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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiostrepton
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Accession:CHEBI:29693 term browser browse the term
Definition:A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitumor agent.
Synonyms:related_synonym: Formula=C72H85N19O18S5;   InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15-/t26-,30-,31-,32-,33+,34+,35+,39+,45+,47-,48-,49-,51-,52+,53+,71+,72+/m0/s1;   InChIKey=NSFFHOGKXHRQEW-AIHSUZKVSA-N;   SMILES=[H][C@]12N=C(CC[C@@]11NC(=O)[C@H](C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N[C@@H]3C=Cc4c(cc(nc4[C@H]3O)C(=O)O[C@H](C)[C@H](NC(=O)c3csc(n3)[C@@H](NC(=O)[C@H]3CSC(=N3)\\C(NC(=O)[C@@H](NC(=O)c3csc1n3)[C@@H](C)O)=C\\C)[C@](C)(O)[C@@H](C)O)c1nc2cs1)[C@H](C)O)[C@@H](C)CC)c1nc(cs1)C(=O)NC(=C)C(=O)NC(=C)C(N)=O
 xref: CAS:1393-48-2;   KEGG:C12054;   KEGG:D06111;   KNApSAcK:C00000753
 xref_mesh: MESH:D013883
 xref: PMID:16076225;   PMID:21107477;   PMID:21323347;   PMID:21365012;   PMID:21620902;   PMID:21860463;   PMID:21903609;   PMID:21908407;   PMID:22049175;   PMID:22108865;   PMID:22271891;   PMID:22321511;   PMID:22353937;   PMID:22357874;   PMID:22391527;   Reaxys:7390758;   VSDB:3007;   Wikipedia:Thiostrepton


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thiostrepton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Thiostrepton results in increased expression of BAX protein CTD PMID:22321511 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Thiostrepton results in decreased expression of BCL2 protein CTD PMID:22321511 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Thiostrepton results in decreased expression of BCL2L1 mRNA CTD PMID:22321511 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Thiostrepton results in decreased expression of CCL3 mRNA CTD PMID:22321511 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Thiostrepton results in decreased expression of CCL4 mRNA CTD PMID:22321511 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Thiostrepton results in decreased expression of CCND1 mRNA CTD PMID:22321511 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Thiostrepton results in increased expression of CDKN1A mRNA CTD PMID:22321511 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cryab crystallin, alpha B increases expression ISO Thiostrepton results in increased expression of CRYAB mRNA CTD PMID:22321511 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Thiostrepton results in decreased expression of CYP1A1 mRNA CTD PMID:22321511 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO Thiostrepton results in decreased expression of CYP2E1 mRNA CTD PMID:22321511 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Thiostrepton results in increased expression of DDIT3 mRNA CTD PMID:22321511 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO Thiostrepton results in increased expression of DNAJA1 mRNA CTD PMID:22321511 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Thiostrepton results in increased expression of DNAJB4 mRNA CTD PMID:22321511 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression ISO Thiostrepton results in increased expression of EIF2S1 protein modified form CTD PMID:22321511 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Thiostrepton results in increased expression of GADD45A mRNA CTD PMID:22321511 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Thiostrepton results in increased expression of GDF15 mRNA CTD PMID:22321511 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Thiostrepton results in increased expression of GSR mRNA CTD PMID:22321511 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Thiostrepton inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Thiostrepton results in increased expression of HMOX1 mRNA; Thiostrepton results in increased expression of HMOX1 protein CTD PMID:22321511 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO Thiostrepton results in increased expression of HSP90AB1 mRNA CTD PMID:22321511 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Thiostrepton results in increased expression of HSPA1A mRNA; Thiostrepton results in increased expression of HSPA1A protein CTD PMID:22321511 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO Thiostrepton results in increased expression of HSPA1L mRNA CTD PMID:22321511 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO Thiostrepton results in increased expression of HSPA2 mRNA CTD PMID:22321511 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO Thiostrepton results in increased expression of HSPA4 mRNA CTD PMID:22321511 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Thiostrepton results in increased expression of HSPA5 mRNA CTD PMID:22321511 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Thiostrepton results in increased expression of HSPA8 mRNA CTD PMID:22321511 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Thiostrepton results in increased expression of HSPB1 mRNA CTD PMID:22321511 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Thiostrepton results in increased expression of HSPD1 mRNA CTD PMID:22321511 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Thiostrepton results in increased expression of HSPH1 mRNA CTD PMID:22321511 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Thiostrepton results in decreased expression of IL1A mRNA CTD PMID:22321511 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Thiostrepton results in decreased expression of IL1B mRNA CTD PMID:22321511 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
increases expression
ISO Thiostrepton results in decreased expression of MCL1 protein
Thiostrepton results in increased expression of MCL1 protein
CTD PMID:22321511 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO Thiostrepton results in decreased expression of NFKB1 mRNA CTD PMID:22321511 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Thiostrepton results in increased expression of PMAIP1 protein CTD PMID:22321511 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Thiostrepton results in increased expression of PTGS1 mRNA CTD PMID:22321511 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Thiostrepton results in increased expression of SOD1 mRNA CTD PMID:22321511 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Thiostrepton results in decreased expression of TP53 mRNA; Thiostrepton results in decreased expression of TP53 protein CTD PMID:22321511 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xrcc2 X-ray repair cross complementing 2 decreases expression ISO Thiostrepton results in decreased expression of XRCC2 mRNA CTD PMID:22321511 NCBI chr 4:5,842,013...5,860,516
Ensembl chr 4:5,841,998...5,860,527
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            thiostrepton 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                peptide 9391
                                                  cyclic peptide 8720
                                                    heterodetic cyclic peptide 1437
                                                      thiostrepton 38
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