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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rifamycin SV
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Accession:CHEBI:29673 term browser browse the term
Definition:A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.
Synonyms:exact_synonym: (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
 related_synonym: Formula=C37H47NO12;   InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1;   InChIKey=HJYYPODYNSCCOU-ODRIEIDWSA-N;   Rifamycin;   Rifocin;   Rifocyn;   SMILES=CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C2=O)c2c(O)cc(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C;   rifamicina;   rifamycine;   rifamycinum
 xref: CAS:6998-60-3;   Drug_Central:4817;   KEGG:C12044;   KEGG:D02549;   LIPID_MAPS_instance:LMPK05000005
 xref_mesh: MESH:C023808
 xref: MetaCyc:CPD-10236;   PMID:25256628;   Reaxys:5401012
 cyclic_relationship: is_conjugate_acid_of CHEBI:84571


show annotations for term's descendants           Sort by:
 
rifamycin SV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO rifamycin SV results in decreased activity of ABCB11 protein CTD PMID:11343252 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Crp C-reactive protein affects expression ISO rifamycin SV affects the expression of CRP protein CTD PMID:1568518 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
decreases activity
ISO rifamycin SV inhibits the reaction [SLCO1B3 protein results in increased import of 8-sulfocholecystokinin octapeptide]
rifamycin SV results in decreased activity of SLCO1B3 protein
CTD PMID:27450509, PMID:31364238 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          rifamycin SV 3
            rifamycin SV hemiaminal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                lactam 8026
                                                  ansamycin 835
                                                    rifamycins 390
                                                      rifamycin SV 3
                                                        rifamycin SV hemiaminal 0
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