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G |
Aif1 |
allograft inflammatory factor 1 |
increases expression multiple interactions |
ISO |
trimethyltin results in increased expression of AIF1 mRNA; trimethyltin results in increased expression of AIF1 protein magnolol inhibits the reaction [trimethyltin results in increased expression of AIF1 protein] |
CTD |
PMID:24002884 PMID:26756313 |
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NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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G |
Arg1 |
arginase 1 |
multiple interactions |
EXP |
[trimethyltin chloride results in increased abundance of trimethyltin] which results in decreased expression of ARG1 mRNA |
CTD |
PMID:30993381 |
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NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
trimethyltin results in increased expression of ATF3 mRNA |
CTD |
PMID:24002884 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions decreases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form] |
CTD |
PMID:25895139 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]; magnolol inhibits the reaction [trimethyltin results in increased expression of BAX protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein] |
CTD |
PMID:25895139 PMID:26756313 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]; magnolol inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein] |
CTD |
PMID:25895139 PMID:26756313 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein] |
CTD |
PMID:25895139 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
C1qa |
complement C1q A chain |
increases expression |
ISO |
trimethyltin results in increased expression of C1QA mRNA |
CTD |
PMID:21435392 |
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NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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G |
C1qb |
complement C1q B chain |
increases expression |
ISO |
trimethyltin results in increased expression of C1QB mRNA |
CTD |
PMID:21435392 PMID:24002884 |
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NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases activity |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; HR protein affects the reaction [trimethyltin results in increased activity of CASP3 protein]; magnolol inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]; rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form] trimethyltin results in increased expression of CASP3 mRNA; trimethyltin results in increased expression of CASP3 protein modified form |
CTD |
PMID:20886113 PMID:21435392 PMID:22634143 PMID:24002884 PMID:25895139 PMID:26756313 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
trimethyltin results in increased expression of CCL2 mRNA |
CTD |
PMID:21435392 PMID:24002884 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression |
ISO |
trimethyltin results in increased expression of CCL3 mRNA |
CTD |
PMID:21435392 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases expression |
ISO |
trimethyltin results in increased expression of CCL4 mRNA |
CTD |
PMID:24002884 |
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NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
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G |
Cd44 |
CD44 molecule (Indian blood group) |
increases expression |
ISO |
trimethyltin results in increased expression of CD44 mRNA |
CTD |
PMID:24002884 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd86 |
CD86 molecule |
multiple interactions |
EXP |
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of CD86 mRNA |
CTD |
PMID:30993381 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases expression |
ISO |
trimethyltin results in increased expression of CFLAR mRNA |
CTD |
PMID:21435392 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
increases expression |
ISO |
trimethyltin results in increased expression of CHUK mRNA |
CTD |
PMID:21435392 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
EXP |
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of CXCL1 mRNA |
CTD |
PMID:30993381 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cycs |
cytochrome c, somatic |
decreases expression |
ISO |
trimethyltin results in decreased expression of CYCS mRNA |
CTD |
PMID:21435392 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression multiple interactions |
EXP |
trimethyltin results in decreased expression of CYP11A1 mRNA trimethyltin results in decreased expression of and results in decreased activity of CYP11A1 protein |
CTD |
PMID:32898603 |
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NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
trimethyltin results in increased expression of FAS mRNA |
CTD |
PMID:24002884 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
increases expression |
ISO |
trimethyltin results in increased expression of FASL mRNA |
CTD |
PMID:24002884 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fgf21 |
fibroblast growth factor 21 |
increases expression |
ISO |
trimethyltin results in increased expression of FGF21 mRNA |
CTD |
PMID:24002884 |
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NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO |
trimethyltin results in increased expression of GCLC mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA] |
CTD |
PMID:25895139 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA] |
CTD |
PMID:25895139 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gfap |
glial fibrillary acidic protein |
increases expression multiple interactions |
ISO |
trimethyltin results in increased expression of GFAP mRNA; trimethyltin results in increased expression of GFAP protein magnolol inhibits the reaction [trimethyltin results in increased expression of GFAP protein] |
CTD |
