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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-(3-oxododecanoyl)homoserine lactone
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Accession:CHEBI:29639 term browser browse the term
Definition:A N-acyl homoserine lactone that is the monocarboxylic acid amide arising from formal condensation of homoserine lactone with 3-oxododecanoic acid.
Synonyms:exact_synonym: 3-oxo-N-(2-oxotetrahydrofuran-3-yl)dodecanamide
 related_synonym: 3-Oxo-N-(tetrahydro-2-oxo-3-furanyl)dodecanamide;   3-oxo-C12-AHL;   3-oxo-C12-HSL;   Formula=C16H27NO4;   InChI=1S/C16H27NO4/c1-2-3-4-5-6-7-8-9-13(18)12-15(19)17-14-10-11-21-16(14)20/h14H,2-12H2,1H3,(H,17,19);   InChIKey=PHSRRHGYXQCRPU-UHFFFAOYSA-N;   N-(3-ketododecanoyl)homoserine lactone;   PA Autoinducer;   Pseudomonas aeruginosa autoinducer;   SMILES=CCCCCCCCCC(=O)CC(=O)NC1CCOC1=O
 xref: CAS:152833-54-0;   KEGG:C11840;   LIPID_MAPS_instance:LMFA08030001
 xref_mesh: MESH:C109860
 xref: PMID:12837389;   PMID:14500500;   PMID:15060029;   PMID:15328111;   PMID:16984415;   PMID:17400249;   PMID:18178738;   PMID:18452426;   PMID:18465897;   PMID:21190852;   PMID:21305014;   PMID:7878006;   PMID:8830697;   Reaxys:10100143


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N-(3-oxododecanoyl)homoserine lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP3 protein CTD PMID:25627690 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP7 protein CTD PMID:25627690 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G P2RY2 purinergic receptor P2Y2 multiple interactions
decreases expression
EXP Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr11:73,200,416...73,246,743
Ensembl chr11:73,218,281...73,242,427
Ensembl chr11:73,218,281...73,242,427
JBrowse link
G P2RY4 pyrimidinergic receptor P2Y4 decreases expression EXP N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA CTD PMID:10496880 NCBI chr  X:70,258,166...70,260,204
Ensembl chr  X:70,258,170...70,259,764
JBrowse link
G PON2 paraoxonase 2 increases response to substance EXP PON2 protein results in increased susceptibility to N-(3-oxododecanoyl)homoserine lactone CTD PMID:25627690 NCBI chr 7:95,404,862...95,435,028
Ensembl chr 7:95,404,862...95,435,329
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24481
    role 24392
      biological role 24359
        molecular messenger 19192
          signalling molecule 8504
            autoinducer 5
              N-acyl homoserine lactone 5
                N-(3-oxododecanoyl)homoserine lactone 5
                  N-(3-oxododecanoyl)-D-homoserine lactone 0
                  N-(3-oxododecanoyl)-L-homoserine lactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24481
    subatomic particle 24438
      composite particle 24438
        hadron 24438
          baryon 24438
            nucleon 24438
              atomic nucleus 24438
                atom 24438
                  main group element atom 24295
                    p-block element atom 24295
                      carbon group element atom 24079
                        carbon atom 24040
                          organic molecular entity 24040
                            organic group 22406
                              organic divalent group 22383
                                organodiyl group 22383
                                  carbonyl group 22368
                                    carbonyl compound 22368
                                      carboxylic acid 21367
                                        carboacyl group 19575
                                          univalent carboacyl group 19575
                                            carbamoyl group 19003
                                              carboxamide 19003
                                                monocarboxylic acid amide 15716
                                                  N-acyl homoserine lactone 5
                                                    N-(3-oxododecanoyl)homoserine lactone 5
                                                      N-(3-oxododecanoyl)-D-homoserine lactone 0
                                                      N-(3-oxododecanoyl)-L-homoserine lactone 0
paths to the root