CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: benzbromarone
Accession: CHEBI:3023
browse the term
Definition: 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.
Synonyms: exact_synonym: (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone
related_synonym: 2-ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran; 3,5-dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; Formula=C17H12Br2O3; InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3; InChIKey=WHQCHUCQKNIQEC-UHFFFAOYSA-N; SMILES=CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1; Uroleap (TN)
xref: Beilstein:273668; CAS:3562-84-3; Drug_Central:318; KEGG:D01056; LINCS:LSM-2239
xref_mesh: MESH:D001553
xref: PMID:18636784; PMID:26693855; PMID:26792818; PMID:27391386; PMID:28131653; PMID:28166217; PMID:28202260; PMID:7661033
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Abcb11
ATP-binding cassette, sub-family B member 11
decreases activity multiple interactions
ISO
Benzbromarone results in decreased activity of ABCB11 protein Benzbromarone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD
PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613
NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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Abcb1a
ATP-binding cassette, sub-family B member 1A
affects expression
ISO
Benzbromarone affects the expression of ABCB1A mRNA
CTD
PMID:19483382
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcb4
ATP-binding cassette, sub-family B member 4
decreases activity
ISO
Benzbromarone results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Abcc1
ATP-binding cassette, sub-family C member 1
multiple interactions affects activity
ISO
Benzbromarone inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]; Benzbromarone inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin] Benzbromarone affects the activity of ABCC1 protein
CTD
PMID:9096673 PMID:9334814 PMID:15041471 PMID:16101123
NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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Abcc2
ATP-binding cassette, sub-family member 2
multiple interactions decreases activity
ISO
[Benzbromarone results in decreased activity of ABCC2 protein] inhibits the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD
PMID:19782883 PMID:19853032 PMID:22646477 PMID:31348918
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abcc3
ATP-binding cassette, sub-family C member 3
multiple interactions
ISO
Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD
PMID:31348918
NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
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Abcc5
ATP-binding cassette, sub-family C member 5
multiple interactions
ISO
Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD
PMID:31348918
NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144
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Abcc6
ATP-binding cassette, sub-family C member 6
multiple interactions decreases activity affects expression
ISO
Benzbromarone inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione] Benzbromarone results in decreased activity of ABCC6 protein Benzbromarone affects the expression of ABCC6 mRNA
CTD
PMID:11880368 PMID:14667841 PMID:19483382
NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
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Abcg5
ATP binding cassette subfamily G member 5
affects expression
ISO
Benzbromarone affects the expression of ABCG5 mRNA
CTD
PMID:19483382
NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439
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Abhd1
abhydrolase domain containing 1
affects expression
ISO
Benzbromarone affects the expression of ABHD1 mRNA
CTD
PMID:19483382
NCBI chr 5:31,107,410...31,112,439
Ensembl chr 5:31,107,410...31,112,435
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Abhd14b
abhydrolase domain containing 14b
affects expression
ISO
Benzbromarone affects the expression of ABHD14B mRNA
CTD
PMID:19483382
NCBI chr 9:106,324,936...106,330,122
Ensembl chr 9:106,324,658...106,330,122
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Abhd17a
abhydrolase domain containing 17A
affects expression
ISO
Benzbromarone affects the expression of ABHD17A mRNA
CTD
PMID:19483382
NCBI chr10:80,419,483...80,426,199
Ensembl chr10:80,419,488...80,426,175
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Acaca
acetyl-Coenzyme A carboxylase alpha
affects expression
ISO
Benzbromarone affects the expression of ACACA mRNA
CTD
PMID:19483382
NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
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Acadl
acyl-Coenzyme A dehydrogenase, long-chain
affects expression
ISO
Benzbromarone affects the expression of ACADL mRNA
CTD
PMID:19483382
NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436
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Ace2
angiotensin converting enzyme 2
decreases expression
ISO
Benzbromarone results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416
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Aco1
aconitase 1
affects expression
ISO
Benzbromarone affects the expression of ACO1 mRNA
CTD
PMID:19483382
NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338
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Aco2
aconitase 2, mitochondrial
affects expression
ISO
Benzbromarone affects the expression of ACO2 mRNA
CTD
PMID:19483382
NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334
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Acot12
acyl-CoA thioesterase 12
affects expression
ISO
Benzbromarone affects the expression of ACOT12 mRNA
CTD
PMID:19483382
NCBI chr13:91,889,635...91,934,271
Ensembl chr13:91,889,631...91,934,267
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Acot4
acyl-CoA thioesterase 4
affects expression
ISO
Benzbromarone affects the expression of ACOT4 mRNA
CTD
PMID:19483382
NCBI chr12:84,084,028...84,091,497
Ensembl chr12:84,085,153...84,095,375
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Adam15
ADAM metallopeptidase domain 15
affects expression
ISO
Benzbromarone affects the expression of ADAM15 mRNA
CTD
PMID:19483382
NCBI chr 3:89,246,947...89,257,589
Ensembl chr 3:89,245,849...89,257,303
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Add1
adducin 1
affects expression
ISO
Benzbromarone affects the expression of ADD1 mRNA
CTD
PMID:19483382
NCBI chr 5:34,731,008...34,789,652
Ensembl chr 5:34,731,008...34,789,652
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
affects expression
ISO
Benzbromarone affects the expression of ADH4 mRNA
CTD
PMID:19483382
NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653
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Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions increases expression
EXP ISO
2-chloro-5-nitrobenzanilide inhibits the reaction [Benzbromarone results in increased expression of ADIPOQ mRNA] Benzbromarone results in increased expression of ADIPOQ protein
CTD
PMID:19048458 PMID:21329621
NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
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Adtrp
androgen dependent TFPI regulating protein
affects expression
ISO
Benzbromarone affects the expression of ADTRP mRNA
CTD
PMID:19483382
NCBI chr13:41,916,621...42,001,092
Ensembl chr13:41,916,624...42,001,160
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Afm
afamin
affects expression
ISO
Benzbromarone affects the expression of AFM mRNA
CTD
PMID:19483382
NCBI chr 5:90,666,808...90,701,403
Ensembl chr 5:90,666,791...90,701,402
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Agt
angiotensinogen
affects expression
ISO
Benzbromarone affects the expression of AGT mRNA
CTD
PMID:19483382
NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
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Agtr1a
angiotensin II receptor, type 1a
affects expression
ISO
Benzbromarone affects the expression of AGTR1A mRNA
CTD
PMID:19483382
NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
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Akr1a1
aldo-keto reductase family 1, member A1
affects expression
ISO
Benzbromarone affects the expression of AKR1A1 mRNA
CTD
PMID:19483382
NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877
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Akr1c18
aldo-keto reductase family 1, member C18
decreases activity
ISO
Benzbromarone results in decreased activity of AKR1C3 protein
CTD
PMID:12604236
NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
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Akr1c20
aldo-keto reductase family 1, member C20
multiple interactions
ISO
Benzbromarone binds to and results in decreased activity of AKR1C1 protein
CTD
PMID:12604236
NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344
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Akr1c21
aldo-keto reductase family 1, member C21
decreases activity
ISO
Benzbromarone results in decreased activity of AKR1C2 protein
CTD
PMID:12604236
NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
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Akr1c6
aldo-keto reductase family 1, member C6
decreases activity
ISO
Benzbromarone results in decreased activity of AKR1C4 protein
CTD
PMID:12604236
NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876
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Akr7a5
aldo-keto reductase family 7, member A5
affects expression
ISO
Benzbromarone affects the expression of AKR7A2 mRNA
CTD
PMID:19483382
NCBI chr 4:139,038,005...139,046,097
Ensembl chr 4:139,038,055...139,045,737
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Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
affects expression
ISO
Benzbromarone affects the expression of ALDH1A1 mRNA
CTD
PMID:19483382
NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
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Aldh2
aldehyde dehydrogenase 2, mitochondrial
affects expression
ISO
Benzbromarone affects the expression of ALDH2 mRNA
CTD
PMID:19483382
NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
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Alkbh7
alkB homolog 7
affects expression
ISO
Benzbromarone affects the expression of ALKBH7 mRNA
CTD
PMID:19483382
NCBI chr17:57,304,339...57,306,340
Ensembl chr17:57,304,339...57,306,322
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Ap2m1
adaptor-related protein complex 2, mu 1 subunit
affects expression
ISO
Benzbromarone affects the expression of AP2M1 mRNA
CTD
PMID:19483382
NCBI chr16:20,354,230...20,363,659
Ensembl chr16:20,354,228...20,363,659
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Apcs
amyloid P component, serum
affects expression
ISO
Benzbromarone affects the expression of APCS mRNA
CTD
PMID:19483382
NCBI chr 1:172,721,528...172,722,516
Ensembl chr 1:172,721,528...172,722,608
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Apoa4
apolipoprotein A-IV
affects expression
ISO
Benzbromarone affects the expression of APOA4 mRNA
CTD
PMID:19483382
NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757
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Apoh
apolipoprotein H
affects expression
ISO
Benzbromarone affects the expression of APOH mRNA
CTD
PMID:19483382
NCBI chr11:108,286,123...108,305,222
Ensembl chr11:108,234,180...108,305,222
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Apool
apolipoprotein O-like
affects expression
ISO
Benzbromarone affects the expression of APOOL mRNA
CTD
PMID:19483382
NCBI chr X:111,221,049...111,282,452
Ensembl chr X:111,221,031...111,282,452
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Arg1
arginase, liver
affects expression
ISO
Benzbromarone affects the expression of ARG1 mRNA
CTD
PMID:19483382
NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
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Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
affects expression
ISO
Benzbromarone affects the expression of ARL6IP1 mRNA
CTD
PMID:19483382
NCBI chr 7:117,718,113...117,728,848
Ensembl chr 7:117,718,114...117,728,885
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Asgr2
asialoglycoprotein receptor 2
affects expression
ISO
Benzbromarone affects the expression of ASGR2 mRNA
CTD
PMID:19483382
NCBI chr11:69,983,470...69,997,013
Ensembl chr11:69,983,470...69,997,013
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Atf5
activating transcription factor 5
affects expression
ISO
Benzbromarone affects the expression of ATF5 mRNA
CTD
PMID:19483382
NCBI chr 7:44,461,680...44,466,082
Ensembl chr 7:44,461,680...44,466,082
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Atp5f1e
ATP synthase F1 subunit epsilon
affects expression
ISO
Benzbromarone affects the expression of ATP5F1E mRNA
CTD
PMID:19483382
NCBI chr 2:174,302,868...174,305,894
Ensembl chr 2:174,302,865...174,305,898
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Atp6ap2
ATPase, H+ transporting, lysosomal accessory protein 2
affects expression
ISO
Benzbromarone affects the expression of ATP6AP2 mRNA
CTD
PMID:19483382
NCBI chr X:12,453,998...12,483,290
