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G |
Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
captax results in increased expression of AHR mRNA |
CTD |
PMID:21590714 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
increases activity increases expression |
ISO |
captax results in increased activity of AKR1C2 promoter captax results in increased expression of AKR1C2 mRNA |
CTD |
PMID:20491607 PMID:20713136 PMID:21195160 |
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NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Ampd3 |
adenosine monophosphate deaminase 3 |
increases expression |
ISO |
captax results in increased expression of AMPD3 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
captax results in increased expression of ATF3 mRNA |
CTD |
PMID:23999411 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
captax results in decreased expression of CCL2 mRNA |
CTD |
PMID:20713136 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases secretion |
ISO |
captax results in increased secretion of CCL4 protein |
CTD |
PMID:16314067 |
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NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
increases expression |
ISO |
captax results in increased expression of CCR2 mRNA |
CTD |
PMID:20713136 |
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NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
increases expression |
ISO |
captax results in increased expression of CCR5 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
captax results in increased expression of CD86 protein |
CTD |
PMID:12423654 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Creb1 |
cAMP responsive element binding protein 1 |
decreases expression |
ISO |
captax results in decreased expression of CREB1 mRNA |
CTD |
PMID:20385217 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression |
ISO |
captax results in increased expression of CXCL1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
decreases expression |
ISO |
captax results in decreased expression of CXCL14 mRNA; captax results in decreased expression of CXCL14 protein |
CTD |
PMID:31734321 |
|
NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
captax results in increased expression of CXCL2 protein |
CTD |
PMID:23178550 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
ISO |
captax results in increased expression of CXCL1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
captax results in increased expression of CYP1A1 mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
captax results in decreased activity of DIO1 protein |
CTD |
PMID:29228274 |
|
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
increases expression |
ISO |
captax results in increased expression of DNAJB4 mRNA |
CTD |
PMID:23999411 PMID:27965148 |
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NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
increases expression |
ISO |
captax results in increased expression of ENPP2 protein |
CTD |
PMID:22952646 |
|
NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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|
G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
captax results in increased expression of F3 protein |
CTD |
PMID:25569083 |
|
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fth1 |
ferritin heavy chain 1 |
increases expression |
ISO |
captax results in increased expression of FTH1 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
captax results in increased expression of FTL mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
captax results in increased expression of GCLC mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
captax results in increased expression of GCLM mRNA |
CTD |
PMID:23999411 PMID:24211530 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
ISO |
captax results in increased expression of H2AX protein 1-aminobenzotriazole inhibits the reaction [captax results in increased expression of H2AX protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [captax results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [captax results in increased expression of H2AX protein]; Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein] |
CTD |
PMID:35279910 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
captax results in increased expression of HMOX1 mRNA |
CTD |
PMID:20713136 PMID:23445166 PMID:24211530 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa6l-ps1 |
heat shock protein family A (Hsp70) member 6 like, pseudogene 1 |
increases expression |
ISO |
captax results in increased expression of HSPA6 mRNA |
CTD |
PMID:23999411 |
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NCBI chr13:83,273,176...83,274,317
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G |
Ifng |
interferon gamma |
increases secretion |
ISO |
captax results in increased secretion of IFNG protein |
CTD |
PMID:22245253 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il18 |
interleukin 18 |
increases expression |
ISO |
captax results in increased expression of IL18 protein |
CTD |
PMID:23063874 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
captax results in increased expression of IL1A protein captax results in increased expression of IL1A mRNA |
CTD |
PMID:23178550 PMID:33715048 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases expression increases secretion |
ISO |
captax results in increased expression of IL1B mRNA captax results in increased secretion of IL1B protein |
CTD |
PMID:33715048 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
increases secretion |
ISO |
captax results in increased secretion of IL2 protein |
CTD |
PMID:22245253 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il6 |
interleukin 6 |
increases secretion |
ISO |
captax results in increased secretion of IL6 protein |
CTD |
PMID:22245253 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Il7r |
interleukin 7 receptor |
increases expression |
ISO |
captax results in increased expression of IL7R mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
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G |
Mir146a |
microRNA 146a |
increases expression |
ISO |
captax results in increased expression of MIR146A mRNA |
CTD |
PMID:37326882 |
|
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
ISO |
captax results in increased expression of MMP9 mRNA; captax results in increased expression of MMP9 protein |
CTD |
PMID:22952646 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
captax results in increased expression of MYC mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
affects expression |
ISO |
captax affects the expression of NFKB1 mRNA |
CTD |
PMID:20385217 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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|
G |
Notch3 |
notch receptor 3 |
decreases expression |
ISO |
captax results in decreased expression of NOTCH3 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
captax results in increased expression of NQO1 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression |
ISO |
captax results in increased expression of PMAIP1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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G |
Rgs1 |
regulator of G-protein signaling 1 |
increases expression |
ISO |
captax results in increased expression of RGS1 mRNA |
CTD |
PMID:20713136 |
|
NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984
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G |
Sel1l3 |
SEL1L family member 3 |
increases expression |
ISO |
captax results in increased expression of SEL1L3 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644
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G |
Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions |
ISO |
captax inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] |
CTD |
PMID:27979590 |
|
NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
captax results in increased expression of SLC7A11 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Sqstm1 |
sequestosome 1 |
increases expression |
ISO |
captax results in increased expression of SQSTM1 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Syne2 |
spectrin repeat containing nuclear envelope protein 2 |
decreases expression |
ISO |
captax results in decreased expression of SYNE2 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr 6:94,537,088...94,848,085
Ensembl chr 6:94,537,088...94,848,064
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G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
captax results in decreased expression of TNF mRNA |
CTD |
PMID:20385217 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnnt2 |
troponin T2, cardiac type |
decreases expression |
ISO |
captax results in decreased expression of TNNT2 mRNA |
CTD |
PMID:24211530 |
|
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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G |
Tpo |
thyroid peroxidase |
multiple interactions decreases activity |
ISO EXP |
captax binds to and results in decreased activity of TPO protein captax results in decreased activity of TPO protein |
CTD |
PMID:23959146 PMID:26865668 PMID:26884060 PMID:31629072 |
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NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
captax results in increased expression of TXNRD1 mRNA |
CTD |
PMID:23445166 PMID:24211530 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
captax results in increased expression of VEGFA protein |
CTD |
PMID:25617811 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Adora1 |
adenosine A1 receptor |
multiple interactions |
EXP |
[Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] |
CTD |
PMID:10413299 |
|
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:12614848 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions increases activity |
ISO EXP |
Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]] Dithiothreitol results in increased activity of ALAD protein [Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein] cadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein] |
CTD |
PMID:2061546 PMID:20472051 PMID:21360559 PMID:21910133 PMID:22180340 PMID:23933410 More...
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
multiple interactions |
ISO |
Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] |
CTD |
PMID:23370007 |
|
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Ar |
androgen receptor |
multiple interactions |
EXP |
Dithiothreitol inhibits the reaction [cadmium sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [Copper Sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]] |
CTD |
PMID:6323860 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
As3mt |
arsenite methyltransferase |
multiple interactions increases reduction |
EXP ISO |
Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic] Dithiothreitol results in increased reduction of AS3MT protein Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite] |
CTD |
PMID:15025511 PMID:25349987 |
|
NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
Dithiothreitol results in increased expression of ATF3 mRNA |
CTD |
PMID:17332266 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
increases expression |
ISO |
Dithiothreitol results in increased expression of ATF4 mRNA |
CTD |
PMID:27226639 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atp7a |
ATPase copper transporting alpha |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] |
CTD |
PMID:20566629 |
|
NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] |
CTD |
PMID:18022205 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Calu |
calumenin |
increases expression |
ISO |
Dithiothreitol results in increased expression of CALU protein |
CTD |
PMID:21692457 |
|
NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] |
CTD |
PMID:25929180 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol promotes the reaction [1-(N-(3-ammoniopropyl)-N-(n-propyl)amino)diazen-1-ium-1,2-diolate results in increased metabolism of CASP3 protein] Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]] Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]] |
CTD |
PMID:9388267 PMID:9441900 PMID:9706149 PMID:9755104 PMID:10673743 PMID:11226294 PMID:26124276 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein] |
CTD |
PMID:11226294 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP9 protein] |
CTD |
PMID:11226294 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
ISO |
CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]; CAT protein inhibits the reaction [Dithiothreitol results in increased abundance of Hydrogen Peroxide] |
CTD |
PMID:7491977 PMID:32493877 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cbr1 |
carbonyl reductase 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]] |
CTD |
PMID:21256830 |
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NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Dithiothreitol results in decreased expression of CCND1 mRNA |
CTD |
PMID:17332266 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccng2 |
cyclin G2 |
increases expression |
ISO |
Dithiothreitol results in increased expression of CCNG2 mRNA |
CTD |
PMID:17332266 |
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NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [4-cresol sulfate results in decreased expression of CDH1 protein] |
CTD |
PMID:31873818 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein] |
CTD |
PMID:15657297 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] |
CTD |
PMID:17067557 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein] |
CTD |
PMID:16280210 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases activity |
EXP |
Dithiothreitol results in increased activity of CYP7A1 protein |
CTD |
PMID:1175606 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO EXP |
Dithiothreitol results in increased expression of DDIT3 mRNA indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of DDIT3 mRNA] |
CTD |
PMID:17332266 PMID:23123503 PMID:27226639 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
EXP |
Dithiothreitol results in increased expression of DNAJB9 mRNA |
CTD |
PMID:23123503 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions |
EXP |
Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2A protein |
CTD |
PMID:12486162 |
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NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation |
EXP ISO |
Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein Dithiothreitol results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:12486162 PMID:25321315 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions increases phosphorylation |
ISO |
EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:30385349 PMID:34244458 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions increases expression |
EXP ISO |
Dithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein Dithiothreitol results in increased expression of ERN1 protein |
CTD |
PMID:12486162 PMID:25321315 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein] |
CTD |
PMID:22403704 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
F3 |
coagulation factor III, tissue factor |
increases activity |
ISO |
Dithiothreitol results in increased activity of F3 protein |
CTD |
PMID:17726162 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fgf21 |
fibroblast growth factor 21 |
increases expression increases secretion multiple interactions |
ISO EXP |
Dithiothreitol results in increased expression of FGF21 mRNA Dithiothreitol results in increased secretion of FGF21 protein indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA] |
CTD |
PMID:23123503 PMID:27226639 |
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NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
Dithiothreitol results in increased expression of GADD45A mRNA |
CTD |
PMID:17332266 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form] |
CTD |
PMID:14695184 PMID:17658243 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein] Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; Dithiothreitol inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein] |
CTD |
PMID:23290930 PMID:24489685 PMID:26111761 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
multiple interactions increases activity |
ISO EXP |
Dithiothreitol inhibits the reaction [perfluorodecanoic acid results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]; perfluorodecanoic acid inhibits the reaction [Dithiothreitol results in increased activity of HSD11B2 protein] |
CTD |
PMID:12901862 PMID:26859423 PMID:36878351 |
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NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions increases activity |
ISO |
Dithiothreitol inhibits the reaction [Chloranil results in decreased activity of HSD3B1 protein]; Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD3B1 protein] Dithiothreitol results in increased activity of HSD3B1 protein |
CTD |
PMID:36965607 PMID:38555059 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
multiple interactions |
ISO |
Dactinomycin inhibits the reaction [Dithiothreitol results in increased expression of HSP90B1 mRNA]; Dithiothreitol results in increased expression of and affects the localization of HSP90B1 mRNA |
CTD |
PMID:34244458 |
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NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO EXP |
Dithiothreitol metabolite results in increased expression of HSPA5 protein; Dithiothreitol results in increased expression of HSPA5 mRNA; Dithiothreitol results in increased expression of HSPA5 protein |
CTD |
PMID:15710169 PMID:17332266 PMID:17416481 PMID:21692457 PMID:23123503 PMID:25321315 PMID:34244458 More...
