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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:3013 term browser browse the term
Definition:A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.
Synonyms:related_synonym: +--3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;   6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide;   Formula=C15H14F3N3O4S2;   InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23);   InChIKey=HDWIHXWEUNVBIY-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F;   bendrofluazide;   bendroflumethiazidum;   bendroflumetiazida;   benzhydroflumethiazide
 alt_id: CHEBI:615239
 xref: Beilstein:373316;   CAS:73-48-3;   DrugBank:DB00436;   Drug_Central:305;   KEGG:C07758;   KEGG:D00650;   LINCS:LSM-1816
 xref_mesh: MESH:D001539
 xref: PMID:19056282;   Patent:GB863474;   Patent:US3392168;   Reaxys:373316;   Wikipedia:Bendroflumethiazide

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bendroflumethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apob apolipoprotein B affects expression ISO Bendroflumethiazide affects the expression of APOB protein CTD PMID:2344503 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Ren renin increases expression ISO Bendroflumethiazide results in increased expression of REN protein CTD PMID:62162 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc12a3 solute carrier family 12 member 3 increases response to substance EXP SLC12A3 protein results in increased susceptibility to Bendroflumethiazide CTD PMID:18480177 NCBI chr19:11,106,033...11,144,674
Ensembl chr19:11,106,033...11,144,641
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases secretion
ISO Bendroflumethiazide results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
increases secretion
ISO Bendroflumethiazide results in decreased activity of SLC22A8 protein
SLC22A8 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Bendroflumethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression EXP Bendroflumethiazide results in decreased expression of VEGFC protein CTD PMID:20625077 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link

Term paths to the root
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  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            diuretic 1122
              bendroflumethiazide 7
                (R)-bendroflumethiazide 0
                (S)-bendroflumethiazide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      chalcogen 19399
                        oxygen atom 19361
                          oxygen molecular entity 19361
                            hydroxides 19107
                              oxoacid 18241
                                chalcogen oxoacid 11491
                                  sulfur oxoacid 11095
                                    sulfonic acid 7340
                                      sulfonic acid derivative 7340
                                        sulfonamide 3174
                                          bendroflumethiazide 7
                                            (R)-bendroflumethiazide 0
                                            (S)-bendroflumethiazide 0
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