Ensembl chr X:12,454,040...12,483,288
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Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
affects expression
ISO
Benzbromarone affects the expression of ATP6V1A mRNA
CTD
PMID:19483382
NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068
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Atp6v1f
ATPase, H+ transporting, lysosomal V1 subunit F
affects expression
ISO
Benzbromarone affects the expression of ATP6V1F mRNA
CTD
PMID:19483382
NCBI chr 6:29,467,782...29,470,508
Ensembl chr 6:29,467,717...29,470,511
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Baat
bile acid-Coenzyme A: amino acid N-acyltransferase
affects expression
ISO
Benzbromarone affects the expression of BAAT mRNA
CTD
PMID:19483382
NCBI chr 4:49,489,416...49,507,915
Ensembl chr 4:49,489,422...49,506,557
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Bcl6b
B cell CLL/lymphoma 6, member B
affects expression
ISO
Benzbromarone affects the expression of BCL6B mRNA
CTD
PMID:19483382
NCBI chr11:70,114,953...70,120,624
Ensembl chr11:70,114,954...70,120,624
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Bltp3b
bridge-like lipid transfer protein family member 3B
affects expression
ISO
Benzbromarone affects the expression of BLTP3B mRNA
CTD
PMID:19483382
NCBI chr10:89,580,830...89,655,753
Ensembl chr10:89,580,853...89,655,733
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Bmf
BCL2 modifying factor
affects expression
ISO
Benzbromarone affects the expression of BMF mRNA
CTD
PMID:19483382
NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168
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Bnip3
BCL2/adenovirus E1B interacting protein 3
affects expression
ISO
Benzbromarone affects the expression of BNIP3 mRNA
CTD
PMID:19483382
NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
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Btf3
basic transcription factor 3
affects expression
ISO
Benzbromarone affects the expression of BTF3 mRNA
CTD
PMID:19483382
NCBI chr13:98,446,405...98,453,514
Ensembl chr13:98,446,404...98,453,514
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C1qbp
complement component 1, q subcomponent binding protein
affects expression
ISO
Benzbromarone affects the expression of C1QBP mRNA
CTD
PMID:19483382
NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852
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C1s1
complement component 1, s subcomponent 1
affects expression
ISO
Benzbromarone affects the expression of C1S mRNA
CTD
PMID:19483382
NCBI chr 6:124,507,303...124,519,340
Ensembl chr 6:124,507,304...124,519,318
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C2cd2
C2 calcium-dependent domain containing 2
affects expression
ISO
Benzbromarone affects the expression of C2CD2 mRNA
CTD
PMID:19483382
NCBI chr16:97,656,409...97,727,248
Ensembl chr16:97,656,409...97,763,798
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C7
complement component 7
affects expression
ISO
Benzbromarone affects the expression of C7 mRNA
CTD
PMID:19483382
NCBI chr15:5,017,232...5,093,230
Ensembl chr15:5,018,244...5,093,222
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C8b
complement component 8, beta polypeptide
affects expression
ISO
Benzbromarone affects the expression of C8B mRNA
CTD
PMID:19483382
NCBI chr 4:104,623,514...104,661,745
Ensembl chr 4:104,623,514...104,661,745
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Cadps2
Ca2+-dependent activator protein for secretion 2
affects expression
ISO
Benzbromarone affects the expression of CADPS2 mRNA
CTD
PMID:19483382
NCBI chr 6:23,262,765...23,840,662
Ensembl chr 6:23,262,772...23,839,420
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Caprin1
cell cycle associated protein 1
affects expression
ISO
Benzbromarone affects the expression of CAPRIN1 mRNA
CTD
PMID:19483382
NCBI chr 2:103,593,292...103,627,946
Ensembl chr 2:103,593,286...103,627,994
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Car2
carbonic anhydrase 2
affects expression
ISO
Benzbromarone affects the expression of CA2 mRNA
CTD
PMID:19483382
NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830
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Car3
carbonic anhydrase 3
affects expression
ISO
Benzbromarone affects the expression of CAR3 mRNA
CTD
PMID:19483382
NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583
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Casp3
caspase 3
affects expression
ISO
Benzbromarone affects the expression of CASP3 mRNA
CTD
PMID:19483382
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Cat
catalase
increases activity
ISO
Benzbromarone results in increased activity of CAT protein
CTD
PMID:2260096
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Cbr1
carbonyl reductase 1
affects expression
ISO
Benzbromarone affects the expression of CBR1 mRNA
CTD
PMID:19483382
NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393
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Cd36
CD36 molecule
increases expression
EXP
Benzbromarone results in increased expression of CD36 mRNA
CTD
PMID:19048458
NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
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Cdo1
cysteine dioxygenase 1, cytosolic
affects expression
ISO
Benzbromarone affects the expression of CDO1 mRNA
CTD
PMID:19483382
NCBI chr18:46,846,260...46,861,569
Ensembl chr18:46,846,260...46,861,462
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Cept1
choline/ethanolaminephosphotransferase 1
affects expression
ISO
Benzbromarone affects the expression of CEPT1 mRNA
CTD
PMID:19483382
NCBI chr 3:106,409,576...106,455,118
Ensembl chr 3:106,409,576...106,455,118
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Ces2h
carboxylesterase 2H
affects expression
ISO
Benzbromarone affects the expression of CES2 mRNA
CTD
PMID:19483382
NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
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Cfi
complement component factor i
affects expression
ISO
Benzbromarone affects the expression of CFI mRNA
CTD
PMID:19483382
NCBI chr 3:129,630,432...129,668,978
Ensembl chr 3:129,629,533...129,668,981
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Chp1
calcineurin-like EF hand protein 1
affects expression
ISO
Benzbromarone affects the expression of CHP1 mRNA
CTD
PMID:19483382
NCBI chr 2:119,378,172...119,417,505
Ensembl chr 2:119,378,178...119,417,508
G
Cisd1
CDGSH iron sulfur domain 1
affects expression
ISO
Benzbromarone affects the expression of CISD1 mRNA
CTD
PMID:19483382
NCBI chr10:71,166,324...71,180,679
Ensembl chr10:71,166,310...71,180,784
G
Clcn4
chloride channel, voltage-sensitive 4
affects expression
ISO
Benzbromarone affects the expression of CLCN4 mRNA
CTD
PMID:19483382
NCBI chr 7:7,285,308...7,303,837
Ensembl chr 7:7,285,308...7,303,850
G
Clpp
caseinolytic mitochondrial matrix peptidase proteolytic subunit
affects expression
ISO
Benzbromarone affects the expression of CLPP mRNA
CTD
PMID:19483382
NCBI chr17:57,297,264...57,303,371
Ensembl chr17:57,297,305...57,303,188
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Clptm1l
CLPTM1-like
affects expression
ISO
Benzbromarone affects the expression of CLPTM1L mRNA
CTD
PMID:19483382
NCBI chr13:73,752,121...73,768,758
Ensembl chr13:73,752,125...73,768,724
G
Cmbl
carboxymethylenebutenolidase homolog
affects expression
ISO
Benzbromarone affects the expression of CMBL mRNA
CTD
PMID:19483382
NCBI chr15:31,565,314...31,590,266
Ensembl chr15:31,565,535...31,590,265
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Cmpk1
cytidine/uridine monophosphate kinase 1
affects expression
ISO
Benzbromarone affects the expression of CMPK1 mRNA
CTD
PMID:19483382
NCBI chr 4:114,817,810...114,844,425
Ensembl chr 4:114,816,533...114,844,438
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Copg1
coatomer protein complex, subunit gamma 1
affects expression
ISO
Benzbromarone affects the expression of COPG1 mRNA
CTD
PMID:19483382
NCBI chr 6:87,864,801...87,890,577
Ensembl chr 6:87,864,796...87,890,577
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Cops4
COP9 signalosome subunit 4
affects expression
ISO
Benzbromarone affects the expression of COPS4 mRNA
CTD
PMID:19483382
NCBI chr 5:100,666,223...100,695,668
Ensembl chr 5:100,666,175...100,695,669
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Coq3
coenzyme Q3 methyltransferase
affects expression
ISO
Benzbromarone affects the expression of COQ3 mRNA
CTD
PMID:19483382
NCBI chr 4:21,879,646...21,912,163
Ensembl chr 4:21,879,673...21,912,162
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Cox4i1
cytochrome c oxidase subunit 4I1
affects expression
ISO
Benzbromarone affects the expression of COX4I1 mRNA
CTD
PMID:19483382
NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946
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Cpn1
carboxypeptidase N, polypeptide 1
affects expression
ISO
Benzbromarone affects the expression of CPN1 mRNA
CTD
PMID:19483382
NCBI chr19:43,944,746...43,974,990
Ensembl chr19:43,944,746...43,974,995
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Cpq
carboxypeptidase Q
affects expression
ISO
Benzbromarone affects the expression of CPQ mRNA
CTD
PMID:19483382
NCBI chr15:33,083,275...33,594,698
Ensembl chr15:33,083,275...33,594,698
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Cpt1a
carnitine palmitoyltransferase 1a, liver
increases expression
ISO
Benzbromarone results in increased expression of CPT1A mRNA; Benzbromarone results in increased expression of CPT1A protein
CTD
PMID:25108121
NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
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Crem
cAMP responsive element modulator
affects expression
ISO
Benzbromarone affects the expression of CREM mRNA
CTD
PMID:19483382
NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748
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Crp
C-reactive protein, pentraxin-related
multiple interactions decreases expression
ISO
Benzbromarone inhibits the reaction [IL1B protein results in increased expression of CRP protein] Benzbromarone results in decreased expression of CRP protein
CTD
PMID:21329621
NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
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Csnk2b
casein kinase 2, beta polypeptide
affects expression
ISO
Benzbromarone affects the expression of CSNK2B mRNA
CTD
PMID:19483382
NCBI chr17:35,335,171...35,341,029
Ensembl chr17:35,335,172...35,341,029
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Csrp1
cysteine and glycine-rich protein 1
affects expression
ISO
Benzbromarone affects the expression of CSRP1 mRNA
CTD
PMID:19483382
NCBI chr 1:135,614,650...135,679,970
Ensembl chr 1:135,647,799...135,679,970
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Ctnna1
catenin alpha 1
affects expression
ISO
Benzbromarone affects the expression of CTNNA1 mRNA
CTD
PMID:19483382
NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Benzbromarone results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Benzbromarone results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
G
Cyp2a22
cytochrome P450, family 2, subfamily a, polypeptide 22
affects expression
ISO
Benzbromarone affects the expression of CYP2A1 mRNA
CTD
PMID:19483382
NCBI chr 7:26,631,564...26,638,838
Ensembl chr 7:26,631,056...26,638,809
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
affects expression
ISO
Benzbromarone affects the expression of CYP2B3 mRNA
CTD
PMID:19483382
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Cyp2b13
cytochrome P450, family 2, subfamily b, polypeptide 13
affects expression
ISO
Benzbromarone affects the expression of CYP2B2 mRNA
CTD
PMID:19483382
NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
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Cyp2c38
cytochrome P450, family 2, subfamily c, polypeptide 38
multiple interactions
ISO
Benzbromarone analog binds to and results in decreased activity of CYP2C19 protein; Benzbromarone binds to and results in decreased activity of CYP2C19 protein
CTD
PMID:15615526
NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
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Cyp2c65
cytochrome P450, family 2, subfamily c, polypeptide 65
affects binding multiple interactions affects metabolic processing
ISO
Benzbromarone binds to CYP2C9 protein Benzbromarone analog binds to and results in decreased activity of CYP2C9 protein; Benzbromarone binds to and results in decreased activity of CYP2C9 protein; Benzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Benzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Warfarin]; Benzbromarone inhibits the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen]; Benzbromarone promotes the reaction [CYP2C9 protein affects the metabolism of Naproxen]; Benzbromarone promotes the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen] CYP2C9 protein affects the metabolism of Benzbromarone
CTD
PMID:10613612 PMID:12814975 PMID:15170332 PMID:15955872 PMID:16081671 PMID:18020424 PMID:21321060 More...
NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
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Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
affects expression
ISO
Benzbromarone affects the expression of CYP2D4 mRNA
CTD
PMID:19483382
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
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Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
affects expression
ISO
Benzbromarone affects the expression of CYP2F4 mRNA
CTD
PMID:19483382
NCBI chr 7:26,819,380...26,833,085
Ensembl chr 7:26,819,334...26,833,085
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Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
affects expression
ISO
Benzbromarone affects the expression of CYP2J4 mRNA
CTD
PMID:19483382
NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815
G
Cyp3a13
cytochrome P450, family 3, subfamily a, polypeptide 13
affects expression
ISO
Benzbromarone affects the expression of CYP3A9 mRNA
CTD
PMID:19483382
NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
G
Cyp4f16
cytochrome P450, family 4, subfamily f, polypeptide 16
affects expression
ISO
Benzbromarone affects the expression of CYP4F6 mRNA
CTD
PMID:19483382
NCBI chr17:32,755,517...32,770,772
Ensembl chr17:32,755,532...32,770,772
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Dbi
diazepam binding inhibitor
affects expression
ISO
Benzbromarone affects the expression of DBI mRNA
CTD
PMID:19483382
NCBI chr 1:120,041,010...120,048,826
Ensembl chr 1:120,041,010...120,048,808
G
Dcaf11
DDB1 and CUL4 associated factor 11
affects expression
ISO
Benzbromarone affects the expression of DCAF11 mRNA
CTD
PMID:19483382
NCBI chr14:55,796,557...55,807,522
Ensembl chr14:55,797,463...55,807,522
G
Dcxr
dicarbonyl L-xylulose reductase
affects expression
ISO
Benzbromarone affects the expression of DCXR mRNA
CTD
PMID:19483382
NCBI chr11:120,615,372...120,618,110
Ensembl chr11:120,616,225...120,618,107
G
Decr1
2,4-dienoyl CoA reductase 1, mitochondrial
affects expression
ISO
Benzbromarone affects the expression of DECR1 mRNA
CTD
PMID:19483382
NCBI chr 4:15,917,240...15,945,377
Ensembl chr 4:15,917,240...15,945,507
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Dexi
dexamethasone-induced transcript
affects expression
ISO
Benzbromarone affects the expression of DEXI mRNA
CTD
PMID:19483382
NCBI chr16:10,348,071...10,360,918
Ensembl chr16:10,320,395...10,360,918
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Dgat1
diacylglycerol O-acyltransferase 1
affects expression
ISO
Benzbromarone affects the expression of DGAT1 mRNA
CTD
PMID:19483382
NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153
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Dhcr24
24-dehydrocholesterol reductase
affects expression
ISO
Benzbromarone affects the expression of DHCR24 mRNA
CTD
PMID:19483382
NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310
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Dhrs4
dehydrogenase/reductase 4
affects expression
ISO
Benzbromarone affects the expression of DHRS4 mRNA
CTD
PMID:19483382
NCBI chr14:55,715,880...55,727,797
Ensembl chr14:55,716,215...55,727,797
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Dhrs7b
dehydrogenase/reductase 7B
affects expression
ISO
Benzbromarone affects the expression of DHRS7B mRNA
CTD
PMID:19483382
NCBI chr11:60,721,457...60,749,249
Ensembl chr11:60,721,457...60,751,021
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Dhx16
DEAH-box helicase 16
affects expression
ISO
Benzbromarone affects the expression of DHX16 mRNA
CTD
PMID:19483382
NCBI chr17:36,190,657...36,203,562
Ensembl chr17:36,190,711...36,203,562
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Dmac2l
distal membrane arm assembly component 2 like
affects expression
ISO
Benzbromarone affects the expression of DMAC2L mRNA
CTD
PMID:19483382
NCBI chr12:69,771,687...69,791,439
Ensembl chr12:69,771,724...69,791,434
G
Dnajc3
DnaJ heat shock protein family (Hsp40) member C3
affects expression
ISO
Benzbromarone affects the expression of DNAJC3 mRNA
CTD
PMID:19483382
NCBI chr14:119,175,371...119,219,114
Ensembl chr14:119,175,388...119,219,109
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Dpp4
dipeptidylpeptidase 4
affects expression
ISO
Benzbromarone affects the expression of DPP4 mRNA
CTD
PMID:19483382
NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575
G
Dpyd
dihydropyrimidine dehydrogenase
affects expression
ISO
Benzbromarone affects the expression of DPYD mRNA
CTD
PMID:19483382
NCBI chr 3:118,355,758...119,226,573
Ensembl chr 3:118,355,778...119,226,573
G
Ears2
glutamyl-tRNA synthetase 2, mitochondrial
affects expression
ISO
Benzbromarone affects the expression of EARS2 mRNA
CTD
PMID:19483382
NCBI chr 7:121,633,385...121,666,436
Ensembl chr 7:121,636,436...121,666,486
G
Echs1
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
affects expression
ISO
Benzbromarone affects the expression of ECHS1 mRNA
CTD
PMID:19483382
NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389
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Eci1
enoyl-Coenzyme A delta isomerase 1
affects expression
ISO
Benzbromarone affects the expression of ECI1 mRNA
CTD
PMID:19483382
NCBI chr17:24,645,657...24,658,290
Ensembl chr17:24,645,615...24,658,322
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Eci2
enoyl-Coenzyme A delta isomerase 2
affects expression
ISO
Benzbromarone affects the expression of ECI2 mRNA
CTD
PMID:19483382
NCBI chr13:35,161,731...35,211,098
Ensembl chr13:35,161,731...35,211,079
G
Eef1g
eukaryotic translation elongation factor 1 gamma
affects expression
ISO
Benzbromarone affects the expression of EEF1G mRNA
CTD
PMID:19483382
NCBI chr19:8,944,405...8,955,544
Ensembl chr19:8,944,405...8,955,843
G
Ehhadh
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
affects expression
ISO
Benzbromarone affects the expression of EHHADH mRNA
CTD
PMID:19483382
NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557
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Eif4a2
eukaryotic translation initiation factor 4A2
affects expression
ISO
Benzbromarone affects the expression of EIF4A2 mRNA
CTD
PMID:19483382
NCBI chr16:22,924,846...22,932,882
Ensembl chr16:22,926,194...22,932,886
G
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
affects expression
ISO
Benzbromarone affects the expression of EIF4EBP1 mRNA
CTD
PMID:19483382
NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702
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Eif4h
eukaryotic translation initiation factor 4H
affects expression
ISO
Benzbromarone affects the expression of EIF4H mRNA
CTD
PMID:19483382
NCBI chr 5:134,648,726...134,668,263
Ensembl chr 5:134,648,575...134,668,344
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Enc1
ectodermal-neural cortex 1
affects expression
ISO
Benzbromarone affects the expression of ENC1 mRNA
CTD
PMID:19483382
NCBI chr13:97,377,613...97,389,548
Ensembl chr13:97,377,613...97,389,542
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Eno1
enolase 1, alpha non-neuron
affects expression
ISO
Benzbromarone affects the expression of ENO1 mRNA
CTD
PMID:19483382
NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
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Enpep
glutamyl aminopeptidase
affects expression
ISO
Benzbromarone affects the expression of ENPEP mRNA
CTD
PMID:19483382
NCBI chr 3:129,062,826...129,126,398
Ensembl chr 3:129,062,824...129,126,369
G
Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
affects expression
ISO
Benzbromarone affects the expression of ENPP1 mRNA
CTD
PMID:19483382
NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057
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Epcam
epithelial cell adhesion molecule
affects expression
ISO
Benzbromarone affects the expression of EPCAM mRNA
CTD
PMID:19483382
NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557
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Erp29
endoplasmic reticulum protein 29
affects expression
ISO
Benzbromarone affects the expression of ERP29 mRNA
CTD
PMID:19483382
NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569
G
Esd
esterase D/formylglutathione hydrolase
affects expression
ISO
Benzbromarone affects the expression of ESD mRNA
CTD
PMID:19483382
NCBI chr14:74,969,591...74,988,205
Ensembl chr14:74,969,737...74,988,205
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Etfb
electron transferring flavoprotein, beta polypeptide
affects expression
ISO