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]] Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]] |
CTD |
PMID:17067557 PMID:20584749 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
[Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA] |
CTD |
PMID:7476933 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]] |
CTD |
PMID:14762100 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] |
CTD |
PMID:7957178 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il5ra |
interleukin 5 receptor subunit alpha |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]] |
CTD |
PMID:7957178 |
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NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544
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G |
Inhbe |
inhibin subunit beta E |
increases expression |
ISO |
Dithiothreitol results in increased expression of INHBE mRNA |
CTD |
PMID:22935518 |
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NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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G |
Ins1 |
insulin 1 |
decreases activity multiple interactions |
EXP |
Dithiothreitol results in decreased activity of INS1 protein Dithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein]; Dithiothreitol inhibits the reaction [INS1 protein results in increased uptake of Glucose] |
CTD |
PMID:2262933 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein] |
CTD |
PMID:11035063 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kif5a |
kinesin family member 5A |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein] |
CTD |
PMID:24853401 |
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NCBI chr 7:63,051,894...63,089,024
Ensembl chr 7:63,049,424...63,092,858
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G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] |
CTD |
PMID:18922898 |
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NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein] Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein] |
CTD |
PMID:11035063 PMID:23370007 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:11035063 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein] |
CTD |
PMID:10644709 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
multiple interactions |
EXP |
Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] |
CTD |
PMID:16125204 PMID:16386761 |
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NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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G |
Msrb2 |
methionine sulfoxide reductase B2 |
increases reduction |
ISO |
Dithiothreitol results in increased reduction of MSRB2 protein |
CTD |
PMID:16735467 |
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NCBI chr17:81,974,378...82,000,044
Ensembl chr17:81,974,196...82,000,043
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G |
Msrb3 |
methionine sulfoxide reductase B3 |
increases reduction |
ISO |
Dithiothreitol results in increased reduction of MSRB3 protein |
CTD |
PMID:16735467 |
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NCBI chr 7:56,260,985...56,426,004
Ensembl chr 7:56,303,308...56,425,496
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G |
Mt1 |
metallothionein 1 |
multiple interactions |
ISO |
Dithiothreitol results in increased reduction of [MT1 protein binds to Zinc] |
CTD |
PMID:22001350 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Mylk |
myosin light chain kinase |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased phosphorylation of MYLK protein] |
CTD |
PMID:31873818 |
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NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Nat1 |
N-acetyltransferase 1 |
increases activity multiple interactions |
ISO |
Dithiothreitol results in increased activity of NAT1 protein Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of NAT1 protein] |
CTD |
PMID:22835378 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein] |
CTD |
PMID:24489685 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]] [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]] |
CTD |
PMID:9281604 PMID:14762100 PMID:16219905 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] Dithiothreitol inhibits the reaction [ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in increased activity of NFKBIA protein] |
CTD |
PMID:17067557 PMID:19509257 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein] Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA] Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] |
CTD |
PMID:7532384 PMID:9706149 PMID:9755104 PMID:15907790 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein] |
CTD |
PMID:24489685 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO EXP |
Dithiothreitol inhibits the reaction [arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]] Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]] |
CTD |
PMID:2226332 PMID:2298732 PMID:15250541 PMID:16857225 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nrgn |
neurogranin |
multiple interactions |
EXP |
Dithiothreitol inhibits the reaction [chloramine-T affects the phosphorylation of NRGN protein] |
CTD |
PMID:21241739 |
|
NCBI chr 8:37,255,462...37,263,659
Ensembl chr 8:37,256,930...37,257,516
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G |
Nudt9 |
nudix hydrolase 9 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [manganese chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]] |
CTD |
PMID:16860484 |
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NCBI chr14:5,675,376...5,693,332
Ensembl chr14:5,675,382...5,693,142
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G |
Ogdh |
oxoglutarate dehydrogenase |
multiple interactions |
EXP |
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]; Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] |
CTD |
PMID:12680778 |
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NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
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G |
P2rx2 |
purinergic receptor P2X 2 |
multiple interactions |
EXP |
Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] |
CTD |
PMID:19793987 |
|
NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891
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G |
Papss1 |
3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
increases activity |
ISO |
Dithiothreitol results in increased activity of PAPSS1 protein |
CTD |
PMID:15065880 |
|
NCBI chr 2:220,040,343...220,114,399
Ensembl chr 2:220,040,312...220,114,395
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein] |
CTD |
PMID:11035063 PMID:18022205 PMID:20438634 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pdcd6ip |
programmed cell death 6 interacting protein |
increases expression |
ISO |
Dithiothreitol results in increased expression of PDCD6IP protein |
CTD |
PMID:21692457 |
|
NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773
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G |
Plod3 |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 |
increases expression |
ISO |
Dithiothreitol results in increased expression of PLOD3 protein |
CTD |
PMID:21692457 |
|
NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
Dithiothreitol results in increased expression of PPARGC1A mRNA |
CTD |
PMID:23056435 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]] |
CTD |
PMID:20584749 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2 |
protein tyrosine kinase 2 |
multiple interactions |
ISO |
Dithiothreitol affects the reaction [4-cresol sulfate affects the localization of PTK2 protein] |
CTD |
PMID:31873818 |
|
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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|
G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
EXP ISO |
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein] [9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein] |
CTD |
PMID:16781456 PMID:32493877 |
|
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Rcn2 |
reticulocalbin 2 |
increases expression |
ISO |
Dithiothreitol results in increased expression of RCN2 protein |
CTD |
PMID:21692457 |
|
NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases activity |
ISO |
Dithiothreitol inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]] Dithiothreitol results in increased activity of RELA protein [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]] |
CTD |
PMID:7491977 PMID:9281604 PMID:16219905 PMID:20351055 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
S100a2 |
S100 calcium binding protein A2 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Dithiothreitol inhibits the reaction [S100A2 protein binds to S100A2 protein] |
CTD |
PMID:21924240 |
|
NCBI chr 2:176,077,081...176,078,325
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|
G |
S100a4 |
S100 calcium-binding protein A4 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] |
CTD |
PMID:21924240 |
|
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] |
CTD |
PMID:15804185 |
|
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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G |
Snai1 |
snail family transcriptional repressor 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased expression of SNAI1 protein] |
CTD |
PMID:31873818 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Snai2 |
snail family transcriptional repressor 2 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased expression of SNAI2 protein] |
CTD |
PMID:31873818 |
|
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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G |
Sod1 |
superoxide dismutase 1 |
affects folding multiple interactions |
ISO |
Dithiothreitol affects the folding of SOD1 protein Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]] [Dithiothreitol results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Dithiothreitol results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Dithiothreitol results in increased reduction of and results in decreased activity of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein] |
CTD |
PMID:22867017 PMID:26694608 PMID:26699812 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions increases expression |
ISO |
[Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA] |
CTD |
PMID:7476933 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Stat6 |
signal transducer and activator of transcription 6 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]] |
CTD |
PMID:26699812 |
|
NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
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G |
Thy1 |
Thy-1 cell surface antigen |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] |
CTD |
PMID:11035063 |
|
NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]] |
CTD |
PMID:19627980 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
[Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA] Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA] [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]] |
CTD |
PMID:7476933 PMID:7532384 PMID:9281604 PMID:9388267 PMID:16219905 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]] |
CTD |
PMID:29272108 |
|
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein] |
CTD |
PMID:17555331 PMID:25446071 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [[hydroquinone results in increased activity of TRPA1 protein] which results in increased import of Calcium]; Dithiothreitol inhibits the reaction [hydroquinone results in increased activity of TRPA1 protein] |
CTD |
PMID:28790335 |
|
NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
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G |
Trpc5 |
transient receptor potential cation channel, subfamily C, member 5 |
multiple interactions increases activity |
ISO |
Dithiothreitol inhibits the reaction [Mercuric Chloride results in increased activity of TRPC5 protein] Dithiothreitol results in increased activity of TRPC5 protein |
CTD |
PMID:21984481 |
|
NCBI chr X:107,946,163...108,230,991
Ensembl chr X:107,939,131...108,230,991
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G |
Trpm4 |
transient receptor potential cation channel, subfamily M, member 4 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased expression of TRPM4 protein] |
CTD |
PMID:28214884 |
|
NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
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G |
Txn1 |
thioredoxin 1 |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]] |
CTD |
PMID:18922898 |
|
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Vim |
vimentin |
multiple interactions |
ISO |
Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased expression of VIM protein] |
CTD |
PMID:31873818 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Xbp1 |
X-box binding protein 1 |
increases splicing |
ISO EXP |
Dithiothreitol results in increased splicing of XBP1 mRNA |
CTD |
PMID:23123503 PMID:34244458 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP |
Dithiothreitol inhibits the reaction [chloramine affects the activity of XDH protein] |
CTD |
PMID:19527742 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
C1s |
complement C1s |
multiple interactions |
ISO |
2-aminothiophenol inhibits the reaction [C4A protein binds to C1S protein]; 2-aminothiophenol inhibits the reaction [C4B protein binds to C1S protein] |
CTD |
PMID:8435078 |
|
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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G |
C4a |
complement C4A |
multiple interactions |
ISO |
2-aminothiophenol inhibits the reaction [C4A protein binds to C1S protein] |
CTD |
PMID:8435078 |
|
NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080
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G |
C4b |
complement C4B |
multiple interactions |
ISO |
2-aminothiophenol inhibits the reaction [C4B protein binds to C1S protein] |
CTD |
PMID:8435078 |
|
NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
affects binding |
ISO |
acetoacetyl CoA binds to HSD17B2 protein |
CTD |
PMID:25526675 |
|
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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G |
Acly |
ATP citrate lyase |
increases abundance affects abundance |
ISO |
ACLY protein results in increased abundance of Acetyl Coenzyme A ACLY protein affects the abundance of Acetyl Coenzyme A |
CTD |
PMID:28077572 PMID:36933457 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
App |
amyloid beta precursor protein |
affects localization increases secretion multiple interactions |
ISO |
APP protein affects the localization of Acetyl Coenzyme A Acetyl Coenzyme A results in increased secretion of APP protein modified form Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form] IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] |
CTD |
PMID:16122837 PMID:22906069 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Crat |
carnitine O-acetyltransferase |
decreases activity |
EXP |
Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein |
CTD |
PMID:8075222 |
|
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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G |
Ercc6 |
ERCC excision repair 6, chromatin remodeling factor |
decreases abundance multiple interactions |
ISO |
ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A] |
CTD |
PMID:25440059 |
|
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
ISO |
[Fluoxetine results in decreased expression of G6PC1 protein] which results in increased abundance of Acetyl Coenzyme A |
CTD |
PMID:33179799 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] |
CTD |
PMID:16122837 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Kat2b |
lysine acetyltransferase 2B |
affects binding |
ISO |
Acetyl Coenzyme A binds to KAT2B protein |
CTD |
PMID:28077572 |
|
NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
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G |
Metrnl |
meteorin-like, glial cell differentiation regulator |
multiple interactions |
ISO |
METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A] |
CTD |
PMID:30213948 |
|
NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869
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G |
Nat1 |
N-acetyltransferase 1 |
multiple interactions affects binding |
ISO |
[NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein] Acetyl Coenzyme A binds to NAT1 protein |
CTD |
PMID:20545351 PMID:22835378 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
multiple interactions |
ISO |
[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] |
CTD |
PMID:20545351 |
|
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone |
CTD |
PMID:20545351 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
increases abundance |
ISO |
ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A |
CTD |
PMID:25125611 |
|
NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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G |
Hibch |
3-hydroxyisobutyryl-CoA hydrolase |
increases abundance |
ISO |
HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A |
CTD |
PMID:25125611 |
|
NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[Amifostine co-treated with Doxorubicin] results in increased expression of BAX mRNA |
CTD |
PMID:15985719 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[Amifostine co-treated with Doxorubicin] results in decreased expression of BCL2 mRNA |
CTD |
PMID:15985719 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[Amifostine co-treated with Doxorubicin] results in increased activity of CASP3 protein; Amifostine inhibits the reaction [Idarubicin results in increased activity of CASP3 protein]; Amifostine promotes the reaction [Idarubicin results in increased activity of CASP3 protein] |
CTD |
PMID:15985719 PMID:18438337 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
Amifostine results in decreased phosphorylation of CDK1 protein olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein] |
CTD |
PMID:16628227 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression increases expression |
ISO |
Amifostine results in decreased expression of CDKN1A mRNA Amifostine results in increased expression of CDKN1A protein |
CTD |
