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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azo group
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Accession:CHEBI:30106 term browser browse the term
Synonyms:exact_synonym: diazenediyl
 related_synonym: -N=N-;   Formula=N2;   SMILES=N(=N/*)\\*;   azo;   diazene-1,2-diyl


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(E)-azobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO azobenzene results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
1,1'-azobis(N,N-dimethylformamide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha multiple interactions ISO Diamide promotes the reaction [CLU protein binds to ATP7A protein] CTD PMID:21242307 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO Diamide promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO [Glutathione co-treated with Diamide] results in decreased activity of CFTR protein CTD PMID:15857825 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Clu clusterin multiple interactions ISO Diamide promotes the reaction [CLU protein binds to ATP7A protein]; Diamide promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
EXP Diamide results in increased activity of GCLC protein
Diamide results in increased expression of GCLC mRNA; Diamide results in increased expression of GCLC protein
CTD PMID:15115889 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP Diamide results in increased expression of GCLM mRNA; Diamide results in increased expression of GCLM protein CTD PMID:15115889 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Diamide results in increased expression of HMOX1 protein CTD PMID:21242307 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity
ISO [Diamide results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Diamide inhibits the reaction [MTOR protein binds to RPTOR protein]; MTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO [NFE2L2 affects the susceptibility to sulforafan] which affects the susceptibility to Diamide CTD PMID:19303893 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Glutathione promotes the reaction [Diamide results in decreased activity of OGDH protein] CTD PMID:12680778 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO Diamide results in increased oxidation of and results in decreased activity of OGG1 protein CTD PMID:16923968 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Ppif peptidylprolyl isomerase F increases oxidation ISO
EXP
Diamide results in increased oxidation of PPIF protein CTD PMID:26975474 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Prdx3 peroxiredoxin 3 increases oxidation ISO
EXP
Diamide results in increased oxidation of PRDX3 protein CTD PMID:26975474 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Rfk riboflavin kinase decreases response to substance ISO RFK protein results in decreased susceptibility to Diamide CTD PMID:21308351 NCBI chr 1:236,494,221...236,501,733
Ensembl chr 1:236,494,221...236,501,733
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation
multiple interactions
ISO Diamide results in increased phosphorylation of RPS6KB1 protein
[Diamide results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; MTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein]; RPTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein]
CTD PMID:16183647 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 multiple interactions ISO Diamide inhibits the reaction [MTOR protein binds to RPTOR protein]; RPTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:108,750,620...109,058,691
Ensembl chr10:108,750,620...109,058,691
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO Diamide results in increased expression of SOD2 mRNA
Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Diamide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Diamide inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
CTD PMID:7476933 PMID:8760145 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects localization ISO Diamide affects the localization of STAT3 protein CTD PMID:10364193 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Diamide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Diamide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases glutathionylation ISO Diamide results in increased glutathionylation of TP53 protein CTD PMID:17555331 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txn1 thioredoxin 1 increases oxidation ISO Diamide results in increased oxidation of TXN protein CTD PMID:26975474 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txn2 thioredoxin 2 increases oxidation ISO
EXP
Diamide results in increased oxidation of TXN2 protein CTD PMID:26975474 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor decreases activity ISO Diamide results in decreased activity of XPA protein CTD PMID:15265038 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity EXP metanil yellow results in decreased activity of CAT protein CTD PMID:26494366 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 multiple interactions EXP [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCNB1 protein CTD PMID:12616621 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
EXP metanil yellow results in increased expression of CCND1 protein
[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 protein; metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]
CTD PMID:10906429 PMID:12616621 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases expression
EXP metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]
metanil yellow results in increased expression of CCNE1 protein
CTD PMID:10906429 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 protein CTD PMID:12616621 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions EXP [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 protein CTD PMID:12616621 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP metanil yellow results in decreased expression of FSHB CTD PMID:26494366 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP metanil yellow results in decreased activity of GSR protein CTD PMID:26494366 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP metanil yellow results in decreased expression of LHB CTD PMID:26494366 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
EXP [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of PCNA protein; metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of PCNA protein]
metanil yellow results in increased expression of PCNA protein
CTD PMID:10906429 PMID:11831363 PMID:12616621 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
