
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Accession:CHEBI:30502 term browser browse the term
Definition:A beryllium cation that has formula Be.
Synonyms:exact_synonym: beryllium(2+) ion;   beryllium(II) cation
 related_synonym: Be(2+);   Formula=Be;   InChI=1S/Be/q+2;   InChIKey=PWOSZCQLSAMRQW-UHFFFAOYSA-N;   SMILES=[Be++]
 xref: CAS:22537-20-8;   Gmelin:6849
 xref_mesh: MESH:D001608


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beryllium sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin, alpha 2, smooth muscle, aorta increases expression ISO beryllium sulfate results in increased expression of ACTA2 mRNA CTD PMID:16314022 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Anxa5 annexin A5 increases expression ISO beryllium sulfate results in increased expression of ANXA5 mRNA CTD PMID:16314022 NCBI chr 3:36,448,923...36,475,887
Ensembl chr 3:36,448,923...36,475,894
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions
increases secretion
ISO beryllium sulfate promotes the reaction [RUNX1 protein binds to CCL3 promoter]
beryllium sulfate results in increased secretion of CCL3 mRNA
CTD PMID:16314022 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 increases secretion ISO beryllium sulfate results in increased secretion of CCL4 mRNA CTD PMID:16314022 NCBI chr11:83,648,624...83,664,683
Ensembl chr11:83,662,584...83,664,683
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 increases expression ISO beryllium sulfate results in increased expression of CCL5 mRNA CTD PMID:16314022 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Cd44 CD44 antigen increases expression ISO beryllium sulfate results in increased expression of CD44 mRNA CTD PMID:16314022 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cd86 CD86 antigen increases expression ISO beryllium sulfate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr16:36,568,956...36,666,158
Ensembl chr16:36,603,869...36,666,081
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
ISO beryllium sulfate promotes the reaction [TP53 protein binds to CDKN1A promoter]
beryllium sulfate results in increased expression of CDKN1A mRNA; beryllium sulfate results in increased expression of CDKN1A protein
CTD PMID:17395767 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases expression ISO beryllium sulfate results in increased expression of CDKN2A mRNA; beryllium sulfate results in increased expression of CDKN2A protein CTD PMID:17395767 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [beryllium sulfate co-treated with IFNG protein] results in increased expression of CREB1 protein CTD PMID:10755711 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Ctsl cathepsin L increases expression ISO beryllium sulfate results in increased expression of CTSL mRNA CTD PMID:16314022 NCBI chr13:64,361,890...64,370,772
Ensembl chr13:64,359,337...64,370,890
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 increases secretion ISO beryllium sulfate results in increased secretion of CXCL1 mRNA CTD PMID:16314022 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 increases secretion ISO beryllium sulfate results in increased secretion of CXCL1 mRNA CTD PMID:16314022 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Egr2 early growth response 2 increases expression ISO beryllium sulfate results in increased expression of EGR2 mRNA CTD PMID:16314022 NCBI chr10:67,534,469...67,542,188
Ensembl chr10:67,535,475...67,542,188
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression
multiple interactions
EXP beryllium sulfate results in increased expression of FOS mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]
CTD PMID:11568973 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta increases expression
increases response to substance
ISO beryllium sulfate results in increased expression of HLA-DRB1 mRNA
HLA-DRB1 protein mutant form results in increased susceptibility to beryllium sulfate
CTD PMID:16272364 PMID:16314022 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 increases expression ISO beryllium sulfate results in increased expression of HLA-A mRNA CTD PMID:16314022 NCBI chr17:35,320,525...35,328,142
Ensembl chr17:35,320,405...35,325,099
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 increases expression ISO beryllium sulfate results in increased expression of HNRNPA1 mRNA CTD PMID:16314022 NCBI chr15:103,239,943...103,246,698
Ensembl chr15:103,240,432...103,246,692
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases secretion
increases expression
ISO 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [beryllium sulfate results in increased expression of ICAM1 mRNA]; 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [beryllium sulfate results in increased secretion of ICAM1 protein]; Dimethyl Sulfoxide inhibits the reaction [beryllium sulfate results in increased secretion of ICAM1 protein]
beryllium sulfate results in increased expression of ICAM1 mRNA; beryllium sulfate results in increased expression of ICAM1 protein
CTD PMID:18539414 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO
EXP
beryllium sulfate results in increased expression of IFNG protein
[beryllium sulfate co-treated with IFNG protein] results in increased expression of CREB1 protein; [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUN protein; [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUNB protein; [beryllium sulfate co-treated with IFNG protein] results in increased expression of NFKB1 protein; beryllium sulfate promotes the reaction [IFNG protein results in increased expression of TNF protein]
CTD PMID:10755710 PMID:10755711 PMID:20974702 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il18 interleukin 18 increases expression ISO beryllium sulfate results in increased expression of IL18 mRNA; beryllium sulfate results in increased expression of IL18 protein CTD PMID:16100009 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il2 interleukin 2 increases expression EXP beryllium sulfate results in increased expression of IL2 mRNA CTD PMID:9328138 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il5 interleukin 5 increases expression EXP beryllium sulfate results in increased expression of IL5 mRNA CTD PMID:9328138 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 increases expression EXP beryllium sulfate results in increased expression of IL6 mRNA CTD PMID:9328138 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itgb3 integrin beta 3 increases expression ISO beryllium sulfate results in increased expression of ITGB3 mRNA CTD PMID:16314022 NCBI chr11:104,608,000...104,670,476