PMID:12618886 PMID:14555708 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Ei24 |
EI24, autophagy associated transmembrane protein |
decreases expression |
ISO |
Amifostine results in decreased expression of EI24 mRNA |
CTD |
PMID:14555708 |
|
NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein] |
CTD |
PMID:19010997 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:19010997 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mdm2 |
MDM2 proto-oncogene |
decreases expression |
ISO |
Amifostine results in decreased expression of MDM2 mRNA |
CTD |
PMID:14555708 |
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NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] |
CTD |
PMID:19010997 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
[Amifostine co-treated with TP53] results in increased expression of MYC mRNA |
CTD |
PMID:14555708 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myl2 |
myosin light chain 2 |
multiple interactions |
ISO |
Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL2 protein] Amifostine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MYL2 protein]; Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein] |
CTD |
PMID:19010997 |
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NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
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G |
Nfkbia |
NFKB inhibitor alpha |
decreases expression multiple interactions |
ISO |
Amifostine results in decreased expression of NFKBIA protein Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:10590050 PMID:19010997 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Amifostine inhibits the reaction [Benzene results in decreased expression of PCNA protein] |
CTD |
PMID:17661222 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases localization |
ISO |
Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] Amifostine results in increased localization of RELA protein |
CTD |
PMID:10590050 PMID:19010997 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression affects response to substance increases activity |
ISO |
[Amifostine co-treated with TP53] results in increased expression of MYC mRNA; olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein] Amifostine results in increased expression of TP53 protein TP53 affects the susceptibility to Amifostine Amifostine results in increased activity of TP53 protein |
CTD |
PMID:12618886 PMID:14555708 PMID:16628227 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp53i3 |
tumor protein p53 inducible protein 3 |
decreases expression |
ISO |
Amifostine results in decreased expression of TP53I3 mRNA |
CTD |
PMID:14555708 |
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NCBI chr 6:27,818,327...27,825,753
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein |
CTD |
PMID:11139385 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Glra1 |
glycine receptor, alpha 1 |
multiple interactions |
ISO |
n-butyl mercaptan promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein] |
CTD |
PMID:11049924 |
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NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
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G |
Kat2b |
lysine acetyltransferase 2B |
affects binding |
ISO |
butyryl-coenzyme A binds to KAT2B protein |
CTD |
PMID:28077572 |
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NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions decreases activity |
EXP ISO |
Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein] Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein] Captopril results in decreased activity of ACE protein |
CTD |
PMID:26851370 PMID:31629013 PMID:33007385 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
decreases response to substance multiple interactions |
ISO EXP |
ACE2 gene SNP results in decreased susceptibility to Captopril Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein] |
CTD |
PMID:17473847 PMID:31629013 PMID:33007385 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein] Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] |
CTD |
PMID:31181250 PMID:33007385 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP ISO |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein] Captopril inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGT protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Cadmium Chloride results in increased expression of AGT protein] |
CTD |
PMID:28130181 PMID:31181250 PMID:31629013 PMID:33007385 PMID:35844137 PMID:38027817 More...
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
EXP ISO |
Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein] Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein] |
CTD |
PMID:28130181 PMID:31629013 PMID:33007385 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Captopril inhibits the reaction [Glucose results in increased expression of AKT1 mRNA] |
CTD |
PMID:38115276 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of ALPL protein] |
CTD |
PMID:27269004 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Bdkrb2 |
bradykinin receptor B2 |
multiple interactions |
ISO |
Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein] |
CTD |
PMID:28130181 |
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NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
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G |
Calb1 |
calbindin 1 |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein] |
CTD |
PMID:28130181 |
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NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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G |
Car2 |
carbonic anhydrase 2 |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA] |
CTD |
PMID:28130181 |
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NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
Captopril inhibits the reaction [Methotrexate results in increased expression of CASP3 protein] Captopril inhibits the reaction [Glucose results in increased expression of CASP3 mRNA] |
CTD |
PMID:27269004 PMID:38115276 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] |
CTD |
PMID:33007385 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] |
CTD |
PMID:33007385 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Gli1 |
GLI family zinc finger 1 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein] |
CTD |
PMID:31181250 |
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NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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G |
Gli2 |
GLI family zinc finger 2 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein] |
CTD |
PMID:31181250 |
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NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
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G |
Gli3 |
GLI family zinc finger 3 |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein] |
CTD |
PMID:31181250 |
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NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GOT1 protein] |
CTD |
PMID:27269004 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GPT protein] |
CTD |
PMID:27269004 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of IL6 protein] Captopril inhibits the reaction [Glucose results in increased expression of IL6 mRNA] |
CTD |
PMID:38027817 PMID:38115276 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Kng1 |
kininogen 1 |
multiple interactions |
EXP |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of KNG1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of KNG1 protein] |
CTD |
PMID:38027817 |
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NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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G |
Lepr |
leptin receptor |
multiple interactions affects response to substance |
ISO |
Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein]; Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein]; Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of VDR protein] LEPR protein affects the susceptibility to Captopril |
CTD |
PMID:28130181 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
multiple interactions |
EXP ISO |
Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein] Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] |
CTD |
PMID:31629013 PMID:33007385 |
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NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
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G |
Mir146a |
microRNA 146a |
multiple interactions |
EXP |
captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir146a miRNA in kidney] |
RGD |
PMID:27760486 |
RGD:155882556 |
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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G |
Mir320a |
microRNA 320a |
multiple interactions |
EXP |
captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in kidney] |
RGD |
PMID:27760486 |
RGD:155882556 |
NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
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G |
Mlkl |
mixed lineage kinase domain like pseudokinase |
multiple interactions |
ISO |
Captopril inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MLKL protein] |
CTD |
PMID:35844137 |
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NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA] |
CTD |
PMID:28130181 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in increased expression of NOS2 protein] |
CTD |
PMID:27269004 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nppb |
natriuretic peptide B |
multiple interactions |
EXP |
Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein] |
CTD |
PMID:31629013 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
multiple interactions |
EXP |
Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] |
CTD |
PMID:31629013 |
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NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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G |
Ptch1 |
patched 1 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein] |
CTD |
PMID:31181250 |
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NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP ISO |
Captopril inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein] Captopril inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA] |
CTD |
PMID:27269004 PMID:38115276 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Pth |
parathyroid hormone |
multiple interactions |
ISO |
Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein] |
CTD |
PMID:28130181 |
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NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Captopril inhibits the reaction [Glucose results in increased phosphorylation of and results in increased localization of RELA protein] |
CTD |
PMID:38115276 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
multiple interactions |
ISO |
Captopril inhibits the reaction [Cadmium Chloride results in increased expression of RIPK3 protein] |
CTD |
PMID:35844137 |
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NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA] |
CTD |
PMID:28130181 |
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NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Shh |
sonic hedgehog signaling molecule |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein] |
CTD |
PMID:31181250 |
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NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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G |
Smo |
smoothened, frizzled class receptor |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] |
CTD |
PMID:31181250 |
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NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
Captopril inhibits the reaction [Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein] |
CTD |
PMID:27269004 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein] |
CTD |
PMID:38027817 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TNF protein] Captopril inhibits the reaction [Glucose results in increased expression of TNF mRNA] |
CTD |
PMID:38027817 PMID:38115276 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
Captopril inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA] |
CTD |
PMID:38115276 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vdr |
vitamin D receptor |
multiple interactions |
ISO |
Captopril promotes the reaction [LEPR protein affects the expression of VDR protein] |
CTD |
PMID:28130181 |
|
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA] |
CTD |
PMID:28130181 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vim |
vimentin |
multiple interactions |
ISO |
Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] |
CTD |
PMID:33007385 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Acot8 |
acyl-CoA thioesterase 8 |
affects hydrolysis |
ISO |
ACOT8 protein affects the hydrolysis of Coenzyme A analog |
CTD |
PMID:16141203 |
|
NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851
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G |
Kat2b |
lysine acetyltransferase 2B |
affects binding |
ISO |
Coenzyme A binds to KAT2B protein |
CTD |
PMID:28077572 |
|
NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:17708605 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] |
CTD |
PMID:17708605 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Tgm2 |
transglutaminase 2 |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 protein] |
CTD |
PMID:17708605 |
|
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] |
CTD |
PMID:17708605 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Adipor2 |
adiponectin receptor 2 |
increases expression |
EXP |
dietary cysteamine increases expression of adipor2 mRNA in soleus muscle and retroperitoneal adipose tissue |
RGD |
PMID:17696487 |
RGD:21079417 |
NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
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G |
Ctsd |
cathepsin D |
increases expression multiple interactions |
EXP |
Cysteamine results in increased expression of CTSD protein Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]; thamira parpam inhibits the reaction [Cysteamine results in increased expression of CTSD protein] |
CTD |
PMID:20165931 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases activity |
EXP |
Cysteamine results in increased activity of CYP7A1 protein |
CTD |
PMID:1175606 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
decreases activity multiple interactions |
ISO |
Cysteamine results in decreased activity of GCLC protein [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione |
CTD |
PMID:15282320 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
decreases expression multiple interactions |
EXP |
Cysteamine results in decreased expression of GHRL mRNA; Cysteamine results in decreased expression of GHRL protein Cysteamine results in increased expression of and results in increased secretion of GHRL protein |
CTD |
PMID:15778430 |
|
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP |
[Cysteamine results in increased expression of HMOX1] which results in increased expression of SOD2; Cysteamine results in increased expression of HMOX1 mRNA; Cysteamine results in increased expression of HMOX1 protein [stannous mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Cysteamine results in increased expression of SOD2 protein] |
CTD |
PMID:10942521 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Mmp12 |
matrix metallopeptidase 12 |
increases expression |
ISO |
Cysteamine results in increased expression of MMP12 mRNA; Cysteamine results in increased expression of MMP12 protein |
CTD |
PMID:22532830 |
|
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
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G |
Mmp14 |
matrix metallopeptidase 14 |
increases expression |
ISO |
Cysteamine results in increased expression of MMP14 mRNA; Cysteamine results in increased expression of MMP14 protein |
CTD |
PMID:22532830 |
|
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases activity multiple interactions increases expression |
ISO |
Cysteamine results in decreased activity of MMP9 protein Cysteamine results in increased expression of and results in decreased activity of MMP9 protein Cysteamine results in increased expression of MMP9 mRNA |
CTD |
PMID:22532830 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
multiple interactions increases expression |
EXP |
geraniol inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; thamira parpam inhibits the reaction [Cysteamine results in increased expression of MPO protein] |
CTD |
PMID:20165931 PMID:24337826 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
EXP |
[Cysteamine results in increased expression of HMOX1] which results in increased expression of SOD2; Cysteamine results in increased expression of SOD2 mRNA; Cysteamine results in increased expression of SOD2 protein [stannous mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Cysteamine results in increased expression of SOD2 protein] |
CTD |
PMID:10942521 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sst |
somatostatin |
decreases expression |
EXP |
Cysteamine results in decreased expression of SST protein |
CTD |
PMID:15778430 |
|
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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G |
Vnn1 |
vanin 1 |
increases chemical synthesis multiple interactions |
ISO |
VNN1 results in increased chemical synthesis of Cysteamine Cysteamine inhibits the reaction [VNN1 gene mutant form results in decreased susceptibility to Paraquat] |
CTD |
PMID:11042271 PMID:15282320 |
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NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
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G |
Ace2 |
angiotensin converting enzyme 2 |
increases expression |
ISO |
Penicillamine results in increased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Ahcy |
adenosylhomocysteinase |
increases activity multiple interactions |
ISO |
Penicillamine results in increased activity of AHCY protein Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein] |
