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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:3013 term browser browse the term
Definition:A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.
Synonyms:related_synonym: +--3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;   6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide;   Formula=C15H14F3N3O4S2;   InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23);   InChIKey=HDWIHXWEUNVBIY-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F;   bendrofluazide;   bendroflumethiazidum;   bendroflumetiazida;   benzhydroflumethiazide
 alt_id: CHEBI:615239
 xref: Beilstein:373316;   CAS:73-48-3;   DrugBank:DB00436;   Drug_Central:305;   KEGG:C07758;   KEGG:D00650;   LINCS:LSM-1816
 xref_mesh: MESH:D001539
 xref: PMID:19056282;   Patent:GB863474;   Patent:US3392168;   Reaxys:373316;   Wikipedia:Bendroflumethiazide

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bendroflumethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apob apolipoprotein B affects expression ISO Bendroflumethiazide affects the expression of APOB protein CTD PMID:2344503 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Ren renin increases expression ISO Bendroflumethiazide results in increased expression of REN protein CTD PMID:62162 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slc12a3 solute carrier family 12 member 3 increases response to substance EXP SLC12A3 protein results in increased susceptibility to Bendroflumethiazide CTD PMID:18480177 NCBI chr19:10,630,649...10,679,250
Ensembl chr19:10,631,393...10,669,091
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases secretion
ISO Bendroflumethiazide results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
increases secretion
ISO Bendroflumethiazide results in decreased activity of SLC22A8 protein
SLC22A8 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Bendroflumethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression EXP Bendroflumethiazide results in decreased expression of VEGFC protein CTD PMID:20625077 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        pharmaceutical 19351
          drug 19351
            diuretic 1135
              bendroflumethiazide 7
                (R)-bendroflumethiazide 0
                (S)-bendroflumethiazide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      chalcogen 19445
                        oxygen atom 19418
                          oxygen molecular entity 19418
                            hydroxides 19152
                              oxoacid 18466
                                chalcogen oxoacid 11497
                                  sulfur oxoacid 11105
                                    sulfonic acid 7370
                                      sulfonic acid derivative 7370
                                        sulfonamide 3195
                                          bendroflumethiazide 7
                                            (R)-bendroflumethiazide 0
                                            (S)-bendroflumethiazide 0
paths to the root