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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:beclomethasone
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Accession:CHEBI:3001 term browser browse the term
Definition:A 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively.
Synonyms:exact_synonym: (11beta,16beta)-9-chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
 related_synonym: 9-chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione;   9alpha-chloro-16beta-methylprednisolone;   Formula=C22H29ClO5;   InChI=1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1;   InChIKey=NBMKJKDGKREAPL-DVTGEIKXSA-N;   SMILES=[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   beclometasona;   beclometasone;   beclometasonum
 xref: Beilstein:5640546;   CAS:4419-39-0;   DrugBank:DB00394;   KEGG:C06842;   KEGG:D07495
 xref_mesh: MESH:D001507
 xref: Patent:GB912378;   Reaxys:5640546


show annotations for term's descendants           Sort by:
beclomethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
increases expression
increases secretion		 ISO Beclomethasone inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]
Beclomethasone results in increased expression of ABCB1 mRNA; Beclomethasone results in increased expression of ABCB1 protein		 CTD PMID:15370884 PMID:16442095 PMID:22464980 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 increases expression ISO Beclomethasone results in increased expression of ABCB4 mRNA CTD PMID:15370884 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 increases expression ISO Beclomethasone results in increased expression of ABCC1 mRNA CTD PMID:15370884 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions
increases activity		 ISO Beclomethasone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Beclomethasone results in increased activity of ABCG2 protein		 CTD PMID:15365089 PMID:16442095 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases activity ISO Beclomethasone results in decreased activity of ACP5 protein CTD PMID:8429434 NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 increases expression ISO Beclomethasone results in increased expression of ADRB2 mRNA CTD PMID:9032216 PMID:15679717 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 decreases expression ISO Beclomethasone results in decreased expression of BDKRB1 mRNA CTD PMID:18039523 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687 		JBrowse link
G Bglap bone gamma carboxyglutamate protein decreases expression ISO Beclomethasone results in decreased expression of BGLAP protein CTD PMID:7746775 PMID:9232087 PMID:9544892 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G Casp9 caspase 9 increases activity ISO Beclomethasone results in increased activity of CASP9 protein CTD PMID:11734450 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase increases expression ISO Beclomethasone results in increased expression of CAT protein CTD PMID:10445599 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein] CTD PMID:17988555 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Beclomethasone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Beclomethasone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Beclomethasone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression		 ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CCL5 protein; [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CCL5 protein; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
Beclomethasone results in decreased expression of CCL5 mRNA; Beclomethasone results in decreased expression of CCL5 protein		 CTD PMID:8534483 PMID:10903220 PMID:14643170 PMID:15679717 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Cd44 CD44 antigen multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]; Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions
increases activity
decreases secretion		 ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CSF2 protein; [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CSF2 protein; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of CSF2 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of CSF2 protein]; Beclomethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Beclomethasone results in increased activity of CSF2 protein
Beclomethasone results in decreased secretion of CSF2 protein		 CTD PMID:7545059 PMID:10460758 PMID:10868704 PMID:11167953 PMID:11730731 More... NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Beclomethasone results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
decreases expression		 ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CXCL8 protein; [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CXCL8 protein; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Beclomethasone results in decreased expression of CXCL8 protein		 CTD PMID:11015126 PMID:14643170 PMID:15679717 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Beclomethasone results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 7:25,501,894...25,515,950
Ensembl chr 7:25,501,900...25,516,338 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases expression
multiple interactions		 ISO Beclomethasone results in increased expression of CYP3A5 mRNA
1-aminobenzotriazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Mifepristone inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Paraoxon inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Physostigmine inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]		 CTD PMID:12538830 PMID:23512537 PMID:24555085 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Ear1 eosinophil-associated, ribonuclease A family, member 1 multiple interactions
decreases expression		 ISO [Salmeterol Xinafoate co-treated with Beclomethasone] affects the reaction [Allergens results in increased expression of RNASE3 protein]; Beclomethasone affects the reaction [Allergens results in increased expression of RNASE3 protein]
Beclomethasone results in decreased expression of RNASE3 protein		 CTD PMID:1443864 PMID:10513351 PMID:10573242 PMID:12166584 PMID:12587966 More... NCBI chr14:44,056,222...44,057,096
Ensembl chr14:44,056,222...44,112,974 		JBrowse link
G Ear6 eosinophil-associated, ribonuclease A family, member 6 decreases expression ISO Beclomethasone results in decreased expression of RNASE2 protein CTD PMID:12166584 NCBI chr14:52,091,225...52,092,100
Ensembl chr14:52,091,156...52,092,100 		JBrowse link
G Epx eosinophil peroxidase multiple interactions ISO Beclomethasone inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362 		JBrowse link
G Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide decreases expression ISO Beclomethasone results in decreased expression of FCER1G protein CTD PMID:1834581 NCBI chr 1:171,057,141...171,061,918
Ensembl chr 1:171,057,141...171,061,934 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases activity		 ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Albuterol promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein] CTD PMID:18076728 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] CTD PMID:18076728 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene decreases expression ISO Beclomethasone results in decreased expression of FOS protein CTD PMID:9797757 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 multiple interactions