Benzbromarone affects the expression of ETFB mRNA
CTD
PMID:19483382
NCBI chr 7:43,093,496...43,107,224
Ensembl chr 7:43,093,507...43,107,224
G
Eya2
EYA transcriptional coactivator and phosphatase 2
decreases activity
ISO
Benzbromarone results in decreased activity of EYA2 protein
CTD
PMID:22545090
NCBI chr 2:165,436,892...165,613,645
Ensembl chr 2:165,436,952...165,613,647
G
Eya3
EYA transcriptional coactivator and phosphatase 3
decreases activity
ISO
Benzbromarone results in decreased activity of EYA3 protein
CTD
PMID:22545090
NCBI chr 4:132,366,303...132,452,076
Ensembl chr 4:132,366,298...132,452,076
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Faah
fatty acid amide hydrolase
affects expression
ISO
Benzbromarone affects the expression of FAAH mRNA
CTD
PMID:19483382
NCBI chr 4:115,853,866...115,876,034
Ensembl chr 4:115,824,342...115,875,123
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Fabp4
fatty acid binding protein 4, adipocyte
increases expression
EXP
Benzbromarone results in increased expression of FABP4 mRNA
CTD
PMID:19048458
NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
G
Fads2
fatty acid desaturase 2
affects expression
ISO
Benzbromarone affects the expression of FADS2 mRNA
CTD
PMID:19483382
NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110
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Fbp1
fructose bisphosphatase 1
affects expression
ISO
Benzbromarone affects the expression of FBP1 mRNA
CTD
PMID:19483382
NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096
G
Fdft1
farnesyl diphosphate farnesyl transferase 1
affects expression
ISO
Benzbromarone affects the expression of FDFT1 mRNA
CTD
PMID:19483382
NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
G
Fdps
farnesyl diphosphate synthetase
affects expression
ISO
Benzbromarone affects the expression of FDPS mRNA
CTD
PMID:19483382
NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266
G
Fdx2
ferredoxin 2
affects expression
ISO
Benzbromarone affects the expression of FDX2 mRNA
CTD
PMID:19483382
NCBI chr 9:20,978,808...20,984,827
Ensembl chr 9:20,978,816...20,984,910
G
Fmo1
flavin containing monooxygenase 1
affects expression
ISO
Benzbromarone affects the expression of FMO1 mRNA
CTD
PMID:19483382
NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179
G
Gamt
guanidinoacetate methyltransferase
affects expression
ISO
Benzbromarone affects the expression of GAMT mRNA
CTD
PMID:19483382
NCBI chr10:80,093,985...80,096,846
Ensembl chr10:80,093,985...80,096,846
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
affects expression
ISO
Benzbromarone affects the expression of GAPDH mRNA
CTD
PMID:19483382
NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
G
Gbe1
1,4-alpha-glucan branching enzyme 1
affects expression
ISO
Benzbromarone affects the expression of GBE1 mRNA
CTD
PMID:19483382
NCBI chr16:70,110,837...70,366,608
Ensembl chr16:70,110,837...70,366,604
G
Gchfr
GTP cyclohydrolase I feedback regulator
affects expression
ISO
Benzbromarone affects the expression of GCHFR mRNA
CTD
PMID:19483382
NCBI chr 2:118,998,269...119,002,870
Ensembl chr 2:118,998,254...119,002,871
G
Ggh
gamma-glutamyl hydrolase
affects expression
ISO
Benzbromarone affects the expression of GGH mRNA
CTD
PMID:19483382
NCBI chr 4:20,041,963...20,066,111
Ensembl chr 4:20,042,052...20,066,750
G
Gjb1
gap junction protein, beta 1
affects expression
ISO
Benzbromarone affects the expression of GJB1 mRNA
CTD
PMID:19483382
NCBI chr X:100,419,982...100,429,235
Ensembl chr X:100,419,984...100,429,235
G
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
affects expression
ISO
Benzbromarone affects the expression of GPLD1 mRNA
CTD
PMID:19483382
NCBI chr13:25,127,135...25,175,919
Ensembl chr13:25,127,135...25,176,484
G
Gpx1
glutathione peroxidase 1
affects expression
ISO
Benzbromarone affects the expression of GPX1 mRNA
CTD
PMID:19483382
NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
G
Gpx4
glutathione peroxidase 4
affects expression
ISO
Benzbromarone affects the expression of GPX4 mRNA
CTD
PMID:19483382
NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
G
Grina
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
affects expression
ISO
Benzbromarone affects the expression of GRINA mRNA
CTD
PMID:19483382
NCBI chr15:76,130,917...76,134,109
Ensembl chr15:76,130,964...76,134,104
G
Grpel1
GrpE-like 1, mitochondrial
affects expression
ISO
Benzbromarone affects the expression of GRPEL1 mRNA
CTD
PMID:19483382
NCBI chr 5:36,622,529...36,631,421
Ensembl chr 5:36,622,342...36,631,424
G
Gstt1
glutathione S-transferase, theta 1
affects expression
ISO
Benzbromarone affects the expression of GSTT1 mRNA
CTD
PMID:19483382
NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
G
Gtf2h5
general transcription factor IIH, polypeptide 5
affects expression
ISO
Benzbromarone affects the expression of GTF2H5 mRNA
CTD
PMID:19483382
NCBI chr17:6,130,103...6,135,763
Ensembl chr17:6,130,061...6,136,792
G
Gzma
granzyme A
affects expression
ISO
Benzbromarone affects the expression of GZMA mRNA
CTD
PMID:19483382
NCBI chr13:113,230,358...113,237,515
Ensembl chr13:113,230,359...113,237,515
G
H3f3b
H3.3 histone B
affects expression
ISO
Benzbromarone affects the expression of H3F3B mRNA
CTD
PMID:19483382
NCBI chr11:115,912,787...115,921,313
Ensembl chr11:115,912,738...115,918,788
G
Hal
histidine ammonia lyase
affects expression
ISO
Benzbromarone affects the expression of HAL mRNA
CTD
PMID:19483382
NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166
G
Hao2
hydroxyacid oxidase 2
affects expression
ISO
Benzbromarone affects the expression of HAO2 mRNA
CTD
PMID:19483382
NCBI chr 3:98,781,835...98,802,692
Ensembl chr 3:98,781,837...98,800,555
G
Hba-a2
hemoglobin alpha, adult chain 2
affects expression
ISO
Benzbromarone affects the expression of HBA-A2 mRNA
CTD
PMID:19483382
NCBI chr11:32,246,492...32,247,310
Ensembl chr11:32,246,489...32,247,298
G
Hbb-b1
hemoglobin, beta adult major chain
affects expression
ISO
Benzbromarone affects the expression of HBB mRNA
CTD
PMID:19483382
G
Hdc
histidine decarboxylase
affects expression
ISO
Benzbromarone affects the expression of HDC mRNA
CTD
PMID:19483382
NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
G
Hgd
homogentisate 1, 2-dioxygenase
affects expression
ISO
Benzbromarone affects the expression of HGD mRNA
CTD
PMID:19483382
NCBI chr16:37,400,104...37,452,388
Ensembl chr16:37,400,515...37,452,382
G
Hmgn1
high mobility group nucleosomal binding domain 1
affects expression
ISO
Benzbromarone affects the expression of HMGN1 mRNA
CTD
PMID:19483382
NCBI chr16:95,922,788...95,928,925
Ensembl chr16:95,921,818...95,928,929
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
affects expression
ISO
Benzbromarone affects the expression of HPRT1 mRNA
CTD
PMID:19483382
NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536
G
Hps5
HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
affects expression
ISO
Benzbromarone affects the expression of HPS5 mRNA
CTD
PMID:19483382
NCBI chr 7:46,409,890...46,445,501
Ensembl chr 7:46,409,890...46,445,488
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
affects expression
ISO
Benzbromarone affects the expression of HSD17B4 mRNA
CTD
PMID:19483382
NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
G
Hsdl2
hydroxysteroid dehydrogenase like 2
affects expression
ISO
Benzbromarone affects the expression of HSDL2 mRNA
CTD
PMID:19483382
NCBI chr 4:59,581,515...59,618,694
Ensembl chr 4:59,581,563...59,618,689
G
Htra1
HtrA serine peptidase 1
affects expression
ISO
Benzbromarone affects the expression of HTRA1 mRNA
CTD
PMID:19483382
NCBI chr 7:130,537,933...130,587,388
Ensembl chr 7:130,537,841...130,587,390
G
Igf1
insulin-like growth factor 1
affects expression
ISO
Benzbromarone affects the expression of IGF1 mRNA
CTD
PMID:19483382
NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
G
Igfals
insulin-like growth factor binding protein, acid labile subunit
affects expression
ISO
Benzbromarone affects the expression of IGFALS mRNA
CTD
PMID:19483382
NCBI chr17:25,096,818...25,100,985
Ensembl chr17:25,084,971...25,100,984
G
Igfbp2
insulin-like growth factor binding protein 2
affects expression
ISO
Benzbromarone affects the expression of IGFBP2 mRNA
CTD
PMID:19483382
NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Benzbromarone
CTD
PMID:19362101
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
G
Il1b
interleukin 1 beta
multiple interactions
ISO
Benzbromarone inhibits the reaction [IL1B protein results in increased expression of CRP protein]
