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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:stannane
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Accession:CHEBI:30419 term browser browse the term
Definition:A tin hydride that has formula H4Sn.
Synonyms:exact_synonym: tetrahydridotin;   tin tetrahydride
 related_synonym: Formula=H4Sn;   InChI=1S/Sn.4H;   InChIKey=KXCAEQNNTZANTK-UHFFFAOYSA-N;   SMILES=[H][Sn]([H])([H])[H];   SnH4
 xref: CAS:2406-52-2;   Gmelin:783

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trimethyltin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions		 ISO trimethyltin results in increased expression of AIF1 mRNA; trimethyltin results in increased expression of AIF1 protein
magnolol inhibits the reaction [trimethyltin results in increased expression of AIF1 protein]		 CTD PMID:24002884 PMID:26756313 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Arg1 arginase 1 multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] which results in decreased expression of ARG1 mRNA CTD PMID:30993381 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO trimethyltin results in increased expression of ATF3 mRNA CTD PMID:24002884 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form] CTD PMID:25895139 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]; magnolol inhibits the reaction [trimethyltin results in increased expression of BAX protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein] CTD PMID:25895139 PMID:26756313 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]; magnolol inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein] CTD PMID:25895139 PMID:26756313 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein] CTD PMID:25895139 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G C1qa complement C1q A chain increases expression ISO trimethyltin results in increased expression of C1QA mRNA CTD PMID:21435392 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain increases expression ISO trimethyltin results in increased expression of C1QB mRNA CTD PMID:21435392 PMID:24002884 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; HR protein affects the reaction [trimethyltin results in increased activity of CASP3 protein]; magnolol inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]; rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]
trimethyltin results in increased expression of CASP3 mRNA; trimethyltin results in increased expression of CASP3 protein modified form		 CTD PMID:20886113 PMID:21435392 PMID:22634143 PMID:24002884 PMID:25895139 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO trimethyltin results in increased expression of CCL2 mRNA CTD PMID:21435392 PMID:24002884 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO trimethyltin results in increased expression of CCL3 mRNA CTD PMID:21435392 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO trimethyltin results in increased expression of CCL4 mRNA CTD PMID:24002884 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO trimethyltin results in increased expression of CD44 mRNA CTD PMID:24002884 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd86 CD86 molecule multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of CD86 mRNA CTD PMID:30993381 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO trimethyltin results in increased expression of CFLAR mRNA CTD PMID:21435392 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases expression ISO trimethyltin results in increased expression of CHUK mRNA CTD PMID:21435392 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of CXCL1 mRNA CTD PMID:30993381 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cycs cytochrome c, somatic decreases expression ISO trimethyltin results in decreased expression of CYCS mRNA CTD PMID:21435392 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions		 EXP trimethyltin results in decreased expression of CYP11A1 mRNA
trimethyltin results in decreased expression of and results in decreased activity of CYP11A1 protein		 CTD PMID:32898603 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO trimethyltin results in increased expression of FAS mRNA CTD PMID:24002884 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO trimethyltin results in increased expression of FASL mRNA CTD PMID:24002884 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression ISO trimethyltin results in increased expression of FGF21 mRNA CTD PMID:24002884 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO trimethyltin results in increased expression of GCLC mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]		 CTD PMID:25895139 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA] CTD PMID:25895139 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions		 ISO trimethyltin results in increased expression of GFAP mRNA; trimethyltin results in increased expression of GFAP protein
magnolol inhibits the reaction [trimethyltin results in increased expression of GFAP protein]		 CTD PMID:24002884 PMID:26756313 PMID:27729293 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Grb2 growth factor receptor bound protein 2 increases expression ISO trimethyltin results in increased expression of GRB2 mRNA CTD PMID:20833246 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression ISO trimethyltin results in decreased expression of GRIN2B mRNA CTD PMID:24002884 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grm3 glutamate metabotropic receptor 3 decreases expression ISO trimethyltin results in decreased expression of GRM3 mRNA CTD PMID:24002884 NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO trimethyltin results in increased expression of HIF1A mRNA CTD PMID:24002884 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO trimethyltin results in increased expression of HMOX1 protein
trimethyltin results in increased expression of HMOX1 mRNA
magnolol inhibits the reaction [trimethyltin results in increased expression of HMOX1 protein]		 CTD PMID:26756313 PMID:27729293 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor affects response to substance
