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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thallium
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Accession:CHEBI:30440 term browser browse the term
Definition:A metallic element first identified and named from the brilliant green line in its flame spectrum (from Greek thetaalphalambdalambdaomicronsigma, a green shoot).
Synonyms:related_synonym: 81Tl;   Formula=Tl;   InChI=1S/Tl;   InChIKey=BKVIYDNLLOSFOA-UHFFFAOYSA-N;   SMILES=[Tl];   Tl;   talio
 xref: CAS:7440-28-0;   Gmelin:16308
 xref_mesh: MESH:D013793
 xref: WebElements:Tl



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thallium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity EXP Thallium results in decreased activity of CAT protein CTD PMID:28866748 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases response to substance EXP CYP2E1 results in increased susceptibility to Thallium CTD PMID:20549620 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Grm4 glutamate metabotropic receptor 4 multiple interactions ISO [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
JBrowse link
G Grm8 glutamate metabotropic receptor 8 multiple interactions ISO [GRM8 protein results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]] which results in increased transport of Thallium CTD PMID:22275899 NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression EXP Thallium results in decreased expression of GSR protein CTD PMID:28866748 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 multiple interactions ISO [Benzethonium results in decreased activity of KCNA3 protein] which results in decreased import of Thallium; [domiphen results in decreased activity of KCNA3 protein] which results in decreased import of Thallium; [Econazole results in decreased activity of KCNA3 protein] which results in decreased import of Thallium; [malachite green results in decreased activity of KCNA3 protein] which results in decreased import of Thallium; [o,p'-DDT results in decreased activity of KCNA3 protein] which results in decreased import of Thallium; [Reserpine results in decreased activity of KCNA3 protein] which results in decreased import of Thallium; [Tamoxifen results in decreased activity of KCNA3 protein] which results in decreased import of Thallium; [tetraoctylammonium bromide results in decreased activity of KCNA3 protein] which results in decreased import of Thallium; [Tritolyl Phosphates results in decreased activity of KCNA3 protein] which results in decreased import of Thallium; [Verapamil results in decreased activity of KCNA3 protein] which results in decreased import of Thallium CTD PMID:21362439 NCBI chr 2:194,632,360...194,633,937
Ensembl chr 2:194,632,196...194,650,138
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
increases import
increases transport
ISO 2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acid inhibits the reaction [Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]]; 2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acid promotes the reaction [KCNH2 protein results in increased transport of Thallium]; 8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a)quinoxalin-5(6H)-one inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; [Benzethonium results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [didecyldimethylammonium results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [diphenylguanidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [domiphen results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [Econazole results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [malachite green results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [o,p'-DDT results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [Quinidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [Reserpine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [Tamoxifen results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [tetraoctylammonium bromide results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [Tritolyl Phosphates results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; [Verapamil results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Amiodarone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; amperozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Aripiprazole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Astemizole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Bepridil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Chlorpheniramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Chlorpromazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Ciclopirox inhibits the reaction [Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]]; Ciclopirox promotes the reaction [KCNH2 protein results in increased transport of Thallium]; Cisapride inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Clomipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Domperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Doxepin inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Droperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; E 4031 inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; eliprodil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Fluoxetine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Fluvoxamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Haloperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Imipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Lidoflazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Loratadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Maprotiline inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Mefloquine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Methadyl Acetate inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Mibefradil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; N-(n-butyl)-(bis-fluorophenyl)methoxytropane inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Nortriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Olanzapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Phentolamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Pimozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Propafenone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Pyrilamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Quetiapine Fumarate inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Quinidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Risperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Ritanserin inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; sertindole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Tamoxifen inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; terodiline inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Trifluoperazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Trifluperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; vanoxerine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Verapamil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; vinpocetine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
KCNH2 protein results in increased import of Thallium
KCNH2 protein results in increased transport of Thallium; KCNH2 results in increased transport of Thallium