CTD |
PMID:22945834 |
|
NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
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G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
increases expression decreases expression |
EXP |
Penicillamine results in increased expression of ALOX12 mRNA Penicillamine results in decreased expression of ALOX12 mRNA |
CTD |
PMID:19575532 |
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NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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G |
Alox5ap |
arachidonate 5-lipoxygenase activating protein |
increases expression |
EXP |
Penicillamine results in increased expression of ALOX5AP mRNA |
CTD |
PMID:19575532 |
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NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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G |
Anxa1 |
annexin A1 |
decreases expression increases expression |
EXP |
Penicillamine results in decreased expression of ANXA1 mRNA Penicillamine results in increased expression of ANXA1 mRNA |
CTD |
PMID:19575532 |
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NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Anxa4 |
annexin A4 |
increases expression decreases expression |
EXP |
Penicillamine results in increased expression of ANXA4 mRNA Penicillamine results in decreased expression of ANXA4 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
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G |
App |
amyloid beta precursor protein |
multiple interactions increases metabolic processing |
ISO |
Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein] Penicillamine results in increased metabolism of APP protein |
CTD |
PMID:10940226 PMID:12963085 PMID:17964426 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO |
Penicillamine results in increased metabolism of and results in increased activity of ATF6 protein |
CTD |
PMID:19722195 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atp7a |
ATPase copper transporting alpha |
multiple interactions |
ISO |
[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein] |
CTD |
PMID:21242307 |
|
NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354
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G |
Atp7b |
ATPase copper transporting beta |
multiple interactions |
ISO |
[Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein] Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA] |
CTD |
PMID:21242307 PMID:22945834 PMID:24368744 |
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NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
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G |
Bbc3 |
Bcl-2 binding component 3 |
decreases expression |
ISO |
Penicillamine results in decreased expression of BBC3 protein |
CTD |
PMID:22843330 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Penicillamine results in decreased expression of BCL2 mRNA; Penicillamine results in decreased expression of BCL2 protein |
CTD |
PMID:22843330 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
EXP |
andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]] |
CTD |
PMID:20946909 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
C1s |
complement C1s |
multiple interactions |
ISO |
Penicillamine inhibits the reaction [C4A protein binds to C1S protein]; Penicillamine inhibits the reaction [C4B protein binds to C1S protein] |
CTD |
PMID:8435078 |
|
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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G |
C3 |
complement C3 |
increases expression |
EXP |
Penicillamine results in increased expression of C3 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C4a |
complement C4A |
multiple interactions |
ISO |
Penicillamine inhibits the reaction [C4A protein binds to C1S protein] |
CTD |
PMID:8435078 |
|
NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080
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G |
C4b |
complement C4B |
multiple interactions |
ISO |
Penicillamine inhibits the reaction [C4B protein binds to C1S protein] |
CTD |
PMID:8435078 |
|
NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage |
EXP ISO |
andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]] Penicillamine results in increased cleavage of CASP3 protein Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein] |
CTD |
PMID:12963085 PMID:19722195 PMID:20946909 PMID:22843330 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]] |
CTD |
PMID:20946909 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression multiple interactions |
ISO |
Penicillamine results in decreased expression of CAT mRNA [Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein |
CTD |
PMID:22843330 PMID:24368744 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression |
ISO |
Penicillamine results in increased expression of CCL3 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases expression |
ISO EXP |
Penicillamine results in increased expression of CCL4 mRNA |
CTD |
PMID:19575532 PMID:22843330 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
increases expression |
EXP |
Penicillamine results in increased expression of CCL5 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
increases expression decreases expression |
EXP |
Penicillamine results in increased expression of CCR5 mRNA Penicillamine results in decreased expression of CCR5 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Cd14 |
CD14 molecule |
decreases expression increases expression |
EXP |
Penicillamine results in decreased expression of CD14 mRNA Penicillamine results in increased expression of CD14 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd163 |
CD163 molecule |
decreases expression increases expression |
EXP |
Penicillamine results in decreased expression of CD163 mRNA Penicillamine results in increased expression of CD163 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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G |
Cd38 |
CD38 molecule |
increases expression |
EXP |
Penicillamine results in increased expression of CD38 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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G |
Cd52 |
CD52 molecule |
decreases expression |
EXP |
Penicillamine results in decreased expression of CD52 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348
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G |
Clu |
clusterin |
multiple interactions |
ISO |
[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] |
CTD |
PMID:21242307 |
|
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Cp |
ceruloplasmin |
decreases expression multiple interactions |
ISO |
Penicillamine results in decreased expression of CP protein Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein] |
CTD |
PMID:24013775 PMID:24368744 |
|
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
decreases expression multiple interactions |
EXP ISO |
Penicillamine results in decreased expression of CPT1A mRNA Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein] |
CTD |
PMID:19575532 PMID:22945834 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Crp |
C-reactive protein |
decreases expression |
ISO |
Penicillamine results in decreased expression of CRP protein |
CTD |
PMID:241598 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Csf2 |
colony stimulating factor 2 |
increases expression |
EXP |
Penicillamine results in increased expression of CSF2 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression decreases expression |
EXP |
Penicillamine results in increased expression of CXCR4 mRNA Penicillamine results in decreased expression of CXCR4 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
Penicillamine results in increased expression of CYP1A1 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression |
ISO |
Penicillamine results in increased expression of CYP2E1 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
Penicillamine results in increased expression of DDIT3 mRNA; Penicillamine results in increased expression of DDIT3 protein |
CTD |
PMID:19722195 PMID:22843330 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression |
ISO |
Penicillamine results in decreased expression of DNMT3A mRNA |
CTD |
PMID:22945834 |
|
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
multiple interactions |
ISO |
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA] |
CTD |
PMID:22945834 |
|
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Dusp1 |
dual specificity phosphatase 1 |
decreases expression |
EXP |
Penicillamine results in decreased expression of DUSP1 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr10:16,680,478...16,683,275
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression |
EXP |
Penicillamine results in increased expression of DUSP6 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
Egr1 |
early growth response 1 |
increases expression |
EXP ISO |
Penicillamine results in increased expression of EGR1 mRNA |
CTD |
PMID:19575532 PMID:22843330 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Penicillamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein |
CTD |
PMID:22843330 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
ISO |
Penicillamine results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:22843330 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Eln |
elastin |
affects localization |
ISO |
Penicillamine affects the localization of ELN protein |
CTD |
PMID:3954958 |
|
NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
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G |
Fcnb |
ficolin B |
increases expression |
EXP |
Penicillamine results in increased expression of FCNB mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 3:11,393,713...11,402,198
Ensembl chr 3:11,393,739...11,402,151
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G |
Fmo1 |
flavin containing dimethylaniline monoxygenase 1 |
increases expression |
ISO |
Penicillamine results in increased expression of FMO1 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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G |
Fmo5 |
flavin containing dimethylaniline monoxygenase 5 |
increases expression |
ISO |
Penicillamine results in increased expression of FMO5 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
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G |
Fn1 |
fibronectin 1 |
increases expression |
EXP |
Penicillamine results in increased expression of FN1 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
Penicillamine results in increased expression of GADD45A mRNA |
CTD |
PMID:22843330 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gatm |
glycine amidinotransferase |
increases expression |
EXP |
Penicillamine results in increased expression of GATM mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
increases expression |
ISO |
Penicillamine results in increased expression of GSTM3 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression decreases expression |
ISO |
[Penicillamine co-treated with bathocuproine sulfonate] results in increased expression of HMOX1 protein Penicillamine results in increased expression of HMOX1 mRNA Penicillamine analog results in decreased expression of HMOX1 protein |
CTD |
PMID:19323979 PMID:21242307 PMID:22843330 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hp |
haptoglobin |
decreases expression |
ISO |
Penicillamine results in decreased expression of HP protein |
CTD |
PMID:241598 |
|
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
increases expression |
ISO |
Penicillamine results in increased expression of HSPA1A mRNA; Penicillamine results in increased expression of HSPA1A protein |
CTD |
PMID:22843330 |
|
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa1l |
heat shock protein family A (Hsp70) member 1 like |
increases expression |
ISO |
Penicillamine results in increased expression of HSPA1L mRNA |
CTD |
PMID:22843330 |
|
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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G |
Hspa2 |
heat shock protein family A (Hsp70) member 2 |
increases expression |
ISO |
Penicillamine results in increased expression of HSPA2 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO |
Penicillamine results in increased expression of HSPA5 protein Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein] |
CTD |
PMID:19722195 PMID:22843330 PMID:22945834 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa6l-ps1 |
heat shock protein family A (Hsp70) member 6 like, pseudogene 1 |
increases expression |
ISO |
Penicillamine results in increased expression of HSPA6 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr13:83,273,176...83,274,317
|
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G |
Ifng |
interferon gamma |
increases expression |
EXP |
Penicillamine results in increased expression of IFNG mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein] |
CTD |
PMID:14745455 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Il10 |
interleukin 10 |
increases expression |
EXP |
Penicillamine results in increased expression of IL10 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il13 |
interleukin 13 |
decreases expression increases expression |
EXP |
Penicillamine results in decreased expression of IL13 mRNA Penicillamine results in increased expression of IL13 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il15 |
interleukin 15 |
increases expression |
EXP |
Penicillamine results in increased expression of IL15 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Il1b |
interleukin 1 beta |
increases expression |
EXP |
Penicillamine results in increased expression of IL1B mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il21 |
interleukin 21 |
increases expression |
EXP |
Penicillamine results in increased expression of IL21 mRNA |
CTD |
PMID:21227906 |
|
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
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G |
Il23a |
interleukin 23 subunit alpha |
increases expression |
ISO |
Penicillamine results in increased expression of IL23A protein |
CTD |
PMID:19575532 |
|
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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G |
Il3ra |
interleukin 3 receptor subunit alpha |
increases expression |
EXP |
Penicillamine results in increased expression of IL3RA mRNA |
CTD |
PMID:19575532 |
|
NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484
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G |
Il4 |
interleukin 4 |
increases expression |
EXP |
Penicillamine results in increased expression of IL4 mRNA |
CTD |
PMID:9182889 PMID:21227906 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
increases expression |
EXP ISO |
Penicillamine results in increased expression of IL6 protein |
CTD |
PMID:19575532 PMID:21227906 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Klf4 |
KLF transcription factor 4 |
increases expression |
EXP |
Penicillamine results in increased expression of KLF4 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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G |
Lgals1 |
galectin 1 |
increases expression |
EXP |
Penicillamine results in increased expression of LGALS1 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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G |
Loxl2 |
lysyl oxidase-like 2 |
decreases activity |
ISO |
Penicillamine results in decreased activity of LOXL2 protein |
CTD |
PMID:16023247 |
|
NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions decreases expression |
ISO |
PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein] |
CTD |
PMID:22843330 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mpo |
myeloperoxidase |
decreases secretion multiple interactions |
ISO |
Penicillamine results in decreased secretion of MPO protein Penicillamine promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Penicillamine promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile] |
CTD |
PMID:6324512 PMID:25614581 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
multiple interactions |
ISO |
Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein] |
CTD |
PMID:14745455 |
|
NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression |
EXP |
Penicillamine results in increased expression of NFE2L2 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression |
ISO |
Penicillamine results in increased expression of NOS2 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
increases expression |
EXP |
Penicillamine results in increased expression of NR4A1 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
Penicillamine results in increased cleavage of PARP1 protein |
CTD |
PMID:22843330 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression multiple interactions |
ISO |
Penicillamine results in increased expression of PMAIP1 mRNA; Penicillamine results in increased expression of PMAIP1 protein PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein] |
CTD |
PMID:22843330 |
|
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA] |
CTD |
PMID:22945834 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Prl |
prolactin |
multiple interactions increases expression |
ISO |
Danazol inhibits the reaction [Penicillamine results in increased expression of PRL] |
CTD |
PMID:4087275 |
|
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Ptger2 |
prostaglandin E receptor 2 |
increases expression |
EXP |
Penicillamine results in increased expression of PTGER2 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
increases expression |
ISO |
Penicillamine results in increased expression of PTGS1 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
RT1-CE16 |
RT1 class I, locus CE16 |
affects response to substance |
ISO |
HLA-A gene polymorphism affects the susceptibility to Penicillamine |
CTD |
PMID:3459889 |
|
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
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G |
RT1-Db1 |
RT1 class II, locus Db1 |
increases response to substance |
ISO |
HLA-DRB1 gene polymorphism results in increased susceptibility to Penicillamine |
CTD |
PMID:6420562 |
|
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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G |
