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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetrahydropterin
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Accession:CHEBI:30436 term browser browse the term
Synonyms:related_synonym: tetrahydropteridines;   tetrahydropterins
 alt_id: CHEBI:13613;   CHEBI:26918



show annotations for term's descendants           Sort by:
5,6,7,8-tetrahydrobiopterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] CTD PMID:17098227 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP sapropterin inhibits the reaction [Methotrexate results in increased expression of CDKN1A protein] CTD PMID:22183962 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G EPO erythropoietin multiple interactions
increases abundance
EXP
ISO
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]
EPO protein results in increased abundance of sapropterin
EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased oxidation of sapropterin]
CTD PMID:25041251 PMID:25490417 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G GCH1 GTP cyclohydrolase 1 decreases abundance
affects abundance
multiple interactions
increases chemical synthesis
EXP
ISO
GCH1 mutant form results in decreased abundance of sapropterin
GCH1 protein affects the abundance of sapropterin
[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; [resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; GCH1 gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin
GCH1 protein results in increased chemical synthesis of sapropterin
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]
CTD PMID:14551046 PMID:20610621 PMID:21963838 PMID:25041251 PMID:25490417 NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G GULOP gulonolactone (L-) oxidase, pseudogene multiple interactions ISO [gulonolactone co-treated with GULO protein] results in increased abundance of sapropterin CTD PMID:16737683 NCBI chr 8:27,577,611...27,589,073
Ensembl chr 8:27,560,274...27,589,073
JBrowse link
G NOS3 nitric oxide synthase 3 increases activity
multiple interactions
EXP
ISO
sapropterin results in increased activity of NOS3 protein
sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]
CTD PMID:19011239 PMID:23753407 PMID:25490417 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G SCT secretin increases abundance EXP SCT protein results in increased abundance of sapropterin CTD PMID:16168596 NCBI chr11:626,309...627,181
Ensembl chr11:626,309...627,181
JBrowse link
G SNCA synuclein alpha increases abundance EXP SNCA mutant form results in increased abundance of sapropterin CTD PMID:24148766 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP sapropterin inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:22183962 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
sapropterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ mRNA]; sapropterin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] CTD PMID:17098227 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin; GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP sapropterin inhibits the reaction [Methotrexate results in increased expression of CDKN1A protein] CTD PMID:22183962 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G EPO erythropoietin multiple interactions
increases abundance
EXP
ISO
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]
EPO protein results in increased abundance of sapropterin
EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; EPO protein inhibits the reaction [HPH1 gene mutant form results in increased oxidation of sapropterin]
CTD PMID:25041251 PMID:25490417 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G GCH1 GTP cyclohydrolase 1 decreases abundance
affects abundance
multiple interactions
increases chemical synthesis
EXP
ISO
GCH1 mutant form results in decreased abundance of sapropterin
GCH1 protein affects the abundance of sapropterin
[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin; [resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin; EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]; GCH1 gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin
GCH1 protein results in increased chemical synthesis of sapropterin
EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]
CTD PMID:14551046 PMID:20610621 PMID:21963838 PMID:25041251 PMID:25490417 NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G GULOP gulonolactone (L-) oxidase, pseudogene multiple interactions ISO [gulonolactone co-treated with GULO protein] results in increased abundance of sapropterin CTD PMID:16737683 NCBI chr 8:27,577,611...27,589,073
Ensembl chr 8:27,560,274...27,589,073
JBrowse link
G NOS3 nitric oxide synthase 3 increases activity
multiple interactions
EXP
ISO
sapropterin results in increased activity of NOS3 protein
sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]
CTD PMID:19011239 PMID:23753407 PMID:25490417 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G SCT secretin increases abundance EXP SCT protein results in increased abundance of sapropterin CTD PMID:16168596 NCBI chr11:626,309...627,181
Ensembl chr11:626,309...627,181
JBrowse link
G SNCA synuclein alpha increases abundance EXP SNCA mutant form results in increased abundance of sapropterin CTD PMID:24148766 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP sapropterin inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:22183962 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    chemical entity 26019
      atom 26015
        nonmetal atom 25504
          nitrogen atom 22544
            nitrogen molecular entity 22544
              organonitrogen compound 21939
                organonitrogen heterocyclic compound 20352
                  pteridines 10534
                    pterins 9572
                      tetrahydropterin 10
                        (7,8-dihydropterin-6-yl)methyl diphosphate 0
                        2-amino-5,6,7,8-tetrahydroxy-6-(1,2,3-trihydroxypropyl)-3,7-dihydropteridin-4-one 0
                        4a-hydroxytetrahydrobiopterin + 0
                        5,6,7,8-tetrahydrobiopterin + 10
                        5,6,7,8-tetrahydropterin-6-carboxylic acid 0
                        6-(1,2,3-trihydroxypropyl)-7,8-dihydroxy-5,6,7,8-tetrahydropterin 0
                        6-lactoyl-5,6,7,8-tetrahydropterin + 0
                        N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate 0
                        dyspropterin + 0
                        tetrahydromonapterin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24279
                                organic heterocyclic compound 22322
                                  organic heteropolycyclic compound 21309
                                    organic heterobicyclic compound 18572
                                      pteridines 10534
                                        pterins 9572
                                          tetrahydropterin 10
                                            (7,8-dihydropterin-6-yl)methyl diphosphate 0
                                            2-amino-5,6,7,8-tetrahydroxy-6-(1,2,3-trihydroxypropyl)-3,7-dihydropteridin-4-one 0
                                            4a-hydroxytetrahydrobiopterin + 0
                                            5,6,7,8-tetrahydrobiopterin + 10
                                            5,6,7,8-tetrahydropterin-6-carboxylic acid 0
                                            6-(1,2,3-trihydroxypropyl)-7,8-dihydroxy-5,6,7,8-tetrahydropterin 0
                                            6-lactoyl-5,6,7,8-tetrahydropterin + 0
                                            N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate 0
                                            dyspropterin + 0
                                            tetrahydromonapterin 0
paths to the root