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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:terbutylazine
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Accession:CHEBI:30263 term browser browse the term
Definition:A diamino-1,3,5-triazine that is N-tert-butyl-N'-methyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Synonyms:exact_synonym: N-(tert-butyl)-6-chloro-N'-ethyl-1,3,5-triazine-2,4-diamine
 related_synonym: Formula=C9H16ClN5;   InChI=1S/C9H16ClN5/c1-5-11-7-12-6(10)13-8(14-7)15-9(2,3)4/h5H2,1-4H3,(H2,11,12,13,14,15);   InChIKey=FZXISNSWEXTPMF-UHFFFAOYSA-N;   SMILES=CCNc1nc(Cl)nc(NC(C)(C)C)n1;   Terbuthylazine;   Terbutylethylazine
 xref: Beilstein:3951137;   CAS:5915-41-3;   KEGG:C18810
 xref_mesh: MESH:C037565
 xref: PMID:16526725;   PMID:23280488;   PMID:23288680;   PMID:24468338;   PPDB:623;   Pesticides:terbuthylazine;   Reaxys:3951137;   Wikipedia:Terbuthylazine


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terbutylazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein; terbutylazine promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:25684042 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein; U 0126 inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein] CTD PMID:27431321 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO terbutylazine inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Ar androgen receptor multiple interactions ISO [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein CTD PMID:23871939 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO terbutylazine results in decreased expression of CYP17A1 mRNA CTD PMID:23591565 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP [bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA CTD PMID:23954766 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO terbutylazine results in increased activity of ESR1 protein CTD PMID:28728110 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 increases expression ISO terbutylazine results in increased expression of HSD17B3 mRNA CTD PMID:23591565 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO terbutylazine results in decreased expression of HSD3B1 mRNA CTD PMID:23591565 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein] CTD PMID:27431321 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein] CTD PMID:27431321 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO terbutylazine results in decreased stability of and results in increased degradation of and results in increased mutagenesis of MYC gene CTD PMID:22445671 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of NOS2 protein]; U 0126 inhibits the reaction [terbutylazine results in decreased expression of NOS2 protein] CTD PMID:27431321 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions
ISO terbutylazine results in decreased expression of NOS3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of NOS3 protein]; U 0126 inhibits the reaction [terbutylazine results in decreased expression of NOS3 protein]
CTD PMID:27431321 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO terbutylazine binds to and results in increased activity of NR1I2 protein
terbutylazine results in increased activity of NR1I2 protein
CTD PMID:20024649 PMID:28728110 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO terbutylazine inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; terbutylazine inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Rln1 relaxin 1 multiple interactions ISO terbutylazine inhibits the reaction [RLN1 protein binds to RXFP1 protein] CTD PMID:27431321 NCBI chr 1:227,079,960...227,082,960
Ensembl chr 1:227,079,966...227,082,882
JBrowse link
G Rxfp1 relaxin family peptide receptor 1 multiple interactions
decreases expression
ISO terbutylazine inhibits the reaction [RLN1 protein binds to RXFP1 protein]
terbutylazine results in decreased expression of RXFP1 protein
CTD PMID:27431321 NCBI chr 2:164,772,270...164,893,484
Ensembl chr 2:164,774,799...164,893,412
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression ISO terbutylazine results in decreased expression of SRD5A1 mRNA CTD PMID:23591565 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO terbutylazine results in increased expression of STAR mRNA CTD PMID:23591565 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO terbutylazine results in decreased stability of and results in increased degradation of and results in increased mutagenesis of TP53 gene CTD PMID:22445671 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 19821
    role 19769
      biological role 19769
        xenobiotic 18452
          terbutylazine 21
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        polyamine 8267
                                          diamine 8195
                                            diamino-1,3,5-triazine 3821
                                              1,3,5-triazine-2,4-diamine 3800
                                                6-chloro-1,3,5-triazine-2,4-diamine 3800
                                                  terbutylazine 21
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