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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:terbutylazine
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Accession:CHEBI:30263 term browser browse the term
Definition:A diamino-1,3,5-triazine that is N-tert-butyl-N'-methyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Synonyms:exact_synonym: N-(tert-butyl)-6-chloro-N'-ethyl-1,3,5-triazine-2,4-diamine
 related_synonym: Formula=C9H16ClN5;   InChI=1S/C9H16ClN5/c1-5-11-7-12-6(10)13-8(14-7)15-9(2,3)4/h5H2,1-4H3,(H2,11,12,13,14,15);   InChIKey=FZXISNSWEXTPMF-UHFFFAOYSA-N;   SMILES=CCNc1nc(Cl)nc(NC(C)(C)C)n1;   Terbuthylazine;   Terbutylethylazine
 xref: Beilstein:3951137;   CAS:5915-41-3;   KEGG:C18810
 xref_mesh: MESH:C037565
 xref: PMID:16526725;   PMID:23280488;   PMID:23288680;   PMID:24468338;   PPDB:623;   Pesticides:terbuthylazine;   Reaxys:3951137;   Wikipedia:Terbuthylazine


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terbutylazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein; terbutylazine promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:25684042 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein; U 0126 inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein] CTD PMID:27431321 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO terbutylazine inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Ar androgen receptor multiple interactions ISO [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein CTD PMID:23871939 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO terbutylazine results in decreased expression of CYP17A1 mRNA CTD PMID:23591565 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP [bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA CTD PMID:23954766 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO terbutylazine results in increased activity of ESR1 protein CTD PMID:28728110 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 increases expression ISO terbutylazine results in increased expression of HSD17B3 mRNA CTD PMID:23591565 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO terbutylazine results in decreased expression of HSD3B1 mRNA CTD PMID:23591565
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein] CTD PMID:27431321 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein] CTD PMID:27431321 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO terbutylazine results in decreased stability of and results in increased degradation of and results in increased mutagenesis of MYC gene CTD PMID:22445671 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of NOS2 protein]; U 0126 inhibits the reaction [terbutylazine results in decreased expression of NOS2 protein] CTD PMID:27431321 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions
ISO terbutylazine results in decreased expression of NOS3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of NOS3 protein]; U 0126 inhibits the reaction [terbutylazine results in decreased expression of NOS3 protein]
CTD PMID:27431321 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO terbutylazine binds to and results in increased activity of NR1I2 protein
terbutylazine results in increased activity of NR1I2 protein
CTD PMID:20024649, PMID:28728110 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO terbutylazine inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; terbutylazine inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Rln1 relaxin 1 multiple interactions ISO terbutylazine inhibits the reaction [RLN1 protein binds to RXFP1 protein] CTD PMID:27431321 NCBI chr 1:247,483,298...247,486,331
Ensembl chr 1:247,483,302...247,486,202
JBrowse link
G Rxfp1 relaxin family peptide receptor 1 multiple interactions
decreases expression
ISO terbutylazine inhibits the reaction [RLN1 protein binds to RXFP1 protein]
terbutylazine results in decreased expression of RXFP1 protein
CTD PMID:27431321 NCBI chr 2:178,402,411...178,520,213
Ensembl chr 2:178,399,274...178,521,038
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression ISO terbutylazine results in decreased expression of SRD5A1 mRNA CTD PMID:23591565 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO terbutylazine results in increased expression of STAR mRNA CTD PMID:23591565 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO terbutylazine results in decreased stability of and results in increased degradation of and results in increased mutagenesis of TP53 gene CTD PMID:22445671 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        xenobiotic 18406
          terbutylazine 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19420
                        hydrogen molecular entity 19411
                          hydrides 18460
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17245
                                  azane 16962
                                    ammonia 16961
                                      organic amino compound 16960
                                        polyamine 8106
                                          diamine 8033
                                            diamino-1,3,5-triazine 3669
                                              1,3,5-triazine-2,4-diamine 3649
                                                6-chloro-1,3,5-triazine-2,4-diamine 3649
                                                  terbutylazine 21
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