S100a4 |
S100 calcium-binding protein A4 |
increases expression |
EXP |
Penicillamine results in increased expression of S100A4 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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G |
S100a6 |
S100 calcium binding protein A6 |
increases expression |
EXP |
Penicillamine results in increased expression of S100A6 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
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G |
S100a8 |
S100 calcium binding protein A8 |
decreases expression increases expression |
EXP |
Penicillamine results in decreased expression of S100A8 mRNA Penicillamine results in increased expression of S100A8 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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G |
S100a9 |
S100 calcium binding protein A9 |
decreases expression increases expression |
EXP |
Penicillamine results in decreased expression of S100A9 mRNA Penicillamine results in increased expression of S100A9 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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G |
Selenbp1 |
selenium binding protein 1 |
decreases expression |
EXP |
Penicillamine results in decreased expression of SELENBP1 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594
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G |
Slc11a1 |
solute carrier family 11 member 1 |
increases expression |
EXP |
Penicillamine results in increased expression of SLC11A1 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
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G |
Slc28a2 |
solute carrier family 28 member 2 |
decreases expression increases expression |
EXP |
Penicillamine results in decreased expression of SLC28A2 mRNA Penicillamine results in increased expression of SLC28A2 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702
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G |
Slc30a1 |
solute carrier family 30 member 1 |
decreases expression increases expression |
EXP |
Penicillamine results in decreased expression of SLC30A1 mRNA Penicillamine results in increased expression of SLC30A1 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
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G |
Slc31a1 |
solute carrier family 31 member 1 |
multiple interactions increases expression |
ISO |
[Penicillamine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to Oxaliplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Cisplatin promotes the reaction [Penicillamine results in increased expression of SLC31A1 mRNA]; Penicillamine promotes the reaction [Cisplatin results in increased expression of SLC31A1 mRNA] |
CTD |
PMID:22914438 |
|
NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
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G |
Slc4a1 |
solute carrier family 4 member 1 (Diego blood group) |
decreases expression |
EXP |
Penicillamine results in decreased expression of SLC4A1 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
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G |
Sod1 |
superoxide dismutase 1 |
decreases activity |
ISO |
Penicillamine analog results in decreased activity of SOD1 protein |
CTD |
PMID:19323979 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sp1 |
Sp1 transcription factor |
increases expression |
ISO |
Penicillamine results in increased expression of SP1 mRNA |
CTD |
PMID:22914438 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA] |
CTD |
PMID:22945834 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Stx3 |
syntaxin 3 |
increases expression decreases expression |
EXP |
Penicillamine results in increased expression of STX3 mRNA Penicillamine results in decreased expression of STX3 mRNA |
CTD |
PMID:19575532 |
|
NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
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G |
Tfrc |
transferrin receptor |
increases expression |
EXP |
Penicillamine results in increased expression of TFRC mRNA |
CTD |
PMID:19575532 |
|
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions |
ISO |
Penicillamine results in increased expression of TNF protein Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA] |
CTD |
PMID:19575532 PMID:22945834 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression decreases expression |
ISO |
Penicillamine results in increased expression of TP53 protein Penicillamine results in decreased expression of TP53 mRNA |
CTD |
PMID:22843330 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Xbp1 |
X-box binding protein 1 |
increases splicing |
ISO |
Penicillamine results in increased splicing of XBP1 mRNA |
CTD |
PMID:19722195 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Hsdl2 |
hydroxysteroid dehydrogenase like 2 |
multiple interactions |
ISO |
[decanoyl-coenzyme A co-treated with NADP] binds to HSDL2 protein |
CTD |
PMID:25526675 |
|
NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
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G |
Pecr |
peroxisomal trans-2-enoyl-CoA reductase |
multiple interactions |
ISO |
[decanoyl-coenzyme A co-treated with NADP] binds to PECR protein |
CTD |
PMID:25526675 |
|
NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
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G |
Ache |
acetylcholinesterase |
decreases activity |
ISO |
demeton-S-methyl results in decreased activity of ACHE protein |
CTD |
PMID:16766477 PMID:21238577 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Bche |
butyrylcholinesterase |
decreases activity |
ISO |
demeton-S-methyl results in decreased activity of BCHE protein |
CTD |
PMID:21238577 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IFNG protein |
CTD |
PMID:12062936 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
[dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein |
CTD |
PMID:12062936 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
|
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
dihydrolipoamide inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:15613977 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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|
G |
Adpgk |
ADP-dependent glucokinase |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [4-aminophenylarsenoxide binds to ADPGK protein] |
CTD |
PMID:26598702 |
|
NCBI chr 8:59,699,400...59,727,352
Ensembl chr 8:59,699,388...59,727,351
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|
G |
Alad |
aminolevulinate dehydratase |
increases expression decreases expression |
ISO |
Dimercaprol results in increased expression of ALAD protein Dimercaprol results in decreased expression of ALAD protein |
CTD |
PMID:15755317 |
|
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
App |
amyloid beta precursor protein |
affects binding multiple interactions |
ISO |
Dimercaprol binds to APP 5' UTR [Dimercaprol binds to APP 5' UTR] which results in decreased expression of APP protein; [Dimercaprol binds to APP 5' UTR] which results in decreased secretion of APP protein modified form |
CTD |
PMID:15681799 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Clcf1 |
cardiotrophin-like cytokine factor 1 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of CXCL2 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of CXCL1 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Fgfr3 |
fibroblast growth factor receptor 3 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of FGFR3 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
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G |
Gas1 |
growth arrest-specific 1 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of GAS1 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr17:4,482,168...4,485,153
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression multiple interactions |
ISO |
Dimercaprol results in increased expression of GSTA1 mRNA Tetradecanoylphorbol Acetate promotes the reaction [Dimercaprol results in increased expression of GSTA1 mRNA] |
CTD |
PMID:7568053 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Hk2 |
hexokinase 2 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [4-aminophenylarsenoxide binds to HK2 protein] |
CTD |
PMID:26598702 |
|
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Dimercaprol results in increased expression of HMOX1 mRNA |
CTD |
PMID:8612205 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]] |
CTD |
PMID:10967126 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]]; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; Dimercaprol inhibits the reaction [p-aminophenylarsine oxide inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]] |
CTD |
PMID:2202293 PMID:3882699 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Ins2 |
insulin 2 |
multiple interactions |
EXP |
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]] |
CTD |
PMID:8048502 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Itgb5 |
integrin subunit beta 5 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of ITGB5 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
affects binding |
ISO |
Dimercaprol binds to KEAP1 protein |
CTD |
PMID:19808700 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Kif16b |
kinesin family member 16B |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of KIF16B mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr 3:129,974,692...130,254,194
Ensembl chr 3:129,974,800...130,254,019
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G |
Kif1b |
kinesin family member 1B |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of KIF1B mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
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G |
Kifap3 |
kinesin-associated protein 3 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of KIFAP3 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr13:76,127,702...76,264,654
Ensembl chr13:76,127,696...76,264,650
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|
G |
Krt17 |
keratin 17 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of KRT17 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392
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G |
Krt18 |
keratin 18 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of KRT18 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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G |
Mafk |
MAF bZIP transcription factor K |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of MAFK mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048 Ensembl chr12:14,833,984...14,837,048
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|
G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]] |
CTD |
PMID:16183647 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mycl |
MYCL proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of MYCL mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr 5:135,274,713...135,281,584
Ensembl chr 5:135,274,748...135,281,582
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
[Dimercaprol co-treated with Mercuric Chloride] inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Dimercaprol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein] |
CTD |
PMID:18838692 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases activity |
ISO |
[Dimercaprol co-treated with Mercuric Chloride] results in increased activity of NQO1 protein Dimercaprol results in increased activity of NQO1 protein |
CTD |
PMID:18838692 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pgk1 |
phosphoglycerate kinase 1 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [4-aminophenylarsenoxide binds to PGK1 protein] |
CTD |
PMID:26598702 |
|
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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G |
Pml |
PML nuclear body scaffold |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [4-aminophenylarsenoxide binds to PML protein] |
CTD |
PMID:26598702 |
|
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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G |
Ppbp |
pro-platelet basic protein |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of PPBP mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
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G |
Ppp2r5c |
protein phosphatase 2, regulatory subunit B', gamma |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP2R5C mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346
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G |
Ppp3ca |
protein phosphatase 3 catalytic subunit alpha |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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G |
Rbl2 |
RB transcriptional corepressor like 2 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of RBL2 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:16183647 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Rptor |
regulatory associated protein of MTOR, complex 1 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]] |
CTD |
PMID:16183647 |
|
NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]] |
CTD |
PMID:8048502 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in increased expression of SOCS3 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Stag1 |
STAG1 cohesin complex component |
multiple interactions |
ISO |
Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of STAG1 mRNA] |
CTD |
PMID:16377760 |
|
NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677
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G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions |
EXP |
Dimercaprol inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein] |
CTD |
PMID:20810785 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Tyr |
tyrosinase |
decreases activity |
ISO |
Dimercaprol results in decreased activity of TYR protein |
CTD |
PMID:16928136 |
|
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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G |
Slc1a5 |
solute carrier family 1 member 5 |
multiple interactions |
EXP |
Dithioerythritol inhibits the reaction [Thiazoles analog results in decreased activity of SLC1A5 protein] |
CTD |
PMID:23010140 |
|
NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
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G |
Slc22a4 |
solute carrier family 22 member 4 |
multiple interactions |
ISO |
Dithioerythritol inhibits the reaction [Cadmium results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein] |
CTD |
PMID:25490951 |
|
NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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G |
Slc22a5 |
solute carrier family 22 member 5 |
multiple interactions |
EXP |
Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]] |
CTD |
PMID:19041296 PMID:22900493 |
|
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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G |
Slc25a20 |
solute carrier family 25 member 20 |
multiple interactions |
EXP ISO |
Dithioerythritol inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein] Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein] |
CTD |
PMID:23402788 PMID:25849418 |
|
NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
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G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
decreases activity |
EXP |
dithiol results in decreased activity of ALOX12 protein |
CTD |
PMID:3928952 |
|
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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G |
Alox5 |
arachidonate 5-lipoxygenase |
decreases activity |
EXP |
dithiol results in decreased activity of ALOX5 protein |
CTD |
PMID:3928952 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
multiple interactions |
EXP |
GSTA4 protein binds to and affects the metabolism of gamma-glutamyl-glutathione |
CTD |
PMID:2619714 |
|
NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
EXP |
GSTP1 protein binds to and affects the metabolism of gamma-glutamyl-glutathione |
CTD |
PMID:2619714 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions decreases expression |
ISO |
glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA] glucobrassicin analog results in decreased expression of GPX2 protein |
CTD |
PMID:20868228 |
|
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions decreases activity |
ISO |
glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein] glucobrassicin analog results in decreased activity of NQO1 protein |
CTD |
PMID:20868228 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
glucoerucin results in increased expression of CYP1A1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
glucoerucin results in increased expression of CYP1A2 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
glucoerucin results in increased expression of CYP1B1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
glucoerucin results in increased expression of EPHX1 protein |
CTD |
PMID:21132492 |
|
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity |
EXP |
glucoerucin results in increased activity of NQO1 protein |
CTD |
PMID:20833222 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
glucoraphanin results in increased expression of CYP1A1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
glucoraphanin results in increased expression of CYP1A2 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
glucoraphanin results in increased expression of CYP1B1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
glucoraphanin results in increased expression of EPHX1 protein |
CTD |
PMID:21132492 |
|
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression |
EXP |
Glucoraphanin decreases expression of Gpx1 mRNA in the jejunum |
RGD |
PMID:23271678 |
RGD:152998882 |
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx2 |
glutathione peroxidase 2 |
increases expression increases expression multiple interactions |
ISO EXP |
glucoraphanin analog results in increased expression of GPX2 mRNA; glucoraphanin analog results in increased expression of GPX2 protein Glucoraphanin increases expression of Gpx2 mRNA in the jejunum Benzo(a)pyrene inhibits the reaction [glucoraphanin results in increased expression of GPX2 mRNA]; glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA] |
CTD RGD |
PMID:20868228 PMID:23271678 |
RGD:152998882 |