CTD
PMID:21329621
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
G
Il6
interleukin 6
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Benzbromarone
CTD
PMID:19362101
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Impa1
inositol (myo)-1(or 4)-monophosphatase 1
affects expression
ISO
Benzbromarone affects the expression of IMPA1 mRNA
CTD
PMID:19483382
NCBI chr 3:10,377,016...10,396,499
Ensembl chr 3:10,377,016...10,396,499
G
Inhbe
inhibin beta-E
affects expression
ISO
Benzbromarone affects the expression of INHBE mRNA
CTD
PMID:19483382
NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280
G
Isyna1
myo-inositol 1-phosphate synthase A1
affects expression
ISO
Benzbromarone affects the expression of ISYNA1 mRNA
CTD
PMID:19483382
NCBI chr 8:71,047,131...71,049,940
Ensembl chr 8:71,047,023...71,049,940
G
Itih4
inter alpha-trypsin inhibitor, heavy chain 4
affects expression
ISO
Benzbromarone affects the expression of ITIH4 mRNA
CTD
PMID:19483382
NCBI chr14:30,608,433...30,623,943
Ensembl chr14:30,608,433...30,624,310
G
Iyd
iodotyrosine deiodinase
decreases activity
ISO
Benzbromarone results in decreased activity of IYD protein
CTD
PMID:24012475
NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877
G
Jak1
Janus kinase 1
affects expression
ISO
Benzbromarone affects the expression of JAK1 mRNA
CTD
PMID:19483382
NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479
G
Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
affects expression
ISO
Benzbromarone affects the expression of KDELR2 mRNA
CTD
PMID:19483382
NCBI chr 5:143,389,575...143,407,659
Ensembl chr 5:143,389,593...143,407,656
G
Kdr
kinase insert domain protein receptor
affects expression
ISO
Benzbromarone affects the expression of KDR mRNA
CTD
PMID:19483382
NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
G
Krt8
keratin 8
affects expression
ISO
Benzbromarone affects the expression of KRT8 mRNA
CTD
PMID:19483382
NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917
G
Lcat
lecithin cholesterol acyltransferase
affects expression
ISO
Benzbromarone affects the expression of LCAT mRNA
CTD
PMID:19483382
NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014
G
Lcmt1
leucine carboxyl methyltransferase 1
affects expression
ISO
Benzbromarone affects the expression of LCMT1 mRNA
CTD
PMID:19483382
NCBI chr 7:122,977,026...123,029,581
Ensembl chr 7:122,969,007...123,029,581
G
Lipc
lipase, hepatic
affects expression
ISO
Benzbromarone affects the expression of LIPC mRNA
CTD
PMID:19483382
NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508
G
Lox
lysyl oxidase
affects expression
ISO
Benzbromarone affects the expression of LOX mRNA
CTD
PMID:19483382
NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939
G
Lpl
lipoprotein lipase
increases expression
ISO
Benzbromarone results in increased expression of LPL protein
CTD
PMID:18274627
NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
G
Lrp3
low density lipoprotein receptor-related protein 3
affects expression
ISO
Benzbromarone affects the expression of LRP3 mRNA
CTD
PMID:19483382
NCBI chr 7:34,900,303...34,914,770
Ensembl chr 7:34,899,452...34,914,923
G
Man2b1
mannosidase 2, alpha B1
affects expression
ISO
Benzbromarone affects the expression of MAN2B1 mRNA
CTD
PMID:19483382
NCBI chr 8:85,809,941...85,824,215
Ensembl chr 8:85,809,899...85,824,911
G
Map2k2
mitogen-activated protein kinase kinase 2
affects expression
ISO
Benzbromarone affects the expression of MAP2K2 mRNA
CTD
PMID:19483382
NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809
G
Masp2
MBL associated serine protease 2
affects expression
ISO
Benzbromarone affects the expression of MASP2 mRNA
CTD
PMID:19483382
NCBI chr 4:148,679,079...148,699,939
Ensembl chr 4:148,687,011...148,699,956
G
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
affects expression
ISO
Benzbromarone affects the expression of ME1 mRNA
CTD
PMID:19483382
NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006
G
Mmut
methylmalonyl-Coenzyme A mutase
affects expression
ISO
Benzbromarone affects the expression of MMUT mRNA
CTD
PMID:19483382
NCBI chr17:41,245,576...41,272,880
Ensembl chr17:41,245,576...41,272,879
G
Mro
maestro
affects expression
ISO
Benzbromarone affects the expression of MRO mRNA
CTD
PMID:19483382
NCBI chr18:73,992,465...74,014,405
Ensembl chr18:73,992,456...74,014,404
G
Mrpl2
mitochondrial ribosomal protein L2
affects expression
ISO
Benzbromarone affects the expression of MRPL2 mRNA
CTD
PMID:19483382
NCBI chr17:46,957,094...46,961,058
Ensembl chr17:46,957,155...46,961,065
G
Mrpl9
mitochondrial ribosomal protein L9
affects expression
ISO
Benzbromarone affects the expression of MRPL9 mRNA
CTD
PMID:19483382
NCBI chr 3:94,350,631...94,355,831
Ensembl chr 3:94,350,625...94,358,437
G
Mug2
murinoglobulin 2
affects expression
ISO
Benzbromarone affects the expression of PZP mRNA
CTD
PMID:19483382
NCBI chr 6:121,983,688...122,062,927
Ensembl chr 6:121,983,720...122,062,924
G
Myadm
myeloid-associated differentiation marker
affects expression
ISO
Benzbromarone affects the expression of MYADM mRNA
CTD
PMID:19483382
NCBI chr 7:3,337,563...3,347,871
Ensembl chr 7:3,337,605...3,348,958
G
Mycbp2
MYC binding protein 2, E3 ubiquitin protein ligase
affects expression
ISO
Benzbromarone affects the expression of MYCBP2 mRNA
CTD
PMID:19483382
NCBI chr14:103,350,847...103,584,276
Ensembl chr14:103,350,847...103,584,250
G
Myo1d
myosin ID
affects expression
ISO
Benzbromarone affects the expression of MYO1D mRNA
CTD
PMID:19483382
NCBI chr11:80,372,945...80,670,881
Ensembl chr11:80,372,952...80,670,851
G
Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
affects expression
ISO
Benzbromarone affects the expression of NAA38 mRNA
CTD
PMID:19483382
NCBI chr11:69,286,617...69,287,497
Ensembl chr11:69,286,313...69,287,506
G
Nap1l1
nucleosome assembly protein 1-like 1
affects expression
ISO
Benzbromarone affects the expression of NAP1L1 mRNA
CTD
PMID:19483382
NCBI chr10:111,308,754...111,334,011
Ensembl chr10:111,309,084...111,334,011
G
Nat8
N-acetyltransferase 8 (GCN5-related)
affects expression
ISO
Benzbromarone affects the expression of NAT8 mRNA
CTD
PMID:19483382
NCBI chr 6:85,807,369...85,813,839
Ensembl chr 6:85,807,370...85,809,064
G
Ndrg2
N-myc downstream regulated gene 2
affects expression
ISO
Benzbromarone affects the expression of NDRG2 mRNA
CTD
PMID:19483382
NCBI chr14:52,142,738...52,151,463
Ensembl chr14:52,142,728...52,151,615
G
Ndufs5
NADH:ubiquinone oxidoreductase core subunit S5
affects expression
ISO
Benzbromarone affects the expression of NDUFS5 mRNA
CTD
PMID:19483382
NCBI chr 4:123,606,503...123,611,979
Ensembl chr 4:123,606,503...123,611,995
G
Ndufv3
NADH:ubiquinone oxidoreductase core subunit V3
affects expression
ISO
Benzbromarone affects the expression of NDUFV3 mRNA
CTD
PMID:19483382
NCBI chr17:31,739,089...31,750,300
Ensembl chr17:31,739,089...31,750,305
G
Neu2
neuraminidase 2
affects expression
ISO
Benzbromarone affects the expression of NEU2 mRNA
CTD
PMID:19483382
NCBI chr 1:87,501,749...87,525,567
Ensembl chr 1:87,437,611...87,525,567
G
Nfx1
nuclear transcription factor, X-box binding 1
affects expression
ISO
Benzbromarone affects the expression of NFX1 mRNA
CTD
PMID:19483382
NCBI chr 4:40,970,906...41,025,992
Ensembl chr 4:40,970,906...41,025,993
G
Nipal2
NIPA-like domain containing 2
affects expression
ISO
Benzbromarone affects the expression of NIPAL2 mRNA
CTD
PMID:19483382
NCBI chr15:34,572,942...34,679,739
Ensembl chr15:34,572,945...34,679,358
G
Nit1
nitrilase 1
affects expression
ISO
Benzbromarone affects the expression of NIT1 mRNA
CTD
PMID:19483382
NCBI chr 1:171,168,145...171,173,209
Ensembl chr 1:171,165,576...171,173,214
G
Nme2
NME/NM23 nucleoside diphosphate kinase 2
affects expression
ISO
Benzbromarone affects the expression of NME2 mRNA
CTD
PMID:19483382
NCBI chr11:93,840,640...93,847,082
Ensembl chr11:93,840,640...93,847,085
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
affects expression
ISO
Benzbromarone affects the expression of NR1I3 mRNA
CTD
PMID:19483382
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects expression
ISO
Benzbromarone affects the expression of NR3C1 mRNA
CTD
PMID:19483382
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
G
Oaf
out at first homolog
affects expression
ISO
Benzbromarone affects the expression of OAF mRNA
CTD
PMID:19483382
NCBI chr 9:43,132,575...43,151,113
Ensembl chr 9:43,132,532...43,151,208
G
Ogdh
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
affects expression
ISO