CTD PMID:19583963 PMID:21158687 PMID:21158688 PMID:21362439 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 increases uptake EXP KCNJ1 protein results in increased uptake of Thallium CTD PMID:22811560 NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; [GRM8 protein results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]] which results in increased transport of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 PMID:22275899 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 increases transport ISO KCNJ4 protein results in increased transport of Thallium CTD PMID:22275899 NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO [GRM8 protein results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]] which results in increased transport of Thallium CTD PMID:22275899 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 affects activity ISO Thallium affects the activity of KCNMA1 protein CTD PMID:16636204 NCBI chr15:302,078...1,001,198
Ensembl chr15:302,214...1,001,198
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 multiple interactions ISO [cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN2 protein] which results in increased import of Thallium; Apamin inhibits the reaction [[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN2 protein] which results in increased import of Thallium] CTD PMID:17486140 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
JBrowse link
G Kcnn3 potassium calcium-activated channel subfamily N member 3 multiple interactions ISO
EXP
[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN3 protein] which results in increased import of Thallium; Apamin inhibits the reaction [[cyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine results in increased activity of KCNN3 protein] which results in increased import of Thallium]
[Ionomycin results in increased activity of KCNN3 protein] which results in increased import of Thallium; Apamin inhibits the reaction [[Ionomycin results in increased activity of KCNN3 protein] which results in increased import of Thallium]
CTD PMID:15634793 PMID:17486140 NCBI chr 2:174,929,846...175,088,910
Ensembl chr 2:174,936,629...175,081,145
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 multiple interactions
increases import
ISO [Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium; [Benzimidazoles analog results in increased activity of KCNQ2 protein] which results in increased import of Thallium; [KCNQ2 protein binds to KCNQ3 protein] which results in increased import of Thallium; [Quinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium; [Quinazolinones analog results in increased activity of KCNQ2 protein] which results in increased import of Thallium
KCNQ2 protein results in increased import of Thallium
10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in increased import of Thallium]; [Potassium results in increased activity of KCNQ2 protein] which results in increased import of Thallium; ezogabine affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in increased import of Thallium]
CTD PMID:15634793 PMID:21723881 NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071
JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 multiple interactions
increases import
ISO [Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium; [KCNQ2 protein binds to KCNQ3 protein] which results in increased import of Thallium; [KCNQ5 protein binds to KCNQ3 protein] which results in increased import of Thallium; [Quinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium; [Quinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ5 protein]] which results in increased import of Thallium; [Quinazolinones analog results in increased activity of KCNQ3 protein] which results in increased import of Thallium
KCNQ3 protein results in increased import of Thallium
CTD PMID:21723881 NCBI chr 7:97,730,219...98,025,652
Ensembl chr 7:97,730,465...98,025,653
JBrowse link
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 multiple interactions
increases import
ISO [ezogabine results in increased activity of KCNQ4 protein] which results in increased import of Thallium; [Quinazolinones analog results in increased activity of KCNQ4 protein] which results in increased import of Thallium
KCNQ4 protein results in increased import of Thallium
CTD PMID:21723881 PMID:21782781 NCBI chr 5:134,275,145...134,326,992
Ensembl chr 5:134,275,934...134,326,932
JBrowse link
G Kcnq5 potassium voltage-gated channel subfamily Q member 5 increases import
multiple interactions
ISO KCNQ5 protein results in increased import of Thallium
[KCNQ5 protein binds to KCNQ3 protein] which results in increased import of Thallium; [Quinazolinones analog results in increased activity of [KCNQ3 protein binds to KCNQ5 protein]] which results in increased import of Thallium; [Quinazolinones analog results in increased activity of KCNQ5 protein] which results in increased import of Thallium
CTD PMID:21723881 NCBI chr 9:23,830,185...24,395,984
Ensembl chr 9:23,833,087...24,394,704
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Thallium results in increased expression of NOS2 protein CTD PMID:28866748 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Slc12a5 solute carrier family 12 member 5 multiple interactions
increases import
ISO ((dihydroindenyl)oxy)alkanoic acid inhibits the reaction [SLC12A5 protein results in increased import of Thallium]; Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]; Furosemide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]; Staurosporine inhibits the reaction [SLC12A5 protein results in increased import of Thallium] CTD PMID:20086212 NCBI chr 3:153,696,522...153,735,801
Ensembl chr 3:153,696,517...153,735,765
JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions EXP Thallium binds to and results in increased activity of SLC1A1 protein CTD PMID:18986164 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP Thallium results in decreased expression of SOD1 protein CTD PMID:28866748 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP Thallium affects the expression of SOD2 protein CTD PMID:28866748 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Txnrd1 thioredoxin reductase 1 affects expression EXP Thallium affects the expression of TXNRD1 protein CTD PMID:28866748 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression EXP Thallium results in decreased expression of TXNRD2 protein CTD PMID:28866748 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link
thallium sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 affects expression EXP thallium sulfate affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
thallium(I) acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sod1 superoxide dismutase 1 decreases activity EXP thallium acetate results in decreased activity of SOD1 protein CTD PMID:15833379 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        main group element atom 19720
          p-block element atom 19720
            boron group element atom 1042
              thallium 26
                thallium molecular entity + 2
                thallium-199 0
                thallium-201 + 0
                thallium-203 0
                thallium-205 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      boron group element atom 1042
                        thallium 26
                          thallium molecular entity + 2
                          thallium-199 0
                          thallium-201 + 0
                          thallium-203 0
                          thallium-205 0
paths to the root