Ensembl chr11:104,608,000...104,670,476
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUN protein; Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA] CTD PMID:10755711 PMID:11568973 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Junb jun B proto-oncogene multiple interactions EXP [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUNB protein CTD PMID:10755711 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO beryllium sulfate results in increased expression of MYC protein CTD PMID:2009323 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nedd8 neural precursor cell expressed, developmentally down-regulated gene 8 increases expression ISO beryllium sulfate results in increased expression of NEDD8 mRNA CTD PMID:16314022 NCBI chr14:55,662,263...55,671,880
Ensembl chr14:55,662,263...55,672,124
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP [beryllium sulfate co-treated with IFNG protein] results in increased expression of NFKB1 protein CTD PMID:10755711 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nova1 NOVA alternative splicing regulator 1 increases expression ISO beryllium sulfate results in increased expression of NOVA1 mRNA CTD PMID:16314022 NCBI chr12:46,697,895...46,819,480
Ensembl chr12:46,694,517...46,818,929
JBrowse link
G Rhoa ras homolog family member A increases expression ISO beryllium sulfate results in increased expression of RHOA mRNA CTD PMID:16314022 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
JBrowse link
G Rpl22 ribosomal protein L22 increases expression ISO beryllium sulfate results in increased expression of RPL22 mRNA CTD PMID:16314022 NCBI chr 4:152,324,436...152,334,082
Ensembl chr 4:152,325,742...152,334,071
JBrowse link
G Rpl30 ribosomal protein L30 increases expression ISO beryllium sulfate results in increased expression of RPL30 mRNA CTD PMID:16314022 NCBI chr15:34,440,505...34,443,276
Ensembl chr15:34,440,505...34,443,640
JBrowse link
G Rpl37a ribosomal protein L37a increases expression ISO beryllium sulfate results in increased expression of RPL37A mRNA CTD PMID:16314022 NCBI chr 1:72,711,260...72,713,813
Ensembl chr 1:72,711,290...72,713,813
JBrowse link
G Rps7 ribosomal protein S7 increases expression ISO beryllium sulfate results in increased expression of RPS7 mRNA CTD PMID:16314022 NCBI chr12:28,630,847...28,635,953
Ensembl chr12:28,630,854...28,635,953
JBrowse link
G Runx1 runt related transcription factor 1 multiple interactions ISO beryllium sulfate promotes the reaction [RUNX1 protein binds to CCL3 promoter] CTD PMID:16314022 NCBI chr16:92,601,466...92,826,074
Ensembl chr16:92,601,466...92,826,149
JBrowse link
G Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 increases expression ISO beryllium sulfate results in increased expression of SERPINB2 mRNA CTD PMID:16314022 NCBI chr 1:107,500,892...107,525,600
Ensembl chr 1:107,511,423...107,535,478
JBrowse link
G Sftpd surfactant associated protein D increases expression ISO beryllium sulfate results in increased expression of SFTPD mRNA CTD PMID:16314022 NCBI chr14:41,172,212...41,185,198
Ensembl chr14:41,172,214...41,185,149
JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO beryllium sulfate inhibits the reaction [Hydrocortisone results in increased expression of TAT protein] CTD PMID:6120038 NCBI chr 8:109,986,078...109,999,804
Ensembl chr 8:109,990,437...109,999,803
JBrowse link
G Tmsb4x thymosin, beta 4, X chromosome increases expression ISO beryllium sulfate results in increased expression of TMSB4X mRNA CTD PMID:16314022 NCBI chr  X:167,207,093...167,213,479
Ensembl chr  X:167,207,093...167,209,315
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP beryllium sulfate results in increased expression of TNF mRNA; beryllium sulfate results in increased expression of TNF protein
beryllium sulfate promotes the reaction [IFNG protein results in increased expression of TNF protein]
CTD PMID:10755710 PMID:10755711 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression
ISO beryllium sulfate promotes the reaction [TP53 protein binds to CDKN1A promoter]
beryllium sulfate results in increased expression of TP53 protein
CTD PMID:17395767 PMID:20974702 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Wnt4 wingless-type MMTV integration site family, member 4 increases expression ISO beryllium sulfate results in increased expression of WNT4 mRNA CTD PMID:16314022 NCBI chr 4:137,277,635...137,299,501
Ensembl chr 4:137,277,489...137,299,726
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21726
    chemical entity 21724
      molecular entity 21711
        ion 16620
          cation 16444
            monoatomic cation 14570
              monoatomic dication 10661
                beryllium(2+) 44
                  beryllium sulfate + 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 21726
    subatomic particle 21712
      composite particle 21712
        hadron 21712
          baryon 21712
            nucleon 21712
              atomic nucleus 21712
                atom 21712
                  main group element atom 21629
                    main group molecular entity 21629
                      s-block molecular entity 21160
                        alkaline earth molecular entity 669
                          beryllium molecular entity 56
                            elemental beryllium 47
                              monoatomic beryllium 44
                                beryllium ion 44
                                  beryllium cation 44
                                    beryllium(2+) 44
                                      beryllium sulfate + 44
paths to the root