Benzbromarone affects the expression of OGDH mRNA
CTD
PMID:19483382
NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642
G
Or51e2
olfactory receptor family 51 subfamily E member 2
affects expression
ISO
Benzbromarone affects the expression of OLR59 mRNA
CTD
PMID:19483382
NCBI chr 7:102,389,928...102,408,678
Ensembl chr 7:102,387,718...102,408,678
G
Ostc
oligosaccharyltransferase complex subunit (non-catalytic)
affects expression
ISO
Benzbromarone affects the expression of OSTC mRNA
CTD
PMID:19483382
NCBI chr 3:130,489,566...130,503,093
Ensembl chr 3:130,489,561...130,503,093
G
Otc
ornithine transcarbamylase
affects expression
ISO
Benzbromarone affects the expression of OTC mRNA
CTD
PMID:19483382
NCBI chr X:10,118,584...10,187,275
Ensembl chr X:10,118,544...10,187,263
G
Pabpc4
poly(A) binding protein, cytoplasmic 4
affects expression
ISO
Benzbromarone affects the expression of PABPC4 mRNA
CTD
PMID:19483382
NCBI chr 4:123,172,722...123,192,718
Ensembl chr 4:123,156,144...123,192,718
G
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
affects expression
ISO
Benzbromarone affects the expression of PAICS mRNA
CTD
PMID:19483382
NCBI chr 5:77,099,149...77,115,356
Ensembl chr 5:77,099,154...77,115,356
G
Pccb
propionyl Coenzyme A carboxylase, beta polypeptide
affects expression
ISO
Benzbromarone affects the expression of PCCB mRNA
CTD
PMID:19483382
NCBI chr 9:100,864,085...100,916,993
Ensembl chr 9:100,864,085...100,916,951
G
Pcsk6
proprotein convertase subtilisin/kexin type 6
affects expression
ISO
Benzbromarone affects the expression of PCSK6 mRNA
CTD
PMID:19483382
NCBI chr 7:65,511,884...65,700,134
Ensembl chr 7:65,511,482...65,700,134
G
Pctp
phosphatidylcholine transfer protein
affects expression
ISO
Benzbromarone affects the expression of PCTP mRNA
CTD
PMID:19483382
NCBI chr11:89,873,370...89,893,720
Ensembl chr11:89,873,491...89,893,720
G
Pcx
pyruvate carboxylase
affects expression
ISO
Benzbromarone affects the expression of PCX mRNA
CTD
PMID:19483382
NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
G
Pdcl3
phosducin-like 3
affects expression
ISO
Benzbromarone affects the expression of PDCL3 mRNA
CTD
PMID:19483382
NCBI chr 1:39,026,895...39,036,317
Ensembl chr 1:39,024,689...39,036,319
G
Pdia3
protein disulfide isomerase associated 3
affects expression
ISO
Benzbromarone affects the expression of PDIA3 mRNA
CTD
PMID:19483382
NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168
G
Pdia6
protein disulfide isomerase associated 6
affects expression
ISO
Benzbromarone affects the expression of PDIA6 mRNA
CTD
PMID:19483382
NCBI chr12:17,316,590...17,334,786
Ensembl chr12:17,316,546...17,334,771
G
Pex19
peroxisomal biogenesis factor 19
affects expression
ISO
Benzbromarone affects the expression of PEX19 mRNA
CTD
PMID:19483382
NCBI chr 1:171,954,322...171,964,064
Ensembl chr 1:171,954,322...171,964,060
G
Pgam1
phosphoglycerate mutase 1
affects expression
ISO
Benzbromarone affects the expression of PGAM1 mRNA
CTD
PMID:19483382
NCBI chr19:41,900,310...41,907,104
Ensembl chr19:41,900,362...41,907,099
G
Pgrmc1
progesterone receptor membrane component 1
affects expression
ISO
Benzbromarone affects the expression of PGRMC1 mRNA
CTD
PMID:19483382
NCBI chr X:35,861,846...35,869,732
Ensembl chr X:35,861,859...35,869,732
G
Phyh
phytanoyl-CoA hydroxylase
affects expression
ISO
Benzbromarone affects the expression of PHYH mRNA
CTD
PMID:19483382
NCBI chr 2:4,923,807...4,943,554
Ensembl chr 2:4,923,830...4,943,541
G
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
affects expression
ISO
Benzbromarone affects the expression of PIGP mRNA
CTD
PMID:19483382
NCBI chr16:94,159,622...94,171,874
Ensembl chr16:94,159,622...94,172,701
G
Pklr
pyruvate kinase liver and red blood cell
affects expression
ISO
Benzbromarone affects the expression of PKLR mRNA
CTD
PMID:19483382
NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091
G
Plbd1
phospholipase B domain containing 1
affects expression
ISO
Benzbromarone affects the expression of PLBD1 mRNA
CTD
PMID:19483382
NCBI chr 6:136,589,069...136,639,301
Ensembl chr 6:136,589,068...136,638,926
G
Plg
plasminogen
affects expression
ISO
Benzbromarone affects the expression of PLG mRNA
CTD
PMID:19483382
NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272
G
Pls3
plastin 3 (T-isoform)
affects expression
ISO
Benzbromarone affects the expression of PLS3 mRNA
CTD
PMID:19483382
NCBI chr X:74,829,259...74,918,788
Ensembl chr X:74,829,260...74,918,788
G
Pon2
paraoxonase 2
affects expression
ISO
Benzbromarone affects the expression of PON2 mRNA
CTD
PMID:19483382
NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455
G
Pparg
peroxisome proliferator activated receptor gamma
affects expression
EXP
Benzbromarone affects the expression of PPARG mRNA
CTD
PMID:19048458
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
G
Ppdpf
pancreatic progenitor cell differentiation and proliferation factor
affects expression
ISO
Benzbromarone affects the expression of PPDPF mRNA
CTD
PMID:19483382
NCBI chr 2:180,828,615...180,830,297
Ensembl chr 2:180,829,040...180,830,564
G
Prdx2
peroxiredoxin 2
affects expression
ISO
Benzbromarone affects the expression of PRDX2 mRNA
CTD
PMID:19483382
NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463
G
Prdx6
peroxiredoxin 6
affects expression
ISO
Benzbromarone affects the expression of PRDX6 mRNA
CTD
PMID:19483382
NCBI chr 1:161,067,682...161,078,780
Ensembl chr 1:161,067,682...161,078,789
G
Proc
protein C
affects expression
ISO
Benzbromarone affects the expression of PROC mRNA
CTD
PMID:19483382
NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623
G
Prpsap1
phosphoribosyl pyrophosphate synthetase-associated protein 1
affects expression
ISO
Benzbromarone affects the expression of PRPSAP1 mRNA
CTD
PMID:19483382
NCBI chr11:116,361,641...116,385,739
Ensembl chr11:116,361,671...116,385,461
G
Psma6
proteasome subunit alpha 6
affects expression
ISO
Benzbromarone affects the expression of PSMA6 mRNA
CTD
PMID:19483382
NCBI chr12:55,431,007...55,465,244
Ensembl chr12:55,431,007...55,465,239
G
Psmb1
proteasome (prosome, macropain) subunit, beta type 1
affects expression
ISO
Benzbromarone affects the expression of PSMB1 mRNA
CTD
PMID:19483382
NCBI chr17:15,695,983...15,718,538
Ensembl chr17:15,695,283...15,720,013
G
Psmb3
proteasome (prosome, macropain) subunit, beta type 3
affects expression
ISO
Benzbromarone affects the expression of PSMB3 mRNA
CTD
PMID:19483382
NCBI chr11:97,594,260...97,604,326
Ensembl chr11:97,594,225...97,604,326
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Psmc1
protease (prosome, macropain) 26S subunit, ATPase 1
affects expression
ISO
Benzbromarone affects the expression of PSMC1 mRNA
CTD
PMID:19483382
NCBI chr12:100,076,461...100,089,623
Ensembl chr12:100,076,413...100,089,664
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Psmc3
proteasome (prosome, macropain) 26S subunit, ATPase 3
affects expression
ISO
Benzbromarone affects the expression of PSMC3 mRNA
CTD
PMID:19483382
NCBI chr 2:90,884,361...90,889,783
Ensembl chr 2:90,884,354...90,896,714
G
Psmc5
protease (prosome, macropain) 26S subunit, ATPase 5
affects expression
ISO
Benzbromarone affects the expression of PSMC5 mRNA
CTD
PMID:19483382
NCBI chr11:106,147,011...106,153,938
Ensembl chr11:106,146,980...106,153,946
G
Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
affects expression
ISO
Benzbromarone affects the expression of PSMD1 mRNA
CTD
PMID:19483382
NCBI chr 1:85,992,341...86,067,017
Ensembl chr 1:85,992,109...86,066,873
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Psmd4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
affects expression
ISO
Benzbromarone affects the expression of PSMD4 mRNA
CTD
PMID:19483382
NCBI chr 3:94,939,999...94,949,880
Ensembl chr 3:94,940,005...94,949,925
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Ptms
parathymosin
affects expression
ISO
Benzbromarone affects the expression of PTMS mRNA
CTD
PMID:19483382
NCBI chr 6:124,890,638...124,894,909
Ensembl chr 6:124,890,644...124,897,066
G
Ptprf
protein tyrosine phosphatase receptor type F
affects expression
ISO
Benzbromarone affects the expression of PTPRF mRNA
CTD
PMID:19483382
NCBI chr 4:118,065,410...118,148,602
Ensembl chr 4:118,065,410...118,148,602
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Pttg1ip
pituitary tumor-transforming 1 interacting protein
affects expression
ISO
Benzbromarone affects the expression of PTTG1IP mRNA
CTD
PMID:19483382
NCBI chr10:77,417,489...77,434,566
