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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzphetamine
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Accession:CHEBI:3044 term browser browse the term
Definition:Dextroamphetamine in which the the hydrogens attached to the amino group are substituted by a methyl and a benzyl group. A sympathomimetic agent with properties similar to dextroamphetamine, it is used as its hydrochloride salt in the treatment of obesity.
Synonyms:exact_synonym: (2S)-N-benzyl-N-methyl-1-phenylpropan-2-amine
 related_synonym: (+)-N,alpha-dimethyl-N-(phenylmethyl)-benzeneethanamine;   (+)-N-benzyl-N,alpha-dimethylphenethylamine;   (S)-(+)-N-benzyl-N,alpha-dimethylphenethylamine;   (S)-benzphetamine;   (alphaS)-N,alpha-dimethylphenethylamine;   Formula=C17H21N;   InChI=1S/C17H21N/c1-15(13-16-9-5-3-6-10-16)18(2)14-17-11-7-4-8-12-17/h3-12,15H,13-14H2,1-2H3/t15-/m0/s1;   InChIKey=YXKTVDFXDRQTKV-HNNXBMFYSA-N;   N-methyl-1-phenyl-N-(phenylmethyl)propan-2-amine;   SMILES=C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1;   benzaphetamine;   benzfetamina;   benzfetamine;   benzfetaminum;   benzylamphetamine;   d-N-methyl-N-benzyl-beta-phenylisopropylamine
 xref: Beilstein:3203999;   CAS:156-08-1;   DrugBank:DB00865;   Drug_Central:329;   KEGG:C07538;   KEGG:D07514
 xref_mesh: MESH:D001589
 xref: Patent:US2789138


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benzphetamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Benzphetamine CTD PMID:12464242 PMID:15769884 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Benzphetamine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        pharmacological role 18847
          neurotransmitter agent 16456
            adrenergic agent 8970
              sympathomimetic agent 5441
                benzphetamine 2
                  benzphetamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        amine 7821
                                          tertiary amine 619
                                            benzphetamine 2
                                              benzphetamine hydrochloride 0
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