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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monoatomic dication
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Accession:CHEBI:30412 term browser browse the term
Synonyms:related_synonym: Divalent cation;   SMILES=[*++];   divalent inorganic cations;   monoatomic dications
 alt_id: CHEBI:23856;   CHEBI:4665
 xref: KEGG:C00572


show annotations for term's descendants           Sort by:
 
cadmium nitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule affects expression EXP cadmium nitrate affects the expression of CD14 mRNA CTD PMID:29421334 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,358...142,349,581
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 affects expression
affects secretion
EXP cadmium nitrate affects the expression of CXCL8 mRNA
cadmium nitrate affects the secretion of CXCL8 protein
CTD PMID:29421334 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G DEFB1 defensin beta 1 increases expression EXP cadmium nitrate results in increased expression of DEFB1 mRNA CTD PMID:29421334
G IFNB1 interferon beta 1 increases expression EXP cadmium nitrate results in increased expression of IFNB1 mRNA CTD PMID:29421334 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
JBrowse link
G IL18 interleukin 18 increases expression EXP cadmium nitrate results in increased expression of IL18 mRNA CTD PMID:29421334 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G IL6 interleukin 6 increases expression EXP cadmium nitrate results in increased expression of IL6 mRNA CTD PMID:29421334 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression EXP cadmium nitrate results in increased expression of IL1B mRNA CTD PMID:29421334
G MAPK14 mitogen-activated protein kinase 14 affects expression EXP cadmium nitrate affects the expression of MAPK14 mRNA CTD PMID:29421334 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,104...31,862,038
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases expression EXP cadmium nitrate results in increased expression of MAPK8 mRNA CTD PMID:29421334 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor affects expression EXP cadmium nitrate affects the expression of MYD88 mRNA CTD PMID:29421334 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 affects expression EXP cadmium nitrate affects the expression of NFKB1 mRNA CTD PMID:29421334 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,637...118,506,691
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases expression EXP cadmium nitrate results in increased expression of RELA mRNA CTD PMID:29421334 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G SOCS1 suppressor of cytokine signaling 1 decreases expression EXP cadmium nitrate results in decreased expression of SOCS1 mRNA CTD PMID:29421334 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,969
JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases expression EXP cadmium nitrate results in decreased expression of STAT3 mRNA CTD PMID:29421334 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G TLR4 toll like receptor 4 affects expression EXP cadmium nitrate affects the expression of TLR4 mRNA CTD PMID:29421334 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TLR5 toll like receptor 5 increases expression EXP cadmium nitrate results in increased expression of TLR5 mRNA CTD PMID:29421334 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024
JBrowse link
G TNF tumor necrosis factor increases expression EXP cadmium nitrate results in increased expression of TNF mRNA CTD PMID:29421334 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
calcium dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions EXP Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [Sodium Bicarbonate co-treated with Calcium Chloride] results in increased activity of GAPDH protein CTD PMID:26582256 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,680...64,133,991
JBrowse link
cobalt dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 affects binding EXP cobaltous chloride binds to AOC1 protein CTD PMID:16842785 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,306,835...6,320,974
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP cobaltous chloride results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP cobaltous chloride results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
copper(II) chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 increases activity EXP cupric chloride results in increased activity of AOC1 protein CTD PMID:16842785 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,306,835...6,320,974
JBrowse link
copper(II) sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOX1 antioxidant 1 copper chaperone increases expression EXP Copper Sulfate results in increased expression of ATOX1 mRNA CTD PMID:22585802 NCBI chr16:71,299,321...71,314,598 JBrowse link
G CCNB1 cyclin B1 increases secretion EXP Copper Sulfate results in increased secretion of CCNB1 protein CTD PMID:24521407 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,381
JBrowse link
G COX17 cytochrome c oxidase copper chaperone COX17 decreases expression EXP Copper Sulfate results in decreased expression of COX17 mRNA CTD PMID:22585802 NCBI chr13:140,584,286...140,594,636
Ensembl chr13:140,584,363...140,614,159
JBrowse link
G GHRH growth hormone releasing hormone increases expression EXP Copper Sulfate results in increased expression of GHRH mRNA CTD PMID:21110139 NCBI chr17:40,386,725...40,398,312
Ensembl chr17:40,387,344...40,397,857
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Copper Sulfate results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Copper Sulfate results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G IGF1 insulin like growth factor 1 increases secretion EXP Copper Sulfate results in increased secretion of IGF1 protein CTD PMID:24521407 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G SST somatostatin decreases expression EXP Copper Sulfate results in decreased expression of SST mRNA; Copper Sulfate results in decreased expression of SST protein CTD PMID:21110139 NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,417...125,338,850
JBrowse link
lead diacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 increases expression EXP lead acetate results in increased expression of AKT1 mRNA CTD PMID:29273543
G AMH anti-Mullerian hormone decreases expression
multiple interactions
EXP lead acetate results in decreased expression of AMH mRNA
lead acetate results in decreased expression of and results in decreased secretion of AMH protein
CTD PMID:29273543 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,405,253...76,418,312