3-methyl-4'-dimethylaminoazobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tat tyrosine aminotransferase multiple interactions EXP Methyldimethylaminoazobenzene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Methyldimethylaminoazobenzene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]; Methyldimethylaminoazobenzene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein] CTD PMID:12882633 PMID:16267830 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
4-(dimethylamino)azobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO p-Dimethylaminoazobenzene results in decreased activity of CAT protein CTD PMID:21376788 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 decreases activity ISO lac dye results in decreased activity of DNMT1 protein CTD PMID:23839987 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
4-Hydroxyazobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 increases activity EXP 4-hydroxyazobenzene results in increased activity of ESR1 protein CTD PMID:12504345 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid results in decreased expression of FN1 mRNA CTD PMID:18210741 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Il6 interleukin 6 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein] CTD PMID:24793913 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] CTD PMID:24912985 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein] CTD PMID:11102496 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein] CTD PMID:21638035 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein] CTD PMID:22253048 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
azobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO azobenzene results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
Congo Red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions
affects binding
EXP
ISO
Congo Red inhibits the reaction [APP protein binds to APP protein]
Congo Red binds to APP protein
CTD PMID:17323972 PMID:17406451 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Prnp prion protein decreases expression ISO Congo Red results in decreased expression of PRNP protein alternative form CTD PMID:11994310 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
ortho-Aminoazotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC2 mRNA] CTD PMID:21672546 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA] CTD PMID:21672546 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR protein affects the reaction [o-Aminoazotoluene affects the expression of CYP1A1 mRNA] CTD PMID:12700417 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO o-Aminoazotoluene results in increased expression of BAX mRNA CTD PMID:15346788 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Ccng1 cyclin G1 increases expression ISO o-Aminoazotoluene results in increased expression of CCNG1 mRNA CTD PMID:15346788 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO o-Aminoazotoluene results in increased expression of CDKN1A mRNA CTD PMID:15346788 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO AHR protein affects the reaction [o-Aminoazotoluene affects the expression of CYP1A1 mRNA]
o-Aminoazotoluene results in increased expression of CYP1A1 mRNA
o-Aminoazotoluene results in increased activity of CYP1A1 protein
CTD PMID:10887293 PMID:12700417 PMID:14562683 PMID:15863256 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
ISO o-Aminoazotoluene results in increased activity of CYP1A2 protein
o-Aminoazotoluene results in increased expression of CYP1A2 mRNA
CTD PMID:10887293 PMID:14562683 PMID:15863256 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 protein]
o-Aminoazotoluene results in increased expression of CYP2B10 mRNA; o-Aminoazotoluene results in increased expression of CYP2B10 protein
CTD PMID:21672546 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2C29 mRNA] CTD PMID:21672546 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Foxa3 forkhead box A3 decreases activity ISO o-Aminoazotoluene results in decreased activity of FOXA3 protein CTD PMID:11398193 NCBI chr 1:79,921,292...79,930,219
Ensembl chr 1:79,920,752...79,930,263
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO o-Aminoazotoluene results in increased expression of MDM2 mRNA CTD PMID:15346788 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC protein]
o-Aminoazotoluene results in increased expression of MYC mRNA; o-Aminoazotoluene results in increased expression of MYC protein
CTD PMID:21672546 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity
increases response to substance
ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC2 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2C29 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP3A11 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA]
o-Aminoazotoluene results in increased activity of NR1I3 protein
NR1I3 protein results in increased susceptibility to o-Aminoazotoluene
CTD PMID:21672546 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO o-Aminoazotoluene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; o-Aminoazotoluene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]; o-Aminoazotoluene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein] CTD PMID:11443928 PMID:12882633 PMID:16267830 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tp53 tumor protein p53 increases expression ISO o-Aminoazotoluene results in increased expression of TRP53 mRNA CTD PMID:15346788 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA] CTD PMID:21672546 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
phenazopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Phenazopyridine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Utrn utrophin increases expression ISO Phenazopyridine results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
JBrowse link
prontosil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO sulfamidochrysoidine binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO sulfamidochrysoidine binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
Sudan I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions EXP
ISO
CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775 PMID:19358889 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases oxidation
ISO
EXP
CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol
1-phenylazo-2-naphthol results in increased expression of CYP1A1 mRNA; 1-phenylazo-2-naphthol results in increased expression of CYP1A1 protein
1-phenylazo-2-naphthol promotes the reaction [aristolochic acid I results in increased expression of and results in increased activity of CYP1A1 protein]; 1-phenylazo-2-naphthol results in increased expression of and results in increased activity of CYP1A1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A1 mRNA; [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol
CTD PMID:12384524 PMID:15766589 PMID:17159775 PMID:18418879 PMID:23289503 PMID:24530354 PMID:26845733 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
increases oxidation
ISO
EXP
CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]
1-phenylazo-2-naphthol results in increased expression of CYP1A2 mRNA
1-phenylazo-2-naphthol affects the expression of and affects the activity of CYP1A2 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A2 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:17159775 PMID:26845733 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases oxidation ISO CYP1B1 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
multiple interactions
ISO CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol
CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity
multiple interactions
EXP 1-phenylazo-2-naphthol results in decreased activity of CYP2C11 protein
[aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in decreased activity of CYP2C11 protein
CTD PMID:26845733 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases oxidation
ISO CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases oxidation ISO CYP2C8 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases oxidation
ISO CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases oxidation ISO CYP2E1 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases oxidation
multiple interactions
ISO CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol
CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775 PMID:19358889 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO 1-phenylazo-2-naphthol results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP 1-phenylazo-2-naphthol results in increased expression of GSTP1 mRNA CTD PMID:2563599 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP 1-phenylazo-2-naphthol results in increased expression of and results in increased activity of NQO1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of NQO1 protein
1-phenylazo-2-naphthol results in increased expression of NQO1 mRNA
CTD PMID:23289503 PMID:26845733 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol CTD PMID:24530354 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
Sudan III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects localization
multiple interactions
ISO
EXP
sudan III affects the localization of AHR protein
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III binds to and results in increased activity of AHR protein
[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]; [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; sudan III binds to and results in increased activity of AHR protein
CTD PMID:15585952 PMID:15788368 PMID:22287322 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:22287322 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity
multiple interactions
ISO
EXP
sudan III results in increased expression of CYP1A1 mRNA
sudan III results in increased expression of CYP1A1 mRNA; sudan III results in increased expression of CYP1A1 protein
sudan III results in increased activity of CYP1A1 protein
[sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]
CTD PMID:18418879 PMID:20308224 PMID:22287322 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP sudan III results in increased expression of CYP1A2 protein CTD PMID:20308224 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B1 protein
sudan III results in decreased expression of CYP2B1 mRNA
CTD PMID:15788368 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B2 protein
sudan III results in decreased expression of CYP2B2 mRNA
CTD PMID:15788368 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III results in decreased expression of and results in decreased activity of CYP2C11 protein
sudan III results in decreased expression of CYP2C11 mRNA
CTD PMID:15788368 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A2 protein
sudan III results in decreased expression of CYP3A2 mRNA
CTD PMID:15788368 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A23-3A1 protein
sudan III results in decreased expression of CYP3A23-3A1 mRNA
CTD PMID:15788368 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP sudan III results in decreased expression of CYP4A1 mRNA CTD PMID:15585952 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 decreases expression EXP sudan III results in decreased expression of CYP4A2 mRNA CTD PMID:15585952 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP sudan III results in decreased expression of CYP4A3 mRNA CTD PMID:15585952 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP sudan III results in increased expression of NQO1 mRNA CTD PMID:20308224 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA] CTD PMID:22287322 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO
EXP
sudan III results in decreased expression of PPARA protein
sudan III results in decreased expression of PPARA mRNA
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]
CTD PMID:15585952 PMID:15788368 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO sudan III results in decreased expression of RXRA protein CTD PMID:15585952 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
Sudan IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Scarlet Red results in increased expression of CYP1A1 mRNA; Scarlet Red results in increased expression of CYP1A1 protein CTD PMID:18418879 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
sulfasalazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase increases expression ISO Sulfasalazine results in increased expression of AADAT mRNA CTD PMID:22016648 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium CTD PMID:19853032 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport
increases activity
affects transport
multiple interactions
decreases methylation
ISO ABCG2 protein results in increased transport of Sulfasalazine
Sulfasalazine results in increased activity of ABCG2 protein
ABCG2 gene polymorphism affects the transport of Sulfasalazine
[Sulfasalazine results in decreased methylation of ABCG2 promoter] which results in increased expression of ABCG2 mRNA; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Sulfasalazine promotes the reaction [Cholesterol results in increased activity of ABCG2 protein]
