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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azelastine
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Accession:CHEBI:2950 term browser browse the term
Definition:A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.
Synonyms:exact_synonym: 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one
 related_synonym: 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone;   Formula=C22H24ClN3O;   InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3;   InChIKey=MBUVEWMHONZEQD-UHFFFAOYSA-N;   SMILES=CN1CCCC(CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O;   azelastina;   azelastinum
 xref: Beilstein:900747;   CAS:58581-89-8;   DrugBank:DB00972;   Drug_Central:271;   KEGG:C07768;   KEGG:D07483;   LINCS:LSM-5127
 xref_mesh: MESH:C020976
 xref: PMID:22339679;   Patent:BE778269;   Patent:US3813384;   Reaxys:900747;   Wikipedia:Azelastine


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azelastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
ISO azelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
azelastine results in decreased activity of ABCB1 protein
CTD PMID:11231118 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO azelastine results in decreased expression of COL1A1 mRNA CTD PMID:8919039 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO azelastine results in decreased expression of COL3A1 mRNA CTD PMID:8919039 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO azelastine results in decreased expression of COL6A1 mRNA CTD PMID:8919039 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO azelastine binds to HRH1 protein CTD PMID:2540229 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO azelastine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO azelastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        anti-asthmatic agent 9229
          anti-asthmatic drug 8597
            azelastine 7
              (R)-azelastine 0
              (S)-azelastine 0
              azelastine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8677
                                          azelastine 7
                                            (R)-azelastine 0
                                            (S)-azelastine 0
                                            azelastine hydrochloride 0
paths to the root