Ensembl chr10:77,417,554...77,434,566
G
Pygl
liver glycogen phosphorylase
affects expression
ISO
Benzbromarone affects the expression of PYGL mRNA
CTD
PMID:19483382
NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262
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Rab5if
RAB5 interacting factor
affects expression
ISO
Benzbromarone affects the expression of RAB5IF mRNA
CTD
PMID:19483382
NCBI chr 2:156,705,042...156,715,483
Ensembl chr 2:156,705,048...156,715,483
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Rida
reactive intermediate imine deaminase A homolog
affects expression
ISO
Benzbromarone affects the expression of RIDA mRNA
CTD
PMID:19483382
NCBI chr15:34,484,168...34,495,392
Ensembl chr15:34,484,167...34,495,401
G
Rnase4
ribonuclease, RNase A family 4
affects expression
ISO
Benzbromarone affects the expression of RNASE4 mRNA
CTD
PMID:19483382
NCBI chr14:51,328,534...51,343,608
Ensembl chr14:51,328,534...51,343,608
G
Rnf103
ring finger protein 103
affects expression
ISO
Benzbromarone affects the expression of RNF103 mRNA
CTD
PMID:19483382
NCBI chr 6:71,470,828...71,487,864
Ensembl chr 6:71,470,878...71,487,865
G
Rnps1
RNA binding protein with serine rich domain 1
affects expression
ISO
Benzbromarone affects the expression of RNPS1 mRNA
CTD
PMID:19483382
NCBI chr17:24,633,620...24,644,872
Ensembl chr17:24,633,539...24,644,875
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Rpl11
ribosomal protein L11
affects expression
ISO
Benzbromarone affects the expression of RPL11 mRNA
CTD
PMID:19483382
NCBI chr 4:135,776,665...135,780,704
Ensembl chr 4:135,755,576...135,780,739
G
Rpl13
ribosomal protein L13
affects expression
ISO
Benzbromarone affects the expression of RPL13 mRNA
CTD
PMID:19483382
NCBI chr 8:123,829,089...123,831,983
Ensembl chr 8:123,829,089...123,831,983
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Rpl15
ribosomal protein L15
affects expression
ISO
Benzbromarone affects the expression of RPL15 mRNA
CTD
PMID:19483382
NCBI chr14:4,198,710...4,201,873
Ensembl chr14:4,198,305...4,201,873
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Rpl17
ribosomal protein L17
affects expression
ISO
Benzbromarone affects the expression of RPL17 mRNA
CTD
PMID:19483382
NCBI chr18:75,132,049...75,136,455
Ensembl chr18:75,131,629...75,136,452
G
Rpl23
ribosomal protein L23
affects expression
ISO
Benzbromarone affects the expression of RPL23 mRNA
CTD
PMID:19483382
NCBI chr11:97,668,352...97,673,265
Ensembl chr11:97,668,353...97,673,263
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Rpl3
ribosomal protein L3
affects expression
ISO
Benzbromarone affects the expression of RPL3 mRNA
CTD
PMID:19483382
NCBI chr15:79,961,993...79,967,553
Ensembl chr15:79,961,992...79,976,069
G
Rpl32
ribosomal protein L32
affects expression
ISO
Benzbromarone affects the expression of RPL32 mRNA
CTD
PMID:19483382
NCBI chr 6:115,782,475...115,785,704
Ensembl chr 6:115,782,466...115,785,708
G
Rpl4
ribosomal protein L4
affects expression
ISO
Benzbromarone affects the expression of RPL4 mRNA
CTD
PMID:19483382
NCBI chr 9:64,080,159...64,085,805
Ensembl chr 9:64,080,657...64,085,948
G
Rpn2
ribophorin II
affects expression
ISO
Benzbromarone affects the expression of RPN2 mRNA
CTD
PMID:19483382
NCBI chr 2:157,121,018...157,168,238
Ensembl chr 2:157,120,937...157,168,239
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Rps14
ribosomal protein S14
affects expression
ISO
Benzbromarone affects the expression of RPS14 mRNA
CTD
PMID:19483382
NCBI chr18:60,907,668...60,911,618
Ensembl chr18:60,880,170...60,911,618
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Rps18
ribosomal protein S18
affects expression
ISO
Benzbromarone affects the expression of RPS18 mRNA
CTD
PMID:19483382
NCBI chr17:34,170,972...34,174,639
Ensembl chr17:34,170,973...34,174,975
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Rps19
ribosomal protein S19
affects expression
ISO
Benzbromarone affects the expression of RPS19 mRNA
CTD
PMID:19483382
NCBI chr 7:24,584,013...24,589,236
Ensembl chr 7:24,583,796...24,589,231
G
Rps20
ribosomal protein S20
affects expression
ISO
Benzbromarone affects the expression of RPS20 mRNA
CTD
PMID:19483382
NCBI chr 4:3,831,334...3,835,600
Ensembl chr 4:3,831,334...3,835,665
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Rps3a1
ribosomal protein S3A1
affects expression
ISO
Benzbromarone affects the expression of RPS3A mRNA
CTD
PMID:19483382
NCBI chr 3:86,045,247...86,049,975
Ensembl chr 3:86,045,247...86,050,009
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Rps6
ribosomal protein S6
affects expression
ISO
Benzbromarone affects the expression of RPS6 mRNA
CTD
PMID:19483382
NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649
G
Rps8
ribosomal protein S8
affects expression
ISO
Benzbromarone affects the expression of RPS8 mRNA
CTD
PMID:19483382
NCBI chr 4:117,011,033...117,013,329
Ensembl chr 4:117,011,024...117,013,440
G
Rras2
related RAS viral (r-ras) oncogene 2
affects expression
ISO
Benzbromarone affects the expression of RRAS2 mRNA
CTD
PMID:19483382
NCBI chr 7:113,646,017...113,717,016
Ensembl chr 7:113,646,017...113,717,016
G
S1pr1
sphingosine-1-phosphate receptor 1
affects expression
ISO
Benzbromarone affects the expression of S1PR1 mRNA
CTD
PMID:19483382
NCBI chr 3:115,504,082...115,508,704
Ensembl chr 3:115,504,082...115,508,721
G
Sbspon
somatomedin B and thrombospondin, type 1 domain containing
affects expression
ISO
Benzbromarone affects the expression of SBSPON mRNA
CTD
PMID:19483382
NCBI chr 1:15,924,086...15,962,946
Ensembl chr 1:15,924,086...15,962,946
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Sdc2
syndecan 2
affects expression
ISO
Benzbromarone affects the expression of SDC2 mRNA
CTD
PMID:19483382
NCBI chr15:32,920,869...33,034,867
Ensembl chr15:32,920,869...33,035,081
G
Sdhc
succinate dehydrogenase complex, subunit C, integral membrane protein
affects expression
ISO
Benzbromarone affects the expression of SDHC mRNA
CTD
PMID:19483382
NCBI chr 1:170,956,726...170,978,209
Ensembl chr 1:170,954,734...170,978,172
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Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
affects expression
ISO
Benzbromarone affects the expression of SDHD mRNA
CTD
PMID:19483382
NCBI chr 9:50,507,640...50,515,149
Ensembl chr 9:50,507,657...50,515,112
G
Serinc3
serine incorporator 3
affects expression
ISO
Benzbromarone affects the expression of SERINC3 mRNA
CTD
PMID:19483382
NCBI chr 2:163,466,577...163,487,767
Ensembl chr 2:163,465,192...163,487,051
G
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
affects expression
ISO
Benzbromarone affects the expression of SERPINA10 mRNA
CTD
PMID:19483382
NCBI chr12:103,582,934...103,597,681
Ensembl chr12:103,581,045...103,597,703
G
Serpina4-ps1
serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1
affects expression
ISO
Benzbromarone affects the expression of SERPINA4 mRNA
CTD
PMID:19483382
NCBI chr12:104,044,218...104,053,179
Ensembl chr12:104,046,908...104,052,983
G
Serpinf2
serine (or cysteine) peptidase inhibitor, clade F, member 2
affects expression
ISO
Benzbromarone affects the expression of SERPINF2 mRNA
CTD
PMID:19483382
NCBI chr11:75,322,562...75,330,327
Ensembl chr11:75,322,558...75,330,417
G
Sfxn1
sideroflexin 1
affects expression
ISO
Benzbromarone affects the expression of SFXN1 mRNA
CTD
PMID:19483382
NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361
G
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
affects expression
ISO
Benzbromarone affects the expression of SHMT2 mRNA
CTD
PMID:19483382
NCBI chr10:127,352,992...127,358,313
Ensembl chr10:127,352,992...127,358,313
G
Slc22a1
solute carrier family 22 (organic cation transporter), member 1
affects expression
ISO
Benzbromarone affects the expression of SLC22A1 mRNA
CTD
PMID:19483382
NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716
G
Slc22a12
solute carrier family 22 (organic anion/cation transporter), member 12
affects activity multiple interactions affects response to substance decreases activity
ISO EXP
Benzbromarone affects the activity of SLC22A12 protein Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]; Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] SLC22A12 protein affects the susceptibility to Benzbromarone Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid] Benzbromarone results in decreased activity of SLC22A12 protein
CTD
PMID:14694169 PMID:14747372 PMID:16135657 PMID:18670416 PMID:20486468 PMID:21074513 PMID:21272127 PMID:21449597 More...