PMID:24002884 PMID:26756313 PMID:27729293 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Grb2 |
growth factor receptor bound protein 2 |
increases expression |
ISO |
trimethyltin results in increased expression of GRB2 mRNA |
CTD |
PMID:20833246 |
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NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
decreases expression |
ISO |
trimethyltin results in decreased expression of GRIN2B mRNA |
CTD |
PMID:24002884 |
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NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Grm3 |
glutamate metabotropic receptor 3 |
decreases expression |
ISO |
trimethyltin results in decreased expression of GRM3 mRNA |
CTD |
PMID:24002884 |
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NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
ISO |
trimethyltin results in increased expression of HIF1A mRNA |
CTD |
PMID:24002884 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
trimethyltin results in increased expression of HMOX1 protein magnolol inhibits the reaction [trimethyltin results in increased expression of HMOX1 protein] trimethyltin results in increased expression of HMOX1 mRNA |
CTD |
PMID:26756313 PMID:27729293 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hr |
HR, lysine demethylase and nuclear receptor corepressor |
affects response to substance multiple interactions |
ISO |
HR protein affects the susceptibility to trimethyltin HR protein affects the reaction [trimethyltin results in increased activity of CASP3 protein] |
CTD |
PMID:20886113 |
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NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313
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G |
Hras |
HRas proto-oncogene, GTPase |
increases expression |
ISO |
trimethyltin results in increased expression of HRAS mRNA |
CTD |
PMID:21435392 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
multiple interactions |
ISO EXP |
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; [[trimethyltin chloride results in increased abundance of trimethyltin] which co-treated with Corticosterone] results in increased expression of HSD11B1 mRNA; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased activity of HSD11B1 protein; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; LY 290042 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]] [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA; Cortisone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; INS protein affects the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA] |
CTD |
PMID:30993381 |
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NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
multiple interactions decreases expression |
EXP |
trimethyltin results in decreased expression of and results in decreased activity of HSD17B3 protein trimethyltin results in decreased expression of HSD17B3 mRNA |
CTD |
PMID:32898603 |
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NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
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G |
Ifng |
interferon gamma |
increases expression |
ISO |
trimethyltin results in increased expression of IFNG mRNA |
CTD |
PMID:24002884 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf1 |
insulin-like growth factor 1 |
increases expression |
ISO |
trimethyltin results in increased expression of IGF1 mRNA |
CTD |
PMID:21435392 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Il10 |
interleukin 10 |
increases expression |
ISO |
trimethyltin results in increased expression of IL10 mRNA |
CTD |
PMID:24002884 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
trimethyltin results in increased expression of IL1A mRNA |
CTD |
PMID:20833246 PMID:21435392 PMID:24002884 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1r1 |
interleukin 1 receptor type 1 |
increases expression |
ISO |
trimethyltin results in increased expression of IL1R1 mRNA |
CTD |
PMID:20833246 |
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NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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G |
Il1rn |
interleukin 1 receptor antagonist |
increases expression |
ISO |
trimethyltin results in increased expression of IL1RN mRNA |
CTD |
PMID:21435392 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il6 |
interleukin 6 |
increases expression decreases response to substance decreases expression multiple interactions |
ISO EXP |
trimethyltin results in increased expression of IL6 mRNA; trimethyltin results in increased expression of IL6 protein IL6 results in decreased susceptibility to trimethyltin trimethyltin results in decreased expression of IL6 mRNA [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; 11-dehydrocorticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased secretion of IL6 protein; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Dexamethasone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; INS1 protein inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; LY 290042 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Resveratrol analog inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]] |
CTD |
PMID:20833246 PMID:21435392 PMID:24002884 PMID:30993381 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il6r |
interleukin 6 receptor |
increases expression |
ISO |
trimethyltin results in increased expression of IL6RA protein |
CTD |
PMID:21435392 |
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NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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G |
Il6st |
interleukin 6 cytokine family signal transducer |
increases expression |
ISO |
trimethyltin results in increased expression of IL6ST mRNA |
CTD |
PMID:20833246 |