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP lead acetate inhibits the reaction [FSHB protein results in increased chemical synthesis of Estradiol] CTD PMID:29273543 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G FSHR follicle stimulating hormone receptor decreases expression EXP lead acetate results in decreased expression of FSHR mRNA CTD PMID:29273543 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP lead acetate results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP lead acetate results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G INHA inhibin subunit alpha multiple interactions EXP lead acetate results in decreased expression of and results in decreased secretion of [INHBB protein binds to INHA protein] CTD PMID:29273543 NCBI chr15:121,581,847...121,586,020
Ensembl chr15:121,580,801...121,586,010
JBrowse link
G INHBB inhibin subunit beta B decreases expression
multiple interactions
EXP lead acetate results in decreased expression of INHBB mRNA
lead acetate results in decreased expression of and results in decreased secretion of [INHBB protein binds to INHA protein]; lead acetate results in decreased expression of and results in decreased secretion of INHBB protein
CTD PMID:29273543 NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405
JBrowse link
G MTOR mechanistic target of rapamycin kinase increases expression EXP lead acetate results in increased expression of MTOR mRNA CTD PMID:29273543 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
lead(2+) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases expression EXP Lead results in increased expression of CASP3 CTD PMID:20390873 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CCNB1 cyclin B1 increases expression EXP Lead results in increased expression of CCNB1 CTD PMID:20390873 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,381
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP [FSHB protein co-treated with Lead co-treated with Mercury] results in decreased secretion of Progesterone CTD PMID:20390873 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G IGF1 insulin like growth factor 1 increases secretion EXP Lead results in increased secretion of IGF1 protein CTD PMID:20390873 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP Lead binds to and results in decreased folding of LDHA protein CTD PMID:18501191 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
zinc sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Zinc Sulfate results in increased expression of BAX mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA]
CTD PMID:28803810 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BECN1 beclin 1 increases expression
multiple interactions
EXP Zinc Sulfate results in increased expression of BECN1 protein
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]
CTD PMID:28803810 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases cleavage
EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]
Zinc Sulfate results in increased expression of CASP3 mRNA
CTD PMID:28803810 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP6 caspase 6 increases expression EXP Zinc Sulfate results in increased expression of CASP6 mRNA CTD PMID:28803810 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,483,392...112,540,550
JBrowse link
G CASP8 caspase 8 multiple interactions
increases cleavage
EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein] CTD PMID:28803810 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CYCS cytochrome c, somatic increases expression
multiple interactions
EXP Zinc Sulfate results in increased expression of CYCS mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA]
CTD PMID:28803810 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 increases expression EXP Zinc Sulfate results in increased expression of HSP70 mRNA CTD PMID:23274768 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586
JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha increases expression EXP Zinc Sulfate results in increased expression of MAP1LC3A mRNA CTD PMID:28803810 NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505
JBrowse link
G MT1A metallothionein 1A increases expression EXP Zinc Sulfate results in increased expression of MT1A mRNA CTD PMID:25895165 NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,660,642...18,673,766
JBrowse link
G SLC30A1 solute carrier family 30 member 1 increases expression EXP Zinc Sulfate results in increased expression of SLC30A1 mRNA CTD PMID:25895165 NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,675
JBrowse link
G SLC39A10 solute carrier family 39 member 10 decreases expression
increases expression
EXP Zinc Sulfate results in decreased expression of SLC39A10 mRNA
Zinc Sulfate results in increased expression of SLC39A10 mRNA
CTD PMID:16804107 NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,839...99,726,404
JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
decreases expression
EXP Zinc Sulfate results in increased expression of SQSTM1 mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein]
CTD PMID:28803810 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 880
    chemical entity 880
      molecular entity 878
        ion 130
          monoatomic ion 85
            monoatomic cation 79
              monoatomic dication 48
                barium(2+) 0
                beryllium(2+) + 0
                cadmium(2+) + 17
                calcium(2+) + 2
                chromium(2+) 0
                cobalt(2+) + 3
                copper(2+) + 9
                europium(2+) 0
                gadolinium(2+) 0
                germanium(2+) 0
                helium(2+) + 0
                iron(2+) + 0
                lanthanum(2+) 0
                lead(2+) + 13
                magnesium(2+) + 0
                manganese(2+) + 0
                mercury(2+) 0
                nickel(2+) + 0
                osmium(2+) 0
                platinum(2+) 0
                ruthenium(2+) 0
                selenium(2+) 0
                strontium(2+) 0
                tin(2+) + 0
                uranium(2+) 0
                vanadium(2+) 0
                yttrium(2+) 0
                zinc(2+) + 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 880
    chemical entity 880
      molecular entity 878
        elemental molecular entity 141
          monoatomic entity 85
            monoatomic ion 85
              monoatomic cation 79
                monoatomic dication 48
                  barium(2+) 0
                  beryllium(2+) + 0
                  cadmium(2+) + 17
                  calcium(2+) + 2
                  chromium(2+) 0
                  cobalt(2+) + 3
                  copper(2+) + 9
                  europium(2+) 0
                  gadolinium(2+) 0
                  germanium(2+) 0
                  helium(2+) + 0
                  iron(2+) + 0
                  lanthanum(2+) 0
                  lead(2+) + 13
                  magnesium(2+) + 0
                  manganese(2+) + 0
                  mercury(2+) 0
                  nickel(2+) + 0
                  osmium(2+) 0
                  platinum(2+) 0
                  ruthenium(2+) 0
                  selenium(2+) 0
                  strontium(2+) 0
                  tin(2+) + 0
                  uranium(2+) 0
                  vanadium(2+) 0
                  yttrium(2+) 0
                  zinc(2+) + 12
paths to the root