CTD PMID:18167504 PMID:18408567 PMID:20019844 PMID:27475308 PMID:30083819 PMID:32003934 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO Sulfasalazine results in increased expression of ACAA1B mRNA CTD PMID:31830553 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO Sulfasalazine results in increased expression of ACOT1 mRNA CTD PMID:31830553 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression ISO Sulfasalazine results in increased expression of ACOT3 mRNA CTD PMID:31830553 NCBI chr 6:107,531,508...107,537,446
Ensembl chr 6:107,531,528...107,536,789
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Sulfasalazine results in increased expression of ACOX1 mRNA CTD PMID:31830553 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:15633128 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
affects localization
ISO BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein] CTD PMID:12381674 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Sulfasalazine results in decreased expression of ALDH1A1 mRNA CTD PMID:31830553 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of ALPI protein] CTD PMID:15867298 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Anxa2 annexin A2 increases expression ISO Sulfasalazine results in increased expression of ANXA2 mRNA CTD PMID:22016648 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Apoa4 apolipoprotein A4 decreases expression ISO Sulfasalazine results in decreased expression of APOA4 mRNA CTD PMID:31830553 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Azin1 antizyme inhibitor 1 increases expression ISO Sulfasalazine results in increased expression of AZIN1 mRNA CTD PMID:22016648 NCBI chr 7:77,345,646...77,372,398
Ensembl chr 7:77,345,646...77,372,398
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
multiple interactions
ISO
EXP
Sulfasalazine affects the localization of BAX protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]
CTD PMID:12381674 PMID:31428839 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]
CTD PMID:12381674 PMID:31428839 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C6 complement C6 decreases expression ISO Sulfasalazine results in decreased expression of C6 mRNA CTD PMID:31830553 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797
JBrowse link
G Casp1 caspase 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein] CTD PMID:30408459 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]; Sulfasalazine results in increased cleavage of and results in increased activity of CASP3 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 protein]
Sulfasalazine results in increased activity of CASP3 protein
CTD PMID:12381674 PMID:16322111 PMID:17051331 PMID:19473188 PMID:19859796 PMID:26165751 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP9 protein]
Sulfasalazine results in increased cleavage of CASP9 protein
CTD PMID:16322111 PMID:19859796 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity EXP Sulfasalazine results in increased activity of CAT protein CTD PMID:19028562 PMID:19071188 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA CTD PMID:19015640 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL2 mRNA] CTD PMID:17449585 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO
EXP
[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA
Sulfasalazine results in decreased expression of CCND1 mRNA
CTD PMID:17202759 PMID:19015640 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng1 cyclin G1 increases expression ISO Sulfasalazine results in increased expression of CCNG1 mRNA CTD PMID:22016648 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA CTD PMID:28863153 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd19 CD19 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA CTD PMID:28863153 NCBI chr 1:197,815,422...197,822,123
Ensembl chr 1:197,815,413...197,821,936
JBrowse link
G Cd27 CD27 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA CTD PMID:28863153 NCBI chr 4:157,744,881...157,751,609
Ensembl chr 4:157,744,882...157,750,088
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA CTD PMID:28863153 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd3d CD3d molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA CTD PMID:28863153 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110
JBrowse link
G Cd46 CD46 molecule decreases expression EXP Sulfasalazine results in decreased expression of CD46 mRNA CTD PMID:15625186 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) decreases expression EXP Sulfasalazine results in decreased expression of CD55 mRNA CTD PMID:15625186 PMID:17166698 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cd59 CD59 molecule decreases expression EXP Sulfasalazine results in decreased expression of CD59 mRNA; Sulfasalazine results in decreased expression of CD59 protein CTD PMID:15625186 PMID:17166698 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cd74 CD74 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA CTD PMID:28863153 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA CTD PMID:19015640 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
EXP protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein] CTD PMID:19234301 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Clu clusterin increases expression ISO Sulfasalazine results in increased expression of CLU mRNA CTD PMID:22016648 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein] CTD PMID:15633128 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein] CTD PMID:17051331 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA CTD PMID:28863153 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO
EXP
[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 protein]
CTD PMID:19015640 PMID:26165751 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
affects secretion
ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein] CTD PMID:12231210 PMID:28863153 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects secretion
multiple interactions
ISO Sulfasalazine affects the secretion of CXCL1 protein
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]
CTD PMID:12231210 PMID:28863153 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Sulfasalazine results in increased expression of CYP1A1 mRNA CTD PMID:17202759 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 decreases expression ISO Sulfasalazine results in decreased expression of CYP27B1 mRNA CTD PMID:15243130 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO Sulfasalazine results in increased expression of CYP2A5 mRNA CTD PMID:31830553 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Sulfasalazine results in increased expression of CYP2B10 mRNA CTD PMID:31830553 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO Sulfasalazine results in increased expression of CYP2C55 mRNA; Sulfasalazine results in increased expression of CYP2C55 protein CTD PMID:31830553 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression ISO Sulfasalazine results in increased expression of CYP2C38 mRNA CTD PMID:31830553 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO Sulfasalazine results in increased expression of CYP2C29 mRNA CTD PMID:31830553 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Sulfasalazine results in increased expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA] CTD PMID:16614379 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]