multiple interactions		 ISO HR protein affects the susceptibility to trimethyltin
HR protein affects the reaction [trimethyltin results in increased activity of CASP3 protein]		 CTD PMID:20886113 NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression ISO trimethyltin results in increased expression of HRAS mRNA CTD PMID:21435392 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions ISO
EXP		 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; [[trimethyltin chloride results in increased abundance of trimethyltin] which co-treated with Corticosterone] results in increased expression of HSD11B1 mRNA; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased activity of HSD11B1 protein; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; LY 290042 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA; Cortisone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; INS protein affects the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]		 CTD PMID:30993381 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression		 EXP trimethyltin results in decreased expression of and results in decreased activity of HSD17B3 protein
trimethyltin results in decreased expression of HSD17B3 mRNA		 CTD PMID:32898603 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Ifng interferon gamma increases expression ISO trimethyltin results in increased expression of IFNG mRNA CTD PMID:24002884 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO trimethyltin results in increased expression of IGF1 mRNA CTD PMID:21435392 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 increases expression ISO trimethyltin results in increased expression of IL10 mRNA CTD PMID:24002884 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO trimethyltin results in increased expression of IL1A mRNA CTD PMID:20833246 PMID:21435392 PMID:24002884 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO trimethyltin results in increased expression of IL1R1 mRNA CTD PMID:20833246 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO trimethyltin results in increased expression of IL1RN mRNA CTD PMID:21435392 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases expression
decreases response to substance		 ISO
EXP		 trimethyltin results in increased expression of IL6 mRNA; trimethyltin results in increased expression of IL6 protein
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; 11-dehydrocorticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased secretion of IL6 protein; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Dexamethasone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; INS1 protein inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; LY 290042 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Resveratrol analog inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]]
trimethyltin results in decreased expression of IL6 mRNA
IL6 results in decreased susceptibility to trimethyltin		 CTD PMID:20833246 PMID:21435392 PMID:24002884 PMID:30993381 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor increases expression ISO trimethyltin results in increased expression of IL6RA protein CTD PMID:21435392 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression ISO trimethyltin results in increased expression of IL6ST mRNA CTD PMID:20833246 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] promotes the reaction [INS protein affects the expression of NEFH mRNA]; INS protein affects the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA] CTD PMID:30993381 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions		 ISO
EXP		 trimethyltin results in increased expression of ITGAM mRNA
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of ITGAM mRNA		 CTD PMID:24002884 PMID:30993381 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jak1 Janus kinase 1 increases expression ISO trimethyltin results in increased expression of JAK1 mRNA CTD PMID:20833246 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO trimethyltin results in increased expression of JUN mRNA CTD PMID:21435392 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO trimethyltin results in increased expression of LCN2 mRNA CTD PMID:24002884 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lynx1 Ly6/neurotoxin 1 decreases expression ISO trimethyltin results in decreased expression of LYNX1 mRNA CTD PMID:24002884 NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases degradation EXP trimethyltin results in decreased degradation of MAP1LC3B protein modified form CTD PMID:26459185 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO trimethyltin results in increased expression of MAP2K1 mRNA CTD PMID:20833246 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 decreases expression ISO trimethyltin results in decreased expression of MAP2K6 mRNA CTD PMID:21435392 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO trimethyltin results in increased expression of MAPK1 mRNA CTD PMID:20833246 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO trimethyltin results in increased expression of MAPK3 mRNA CTD PMID:20833246 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO trimethyltin results in increased phosphorylation of MAPK8 protein
magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK8 protein]		 CTD PMID:26756313 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK9 protein] CTD PMID:26756313 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO trimethyltin results in increased expression of MKI67 mRNA CTD PMID:24002884 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of MRC1 mRNA CTD PMID:30993381 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression ISO trimethyltin results in increased expression of MYD88 mRNA CTD PMID:21435392 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nefh neurofilament heavy chain multiple interactions EXP [trimethyltin chloride results in increased abundance of trimethyltin] promotes the reaction [INS protein affects the expression of NEFH mRNA] CTD PMID:30993381 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]; trimethyltin affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:25895139 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation		 ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of NFKBIA protein] CTD PMID:26756313 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA]; [trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA; magnolol inhibits the reaction [trimethyltin results in increased expression of NOS2 protein]; SB 203580 inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of NOS2 mRNA] CTD PMID:26756313 PMID:30993381 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression EXP trimethyltin results in decreased expression of NR5A1 mRNA; trimethyltin results in decreased expression of NR5A1 protein CTD PMID:32898603 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Ntf3 neurotrophin 3 decreases expression ISO trimethyltin results in decreased expression of NTF3 mRNA CTD PMID:24002884 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 decreases expression ISO trimethyltin results in decreased expression of NTRK3 mRNA CTD PMID:24002884 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO rottlerin inhibits the reaction [trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein]; trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein CTD PMID:25895139 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases expression ISO trimethyltin results in increased expression of PTPN11 mRNA CTD PMID:21435392 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases expression ISO trimethyltin results in increased expression of PTPN6 mRNA CTD PMID:20833246 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Rac1 Rac family small GTPase 1 increases expression ISO trimethyltin results in increased expression of RAC1 mRNA CTD PMID:20833246 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO trimethyltin results in increased expression of RAF1 mRNA CTD PMID:20833246 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [trimethyltin chloride results in increased abundance of trimethyltin] which affects the localization of RELA protein; Resveratrol analog inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which affects the localization of RELA protein] CTD PMID:30993381 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rras2 RAS related 2 increases expression ISO trimethyltin results in increased expression of RRAS2 mRNA CTD PMID:20833246 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111 		JBrowse link
G Shc1 SHC adaptor protein 1 increases expression ISO trimethyltin results in increased expression of SHC1 mRNA CTD PMID:20833246 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 increases expression ISO trimethyltin results in increased expression of SOS1 mRNA CTD PMID:20833246 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO trimethyltin results in increased expression of SPP1 mRNA CTD PMID:24002884 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sqstm1 sequestosome 1 decreases degradation EXP trimethyltin results in decreased degradation of SQSTM1 protein CTD PMID:26459185 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srf serum response factor decreases expression ISO trimethyltin results in decreased expression of SRF mRNA CTD PMID:21435392 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP trimethyltin results in decreased expression of STAR mRNA; trimethyltin results in decreased expression of STAR protein CTD PMID:32898603 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO trimethyltin results in increased expression of STAT3 mRNA; trimethyltin results in increased expression of STAT3 protein CTD PMID:21435392 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO trimethyltin results in increased expression of TGFB1 mRNA CTD PMID:21435392 PMID:24002884 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion		 ISO
EXP		 trimethyltin results in increased expression of TNF mRNA
[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of TNF mRNA
magnolol inhibits the reaction [trimethyltin results in increased secretion of TNF protein]		 CTD PMID:21435392 PMID:24002884 PMID:26756313 PMID:30993381 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO trimethyltin results in increased expression of TNFAIP3 mRNA CTD PMID:24002884 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO trimethyltin results in increased expression of TNFRSF1A mRNA CTD PMID:21435392 PMID:24002884 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO trimethyltin results in increased expression of TNFRSF25 mRNA CTD PMID:21435392 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Tollip toll interacting protein increases expression ISO trimethyltin results in increased expression of TOLLIP mRNA CTD PMID:21435392 NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625 		JBrowse link
G Tp53 tumor protein p53 increases activity ISO trimethyltin results in increased activity of TRP53 protein CTD PMID:22634143 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      molecular entity 19811
        polyatomic entity 19732
          heteroatomic molecular entity 19673
            hydrides 18845
              mononuclear parent hydride 17633
                stannane 88
                  stannanetriyl group 0
                  stannyl group 0
                  stannylidene group 0
                  stannylidyne group 0
                  trimethyltin 88
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              metal hydride 321
                                tin hydride 88
                                  stannane 88
                                    stannanetriyl group 0
                                    stannyl group 0
                                    stannylidene group 0
                                    stannylidyne group 0
                                    trimethyltin 88
paths to the root