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization |
ISO |
glucoraphanin analog affects the localization of NFE2L2 protein |
CTD |
PMID:20868228 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases activity |
ISO EXP |
glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein] glucoraphanin analog results in increased activity of NQO1 protein |
CTD |
PMID:20833222 PMID:20868228 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Acot4 |
acyl-CoA thioesterase 4 |
affects hydrolysis |
ISO |
ACOT4 protein affects the hydrolysis of glutaryl-coenzyme A |
CTD |
PMID:16141203 |
|
NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
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G |
Acot8 |
acyl-CoA thioesterase 8 |
affects hydrolysis |
ISO |
ACOT8 protein affects the hydrolysis of glutaryl-coenzyme A |
CTD |
PMID:16141203 |
|
NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions increases expression |
ISO |
Glutathione promotes the reaction [Quercetin results in increased expression of ABCA1 mRNA]; Quercetin promotes the reaction [Glutathione results in increased expression of ABCA1 mRNA] |
CTD |
PMID:25204422 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Glutathione inhibits the reaction [Ethanol results in increased expression of ABCB1 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide affects the expression of ABCB1 mRNA]; Glutathione inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA] |
CTD |
PMID:33766574 PMID:35478211 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
affects export |
ISO |
ABCB4 protein affects the export of Glutathione |
CTD |
PMID:11302927 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc1 |
ATP binding cassette subfamily C member 1 |
affects export increases uptake multiple interactions increases export affects transport |
ISO EXP |
ABCC1 protein affects the export of Glutathione ABCC1 protein results in increased uptake of Glutathione [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to monomethylarsonous acid analog]; [Glutathione binds to 10-nitro-oleic acid] promotes the reaction [ABCC1 protein results in increased export of 10-nitro-oleic acid metabolite]; [Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione]; ABCC1 protein affects the transport of [arsenite co-treated with Glutathione]; Apigenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]; Genistein promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of Antimony Potassium Tartrate]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of Arsenic Trioxide]; Glutathione binds to and affects the folding of and affects the activity of ABCC1 protein; Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA]; Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; Glutathione results in increased stability of and results in decreased degradation of and affects the localization of ABCC1 protein mutant form; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; PAK 104P promotes the reaction [ABCC1 protein affects the export of Glutathione]; Quercetin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the transport of Glutathione]; Verapamil promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Vincristine inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]] [verlukast results in decreased activity of ABCC1 protein] inhibits the reaction [Arsenates results in increased export of Glutathione] ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione] ABCC1 protein affects the transport of Glutathione; ABCC1 protein affects the transport of Glutathione analog |
CTD |
PMID:11278867 PMID:11306701 PMID:12018890 PMID:12485947 PMID:12504668 PMID:15161912 PMID:15245331 PMID:15498506 PMID:15561710 PMID:15579473 PMID:15581632 PMID:15766272 PMID:16679408 PMID:17272743 PMID:20584751 PMID:21856323 PMID:21918036 PMID:23542460 PMID:29158255 PMID:33766574 More...
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions affects abundance affects transport |
ISO EXP |
ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione]; Glutathione promotes the reaction [ABCC2 protein affects the export of phenethyl isothiocyanate] ABCC2 protein affects the abundance of Glutathione ABCC2 protein affects the transport of Glutathione ABCC2 protein affects the transport of Glutathione analog |
CTD |
PMID:16002050 PMID:16049127 PMID:16611851 PMID:20584751 PMID:25450747 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 PMID:21856323 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions affects transport |
ISO |
ABCC4 protein results in increased export of [2,6-dibromobenzoquinone binds to Glutathione]; ABCC4 protein results in increased export of [2,6-dichloro-(1,4)benzoquinone binds to Glutathione]; Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] ABCC4 protein affects the transport of Glutathione analog |
CTD |
PMID:15210835 PMID:20584751 PMID:28885828 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions affects transport |
ISO |
ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione] ABCC5 protein affects the transport of Glutathione analog |
CTD |
PMID:20584751 PMID:21856323 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
multiple interactions |
ISO |
Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases export |
ISO |
2',5'-dihydroxychalcone promotes the reaction [ABCG2 protein results in increased export of Glutathione]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of Glutathione] |
CTD |
PMID:20332504 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein] |
CTD |
PMID:20100039 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ACOX1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ACSL4 mRNA |
CTD |
PMID:15345336 |
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NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
multiple interactions |
ISO |
Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] |
CTD |
PMID:19428350 |
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NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
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Agt |
angiotensinogen |
multiple interactions decreases abundance |
ISO |
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione] AGT protein modified form results in increased chemical synthesis of [4-oxo-2-nonenal binds to Glutathione] AGT protein modified form results in decreased abundance of Glutathione; AGT protein results in decreased abundance of Glutathione |
CTD |
PMID:17272743 PMID:30703374 PMID:31144504 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased abundance of Glutathione] |
CTD |
PMID:12398935 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
AIFM1 protein inhibits the reaction [arsenic acid results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Nitroprusside results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Paraquat results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione] |
CTD |
PMID:15316071 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Akap1 |
A-kinase anchoring protein 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AKAP1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases glutathionylation increases reduction affects binding |
ISO |
Glutathione results in increased glutathionylation of AKR1B1 protein modified form Glutathione results in increased reduction of AKR1B1 protein modified form AKR1B1 protein binds to Glutathione |
CTD |
PMID:11306073 PMID:19061876 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akr1d1 |
aldo-keto reductase family 1, member D1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AKR1D1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
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G |
Akr7a2 |
aldo-keto reductase family 7, member A2 |
increases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in increased expression of AKR7A2 mRNA AKR7A2 protein inhibits the reaction [Vitamin K 3 results in decreased abundance of Glutathione] |
CTD |
PMID:15345336 PMID:22001351 |
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NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AKR7A3 mRNA |
CTD |
PMID:15345336 PMID:20621112 |
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NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:17640567 PMID:24015256 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP |
Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein] |
CTD |
PMID:21620807 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Alb |
albumin |
multiple interactions |
ISO |
[4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein |
CTD |
PMID:23791970 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Ap2m1 |
adaptor related protein complex 2 subunit mu 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AP2M1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
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G |
Aplp2 |
amyloid beta precursor like protein 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of APLP2 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions |
ISO |
[Glutathione co-treated with Quercetin] promotes the reaction [APOA1 protein results in increased export of Cholesterol] |
CTD |
PMID:25204422 |
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apoe |
apolipoprotein E |
decreases abundance multiple interactions |
ISO |
APOE gene mutant form results in decreased abundance of Glutathione notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:24933211 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
Apol9a-Apol7a |
Apol9a-Apol7a readthrough |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of APOL7B mRNA |
CTD |
PMID:20621112 |
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NCBI chr 7:109,118,559...109,149,798
Ensembl chr 7:109,131,064...109,147,649
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G |
App |
amyloid beta precursor protein |
decreases abundance multiple interactions |
EXP ISO |
APP protein modified form results in decreased abundance of Glutathione vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] |
CTD |
PMID:25654502 PMID:29545167 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
As3mt |
arsenite methyltransferase |
multiple interactions affects folding |
EXP ISO |
Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenous acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of dimethylarsine]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine] Glutathione affects the folding of AS3MT protein Glutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]; Glutathione promotes the reaction [AS3MT protein results in increased methylation of arsenite]; Glutathione results in increased reduction of and affects the folding of AS3MT protein |
CTD |
PMID:15606138 PMID:22868225 PMID:22955273 PMID:25349987 |
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NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [Camptothecin results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein] |
CTD |
PMID:24515801 PMID:30266318 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO |
SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form] |
CTD |
PMID:27349771 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atg5 |
autophagy related 5 |
multiple interactions affects abundance |
ISO |
[ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]; [ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione; ATG5 protein affects the reaction [Acetaminophen affects the abundance of Glutathione] ATG5 protein affects the abundance of Glutathione |
CTD |
PMID:22491424 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Atg7 |
autophagy related 7 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein] |
CTD |
PMID:29247770 |
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NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ATP1B1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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G |
Atp7b |
ATPase copper transporting beta |
decreases abundance multiple interactions |
ISO |
ATP7B gene mutant form results in decreased abundance of Glutathione Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Zinc Sulfate inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:24368744 |
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NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Glutathione results in increased expression of BAX protein Glutathione inhibits the reaction [Acrolein results in increased expression of BAX protein] [[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; Glutathione inhibits the reaction [Ivermectin results in increased expression of BAX protein] |
CTD |
PMID:10897038 PMID:21621595 PMID:24036456 PMID:24376112 PMID:34904774 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases export |
ISO |
Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Ivermectin results in decreased expression of BCL2 protein] [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA; Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 protein]; Glutathione inhibits the reaction [Acrolein results in decreased expression of BCL2 protein] BCL2 protein results in decreased export of Glutathione |
CTD |
PMID:15561710 PMID:17640567 PMID:22564015 PMID:24036456 PMID:24376112 PMID:34904774 PMID:36689145 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]] |
CTD |
PMID:17640567 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl3 |
BCL3, transcription coactivator |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of BCL3 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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G |
Bdh2 |
3-hydroxybutyrate dehydrogenase 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of BDH2 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
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G |
Bgn |
biglycan |
multiple interactions |
ISO |
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:35234341 |
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NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]] |
CTD |
PMID:17640567 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Thimerosal results in decreased expression of BIRC3 protein] |
CTD |
PMID:12140745 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Bmi1 |
BMI1 proto-oncogene, polycomb ring finger |
increases abundance |
ISO |
BMI1 protein results in increased abundance of Glutathione |
CTD |
PMID:21445297 |
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NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
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G |
Bnip3 |
BCL2 interacting protein 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] |
CTD |
PMID:19442826 |
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NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Bst2 |
bone marrow stromal cell antigen 2 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of BST2 mRNA |
CTD |
PMID:20621112 |
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NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
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G |
C5 |
complement C5 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of C5 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO EXP |
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [aristolochic acid I results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP3 protein] Glutathione results in increased activity of CASP3 protein Glutathione inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [JP8 aviation fuel results in increased activity of CASP3 protein] Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein] |
CTD |
PMID:10385654 PMID:11969376 PMID:12140745 PMID:14660655 PMID:15683462 PMID:17640567 PMID:21300145 PMID:21621595 PMID:24036456 PMID:24376112 PMID:33309544 PMID:36689145 PMID:38128689 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CASP6 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP7 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein] |
CTD |
PMID:24515801 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein] Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP8 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein] |
CTD |
PMID:24376112 PMID:24515801 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP9 protein] Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP9 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein] |
CTD |
PMID:12140745 PMID:18594523 PMID:33309544 PMID:36689145 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions decreases response to substance |
ISO EXP |
[INS1 protein co-treated with Glutathione] affects the activity of CAT protein; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of CAT mRNA; CAT inhibits the reaction [Buthionine Sulfoximine results in decreased abundance of Glutathione]; CAT protein inhibits the reaction [casiopeina II results in decreased abundance of Glutathione] CAT protein results in decreased susceptibility to Glutathione Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of CAT protein]; Glutathione inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Glutathione inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein] |
CTD |
PMID:19419996 PMID:20580664 PMID:21354300 PMID:21620807 PMID:25362599 PMID:26187465 PMID:27718046 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav2 |
caveolin 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CAV2 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
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G |
Cbr3 |
carbonyl reductase 3 |
multiple interactions |
ISO |
[GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein |
CTD |
PMID:25446851 |
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NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
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G |
Cbs |
cystathionine beta synthase |
decreases abundance |
ISO |
CBS gene mutant form results in decreased abundance of Glutathione |
CTD |
PMID:15016621 |
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NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein] |
CTD |
PMID:10919993 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
decreases expression |
ISO |
Glutathione results in decreased expression of CCL20 mRNA |
CTD |
PMID:22385246 |