increases activity
increases expression		 ISO [Beclomethasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4
Beclomethasone results in increased expression of GGT5 mRNA		 CTD PMID:11447392 NCBI chr10:75,425,161...75,453,034
Ensembl chr10:75,425,174...75,453,034 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases metabolic processing ISO HSD11B2 protein results in increased metabolism of Beclomethasone CTD PMID:16549198 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Beclomethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:9150321 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il10 interleukin 10 decreases secretion ISO Beclomethasone results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 multiple interactions
increases activity		 ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 protein]
Beclomethasone results in increased activity of IL13 protein		 CTD PMID:17988555 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
decreases secretion		 ISO Beclomethasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Beclomethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Beclomethasone results in decreased expression of IL1B protein
Beclomethasone results in decreased secretion of IL1B protein		 CTD PMID:7545059 PMID:9176529 PMID:9371735 PMID:10460758 PMID:15337628 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Beclomethasone results in decreased expression of IL1RN protein CTD PMID:11015126 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain decreases expression ISO Beclomethasone results in decreased expression of IL2RA protein CTD PMID:8111605 PMID:9314351 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL3 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL3 protein] CTD PMID:11167953 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression		 ISO
EXP		 Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]; Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]
Beclomethasone results in decreased expression of IL4 protein		 CTD PMID:7988651 PMID:18076728 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression		 ISO
EXP		 Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL5 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL5 protein]
Beclomethasone results in decreased expression of IL5 protein		 CTD PMID:7988651 PMID:10813552 PMID:11167953 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 protein] CTD PMID:17988555 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ltf lactotransferrin multiple interactions
decreases secretion		 ISO Beclomethasone inhibits the reaction [methylcholine results in increased secretion of LTF protein]
Beclomethasone results in decreased secretion of LTF protein		 CTD PMID:11112886 NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835 		JBrowse link
G Mefv Mediterranean fever increases response to substance ISO MEFV mutant form results in increased susceptibility to Beclomethasone CTD PMID:20828792 NCBI chr16:3,524,838...3,536,073
Ensembl chr16:3,525,082...3,535,961 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Beclomethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein] CTD PMID:10455257 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO Beclomethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
Beclomethasone results in decreased expression of MMP9 protein		 CTD PMID:10452757 PMID:10455257 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases expression ISO Beclomethasone results in decreased expression of NOS2 protein CTD PMID:12668791 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Beclomethasone results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects localization
affects binding
increases activity
multiple interactions
increases expression		 ISO Beclomethasone affects the localization of NR3C1 protein
Beclomethasone binds to NR3C1 protein
Beclomethasone results in increased activity of NR3C1 protein
[Beclomethasone co-treated with Albuterol] affects the localization of NR3C1 protein; [Beclomethasone co-treated with Formoterol Fumarate] affects the localization of NR3C1 protein; Beclomethasone affects the localization of and results in increased activity of NR3C1 protein; Beclomethasone binds to and results in increased activity of NR3C1 protein
Beclomethasone results in increased expression of NR3C1 mRNA		 CTD PMID:16814 PMID:2207292 PMID:15362971 PMID:15679717 PMID:15860753 More... NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Beclomethasone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr16:38,214,245...38,253,553
Ensembl chr16:38,216,479...38,253,507 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) decreases activity
multiple interactions		 ISO Beclomethasone results in decreased activity of PLA2G4A protein
Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA]		 CTD PMID:15337628 PMID:20573295 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory inhibitor subunit 14A multiple interactions ISO Beclomethasone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein] CTD PMID:18577381 NCBI chr 7:28,988,732...28,992,817
Ensembl chr 7:28,988,733...28,993,226 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]; Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA] CTD PMID:18391481 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO Beclomethasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA] CTD PMID:9371735 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Beclomethasone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Thy1 thymus cell antigen 1, theta multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] CTD PMID:18076728 NCBI chr 9:43,954,681...43,959,876
Ensembl chr 9:43,954,681...43,959,876 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO Beclomethasone results in increased expression of TIMP1 protein CTD PMID:10452757 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion		 ISO Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Beclomethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Beclomethasone results in decreased secretion of TNF protein		 CTD PMID:8937731 PMID:9150321 PMID:9819297 PMID:10100995 PMID:10903220 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Beclomethasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Beclomethasone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        anti-inflammatory agent 17331
          anti-inflammatory drug 15203
            beclomethasone 59
              beclomethasone dipropionate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbonyl compound 20172
                                    ketone 17949
                                      oxo steroid 10655
                                        3-oxo steroid 9988
                                          3-oxo-Delta(4) steroid 9226
                                            progesterone 2783
                                              Delta(1)-progesterone 255
                                                prednisolone 245
                                                  beclomethasone 59
                                                    beclomethasone dipropionate 0
paths to the root