NCBI chr19:6,585,884...6,593,100
Ensembl chr19:6,585,875...6,593,062
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Slc22a6
solute carrier family 22 (organic anion transporter), member 6
multiple interactions
ISO
Benzbromarone inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]
CTD
PMID:12472777
NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663
G
Slc23a1
solute carrier family 23 (nucleobase transporters), member 1
affects expression
ISO
Benzbromarone affects the expression of SLC23A1 mRNA
CTD
PMID:19483382
NCBI chr18:35,747,657...35,762,900
Ensembl chr18:35,747,657...35,760,297
G
Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
affects expression
ISO
Benzbromarone affects the expression of SLC25A13 mRNA
CTD
PMID:19483382
NCBI chr 6:6,041,218...6,217,304
Ensembl chr 6:6,041,218...6,217,173
G
Slc25a3
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
affects expression
ISO
Benzbromarone affects the expression of SLC25A3 mRNA
CTD
PMID:19483382
NCBI chr10:90,952,436...90,959,902
Ensembl chr10:90,952,436...90,959,921
G
Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
affects expression
ISO
Benzbromarone affects the expression of SLC27A2 mRNA
CTD
PMID:19483382
NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163
G
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
multiple interactions
EXP ISO
Benzbromarone inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid] Benzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]
CTD
PMID:18842065 PMID:19587147
NCBI chr 5:38,506,616...38,660,488
Ensembl chr 5:38,506,616...38,660,486
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Slc39a8
solute carrier family 39 (metal ion transporter), member 8
affects expression
ISO
Benzbromarone affects the expression of SLC39A8 mRNA
CTD
PMID:19483382
NCBI chr 3:135,522,644...135,594,333
Ensembl chr 3:135,531,040...135,594,333
G
Slc46a1
solute carrier family 46, member 1
affects expression
ISO
Benzbromarone affects the expression of SLC46A1 mRNA
CTD
PMID:19483382
NCBI chr11:78,356,527...78,362,771
Ensembl chr11:78,356,523...78,362,885
G
Slc66a2
solute carrier family 66 member 2
affects expression
ISO
Benzbromarone affects the expression of SLC66A2 mRNA
CTD
PMID:19483382
NCBI chr18:80,298,458...80,335,940
Ensembl chr18:80,296,507...80,335,940
G
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
affects expression
ISO
Benzbromarone affects the expression of SLC6A6 mRNA
CTD
PMID:19483382
NCBI chr 6:91,661,031...91,736,044
Ensembl chr 6:91,661,034...91,736,047
G
Sod2
superoxide dismutase 2, mitochondrial
increases expression
ISO
Benzbromarone results in increased expression of SOD2 mRNA
CTD
PMID:25108121
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
G
Sppl2a
signal peptide peptidase like 2A
affects expression
ISO
Benzbromarone affects the expression of SPPL2A mRNA
CTD
PMID:19483382
NCBI chr 2:126,732,311...126,775,706
Ensembl chr 2:126,732,311...126,775,155
G
Srm
spermidine synthase
affects expression
ISO
Benzbromarone affects the expression of SRM mRNA
CTD
PMID:19483382
NCBI chr 4:148,675,970...148,679,076
Ensembl chr 4:148,675,960...148,679,450
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Srprb
signal recognition particle receptor, B subunit
affects expression
ISO
Benzbromarone affects the expression of SRPRB mRNA
CTD
PMID:19483382
NCBI chr 9:103,065,232...103,079,264
Ensembl chr 9:103,065,231...103,079,336
G
Ssx2ip
SSX family member 2 interacting protein
affects expression
ISO
Benzbromarone affects the expression of SSX2IP mRNA
CTD
PMID:19483382
NCBI chr 3:146,110,397...146,145,899
Ensembl chr 3:146,110,397...146,145,899
G
St3gal6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
affects expression
ISO
Benzbromarone affects the expression of ST3GAL6 mRNA
CTD
PMID:19483382
NCBI chr16:58,290,105...58,344,614
Ensembl chr16:58,288,488...58,344,606
G
St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
affects expression
ISO
Benzbromarone affects the expression of ST6GAL1 mRNA
CTD
PMID:19483382
NCBI chr16:23,043,478...23,179,100
Ensembl chr16:23,043,490...23,179,100
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Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
affects expression
ISO
Benzbromarone affects the expression of SUCLG1 mRNA
CTD
PMID:19483382
NCBI chr 6:73,225,488...73,253,890
Ensembl chr 6:73,225,365...73,253,894
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Surf4
surfeit gene 4
affects expression
ISO
Benzbromarone affects the expression of SURF4 mRNA
CTD
PMID:19483382
NCBI chr 2:26,810,052...26,823,801
Ensembl chr 2:26,810,052...26,823,940
G
Synj2bp
synaptojanin 2 binding protein
affects expression
ISO
Benzbromarone affects the expression of SYNJ2BP mRNA
CTD
PMID:19483382
NCBI chr12:81,538,968...81,579,685
Ensembl chr12:81,544,715...81,579,685
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Tgfbi
transforming growth factor, beta induced
affects expression
ISO
Benzbromarone affects the expression of TGFBI mRNA
CTD
PMID:19483382
NCBI chr13:56,757,399...56,787,172
Ensembl chr13:56,757,336...56,787,375
G
Thnsl2
threonine synthase-like 2 (bacterial)
affects expression
ISO
Benzbromarone affects the expression of THNSL2 mRNA
CTD
PMID:19483382
NCBI chr 6:71,105,150...71,121,364
Ensembl chr 6:71,105,150...71,121,423
G
Timm21
translocase of inner mitochondrial membrane 21
affects expression
ISO
Benzbromarone affects the expression of TIMM21 mRNA
CTD
PMID:19483382
NCBI chr18:84,964,316...84,970,168
Ensembl chr18:84,964,316...84,969,649
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Tkfc
triokinase, FMN cyclase
affects expression
ISO
Benzbromarone affects the expression of TKFC mRNA
CTD
PMID:19483382
NCBI chr19:10,565,153...10,583,257
Ensembl chr19:10,565,155...10,583,018
G
Tmbim1
transmembrane BAX inhibitor motif containing 1
affects expression
ISO
Benzbromarone affects the expression of TMBIM1 mRNA
CTD
PMID:19483382
NCBI chr 1:74,327,406...74,343,495
Ensembl chr 1:74,327,406...74,344,781
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Tmco1
transmembrane and coiled-coil domains 1
affects expression
ISO
Benzbromarone affects the expression of TMCO1 mRNA
CTD
PMID:19483382
NCBI chr 1:167,136,239...167,161,547
Ensembl chr 1:167,135,947...167,161,547
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Tmed2
transmembrane p24 trafficking protein 2
affects expression
ISO
Benzbromarone affects the expression of TMED2 mRNA
CTD
PMID:19483382
NCBI chr 5:124,678,835...124,688,566
Ensembl chr 5:124,678,758...124,688,569
G
Tmed7
transmembrane p24 trafficking protein 7
affects expression
ISO
Benzbromarone affects the expression of TMED7 mRNA
CTD
PMID:19483382
NCBI chr18:46,718,995...46,730,602
Ensembl chr18:46,693,302...46,730,602
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Tmem123
transmembrane protein 123
affects expression
ISO
Benzbromarone affects the expression of TMEM123 mRNA
CTD
PMID:19483382
NCBI chr 9:7,764,078...7,794,334
Ensembl chr 9:7,764,042...7,794,334
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Tmem97
transmembrane protein 97
affects expression
ISO
Benzbromarone affects the expression of TMEM97 mRNA
CTD
PMID:19483382
NCBI chr11:78,432,643...78,441,561
Ensembl chr11:78,432,643...78,441,603
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Tnf
tumor necrosis factor
increases expression multiple interactions
ISO
Benzbromarone results in increased expression of TNF protein [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Benzbromarone
CTD
PMID:19362101 PMID:19933411
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Txn1
thioredoxin 1
affects expression
ISO
Benzbromarone affects the expression of TXN1 mRNA
CTD
PMID:19483382
NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
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Txnl1
thioredoxin-like 1
affects expression
ISO
Benzbromarone affects the expression of TXNL1 mRNA
CTD
PMID:19483382
NCBI chr18:63,795,872...63,825,535
Ensembl chr18:63,794,165...63,841,872
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Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
affects expression
ISO
Benzbromarone affects the expression of UBA52 mRNA
CTD
PMID:19483382
NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451
G
Ube2n
ubiquitin-conjugating enzyme E2N
affects expression
ISO
Benzbromarone affects the expression of UBE2N mRNA
CTD
PMID:19483382
NCBI chr10:95,351,024...95,381,520
Ensembl chr10:95,351,007...95,381,519
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Ufd1
ubiquitin recognition factor in ER-associated degradation 1
affects expression
ISO
Benzbromarone affects the expression of UFD1 mRNA
CTD
PMID:19483382
NCBI chr16:18,630,486...18,654,011
Ensembl chr16:18,630,529...18,654,011
G
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
affects expression
ISO
Benzbromarone affects the expression of UGT1A1 mRNA
CTD
PMID:19483382
NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
G
Uqcr11
ubiquinol-cytochrome c reductase, complex III subunit XI
affects expression
ISO
Benzbromarone affects the expression of UQCR11 mRNA
CTD
PMID:19483382
NCBI chr10:80,238,831...80,242,655
Ensembl chr10:80,238,831...80,242,664
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Vnn1
vanin 1
affects expression
ISO
Benzbromarone affects the expression of VNN1 mRNA
CTD
PMID:19483382
NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241
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Wdr26
WD repeat domain 26
affects expression
ISO
Benzbromarone affects the expression of WDR26 mRNA
CTD
PMID:19483382
NCBI chr 1:181,000,791...181,046,211
Ensembl chr 1:181,000,793...181,039,566
G
Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
affects expression
ISO
Benzbromarone affects the expression of YWHAG mRNA
CTD
PMID:19483382
NCBI chr 5:135,937,233...135,963,495
Ensembl chr 5:135,937,263...135,963,470
G
Zdhhc23
zinc finger, DHHC domain containing 23
affects expression
ISO
Benzbromarone affects the expression of ZDHHC23 mRNA
CTD
PMID:19483382
NCBI chr16:43,785,396...43,800,295
Ensembl chr16:43,785,396...43,800,154
G
Zp3r
zona pellucida 3 receptor
affects expression
ISO
Benzbromarone affects the expression of C4BPA mRNA
CTD
PMID:19483382
NCBI chr 1:130,474,847...130,557,371
Ensembl chr 1:130,504,450...130,557,358
G
Zwint
ZW10 interactor
affects expression
ISO
Benzbromarone affects the expression of ZWINT mRNA
CTD
PMID:19483382
NCBI chr10:72,490,678...72,510,796
Ensembl chr10:72,490,677...72,510,796
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