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NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Particulate Matter analog results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Vehicle Emissions analog results in increased secretion of CCL5 protein] |
CTD |
PMID:10919993 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccna2 |
cyclin A2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [rubimaillin results in decreased expression of CCNA2 protein] |
CTD |
PMID:35007525 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]] |
CTD |
PMID:17640567 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cd14 |
CD14 molecule |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CD14 mRNA |
CTD |
PMID:15345336 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd36 |
CD36 molecule |
multiple interactions decreases expression |
ISO |
[GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein Glutathione results in decreased expression of CD36 protein |
CTD |
PMID:26187465 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd40lg |
CD40 ligand |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein] |
CTD |
PMID:27634759 |
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NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Cd86 |
CD86 molecule |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Thimerosal results in increased expression of CD86 protein] |
CTD |
PMID:20457211 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Cdc25b |
cell division cycle 25B |
multiple interactions |
ISO |
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate |
CTD |
PMID:20025242 |
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NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
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G |
Cdc25c |
cell division cycle 25C |
multiple interactions |
ISO |
[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate |
CTD |
PMID:20025242 |
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NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [rubimaillin results in decreased expression of CDK2 protein] |
CTD |
PMID:35007525 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CDK4 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein] |
CTD |
PMID:22927544 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdo1 |
cysteine dioxygenase type 1 |
increases abundance |
EXP |
CDO1 protein results in increased abundance of Glutathione |
CTD |
PMID:23665415 |
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NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA] |
CTD |
PMID:21220312 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Ces1c |
carboxylesterase 1C |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ES2 mRNA |
CTD |
PMID:15345336 |
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NCBI chr19:13,926,401...13,955,527
Ensembl chr19:13,926,260...13,955,524
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions affects export decreases activity |
ISO |
[Bicarbonates co-treated with Glutathione co-treated with Ascorbic Acid] results in increased activity of CFTR protein; [Glutathione co-treated with Diamide] results in decreased activity of CFTR protein; Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein]; Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CFTR protein affects the export of Glutathione Glutathione analog results in decreased activity of CFTR protein |
CTD |
PMID:15561710 PMID:15657297 PMID:15857825 PMID:32374624 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] |
CTD |
PMID:17067557 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cldn4 |
claudin 4 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] |
CTD |
PMID:23816505 |
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NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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G |
Clu |
clusterin |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CLU mRNA |
CTD |
PMID:15345336 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Cntf |
ciliary neurotrophic factor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]] |
CTD |
PMID:16896058 |
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NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CPT1A mRNA |
CTD |
PMID:15345336 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Creg1 |
cellular repressor of E1A-stimulated genes 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CREG1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:15175009 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Ctps1 |
CTP synthase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CTPS1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of CXCL1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Glutathione deficiency promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of CXCL1 protein] |
CTD |
PMID:26149495 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein |
CTD |
PMID:21621595 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of CYP1A1 mRNA; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] [CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A1 protein results in increased susceptibility to 4,4'-hexafluorisopropylidene diphenol] which results in increased abundance of Glutathione |
CTD |
PMID:18078826 PMID:21094198 PMID:24246759 PMID:35395335 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP1A2 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP1A2 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [myristicin results in decreased activity of CYP1A2 protein] |
CTD |
PMID:20825217 PMID:24246759 PMID:26091900 PMID:31102647 PMID:32198085 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
[CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; CYP1B1 protein affects the metabolism of [2-hydroxyestradiol co-treated with Glutathione]; CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione] |
CTD |
PMID:14679015 PMID:24246759 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2a2 |
cytochrome P450, family 2, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
[CYP2A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine |
CTD |
PMID:20825217 |
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NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] |
CTD |
PMID:24246759 PMID:32198085 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
ISO |
[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions |
ISO |
[CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2C19 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] |
CTD |
PMID:24246759 PMID:31102647 PMID:32198085 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
multiple interactions |
ISO |
[CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac |
CTD |
PMID:24246759 |
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2D6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein] |
CTD |
PMID:20825217 PMID:24246759 PMID:31102647 PMID:32198085 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO EXP |
[CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione; [CYP2E1 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene] Glutathione inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein] 1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; [[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde; [Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite] |
CTD |
PMID:8211999 PMID:10573527 PMID:16872732 PMID:21842885 PMID:24246759 PMID:28803762 PMID:32198085 More...
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
multiple interactions |
ISO |
[CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions affects binding |
EXP ISO |
[CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione; [CYP3A4 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP3A4 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; CYP3A4 protein promotes the reaction [Acetaminophen results in decreased abundance of Glutathione]; Glutathione affects the reaction [CYP3A4 protein binds to 1-pyrenebutanol]; Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxyquinoline]; Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] Glutathione binds to CYP3A4 protein |
CTD |
PMID:15523003 PMID:18206979 PMID:20825217 PMID:24246759 PMID:25451576 PMID:27485346 PMID:31102647 PMID:32198085 More...
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions |
EXP |
[CYP3A23-3A1 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine |
CTD |
PMID:20825217 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
[CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione] |
CTD |
PMID:24246759 PMID:26302866 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein] Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] |
CTD |
PMID:17171638 PMID:20493918 PMID:24515801 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Decr1 |
2,4-dienoyl-CoA reductase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of DECR1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
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G |
Decr2 |
2,4-dienoyl-CoA reductase 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of DECR2 mRNA |
CTD |
PMID:15345336 |
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NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479
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G |
Defb5 |
defensin beta 5 |
decreases expression |
ISO |
Glutathione results in decreased expression of DEFB4A mRNA |
CTD |
PMID:22385246 |
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NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467
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G |
Dek |
DEK proto-oncogene |
decreases chemical synthesis |
ISO |
DEK protein results in decreased chemical synthesis of Glutathione |
CTD |
PMID:28558019 |
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NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Alcohols results in increased expression of DGAT1 protein] |
CTD |
PMID:28803762 |
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NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of DIABLO mRNA]; Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of DIABLO protein] |
CTD |
PMID:36689145 |
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NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Dio1 |
iodothyronine deiodinase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of DIO1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] |
CTD |
PMID:27624276 PMID:28153600 |
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NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 mRNA]; Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 protein] |
CTD |
PMID:18573614 |
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NCBI chr10:16,680,478...16,683,275
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G |
Egf |
epidermal growth factor |
affects abundance |
EXP |
EGF protein affects the abundance of Glutathione |
CTD |
PMID:10544272 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased phosphorylation of EGFR protein] [Acetaminophen results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein; [phorone results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein |
CTD |
PMID:14660655 PMID:28123000 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of EIF2AK2 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] |
CTD |
PMID:24515801 PMID:30266318 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:30266318 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] |
CTD |
PMID:23958427 |
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NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of EPHX1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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G |
Epo |
erythropoietin |
multiple interactions |
EXP ISO |
EPO protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione] EPO protein inhibits the reaction [Cisplatin results in decreased abundance of Glutathione] |
CTD |
PMID:16405037 PMID:22013135 |
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NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Extl1 |
exostosin-like glycosyltransferase 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of EXTL1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115
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G |
F3 |
coagulation factor III, tissue factor |
increases activity |
ISO |
Glutathione results in increased activity of F3 protein |
CTD |
PMID:17726162 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fahd1 |
fumarylacetoacetate hydrolase domain containing 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of FAHD1 mRNA |
CTD |
PMID:20621112 |
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NCBI chr10:13,873,539...13,874,978
Ensembl chr10:13,873,527...13,875,012
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G |
Fas |
Fas cell surface death receptor |
multiple interactions affects chemical synthesis |
ISO |
[FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; FAS protein affects the reaction [Acetaminophen affects the chemical synthesis of Glutathione]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein] FAS protein affects the chemical synthesis of Glutathione |
CTD |
PMID:10385654 PMID:23628456 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
decreases abundance multiple interactions |
ISO |
FASL protein results in decreased abundance of Glutathione Glutathione inhibits the reaction [Acrolein results in increased expression of FASL protein] verlukast promotes the reaction [FASL protein results in decreased abundance of Glutathione] |
CTD |
PMID:17724027 PMID:24376112 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
decreases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in decreased expression of FASN mRNA Glutathione inhibits the reaction [Alcohols results in increased expression of FASN protein] |
CTD |
PMID:20621112 PMID:28803762 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fgf1 |
fibroblast growth factor 1 |
multiple interactions |
EXP |
2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]; FGF1 protein results in increased abundance of and results in increased secretion of Glutathione |
CTD |
PMID:16524372 |
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NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] |
CTD |
PMID:19524604 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fndc5 |
fibronectin type III domain containing 5 |
multiple interactions increases abundance |
ISO EXP |
FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione] FNDC5 protein results in increased abundance of Glutathione |
CTD |
PMID:30703374 PMID:32165127 |
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NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Glutathione affects the reaction [Sodium Selenite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] |
CTD |
PMID:15105052 PMID:15520183 PMID:18449455 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA] |
CTD |
PMID:15520183 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Foxa2 |
forkhead box A2 |
multiple interactions |
ISO |
Glutathione affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of FOXA2 mRNA]; Glutathione affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of FOXA2 protein] |
CTD |
PMID:36689145 |
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NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Glutathione inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] |
CTD |
PMID:20580664 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA] |
CTD |
PMID:16631525 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Ftl1 |
ferritin light chain 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of FTL1 protein] |
CTD |
PMID:15175009 |
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NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein] |
CTD |
PMID:14572611 |
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NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
ISO EXP |
Glutathione inhibits the reaction [Quartz results in decreased activity of G6PDX protein] Glutathione inhibits the reaction [Asbestos, Amosite results in decreased activity of G6PD protein] Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA] |
CTD |
PMID:14613721 PMID:15225644 PMID:18370412 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO EXP |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]; [GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog; Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Glutathione results in increased metabolism of and results in increased activity of GAPDH protein modified form; NAD analog inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NADP inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] Glutathione inhibits the reaction [arsenite results in decreased expression of GAPDH protein] |
CTD |
PMID:15175009 PMID:15788719 PMID:21827172 |
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NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gch1 |
GTP cyclohydrolase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of GCH1 mRNA |
CTD |
PMID:15345336 |
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NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases abundance increases expression affects chemical synthesis |
ISO EXP |
[[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride; [Ginkgo biloba extract results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]] GCLC mRNA results in increased abundance of Glutathione; GCLC protein results in increased abundance of Glutathione [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione; [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein; [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione]; GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione]; GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione] Glutathione deficiency results in increased expression of GCLC mRNA GCLC polymorphism affects the chemical synthesis of Glutathione [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:7955076 PMID:10544272 PMID:11673643 PMID:12504668 PMID:14978233 PMID:15282320 PMID:15345336 PMID:15707499 PMID:16599007 PMID:17724089 PMID:18556457 PMID:19914271 PMID:20159942 PMID:20621112 PMID:21728338 PMID:21833590 PMID:22762311 PMID:23628456 PMID:26187465 More...