CTD PMID:16728495 PMID:21068073 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 increases expression ISO Sulfasalazine results in increased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr19:22,569,999...22,588,143
Ensembl chr19:22,569,999...22,588,137
JBrowse link
G Egf epidermal growth factor increases expression ISO Sulfasalazine results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO [Sulfasalazine co-treated with tripterine] affects the expression of EGFR protein; [Sulfasalazine co-treated with tripterine] results in decreased expression of EGFR protein; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
Sulfasalazine results in decreased expression of EGFR mRNA; Sulfasalazine results in decreased expression of EGFR protein
CTD PMID:20007406 PMID:31830553 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 decreases expression ISO Sulfasalazine results in decreased expression of EGR1 mRNA CTD PMID:31830553 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Sulfasalazine results in increased expression of EPHX1 mRNA CTD PMID:22016648 PMID:31830553 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Sulfasalazine results in increased expression of FABP4 mRNA CTD PMID:22016648 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fga fibrinogen alpha chain increases expression ISO Sulfasalazine results in increased expression of FGA mRNA CTD PMID:22016648 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 decreases expression ISO Sulfasalazine results in decreased expression of FMC1 mRNA CTD PMID:31830553 NCBI chr 4:66,276,835...66,284,868
Ensembl chr 4:66,276,835...66,284,868
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Sulfasalazine results in increased expression of FTL1 mRNA CTD PMID:22016648 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G G0s2 G0/G1switch 2 increases expression ISO Sulfasalazine results in increased expression of G0S2 mRNA CTD PMID:31830553 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression EXP Sulfasalazine results in decreased expression of GADD45B mRNA CTD PMID:15633128 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein] CTD PMID:14687604 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Sulfasalazine results in increased expression of GPT protein CTD PMID:31830553 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Sulfasalazine results in decreased expression of GPX3 mRNA CTD PMID:31830553 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein] CTD PMID:26165751 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Sulfasalazine results in decreased activity of GSR protein CTD PMID:19028562 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO Sulfasalazine results in increased expression of GSTA2 mRNA CTD PMID:31830553 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP
ISO
Sulfasalazine results in increased expression of GSTA5 mRNA
Sulfasalazine results in increased expression of GSTA1 mRNA
CTD PMID:17202759 PMID:31830553 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO Sulfasalazine results in increased expression of GSTA2 mRNA CTD PMID:31830553 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Sulfasalazine results in increased expression of GSTM2 mRNA CTD PMID:31830553 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Sulfasalazine results in increased expression of GSTM3 mRNA CTD PMID:31830553 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Sulfasalazine results in decreased expression of GSTP1 mRNA CTD PMID:16141653 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression ISO Sulfasalazine results in increased expression of GSTT2 mRNA CTD PMID:31830553 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA] CTD PMID:12745093 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]
Sulfasalazine results in increased activity of HIF1A protein
CTD PMID:12808024 PMID:19502547 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Sulfasalazine results in increased expression of HINT1 mRNA CTD PMID:22016648 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hmgb1 high mobility group box 1 increases expression EXP Sulfasalazine results in increased expression of HMGB1 mRNA CTD PMID:16141653 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
increases expression
multiple interactions
EXP HMOX1 protein results in increased susceptibility to Sulfasalazine
[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein; Sulfasalazine results in increased expression of HMOX1 mRNA; Sulfasalazine results in increased expression of HMOX1 protein
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]
CTD PMID:19234301 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression EXP Sulfasalazine results in decreased expression of HSD17B3 mRNA CTD PMID:29197623 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO Sulfasalazine results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Sulfasalazine results in decreased expression of HSD3B1 mRNA CTD PMID:29197623
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO Sulfasalazine results in increased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Sulfasalazine results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression EXP Sulfasalazine results in decreased expression of HSPA1B mRNA CTD PMID:16141653 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
increases expression
ISO
EXP
Sulfasalazine results in decreased expression of ICAM1 mRNA; Sulfasalazine results in decreased expression of ICAM1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]
Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]
Sulfasalazine results in increased expression of ICAM1 protein
CTD PMID:11264155 PMID:15553846 PMID:17259377 PMID:20823682 PMID:26165751 PMID:31428839 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta increases expression ISO Sulfasalazine results in increased expression of IDH3B mRNA CTD PMID:22016648 NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IDO1 mRNA] CTD PMID:20884048 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased expression of CXCL8 protein]
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]
