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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:baclofen
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Accession:CHEBI:2972 term browser browse the term
Definition:A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.
Synonyms:exact_synonym: 4-amino-3-(4-chlorophenyl)butanoic acid
 related_synonym: 4-Amino-3-(4-chlorophenyl)butyric acid;   DL-4-Amino-3-p-chlorophenylbutanoic acid;   DL-Baclofen;   Formula=C10H12ClNO2;   InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14);   InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N;   SMILES=NCC(CC(O)=O)c1ccc(Cl)cc1;   baclofene;   baclofeno;   baclofenum;   beta-(4-Chlorophenyl)gaba;   beta-(Aminomethyl)-4-chlorobenzenepropanoic acid;   beta-(Aminomethyl)-p-chlorohydrocinnamic acid;   beta-(p-Chlorophenyl)-gamma-aminobutyric acid;   gamma-Amino-beta-(p-chlorophenyl)butyric acid
 xref: Beilstein:2104494;   CAS:1134-47-0;   DrugBank:DB00181;   Drug_Central:282;   HMDB:HMDB0014327;   KEGG:D00241;   LINCS:LSM-5169
 xref_mesh: MESH:D001418
 xref: PMID:11772961;   PMID:18682277;   PMID:18824012;   Patent:NL6407755;   Patent:US3471548;   Reaxys:2104494;   Wikipedia:Baclofen
 cyclic_relationship: is_tautomer_of CHEBI:187893



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baclofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Baclofen CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Baclofen promotes the reaction [Isoproterenol results in increased activity of CFTR protein] CTD PMID:15151902 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Baclofen inhibits the reaction [Amphetamine affects the phosphorylation of CREB1 protein] CTD PMID:16983645 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Drd3 dopamine receptor D3 decreases expression EXP Baclofen results in decreased expression of DRD3 mRNA CTD PMID:7878047 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
Baclofen inhibits the reaction [Cocaine results in increased expression of FOS protein] CTD PMID:16710312 PMID:16930414 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression
multiple interactions
EXP Baclofen results in decreased expression of FSHB protein
Baclofen inhibits the reaction [Diethylhexyl Phthalate results in increased expression of FSHB protein]
CTD PMID:29774754 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 increases response to substance ISO GABBR1 results in increased susceptibility to Baclofen CTD PMID:16990508 PMID:20138995 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 increases response to substance ISO GABBR2 results in increased susceptibility to Baclofen CTD PMID:20138995 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 increases response to substance ISO KCNJ6 results in increased susceptibility to Baclofen CTD PMID:12836919 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
multiple interactions
EXP Baclofen results in decreased expression of LHB protein
Baclofen inhibits the reaction [Diethylhexyl Phthalate results in increased expression of LHB protein]
CTD PMID:29774754 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO Baclofen affects the reaction [MAOB gene mutant form results in decreased susceptibility to Amphetamine] CTD PMID:16983645 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Baclofen results in increased phosphorylation of MAPK1 protein
CGP 56999A inhibits the reaction [Baclofen results in increased phosphorylation of MAPK1 protein]
CTD PMID:24668805 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP CGP 56999A inhibits the reaction [Baclofen results in increased phosphorylation of MAPK3 protein] CTD PMID:24668805 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Pdyn prodynorphin multiple interactions EXP Baclofen inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA] CTD PMID:15033416 PMID:15592348 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Penk proenkephalin multiple interactions EXP Baclofen inhibits the reaction [Amphetamine results in increased expression of PENK mRNA] CTD PMID:15033416 PMID:15592348 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO Baclofen inhibits the reaction [A 68930 results in increased expression of RYR1 protein]; Baclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR1 protein] CTD PMID:22504960 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions ISO Baclofen inhibits the reaction [A 68930 results in increased expression of RYR2 protein]; Baclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein] CTD PMID:22504960 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Scg2 secretogranin II multiple interactions EXP Baclofen inhibits the reaction [Amphetamine results in increased expression of SCG2 mRNA] CTD PMID:15033416 PMID:15592348 NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Baclofen inhibits the reaction [Amphetamine results in increased expression of TAC1 mRNA] CTD PMID:15033416 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO Baclofen results in decreased secretion of TNF protein CTD PMID:20201957 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            central nervous system drug 16568
              central nervous system depressant 16089
                baclofen 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        amino acid 14920
                                          non-proteinogenic amino acid 2022
                                            gamma-amino acid 178
                                              baclofen 20
paths to the root