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases abundance increases chemical synthesis affects response to substance affects metabolic processing decreases abundance increases expression |
ISO EXP |
[Chenodeoxycholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]; GCLM gene SNP results in decreased chemical synthesis of and results in decreased abundance of Glutathione GCLM gene SNP results in increased abundance of Glutathione GCLM protein results in increased chemical synthesis of Glutathione GCLM protein affects the susceptibility to Glutathione GCLM protein affects the metabolism of Glutathione GCLM gene mutant form results in decreased abundance of Glutathione; GCLM protein mutant form results in decreased abundance of Glutathione Glutathione deficiency results in increased expression of GCLM mRNA [GCLM gene mutant form results in decreased abundance of Glutathione] which results in decreased susceptibility to Benzo(a)pyrene; [GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein; GCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:12975258 PMID:15345336 PMID:17584759 PMID:17724089 PMID:20159942 PMID:20417186 PMID:20621112 PMID:22253057 PMID:23135907 PMID:23704229 PMID:24107266 PMID:25446851 PMID:32715377 More...
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
ISO |
[acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; [hexylglutathione results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; GGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione] |
CTD |
PMID:15629191 PMID:19419996 |
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NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Glrx |
glutaredoxin |
multiple interactions |
ISO EXP |
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] [GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] |
CTD |
PMID:12680778 PMID:20025242 PMID:24451382 |
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NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
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G |
Glrx3 |
glutaredoxin 3 |
multiple interactions |
ISO |
[frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione |
CTD |
PMID:30661989 |
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NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
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G |
Gne |
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of GNE mRNA |
CTD |
PMID:20621112 |
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NCBI chr 5:58,267,189...58,307,396
Ensembl chr 5:58,267,210...58,307,499
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G |
Gnl3 |
G protein nucleolar 3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of GNL3 mRNA |
CTD |
PMID:20621112 |
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NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
Glutathione inhibits the reaction [Methyl Parathion results in increased activity of GPT protein] Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of GPT protein] |
CTD |
PMID:20100039 PMID:36689145 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
[GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; GPX1 protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] |
CTD |
PMID:16636302 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gsdme |
gasdermin E |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Diquat results in increased cleavage of GSDME protein] |
CTD |
PMID:38128689 |
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NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases abundance |
ISO |
GSK3B protein mutant form results in increased abundance of Glutathione |
CTD |
PMID:25246272 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases activity affects activity increases expression |
ISO EXP |
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate Glutathione results in decreased activity of GSR protein Glutathione inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein] Glutathione deficiency affects the activity of GSR protein Glutathione deficiency results in increased expression of GSR mRNA 1'-acetoxychavicol acetate analog inhibits the reaction [GSR protein results in increased reduction of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; Glutathione inhibits the reaction [Alcohols results in decreased expression of GSR protein] |
CTD |
PMID:15345336 PMID:15707499 PMID:17272743 PMID:20025242 PMID:20230805 PMID:23172834 PMID:24038001 PMID:28803762 More...
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gss |
glutathione synthetase |
multiple interactions |
ISO |
[Arsenic results in increased expression of GSS protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:18487201 |
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NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions affects binding affects metabolic processing |
ISO EXP |
GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione] Glutathione binds to GSTA1 protein [GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]; GSTA1 protein affects the metabolism of [2-hydroxymenthofuran co-treated with Glutathione] GSTA1 protein affects the metabolism of Glutathione |
CTD |
PMID:3783048 PMID:7712478 PMID:8886613 PMID:9084911 PMID:9877184 PMID:10437668 PMID:10496977 PMID:10751412 PMID:11115505 PMID:11368548 PMID:11849043 PMID:12147362 PMID:12516103 PMID:14690442 PMID:16890185 More...
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NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions affects metabolic processing |
ISO EXP |
[GSTA2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine GSTA2 protein affects the metabolism of Glutathione [GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; GSTA2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione] |
CTD |
PMID:8973562 PMID:9084911 PMID:9877184 PMID:28478157 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
affects metabolic processing multiple interactions increases expression |
EXP |
GSTA3 protein affects the metabolism of Glutathione Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]] Glutathione deficiency results in increased expression of GSTA3 mRNA |
CTD |
PMID:3783048 PMID:6095330 PMID:15345336 |
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NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
affects metabolic processing multiple interactions |
ISO EXP |
GSTA4 protein affects the metabolism of Glutathione [GSTA4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine |
CTD |
PMID:14727915 PMID:28478157 |
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NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of GSTA5 mRNA |
CTD |
PMID:15345336 |
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NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstk1 |
glutathione S-transferase kappa 1 |
multiple interactions |
ISO |
[diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA |
CTD |
PMID:22564015 |
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NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
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G |
Gstm1 |
glutathione S-transferase mu 1 |
multiple interactions decreases abundance affects metabolic processing increases expression affects binding |
ISO EXP |
4-O-decyl-gabosine D inhibits the reaction [Glutathione binds to GSTM1 protein]; [GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; GSTM1 protein affects the metabolism of [1,2,5,6-dibenzanthracene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione]; GSTM1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Benzo(a)pyrene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [chrysene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione] GSTM1 gene mutant form results in decreased abundance of Glutathione Glutathione analog binds to and results in decreased activity of GSTM1 protein; GSTM1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione analog]; GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione] GSTM1 protein affects the metabolism of Glutathione Glutathione deficiency results in increased expression of GSTM1 mRNA |
CTD |
PMID:1883342 PMID:2604743 PMID:2904809 PMID:6095330 PMID:7826396 PMID:8886613 PMID:8973562 PMID:9084911 PMID:9403173 PMID:9545290 PMID:11368548 PMID:11849043 PMID:14979731 PMID:15345336 PMID:21925487 PMID:22085405 PMID:25420021 More...
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
affects metabolic processing multiple interactions |
ISO EXP |
GSTM2 protein affects the metabolism of Glutathione GSTM5 protein affects the metabolism of Glutathione [GSTM2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine Dinitrochlorobenzene promotes the reaction [GSTM2 protein affects the metabolism of Glutathione]; GSTM2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione] |
CTD |
PMID:2604743 PMID:8924604 PMID:8973562 PMID:9545290 PMID:9794801 PMID:10858281 PMID:28478157 More...
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm4 |
glutathione S-transferase mu 4 |
multiple interactions |
ISO |
[GSTM4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTM4 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione] |
CTD |
PMID:8203914 PMID:28478157 |
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NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
affects metabolic processing |
ISO |
GSTM3 protein affects the metabolism of Glutathione |
CTD |
PMID:9545290 |
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NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Gstm5l |
glutathione S-transferase, mu 5-like |
affects metabolic processing |
EXP |
GSTM5 protein affects the metabolism of Glutathione |
CTD |
PMID:9545290 |
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NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity multiple interactions increases expression affects metabolic processing |
ISO EXP |
Glutathione analog results in decreased activity of GSTP1 protein GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione] Glutathione deficiency results in increased expression of GSTP1 mRNA GSTP1 protein affects the metabolism of Glutathione Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein]; GSTP1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione] [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2A6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTP1 gene affects the reaction [Glutathione affects the metabolism of Thiotepa]; GSTP1 protein affects the metabolism of [4-oxo-2-nonenal co-treated with Glutathione]; GSTP1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of [acrylodan co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)phenanthrene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(g)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTP1 protein promotes the reaction [Glutathione binds to Atrazine]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] |
CTD |
PMID:7712478 PMID:7826396 PMID:8886613 PMID:8973562 PMID:9403173 PMID:9877184 PMID:10334868 PMID:11196146 PMID:11368548 PMID:11849043 PMID:12470677 PMID:13679171 PMID:15115887 PMID:15528046 PMID:18607078 PMID:20570720 PMID:20621112 PMID:24246759 PMID:28478157 More...
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gstt1 |
glutathione S-transferase theta 1 |
affects metabolic processing multiple interactions |
ISO EXP |
GSTT1 protein affects the metabolism of Glutathione GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione] GSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]; GSTT1 protein promotes the reaction [diepoxybutane binds to Glutathione] |
CTD |
PMID:14727918 PMID:14998683 PMID:15533900 PMID:33381973 |
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NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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G |
Gstz1 |
glutathione S-transferase zeta 1 |
affects metabolic processing affects binding multiple interactions |
ISO |
GSTZ1 protein affects the metabolism of Glutathione Glutathione binds to GSTZ1 protein GSTZ1 protein binds to and affects the metabolism of Glutathione |
CTD |
PMID:1846734 PMID:9396740 PMID:11327815 PMID:12852784 PMID:15173170 |
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NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AX protein] Glutathione inhibits the reaction [rubimaillin results in increased phosphorylation of H2AX protein] |
CTD |
PMID:21722719 PMID:35007525 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HADHA mRNA |
CTD |
PMID:15345336 |
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NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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G |
Has2 |
hyaluronan synthase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA] |
CTD |
PMID:21220312 |
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NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
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G |
Hfe |
homeostatic iron regulator |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HFE mRNA |
CTD |
PMID:15345336 |
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NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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G |
Hgf |
hepatocyte growth factor |
increases abundance multiple interactions |
EXP |
HGF protein results in increased abundance of Glutathione [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:10544272 |
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NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [Vanadates results in increased expression of HIF1A protein] |
CTD |
PMID:11641398 PMID:16678800 PMID:17658243 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hk2 |
hexokinase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Ivermectin results in decreased expression of HK2 protein] |
CTD |
PMID:34904774 |
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NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HMGCR mRNA |
CTD |
PMID:15345336 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression affects expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; [Acetylcysteine results in increased abundance of Glutathione] inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]; [Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Air Pollutants results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]] [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [resveratrol results in increased abundance of Glutathione]; Glutathione inhibits the reaction [arsenite results in increased expression of HMOX1 protein] Glutathione deficiency results in increased expression of HMOX1 mRNA; Glutathione results in increased expression of HMOX1 mRNA Glutathione affects the expression of HMOX1 mRNA |
CTD |
PMID:8743975 PMID:12420312 PMID:15175009 PMID:15602829 PMID:16631525 PMID:18078826 PMID:18332044 PMID:20020861 PMID:20621112 PMID:20888885 PMID:20934533 PMID:20961405 PMID:21971136 PMID:23649983 PMID:23691207 PMID:26945724 More...
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
increases expression |
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