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NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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G |
Ins2 |
insulin 2 |
multiple interactions |
EXP |
[trimethyltin chloride results in increased abundance of trimethyltin] promotes the reaction [INS protein affects the expression of NEFH mRNA]; INS protein affects the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA] |
CTD |
PMID:30993381 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Itgam |
integrin subunit alpha M |
increases expression multiple interactions |
ISO EXP |
trimethyltin results in increased expression of ITGAM mRNA [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of ITGAM mRNA |
CTD |
PMID:24002884 PMID:30993381 |
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NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
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G |
Jak1 |
Janus kinase 1 |
increases expression |
ISO |
trimethyltin results in increased expression of JAK1 mRNA |
CTD |
PMID:20833246 |
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NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
trimethyltin results in increased expression of JUN mRNA |
CTD |
PMID:21435392 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Lcn2 |
lipocalin 2 |
increases expression |
ISO |
trimethyltin results in increased expression of LCN2 mRNA |
CTD |
PMID:24002884 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lynx1 |
Ly6/neurotoxin 1 |
decreases expression |
ISO |
trimethyltin results in decreased expression of LYNX1 mRNA |
CTD |
PMID:24002884 |
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NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
decreases degradation |
EXP |
trimethyltin results in decreased degradation of MAP1LC3B protein modified form |
CTD |
PMID:26459185 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
increases expression |
ISO |
trimethyltin results in increased expression of MAP2K1 mRNA |
CTD |
PMID:20833246 |
|
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k6 |
mitogen-activated protein kinase kinase 6 |
decreases expression |
ISO |
trimethyltin results in decreased expression of MAP2K6 mRNA |
CTD |
PMID:21435392 |
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NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases expression |
ISO |
trimethyltin results in increased expression of MAPK1 mRNA |
CTD |
PMID:20833246 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases expression |
ISO |
trimethyltin results in increased expression of MAPK3 mRNA |
CTD |
PMID:20833246 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO |
trimethyltin results in increased phosphorylation of MAPK8 protein magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:26756313 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions increases phosphorylation |
ISO |
magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:26756313 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mki67 |
marker of proliferation Ki-67 |
increases expression |
ISO |
trimethyltin results in increased expression of MKI67 mRNA |
CTD |
PMID:24002884 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mrc1 |
mannose receptor, C type 1 |
multiple interactions |
EXP |
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of MRC1 mRNA |
CTD |
PMID:30993381 |
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NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
increases expression |
ISO |
trimethyltin results in increased expression of MYD88 mRNA |
CTD |
PMID:21435392 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Nefh |
neurofilament heavy chain |
multiple interactions |
EXP |
[trimethyltin chloride results in increased abundance of trimethyltin] promotes the reaction [INS protein affects the expression of NEFH mRNA] |
CTD |
PMID:30993381 |
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NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nefl |
neurofilament light chain |
increases secretion |
EXP |
trimethyltin results in increased secretion of NEFL protein |
CTD |
PMID:34677616 |
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NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]; trimethyltin affects the localization of and results in increased activity of NFE2L2 protein |
CTD |
PMID:25895139 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia |
NFKB inhibitor alpha |
multiple interactions increases phosphorylation |
ISO |
magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:26756313 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA]; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA; magnolol inhibits the reaction [trimethyltin results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA] |
CTD |
PMID:26756313 PMID:30993381 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
decreases expression |
EXP |
trimethyltin results in decreased expression of NR5A1 mRNA; trimethyltin results in decreased expression of NR5A1 protein |
CTD |
PMID:32898603 |
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NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
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G |
Ntf3 |
neurotrophin 3 |
decreases expression |
ISO |
trimethyltin results in decreased expression of NTF3 mRNA |
CTD |
PMID:24002884 |
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NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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G |
Ntrk3 |
neurotrophic receptor tyrosine kinase 3 |
decreases expression |
ISO |
trimethyltin results in decreased expression of NTRK3 mRNA |
CTD |
PMID:24002884 |
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NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
ISO |
rottlerin inhibits the reaction [trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein]; trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein |
CTD |
PMID:25895139 |
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NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
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G |
Ptpn11 |
protein tyrosine phosphatase, non-receptor type 11 |
increases expression |
ISO |
trimethyltin results in increased expression of PTPN11 mRNA |
CTD |
PMID:21435392 |
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NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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G |
Ptpn6 |
protein tyrosine phosphatase, non-receptor type 6 |
increases expression |
ISO |
trimethyltin results in increased expression of PTPN6 mRNA |
CTD |
PMID:20833246 |
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NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
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Rac1 |
Rac family small GTPase 1 |
increases expression |
ISO |
trimethyltin results in increased expression of RAC1 mRNA |
CTD |
PMID:20833246 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
increases expression |
ISO |
trimethyltin results in increased expression of RAF1 mRNA |
CTD |
PMID:20833246 |
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NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[trimethyltin chloride results in increased abundance of trimethyltin] which affects the localization of RELA protein; Resveratrol analog inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which affects the localization of RELA protein] |
CTD |
PMID:30993381 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rras2 |
RAS related 2 |
increases expression |
ISO |
trimethyltin results in increased expression of RRAS2 mRNA |
CTD |
PMID:20833246 |
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NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111
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G |
Shc1 |
SHC adaptor protein 1 |
increases expression |
ISO |
trimethyltin results in increased expression of SHC1 mRNA |
CTD |
PMID:20833246 |
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NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
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G |
Sos1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
increases expression |
ISO |
trimethyltin results in increased expression of SOS1 mRNA |
CTD |
PMID:20833246 |
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NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
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G |
Spp1 |
secreted phosphoprotein 1 |
increases expression |
ISO |
trimethyltin results in increased expression of SPP1 mRNA |
CTD |
PMID:24002884 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Sqstm1 |
sequestosome 1 |
decreases degradation |
EXP |
trimethyltin results in decreased degradation of SQSTM1 protein |
CTD |
PMID:26459185 |
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NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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G |
Srf |
serum response factor |
decreases expression |
ISO |
trimethyltin results in decreased expression of SRF mRNA |
CTD |
PMID:21435392 |
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NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
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Star |
steroidogenic acute regulatory protein |
decreases expression |
EXP |
trimethyltin results in decreased expression of STAR mRNA; trimethyltin results in decreased expression of STAR protein |
CTD |
PMID:32898603 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stat3 |
signal transducer and activator of transcription 3 |
increases expression |
ISO |
trimethyltin results in increased expression of STAT3 mRNA; trimethyltin results in increased expression of STAT3 protein |
CTD |
PMID:21435392 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
ISO |
trimethyltin results in increased expression of TGFB1 mRNA |
CTD |
PMID:21435392 PMID:24002884 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf |
tumor necrosis factor |
increases expression increases secretion multiple interactions |
ISO EXP |
trimethyltin results in increased expression of TNF mRNA trimethyltin results in increased secretion of TNF protein magnolol inhibits the reaction [trimethyltin results in increased secretion of TNF protein] [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of TNF mRNA |
CTD |
PMID:21435392 PMID:24002884 PMID:26756313 PMID:30993381 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip3 |
TNF alpha induced protein 3 |
increases expression |
ISO |
trimethyltin results in increased expression of TNFAIP3 mRNA |
CTD |
PMID:24002884 |
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NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
increases expression |
ISO |
trimethyltin results in increased expression of TNFRSF1A mRNA |
CTD |
PMID:21435392 PMID:24002884 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tnfrsf25 |
TNF receptor superfamily member 25 |
increases expression |
ISO |
trimethyltin results in increased expression of TNFRSF25 mRNA |
CTD |
PMID:21435392 |
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NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
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G |
Tollip |
toll interacting protein |
increases expression |
ISO |
trimethyltin results in increased expression of TOLLIP mRNA |
CTD |
PMID:21435392 |
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NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625
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G |
Tp53 |
tumor protein p53 |
increases activity |
ISO |
trimethyltin results in increased activity of TRP53 protein |
CTD |
PMID:22634143 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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