CTD PMID:11529938 PMID:15269287 PMID:17051331 PMID:25231984 PMID:29594315 PMID:32272095 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression EXP Sulfasalazine affects the expression of IGFBP3 mRNA CTD PMID:16141653 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO Sulfasalazine results in decreased expression of IKBKB protein CTD PMID:15564333 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; Sulfasalazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
CTD PMID:15604057 PMID:17051331 PMID:25231984 PMID:25727887 PMID:29731490 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA CTD PMID:28863153 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]] CTD PMID:11529938 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL8 protein]; Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
Sulfasalazine results in decreased expression of IL1B mRNA
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
CTD PMID:12133438 PMID:12231210 PMID:15604057 PMID:15793857 PMID:15867298 PMID:15955209 PMID:16614379 PMID:17375077 PMID:17449585 PMID:17641275 PMID:19956958 PMID:20884048 PMID:22119283 PMID:25231984 PMID:25576893 PMID:25727887 PMID:25729217 PMID:26165751 PMID:29594315 PMID:29731490 PMID:30408459 PMID:32272095 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA] CTD PMID:17449585 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA] CTD PMID:15867298 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL2 protein]
CTD PMID:17051331 PMID:29594315 PMID:32272095 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein] CTD PMID:7815356 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein] CTD PMID:25729217 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
CTD PMID:12135912 PMID:17051331 PMID:19956958 PMID:20884048 PMID:21070844 PMID:25231984 PMID:25576893 PMID:26102009 PMID:29731490 PMID:31428839 PMID:32272095 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor increases expression ISO Sulfasalazine results in increased expression of INSR protein CTD PMID:15564333 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA CTD PMID:28863153 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression ISO Sulfasalazine results in decreased expression of IRS2 mRNA CTD PMID:31830553 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein] CTD PMID:8094364 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein] CTD PMID:8094364 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itk IL2-inducible T-cell kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA CTD PMID:28863153 NCBI chr10:31,431,820...31,493,413
Ensembl chr10:31,431,809...31,493,419
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of JAK2 protein] CTD PMID:32272095 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jchain joining chain of multimeric IgA and IgM multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA CTD PMID:28863153 NCBI chr14:21,176,841...21,183,731
Ensembl chr14:21,177,237...21,183,542
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA CTD PMID:28863153 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Lsm10 LSM10, U7 small nuclear RNA associated decreases expression ISO Sulfasalazine results in decreased expression of LSM10 mRNA CTD PMID:31830553 NCBI chr 5:144,106,339...144,108,703
Ensembl chr 5:144,106,802...144,108,708
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP Sulfasalazine results in increased phosphorylation of MAPK9 protein CTD PMID:15633128 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mill1 MHC I like leukocyte 1 decreases expression ISO Sulfasalazine results in decreased expression of MICA mRNA; Sulfasalazine results in decreased expression of MICA protein CTD PMID:15494508 NCBI chr 1:79,631,266...79,657,943
Ensembl chr 1:79,631,668...79,657,941
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA CTD PMID:28863153 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Sulfasalazine promotes the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein] CTD PMID:15633128 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein]
CTD PMID:12745093 PMID:22119283 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
Sulfasalazine results in decreased activity of MPO protein
CTD PMID:17373747 PMID:20380826 PMID:22119283 PMID:23665423 PMID:25231984 PMID:25576893 PMID:26102009 PMID:26165751 PMID:31428839 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Sulfasalazine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Ms4a1 membrane spanning 4-domains A1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA CTD PMID:28863153 NCBI chr 1:227,429,241...227,441,492
Ensembl chr 1:227,429,596...227,441,442
JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases response to substance ISO MTHFR gene polymorphism results in increased susceptibility to Sulfasalazine; MTHFR protein results in increased susceptibility to Sulfasalazine CTD PMID:19578646 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA] CTD PMID:17449585 NCBI chr 1:214,663,929...214,693,197 JBrowse link
G Muc3 mucin 3, intestinal multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC3 mRNA] CTD PMID:17449585 NCBI chr12:22,535,663...22,584,775 JBrowse link
G Muc4 mucin 4, cell surface associated multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA] CTD PMID:17449585 NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939
JBrowse link
G Nat2 N-acetyltransferase 2 affects metabolic processing
increases acetylation
increases metabolic processing
affects response to substance
ISO NAT2 gene polymorphism affects the metabolism of Sulfasalazine; NAT2 protein affects the metabolism of Sulfasalazine; NAT2 protein polymorphism affects the metabolism of Sulfasalazine
NAT2 protein results in increased acetylation of Sulfasalazine
NAT2 protein results in increased metabolism of Sulfasalazine
NAT2 protein affects the susceptibility to Sulfasalazine
CTD PMID:12465141 PMID:15032315 PMID:17377643 PMID:17502830 PMID:19560446 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein; Acetylcysteine inhibits the reaction [[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein]
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]
CTD PMID:19234301 PMID:31428839 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases localization
decreases expression
ISO
EXP
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NFKB1 protein]
Sulfasalazine results in decreased localization of NFKB1 protein
Sulfasalazine results in decreased expression of NFKB1 protein
CTD PMID:9486988 PMID:12135912 PMID:15269287 PMID:17259377 PMID:26165751 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
decreases expression
increases degradation
ISO
EXP
Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased phosphorylation of NFKBIA protein
Sulfasalazine inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased expression of NFKBIA protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Sulfasalazine results in increased degradation of NFKBIA protein
CTD PMID:9486988 PMID:11786414 PMID:15494508 PMID:15793857 PMID:16934226 PMID:17051331 PMID:19365232 PMID:20823682 PMID:22245600 PMID:32272095 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30408459 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Sulfasalazine results in decreased expression of NOS2 mRNA
Sulfasalazine affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]
CTD PMID:11529938 PMID:15867298 PMID:16925772 PMID:16934226 PMID:17259377 PMID:17375077 PMID:20712904 PMID:31428839 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP
ISO
Sulfasalazine results in increased expression of NQO1 mRNA CTD PMID:19234301 PMID:22016648 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Sulfasalazine results in increased expression of NR3C1 mRNA; Sulfasalazine results in increased expression of NR3C1 protein CTD PMID:17267514 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Oat ornithine aminotransferase increases expression ISO Sulfasalazine results in increased expression of OAT mRNA CTD PMID:22016648 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO Sulfasalazine results in increased expression of ODC1 mRNA CTD PMID:22016648 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA] CTD PMID:11901219 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Sulfasalazine results in increased expression of PCNA mRNA CTD PMID:22016648 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgam2 phosphoglycerate mutase 2 increases expression ISO Sulfasalazine results in increased expression of PGAM2 mRNA CTD PMID:22016648 NCBI chr14:86,045,005...86,047,116
Ensembl chr14:86,044,969...86,047,162
JBrowse link
G Pla2g1b phospholipase A2 group IB multiple interactions ISO Sulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein] CTD PMID:15528384 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
EXP
ISO
Sulfasalazine results in increased expression of PPARG mRNA
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]
CTD PMID:19365232 PMID:26165751 PMID:31830553 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA CTD PMID:28863153 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP
ISO
Sulfasalazine results in increased expression of PRDX1 mRNA CTD PMID:16141653 PMID:22016648 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Sulfasalazine results in increased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression EXP Sulfasalazine results in decreased expression of PSMB9 mRNA CTD PMID:17202759 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP
ISO
Sulfasalazine results in decreased expression of PTGS2 mRNA
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]
CTD PMID:17259377 PMID:19956958 PMID:25576893 PMID:30408459 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 increases expression ISO Sulfasalazine results in increased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 3:79,734,961...79,743,737
Ensembl chr 3:79,734,961...79,743,737
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA CTD PMID:28863153 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Rbp4 retinol binding protein 4 affects expression ISO Sulfasalazine affects the expression of RBP4 mRNA CTD PMID:22016648 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization
affects localization
increases localization
decreases activity
ISO
EXP
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine results in decreased expression of and results in decreased activity of RELA protein; Sulfasalazine results in decreased phosphorylation of and results in decreased activity of RELA protein
Sulfasalazine results in decreased localization of RELA protein
Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]
Sulfasalazine affects the localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine results in increased localization of RELA protein
Sulfasalazine results in decreased activity of RELA protein
CTD PMID:9486988 PMID:12135912 PMID:14687604 PMID:15269287 PMID:15564333 PMID:15955209 PMID:16626516 PMID:16728495 PMID:16925772 PMID:17259377 PMID:18089796 PMID:19956958 PMID:20823682 PMID:21070844 PMID:26102009 PMID:32272095 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Sulfasalazine results in increased expression of RGS16 mRNA CTD PMID:31830553 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA] CTD PMID:19693652 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Rnf186 ring finger protein 186 decreases expression ISO Sulfasalazine results in decreased expression of RNF186 mRNA CTD PMID:31830553 NCBI chr 5:157,416,897...157,418,121
Ensembl chr 5:157,416,897...157,418,121
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression EXP Sulfasalazine affects the expression of RT1-BB mRNA CTD PMID:17202759 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA CTD PMID:28863153 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Sele selectin E increases expression ISO Sulfasalazine results in increased expression of SELE protein CTD PMID:11264155 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpina4 serpin family A member 4 decreases expression ISO Sulfasalazine results in decreased expression of SERPINA4-PS1 mRNA CTD PMID:31830553 NCBI chr 6:127,743,883...127,753,047
Ensembl chr 6:127,743,971...127,753,046
JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Sulfasalazine results in increased expression of SERPINC1 mRNA CTD PMID:22016648 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression ISO Sulfasalazine results in decreased expression of SIK1 mRNA CTD PMID:31830553 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Slamf7 SLAM family member 7 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA CTD PMID:28863153 NCBI chr13:90,056,726...90,075,159
Ensembl chr13:90,058,127...90,075,144
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO Sulfasalazine results in decreased expression of SLC22A7 mRNA CTD PMID:31830553 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc25a24 solute carrier family 25 member 24 decreases expression ISO Sulfasalazine results in decreased expression of SLC25A24 mRNA CTD PMID:31830553 NCBI chr 2:211,930,371...211,967,511
Ensembl chr 2:211,930,326...211,967,505
JBrowse link
