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ONTOLOGY REPORT - ANNOTATIONS


Term:ascomycin
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Accession:CHEBI:29582 term browser browse the term
Definition:A macrolide that is produced by the fermentation of Streptomyces hygroscopicus and exhibits strong immunosuppressant properties.
Synonyms:exact_synonym: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-ethyl-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
 related_synonym: FK 520;   FK520;   FR 900520;   Formula=C43H69NO12;   Immunomycin;   InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35+,36-,37-,38+,39+,43+/m0/s1;   InChIKey=ZDQSOHOQTUFQEM-NURRSENYSA-N;   L 683590;   SMILES=CC[C@@H]1\\C=C(C)\\C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)C(\\C)=C\\[C@@H]1CC[C@@H](O)[C@@H](C1)OC
 xref: CAS:104987-12-4 "ChemIDplus";   CAS:104987-12-4 "KEGG COMPOUND";   KEGG:C12102;   KNApSAcK:C00017631
 xref_mesh: MESH:C058028
 xref: PMID:21833838 "Europe PMC";   PMID:23435975 "Europe PMC";   PMID:24628911 "Europe PMC";   PMID:3198493 "Europe PMC";   PMID:7520900 "Europe PMC";   Reaxys:5372600 "Reaxys";   Wikipedia:Ascomycin


show annotations for term's descendants       view all columns           Sort by:
 
ascomycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fkbp1a FKBP prolyl isomerase 1A JBrowse link 3 147,042,944 147,062,725 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        immunomodulator 12649
          immunosuppressive agent 11917
            ascomycin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic ester 13930
                                        lactone 5862
                                          macrocyclic lactone 1516
                                            macrolide 1455
                                              ascomycin 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.