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ONTOLOGY REPORT - ANNOTATIONS


Term:baclofen
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Accession:CHEBI:2972 term browser browse the term
Definition:A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.
Synonyms:exact_synonym: 4-amino-3-(4-chlorophenyl)butanoic acid
 related_synonym: 4-Amino-3-(4-chlorophenyl)butyric acid;   DL-4-Amino-3-p-chlorophenylbutanoic acid;   DL-Baclofen;   Formula=C10H12ClNO2;   InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14);   InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N;   SMILES=NCC(CC(O)=O)c1ccc(Cl)cc1;   baclofene;   baclofeno;   baclofenum;   beta-(4-Chlorophenyl)gaba;   beta-(Aminomethyl)-4-chlorobenzenepropanoic acid;   beta-(Aminomethyl)-p-chlorohydrocinnamic acid;   beta-(p-Chlorophenyl)-gamma-aminobutyric acid;   gamma-Amino-beta-(p-chlorophenyl)butyric acid
 xref: Beilstein:2104494 "Beilstein";   CAS:1134-47-0 "ChemIDplus";   CAS:1134-47-0 "NIST Chemistry WebBook";   DrugBank:DB00181;   Drug_Central:282 "DrugCentral";   HMDB:HMDB0014327;   KEGG:D00241;   LINCS:LSM-5169
 xref_mesh: MESH:D001418
 xref: PMID:11772961 "Europe PMC";   PMID:18682277 "Europe PMC";   PMID:18824012 "Europe PMC";   Patent:NL6407755;   Patent:US3471548;   Reaxys:2104494 "Reaxys";   Wikipedia:Baclofen


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baclofen term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 JBrowse link 20 1,955,344 1,984,907 RGD:6480464
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 JBrowse link 5 62,276,100 62,621,737 RGD:6480464
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 JBrowse link 11 35,011,007 35,262,362 RGD:6480464
G Maob monoamine oxidase B JBrowse link X 6,430,694 6,533,520 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Pdyn prodynorphin JBrowse link 3 122,194,327 122,206,671 RGD:6480464
G Penk proenkephalin JBrowse link 5 17,056,412 17,061,762 RGD:6480464
G Ryr1 ryanodine receptor 1 JBrowse link 1 87,959,596 88,066,252 RGD:6480464
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:6480464
G Scg2 secretogranin II JBrowse link 9 85,237,460 85,243,024 RGD:6480464
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            central nervous system drug 16260
              central nervous system depressant 15980
                baclofen 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        amino acid 12313
                                          non-proteinogenic amino acid 1726
                                            gamma-amino acid 129
                                              baclofen 18
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