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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetrahydropterin
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Accession:CHEBI:30436 term browser browse the term
Synonyms:related_synonym: tetrahydropteridines;   tetrahydropterins
 alt_id: CHEBI:13613;   CHEBI:26918



show annotations for term's descendants           Sort by:
5,6,7,8-tetrahydrobiopterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] CTD PMID:17098227 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO sapropterin inhibits the reaction [Methotrexate results in increased expression of CDKN1A protein] CTD PMID:22183962 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Epo erythropoietin multiple interactions
increases abundance
ISO
EXP
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]
EPO protein results in increased abundance of sapropterin
EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased oxidation of sapropterin]
CTD PMID:25041251 PMID:25490417 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases abundance
affects abundance
multiple interactions
increases chemical synthesis
ISO
EXP
GCH1 mutant form results in decreased abundance of sapropterin
GCH1 protein affects the abundance of sapropterin
[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; [resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; GCH1 gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin
GCH1 protein results in increased chemical synthesis of sapropterin
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]
CTD PMID:14551046 PMID:20610621 PMID:21963838 PMID:25041251 PMID:25490417 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870
JBrowse link
G Gulo gulonolactone (L-) oxidase multiple interactions EXP [gulonolactone co-treated with GULO protein] results in increased abundance of sapropterin CTD PMID:16737683 NCBI chr14:66,224,235...66,246,703
Ensembl chr14:66,224,235...66,246,656
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases activity
multiple interactions
ISO
EXP
sapropterin results in increased activity of NOS3 protein
sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]
CTD PMID:19011239 PMID:23753407 PMID:25490417 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Sct secretin increases abundance ISO SCT protein results in increased abundance of sapropterin CTD PMID:16168596 NCBI chr 7:140,858,243...140,859,082
Ensembl chr 7:140,858,243...140,859,046
JBrowse link
G Snca synuclein, alpha increases abundance ISO SNCA mutant form results in increased abundance of sapropterin CTD PMID:24148766 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO sapropterin inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:22183962 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
sapropterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] CTD PMID:17098227 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO sapropterin inhibits the reaction [Methotrexate results in increased expression of CDKN1A protein] CTD PMID:22183962 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Epo erythropoietin multiple interactions
increases abundance
ISO
EXP
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]
EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased oxidation of sapropterin]
EPO protein results in increased abundance of sapropterin
CTD PMID:25041251 PMID:25490417 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases abundance
multiple interactions
increases chemical synthesis
affects abundance
ISO
EXP
GCH1 mutant form results in decreased abundance of sapropterin
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]
GCH1 protein results in increased chemical synthesis of sapropterin
[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; [Resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; GCH1 gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin
GCH1 protein affects the abundance of sapropterin
CTD PMID:14551046 PMID:20610621 PMID:21963838 PMID:25041251 PMID:25490417 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870
JBrowse link
G Gulo gulonolactone (L-) oxidase multiple interactions EXP [gulonolactone co-treated with GULO protein] results in increased abundance of sapropterin CTD PMID:16737683 NCBI chr14:66,224,235...66,246,703
Ensembl chr14:66,224,235...66,246,656
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases activity
multiple interactions
ISO
EXP
sapropterin results in increased activity of NOS3 protein
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]
sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]
CTD PMID:19011239 PMID:23753407 PMID:25490417 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Sct secretin increases abundance ISO SCT protein results in increased abundance of sapropterin CTD PMID:16168596 NCBI chr 7:140,858,243...140,859,082
Ensembl chr 7:140,858,243...140,859,046
JBrowse link
G Snca synuclein, alpha increases abundance ISO SNCA mutant form results in increased abundance of sapropterin CTD PMID:24148766 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO sapropterin inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:22183962 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      atom 22170
        nonmetal atom 22055
          nitrogen atom 20030
            nitrogen molecular entity 20004
              organonitrogen compound 19809
                organonitrogen heterocyclic compound 19099
                  pteridines 10718
                    pterins 9828
                      tetrahydropterin 10
                        (7,8-dihydropterin-6-yl)methyl diphosphate 0
                        2-amino-5,6,7,8-tetrahydroxy-6-(1,2,3-trihydroxypropyl)-3,7-dihydropteridin-4-one 0
                        4a-hydroxytetrahydrobiopterin + 0
                        5,6,7,8-tetrahydrobiopterin + 10
                        5,6,7,8-tetrahydropterin-6-carboxylic acid 0
                        6-(1,2,3-trihydroxypropyl)-7,8-dihydroxy-5,6,7,8-tetrahydropterin 0
                        6-lactoyl-5,6,7,8-tetrahydropterin + 0
                        N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate 0
                        dyspropterin + 0
                        tetrahydromonapterin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteropolycyclic compound 19645
                                    organic heterobicyclic compound 18203
                                      pteridines 10718
                                        pterins 9828
                                          tetrahydropterin 10
                                            (7,8-dihydropterin-6-yl)methyl diphosphate 0
                                            2-amino-5,6,7,8-tetrahydroxy-6-(1,2,3-trihydroxypropyl)-3,7-dihydropteridin-4-one 0
                                            4a-hydroxytetrahydrobiopterin + 0
                                            5,6,7,8-tetrahydrobiopterin + 10
                                            5,6,7,8-tetrahydropterin-6-carboxylic acid 0
                                            6-(1,2,3-trihydroxypropyl)-7,8-dihydroxy-5,6,7,8-tetrahydropterin 0
                                            6-lactoyl-5,6,7,8-tetrahydropterin + 0
                                            N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate 0
                                            dyspropterin + 0
                                            tetrahydromonapterin 0
paths to the root