G Slc25a5 solute carrier family 25 member 5 increases expression ISO Sulfasalazine results in increased expression of SLC25A6 mRNA CTD PMID:22016648 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression ISO Sulfasalazine results in decreased expression of SLC30A1 mRNA CTD PMID:31830553 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine] CTD PMID:19576933 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity
ISO
EXP
Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Methotrexate]
Sulfasalazine results in decreased activity of SLC46A1 protein
Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
CTD PMID:17475902 PMID:18174275 PMID:19762432 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases activity
multiple interactions
ISO Sulfasalazine results in decreased activity of SLC7A11 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
CTD PMID:19015640 PMID:19576933 PMID:20007406 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression ISO Sulfasalazine results in decreased expression of SOCS2 mRNA CTD PMID:31830553 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Sulfasalazine results in increased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO Sulfasalazine results in decreased expression of SOD3 mRNA CTD PMID:31830553 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Sulfasalazine results in increased expression of SPP1 mRNA CTD PMID:22016648 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
affects expression
EXP Sulfasalazine results in decreased expression of STAR protein
Sulfasalazine affects the expression of STAR mRNA
CTD PMID:29197623 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of STAT3 protein] CTD PMID:32272095 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions
decreases activity
ISO [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2 CTD PMID:2572437 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA] CTD PMID:20884048 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tff3 trefoil factor 3 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA] CTD PMID:17449585 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
decreases expression
ISO [Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of THRA mRNA; Sulfasalazine results in decreased expression of THRA mRNA alternative form
CTD PMID:17641275 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA] CTD PMID:16614379 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:15633128 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Sulfasalazine results in increased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO Sulfasalazine results in increased expression of TIMP3 mRNA CTD PMID:22016648 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:12888452 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] CTD PMID:19956958 PMID:32272095 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression
increases response to substance
ISO
EXP
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Sulfasalazine results in decreased secretion of TNF protein
Sulfasalazine results in decreased expression of TNF mRNA
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine binds to and results in decreased activity of TNF protein; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased secretion of TNF protein]
Sulfasalazine results in increased susceptibility to TNF protein
CTD PMID:8094364 PMID:8598465 PMID:9486988 PMID:11901219 PMID:12135912 PMID:12745093 PMID:12808024 PMID:15269287 PMID:17051331 PMID:17143539 PMID:17449585 PMID:19693652 PMID:19956958 PMID:20712904 PMID:20884048 PMID:21070844 PMID:22119283 PMID:23665423 PMID:25231984 PMID:25576893 PMID:25727887 PMID:25729217 PMID:26102009 PMID:28863153 PMID:29731490 PMID:30408459 PMID:32272095 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases secretion ISO Sulfasalazine results in increased secretion of TNFRSF11B protein CTD PMID:15593184 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA CTD PMID:28863153 NCBI chr10:4,252,097...4,258,335
Ensembl chr10:4,251,941...4,257,868
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Sulfasalazine results in decreased expression of TNFSF11 mRNA; Sulfasalazine results in decreased expression of TNFSF11 protein CTD PMID:15593184 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tpm3 tropomyosin 3 decreases expression ISO Sulfasalazine results in decreased expression of TPM3 mRNA alternative form; Sulfasalazine results in decreased expression of TPM3 protein alternative form CTD PMID:19369484 NCBI chr 2:189,423,534...189,451,340
Ensembl chr 2:189,423,559...189,451,029
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TRAF6 protein] CTD PMID:32272095 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases secretion ISO Sulfasalazine results in increased secretion of TSHB protein CTD PMID:12587019 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO Sulfasalazine results in increased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tymp thymidine phosphorylase multiple interactions
decreases expression
ISO Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine results in decreased expression of and results in decreased activity of TYMP protein
Sulfasalazine results in decreased expression of TYMP mRNA
CTD PMID:15269287 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Ubc ubiquitin C increases expression ISO Sulfasalazine results in increased expression of UBC mRNA CTD PMID:22016648 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
increases expression
ISO
EXP
Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
Sulfasalazine results in decreased expression of VCAM1 mRNA
Sulfasalazine results in increased expression of VCAM1 protein
Sulfasalazine results in decreased expression of VCAM1 mRNA; Sulfasalazine results in decreased expression of VCAM1 protein
CTD PMID:11264155 PMID:15553846 PMID:17259377 PMID:19693652 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vim vimentin increases expression ISO Sulfasalazine results in increased expression of VIM mRNA CTD PMID:22016648 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA CTD PMID:28863153 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      group 19787
        inorganic group 19219
          azo group 262
            azo compound + 262
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    main group molecular entity 19763
                      s-block molecular entity 19511
                        hydrogen molecular entity 19503
                          hydrides 18775
                            inorganic hydride 17505
                              pnictogen hydride 17478
                                nitrogen hydride 17323
                                  diazene 263
                                    azo group 262
                                      azo compound + 262
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